Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 1480K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Loder, B. F. Articles by Carsetti, R. Search for Related Content PubMed PubMed Citation Articles by Loder, B. F. Articles by Carsetti, R. Social Bookmarking                            What's this?

Original Article

^a From the Department of Molecular Immunology, Institute of Biology III, University of Freiburg, and the Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany
^b Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany
^c Wellesley Hospital Research Institute, Toronto, Ontario M4Y 1J3, Canada
^d Department of Applied Cellular and Molecular Biology, Umeå University, S-901 87 Umeå, Sweden
^e Basel Institute for Immunology, 4005 Basel, Switzerland

Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cells were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated from T1 or T2 B cells.

Key Words: B cell development • transitional B cells • spleen • CD45 • Bruton's tyrosine kinase

© 1999 The Rockefeller University Press

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Suryani, S., Fulcher, D. A., Santner-Nanan, B., Nanan, R., Wong, M., Shaw, P. J., Gibson, J., Williams, A., Tangye, S. G. (2010). Differential expression of CD21 identifies developmentally and functionally distinct subsets of human transitional B cells. Blood 115: 519-529 [Abstract] [Full Text]  
• Kat, I., Makdasi, E., Fischel, R., Eilat, D. (2009). B-cell anergy is maintained in anti-DNA transgenic NZB/NZW mice. Int Immunol 0: dxp120v1-dxp120 [Abstract] [Full Text]  
• Lartigue, A., Colliou, N., Calbo, S., Francois, A., Jacquot, S., Arnoult, C., Tron, F., Gilbert, D., Musette, P. (2009). Critical Role of TLR2 and TLR4 in Autoantibody Production and Glomerulonephritis in lpr Mutation-Induced Mouse Lupus. J. Immunol. 183: 6207-6216 [Abstract] [Full Text]  
• Hoek, K. L., Carlesso, G., Clark, E. S., Khan, W. N. (2009). Absence of Mature Peripheral B Cell Populations in Mice with Concomitant Defects in B Cell Receptor and BAFF-R Signaling. J. Immunol. 183: 5630-5643 [Abstract] [Full Text]  
• Giles, A. J., Bender, T. P., Ravichandran, K. S. (2009). The Adaptor Protein Shc Plays a Key Role during Early B Cell Development. J. Immunol. 183: 5468-5476 [Abstract] [Full Text]  
• Khan, W. N. (2009). B Cell Receptor and BAFF Receptor Signaling Regulation of B Cell Homeostasis. J. Immunol. 183: 3561-3567 [Abstract] [Full Text]  
• Castro, I., Wright, J. A., Damdinsuren, B., Hoek, K. L., Carlesso, G., Shinners, N. P., Gerstein, R. M., Woodland, R. T., Sen, R., Khan, W. N. (2009). B Cell Receptor-Mediated Sustained c-Rel Activation Facilitates Late Transitional B Cell Survival through Control of B Cell Activating Factor Receptor and NF-{kappa}B2. J. Immunol. 182: 7729-7737 [Abstract] [Full Text]  
• Palanichamy, A., Barnard, J., Zheng, B., Owen, T., Quach, T., Wei, C., Looney, R. J., Sanz, I., Anolik, J. H. (2009). Novel Human Transitional B Cell Populations Revealed by B Cell Depletion Therapy. J. Immunol. 182: 5982-5993 [Abstract] [Full Text]  
• Schuman, J., Chen, Y., Podd, A., Yu, M., Liu, H.-H., Wen, R., Chen, Z. J., Wang, D. (2009). A critical role of TAK1 in B-cell receptor-mediated nuclear factor {kappa}B activation. Blood 113: 4566-4574 [Abstract] [Full Text]  
• Gross, A. J., Lyandres, J. R., Panigrahi, A. K., Prak, E. T. L., DeFranco, A. L. (2009). Developmental Acquisition of the Lyn-CD22-SHP-1 Inhibitory Pathway Promotes B Cell Tolerance. J. Immunol. 182: 5382-5392 [Abstract] [Full Text]  
