A Proinflammatory Cytokine Inhibits p53 Tumor Suppressor Activity

doi:10.1084/jem.190.10.1375

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© The Rockefeller University Press, 0022-1007/1999/11/1375/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 10, November 15, 1999 1375-1382

Original Article

A Proinflammatory Cytokine Inhibits p53 Tumor Suppressor Activity

James D. Hudson^a, Mahmood A. Shoaibi^a, Roberta Maestro^b, Amancio Carnero^a, Gregory J. Hannon^c, and David H. Beach^a
^a Unit of Cancer Biology, Institute of Child Health, London WC1N 1EH, United Kingdom
^b Experimental Oncology 1, Centro di Riferimento Oncologico, 33081 Aviano, Italy
^c Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724

Correspondence to: David H. Beach, Institute of Child Health, University College London, Cruciform Building, Gower Street, London WC1E 6BT, UK. Tel:171-813-8495 Fax:171-813-0358 E-mail:D.Beach{at}ich.ucl.ac.uk.

p53 has a key role in the negative regulation of cell proliferation,in the maintenance of genomic stability, and in the suppressionof transformation and tumorigenesis. To identify novel regulatorsof p53, we undertook two functional screens to isolate geneswhich bypassed either p53-mediated growth arrest or apoptosis.In both screens, we isolated cDNAs encoding macrophage migrationinhibitory factor (MIF), a cytokine that was shown previouslyto exert both local and systemic proinflammatory activities.Treatment with MIF overcame p53 activity in three differentbiological assays, and suppressed its activity as a transcriptionalactivator. The observation that a proinflammatory cytokine,MIF, is capable of functionally inactivating a tumor suppressor,p53, may provide a link between inflammation and tumorigenesis.

Key Words: macrophage migration inhibitory factor, p53, inflammation andcancer, growth arrest, apoptosis

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Nguyen, M. T., Lue, H., Kleemann, R., Thiele, M., Tolle, G., Finkelmeier, D., Wagner, E., Braun, A., Bernhagen, J. (2003). The Cytokine Macrophage Migration Inhibitory Factor Reduces Pro-Oxidative Stress-Induced Apoptosis. J. Immunol. 170: 3337-3347 [Abstract] [Full Text]
Yamada, H., Kato, E. H., Morikawa, M., Shimada, S., Saito, H., Watari, M., Minakami, H., Nishihira, J. (2003). Decreased serum levels of macrophage migration inhibition factor in miscarriages with normal chromosome karyotype. Hum Reprod 18: 616-620 [Abstract] [Full Text]
White, E. S., Flaherty, K. R., Carskadon, S., Brant, A., Iannettoni, M. D., Yee, J., Orringer, M. B., Arenberg, D. A. (2003). Macrophage Migration Inhibitory Factor and CXC Chemokine Expression in Non-Small Cell Lung Cancer: Role in Angiogenesis and Prognosis. Clin. Cancer Res. 9: 853-860 [Abstract] [Full Text]
Hofseth, L. J., Saito, S.'i., Hussain, S. P., Espey, M. G., Miranda, K. M., Araki, Y., Jhappan, C., Higashimoto, Y., He, P., Linke, S. P., Quezado, M. M., Zurer, I., Rotter, V., Wink, D. A., Appella, E., Harris, C. C. (2003). Nitric oxide-induced cellular stress and p53 activation in chronic inflammation. Proc. Natl. Acad. Sci. USA 100: 143-148 [Abstract] [Full Text]
Liao, H., Bucala, R., Mitchell, R. A. (2003). Adhesion-dependent Signaling by Macrophage Migration Inhibitory Factor (MIF). J. Biol. Chem. 278: 76-81 [Abstract] [Full Text]
Fingerle-Rowson, G., Koch, P., Bikoff, R., Lin, X., Metz, C. N., Dhabhar, F. S., Meinhardt, A., Bucala, R. (2003). Regulation of Macrophage Migration Inhibitory Factor Expression by Glucocorticoids in Vivo. Am. J. Pathol. 162: 47-56 [Abstract] [Full Text]
Tomiyasu, M., Yoshino, I., Suemitsu, R., Okamoto, T., Sugimachi, K. (2002). Quantification of Macrophage Migration Inhibitory Factor mRNA Expression in Non-Small Cell Lung Cancer Tissues and Its Clinical Significance. Clin. Cancer Res. 8: 3755-3760 [Abstract] [Full Text]
Zheng, M., McKeown-Longo, P. J. (2002). Regulation of HEF1 Expression and Phosphorylation by TGF-beta 1 and Cell Adhesion. J. Biol. Chem. 277: 39599-39608 [Abstract] [Full Text]
Arndt, U., Wennemuth, G., Barth, P., Nain, M., Al-Abed, Y., Meinhardt, A., Gemsa, D., Bacher, M. (2002). Release of Macrophage Migration Inhibitory Factor and CXCL8/Interleukin-8 from Lung Epithelial Cells Rendered Necrotic by Influenza A Virus Infection. J. Virol. 76: 9298-9306 [Abstract] [Full Text]
Lubetsky, J. B., Dios, A., Han, J., Aljabari, B., Ruzsicska, B., Mitchell, R., Lolis, E., Al-Abed, Y. (2002). The Tautomerase Active Site of Macrophage Migration Inhibitory Factor Is a Potential Target for Discovery of Novel Anti-inflammatory Agents. J. Biol. Chem. 277: 24976-24982 [Abstract] [Full Text]
Sugerman, P.B., Savage, N.W., Walsh, L.J., Zhao, Z.Z., Zhou, X.J., Khan, A., Seymour, G.J., Bigby, M. (2002). THE PATHOGENESIS OF ORAL LICHEN PLANUS. CROBM 13: 350-365 [Abstract] [Full Text]
Chong, J.-M., Sakuma, K., Sudo, M., Osawa, T., Ohara, E., Uozaki, H., Shibahara, J., Kuroiwa, K., Tominaga, S.-i., Hippo, Y., Aburatani, H., Funata, N., Fukayama, M. (2002). Interleukin-1{beta} Expression in Human Gastric Carcinoma with Epstein-Barr Virus Infection. J. Virol. 76: 6825-6831 [Abstract] [Full Text]
Isidori, A. M., Kaltsas, G. A., Korbonits, M., Pyle, M., Gueorguiev, M., Meinhardt, A., Metz, C., Petrovsky, N., Popovic, V., Bucala, R., Grossman, A. B. (2002). Response of Serum Macrophage Migration Inhibitory Factor Levels to Stimulation or Suppression of the Hypothalamo-Pituitary-Adrenal Axis in Normal Subjects and Patients with Cushing's Disease. J. Clin. Endocrinol. Metab. 87: 1834-1840 [Abstract] [Full Text]
Yamanishi, Y., Boyle, D. L., Pinkoski, M. J., Mahboubi, A., Lin, T., Han, Z., Zvaifler, N. J., Green, D. R., Firestein, G. S. (2002). Regulation of Joint Destruction and Inflammation by p53 in Collagen-Induced Arthritis. Am. J. Pathol. 160: 123-130 [Abstract] [Full Text]
Senter, P. D., Al-Abed, Y., Metz, C. N., Benigni, F., Mitchell, R. A., Chesney, J., Han, J., Gartner, C. G., Nelson, S. D., Todaro, G. J., Bucala, R. (2002). Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites. Proc. Natl. Acad. Sci. USA 10.1073/pnas.011569399v1 [Abstract] [Full Text]
Mitchell, R. A., Liao, H., Chesney, J., Fingerle-Rowson, G., Baugh, J., David, J., Bucala, R. (2001). Macrophage migration inhibitory factor (MIF) sustains macrophage proinflammatory function by inhibiting p53: Regulatory role in the innate immune response. Proc. Natl. Acad. Sci. USA 10.1073/pnas.012511599v1 [Abstract] [Full Text]
Busche, S., Gallinat, S., Fleegal, M. A., Raizada, M. K., Sumners, C. (2001). Novel Role of Macrophage Migration Inhibitory Factor in Angiotensin II Regulation of Neuromodulation in Rat Brain. Endocrinology 142: 4623-4630 [Abstract] [Full Text]
Jiang, W., Ananthaswamy, H. N., Muller, H. K., Ouhtit, A., Bolshakov, S., Ullrich, S. E., El-Naggar, A. K., Kripke, M. L. (2001). UV irradiation augments lymphoid malignancies in mice with one functional copy of wild-type p53. Proc. Natl. Acad. Sci. USA 10.1073/pnas.171066498v1 [Abstract] [Full Text]
Coussens, L. M., Werb, Z. (2001). Inflammatory Cells and Cancer: Think Different!. JEM 193: F23-F26 [Full Text]
MARKERT, J. M., FULLER, C. M., GILLESPIE, G. Y., BUBIEN, J. K., MCLEAN, L. A., HONG, R. L., LEE, K., GULLANS, S. R., MAPSTONE, T. B., BENOS, D. J. (2001). Differential gene expression profiling in human brain tumors. Physiol. Genomics 5: 21-33 [Abstract] [Full Text]
Satoskar, A. R., Bozza, M., Rodriguez Sosa, M., Lin, G., David, J. R. (2001). Migration-Inhibitory Factor Gene-Deficient Mice Are Susceptible to Cutaneous Leishmania major Infection. Infect. Immun. 69: 906-911 [Abstract] [Full Text]
Fehniger, T. A., Suzuki, K., Ponnappan, A., VanDeusen, J. B., Cooper, M. A., Florea, S. M., Freud, A. G., Robinson, M. L., Durbin, J., Caligiuri, M. A. (2001). Fatal Leukemia in Interleukin 15 Transgenic Mice Follows Early Expansions in Natural Killer and Memory Phenotype CD8+ T Cells. JEM 193: 219-232 [Abstract] [Full Text]
Abe, R., Peng, T., Sailors, J., Bucala, R., Metz, C. N. (2001). Regulation of the CTL Response by Macrophage Migration Inhibitory Factor. J. Immunol. 166: 747-753 [Abstract] [Full Text]
Cordon-Cardo, C., Prives, C. (1999). At the Crossroads of Inflammation and Tumorigenesis. JEM 190: 1367-1370 [Full Text]
Senter, P. D., Al-Abed, Y., Metz, C. N., Benigni, F., Mitchell, R. A., Chesney, J., Han, J., Gartner, C. G., Nelson, S. D., Todaro, G. J., Bucala, R. (2002). Inhibition of macrophage migration inhibitory factor (MIF) tautomerase and biological activities by acetaminophen metabolites. Proc. Natl. Acad. Sci. USA 99: 144-149 [Abstract] [Full Text]
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