• Lee, J., Kuchen, S., Fischer, R., Chang, S., Lipsky, P. E. (2009). Identification and Characterization of a Human CD5+ Pre-Naive B Cell Population. J. Immunol. 182: 4116-4126 [Abstract] [Full Text]  
• Blair, P. A., Chavez-Rueda, K. A., Evans, J. G., Shlomchik, M. J., Eddaoudi, A., Isenberg, D. A., Ehrenstein, M. R., Mauri, C. (2009). Selective Targeting of B Cells with Agonistic Anti-CD40 Is an Efficacious Strategy for the Generation of Induced Regulatory T2-Like B Cells and for the Suppression of Lupus in MRL/lpr Mice. J. Immunol. 182: 3492-3502 [Abstract] [Full Text]  
• Le Pottier, L., Devauchelle, V., Fautrel, A., Daridon, C., Saraux, A., Youinou, P., Pers, J.-O. (2009). Ectopic Germinal Centers Are Rare in Sjogren's Syndrome Salivary Glands and Do Not Exclude Autoreactive B Cells. J. Immunol. 182: 3540-3547 [Abstract] [Full Text]  
• Matsuda, S., Mikami, Y., Ohtani, M., Fujiwara, M., Hirata, Y., Minowa, A., Terauchi, Y., Kadowaki, T., Koyasu, S. (2009). Critical role of class IA PI3K for c-Rel expression in B lymphocytes. Blood 113: 1037-1044 [Abstract] [Full Text]  
• Schelonka, R. L., Zemlin, M., Kobayashi, R., Ippolito, G. C., Zhuang, Y., Gartland, G. L., Szalai, A., Fujihashi, K., Rajewsky, K., Schroeder, H. W. Jr. (2008). Preferential Use of DH Reading Frame 2 Alters B Cell Development and Antigen-Specific Antibody Production. J. Immunol. 181: 8409-8415 [Abstract] [Full Text]  
• Khuda, S. E., Loo, W. M., Janz, S., Van Ness, B., Erickson, L. D. (2008). Deregulation of c-Myc Confers Distinct Survival Requirements for Memory B Cells, Plasma Cells, and Their Progenitors. J. Immunol. 181: 7537-7549 [Abstract] [Full Text]  
• Tsao, P. Y., Jiao, J., Ji, M. Q., Cohen, P. L., Eisenberg, R. A. (2008). T Cell-Independent Spontaneous Loss of Tolerance by Anti-Double-Stranded DNA B Cells in C57BL/6 Mice. J. Immunol. 181: 7770-7777 [Abstract] [Full Text]  
• Purtha, W. E., Chachu, K. A., Virgin, H. W. IV, Diamond, M. S. (2008). Early B-Cell Activation after West Nile Virus Infection Requires Alpha/Beta Interferon but Not Antigen Receptor Signaling. J. Virol. 82: 10964-10974 [Abstract] [Full Text]  
• Song, R., Kim, Y.-W., Koo, B.-K., Jeong, H.-W., Yoon, M.-J., Yoon, K.-J., Jun, D.-J., Im, S.-K., Shin, J., Kong, M.-P., Kim, K.-T., Yoon, K., Kong, Y.-Y. (2008). Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development. JEM 205: 2525-2536 [Abstract] [Full Text]  
• Jing, X., Zhao, D.-M., Waldschmidt, T. J., Xue, H.-H. (2008). GABP{beta}2 Is Dispensible for Normal Lymphocyte Development but Moderately Affects B Cell Responses. J. Biol. Chem. 283: 24326-24333 [Abstract] [Full Text]  
• Bunch, D. O., Silver, J. S., Majure, M. C., Sullivan, P., Alcorta, D. A., Chin, H., Hogan, S. L., Lindstrom, Y. I., Clarke, S. H., Falk, R. J., Nachman, P. H. (2008). Maintenance of Tolerance by Regulation of Anti-myeloperoxidase B Cells. J. Am. Soc. Nephrol. 19: 1763-1773 [Abstract] [Full Text]  
• Zhang, X. K., Moussa, O., LaRue, A., Bradshaw, S., Molano, I., Spyropoulos, D. D., Gilkeson, G. S., Watson, D. K. (2008). The Transcription Factor Fli-1 Modulates Marginal Zone and Follicular B Cell Development in Mice. J. Immunol. 181: 1644-1654 [Abstract] [Full Text]  
• Shimomura, Y., Ogawa, A., Kawada, M., Sugimoto, K., Mizoguchi, E., Shi, H.-N., Pillai, S., Bhan, A. K., Mizoguchi, A. (2008). A unique B2 B cell subset in the intestine. JEM 205: 1343-1355 [Abstract] [Full Text]  
• Kiefer, K., Nakajima, P. B., Oshinsky, J., Seeholzer, S. H., Radic, M., Bosma, G. C., Bosma, M. J. (2008). Antigen Receptor Editing in Anti-DNA Transitional B Cells Deficient for Surface IgM. J. Immunol. 180: 6094-6106 [Abstract] [Full Text]  
• Chen, Y., Yu, M., Podd, A., Wen, R., Chrzanowska-Wodnicka, M., White, G. C., Wang, D. (2008). A critical role of Rap1b in B-cell trafficking and marginal zone B-cell development. Blood 111: 4627-4636 [Abstract] [Full Text]  
• Rodriguez-Alba, J. C., Moreno-Garcia, M. E., Sandoval-Montes, C., Rosales-Garcia, V. H., Santos-Argumedo, L. (2008). CD38 induces differentiation of immature transitional 2 B lymphocytes in the spleen. Blood 111: 3644-3652 [Abstract] [Full Text]  
• Labi, V., Erlacher, M., Kiessling, S., Manzl, C., Frenzel, A., O'Reilly, L., Strasser, A., Villunger, A. (2008). Loss of the BH3-only protein Bmf impairs B cell homeostasis and accelerates {gamma} irradiation-induced thymic lymphoma development. JEM 205: 641-655 [Abstract] [Full Text]  
• Marino, E., Batten, M., Groom, J., Walters, S., Liuwantara, D., Mackay, F., Grey, S. T. (2008). Marginal-Zone B-Cells of Nonobese Diabetic Mice Expand With Diabetes Onset, Invade the Pancreatic Lymph Nodes, and Present Autoantigen to Diabetogenic T-Cells. Diabetes 57: 395-404 [Abstract] [Full Text]  
• Meyer-Bahlburg, A., Andrews, S. F., Yu, K. O.A., Porcelli, S. A., Rawlings, D. J. (2008). Characterization of a late transitional B cell population highly sensitive to BAFF-mediated homeostatic proliferation. JEM 205: 155-168 [Abstract] [Full Text]  
• Wang, H., Feng, J., Qi, C.-F., Li, Z., Morse, H. C. III, Clarke, S. H. (2007). Transitional B Cells Lose Their Ability to Receptor Edit but Retain Their Potential for Positive and Negative Selection. J. Immunol. 179: 7544-7552 [Abstract] [Full Text]  
• Spillmann, F. J. X., Beck-Engeser, G., Wabl, M. (2007). Differentiation and Ig-Allele Switch in Cell Line WEHI-231. J. Immunol. 179: 6395-6402 [Abstract] [Full Text]  
• Quah, B. J. C., O'Neill, H. C. (2007). Mycoplasma contaminants present in exosome preparations induce polyclonal B cell responses. J. Leukoc. Biol. 82: 1070-1082 [Abstract] [Full Text]  
• de Andres, B., Cortegano, I., Serrano, N., del Rio, B., Martin, P., Gonzalo, P., Marcos, M. A. R., Gaspar, M. L. (2007). A Population of CD19highCD45R /lowCD21low B Lymphocytes Poised for Spontaneous Secretion of IgG and IgA Antibodies. J. Immunol. 179: 5326-5334 [Abstract] [Full Text]  
• Uhmann, A., Dittmann, K., Nitzki, F., Dressel, R., Koleva, M., Frommhold, A., Zibat, A., Binder, C., Adham, I., Nitsche, M., Heller, T., Armstrong, V., Schulz-Schaeffer, W., Wienands, J., Hahn, H. (2007). The Hedgehog receptor Patched controls lymphoid lineage commitment. Blood 110: 1814-1823 [Abstract] [Full Text]  
• Bai, L., Chen, Y., He, Y., Dai, X., Lin, X., Wen, R., Wang, D. (2007). Phospholipase C{gamma}2 Contributes to Light-Chain Gene Activation and Receptor Editing. Mol. Cell. Biol. 27: 5957-5967 [Abstract] [Full Text]  
• Cariappa, A., Boboila, C., Moran, S. T., Liu, H., Shi, H. N., Pillai, S. (2007). The Recirculating B Cell Pool Contains Two Functionally Distinct, Long-Lived, Posttransitional, Follicular B Cell Populations. J. Immunol. 179: 2270-2281 [Abstract] [Full Text]  
• Li, Y., Ma, L., Shen, J., Chong, A. S. (2007). Peripheral deletion of mature alloreactive B cells induced by costimulation blockade. Proc. Natl. Acad. Sci. USA 104: 12093-12098 [Abstract] [Full Text]  
• Dai, X., Chen, Y., Di, L., Podd, A., Li, G., Bunting, K. D., Hennighausen, L., Wen, R., Wang, D. (2007). Stat5 Is Essential for Early B Cell Development but Not for B Cell Maturation and Function. J. Immunol. 179: 1068-1079 [Abstract] [Full Text]  
• Teague, B. N., Pan, Y., Mudd, P. A., Nakken, B., Zhang, Q., Szodoray, P., Kim-Howard, X., Wilson, P. C., Farris, A. D. (2007). Cutting Edge: Transitional T3 B Cells Do Not Give Rise to Mature B Cells, Have Undergone Selection, and Are Reduced in Murine Lupus. J. Immunol. 178: 7511-7515 [Abstract] [Full Text]  
• Evans, J. G., Chavez-Rueda, K. A., Eddaoudi, A., Meyer-Bahlburg, A., Rawlings, D. J., Ehrenstein, M. R., Mauri, C. (2007). Novel Suppressive Function of Transitional 2 B Cells in Experimental Arthritis. J. Immunol. 178: 7868-7878 [Abstract] [Full Text]  
• Debnath, I., Roundy, K. M., Weis, J. J., Weis, J. H. (2007). Defining In Vivo Transcription Factor Complexes of the Murine CD21 and CD23 Genes. J. Immunol. 178: 7139-7150 [Abstract] [Full Text]  
• Liu, X., Wysocki, L. J., Manser, T. (2007). Autoantigen-B Cell Antigen Receptor Interactions That Regulate Expression of B Cell Antigen Receptor Loci. J. Immunol. 178: 5035-5047 [Abstract] [Full Text]  
• Hsu, H.-C., Wu, Y., Yang, P., Wu, Q., Job, G., Chen, J., Wang, J., Accavitti-Loper, M. A. V., Grizzle, W. E., Carter, R. H., Mountz, J. D. (2007). Overexpression of Activation-Induced Cytidine Deaminase in B Cells Is Associated with Production of Highly Pathogenic Autoantibodies. J. Immunol. 178: 5357-5365 [Abstract] [Full Text]  
• Li, N., Boyd, K., Dempsey, P. J., Vignali, D. A. A. (2007). Non-Cell Autonomous Expression of TNF-{alpha}-Converting Enzyme ADAM17 Is Required for Normal Lymphocyte Development. J. Immunol. 178: 4214-4221 [Abstract] [Full Text]  
• Alam, S. M., McAdams, M., Boren, D., Rak, M., Scearce, R. M., Gao, F., Camacho, Z. T., Gewirth, D., Kelsoe, G., Chen, P., Haynes, B. F. (2007). The Role of Antibody Polyspecificity and Lipid Reactivity in Binding of Broadly Neutralizing Anti-HIV-1 Envelope Human Monoclonal Antibodies 2F5 and 4E10 to Glycoprotein 41 Membrane Proximal Envelope Epitopes. J. Immunol. 178: 4424-4435 [Abstract] [Full Text]  
• van Zelm, M. C., Szczepanski, T., van der Burg, M., van Dongen, J. J.M. (2007). Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. JEM 204: 645-655 [Abstract] [Full Text]  
• Lindsley, R. C., Thomas, M., Srivastava, B., Allman, D. (2007). Generation of peripheral B cells occurs via two spatially and temporally distinct pathways. Blood 109: 2521-2528 [Abstract] [Full Text]  
• Cariappa, A., Chase, C., Liu, H., Russell, P., Pillai, S. (2007). Naive recirculating B cells mature simultaneously in the spleen and bone marrow. Blood 109: 2339-2345 [Abstract] [Full Text]  
• Shankar, M., Nixon, J. C., Maier, S., Workman, J., Farris, A. D., Webb, C. F. (2007). Anti-Nuclear Antibody Production and Autoimmunity in Transgenic Mice That Overexpress the Transcription Factor Bright. J. Immunol. 178: 2996-3006 [Abstract] [Full Text]  
• Song, H., Zhang, J., Chiang, Y. J., Siraganian, R. P., Hodes, R. J. (2007). Redundancy in B Cell Developmental Pathways: c-Cbl Inactivation Rescues Early B Cell Development through a B Cell Linker Protein-Independent Pathway. J. Immunol. 178: 926-935 [Abstract] [Full Text]  
• Wen, R., Chen, Y., Bai, L., Fu, G., Schuman, J., Dai, X., Zeng, H., Yang, C., Stephan, R. P., Cleveland, J. L., Wang, D. (2006). Essential Role of Phospholipase C{gamma}2 in Early B-Cell Development and Myc-Mediated Lymphomagenesis. Mol. Cell. Biol. 26: 9364-9376 [Abstract] [Full Text]  
• Won, W.-J., Foote, J. B., Odom, M. R., Pan, J., Kearney, J. F., Davis, R. S. (2006). Fc Receptor Homolog 3 Is a Novel Immunoregulatory Marker of Marginal Zone and B1 B Cells. J. Immunol. 177: 6815-6823 [Abstract] [Full Text]  
• Cancro, M P (2006). The BLyS/BAFF family of ligands and receptors: key targets in the therapy and understanding of autoimmunity. Ann Rheum Dis 65: iii34-iii36 [Abstract] [Full Text]  
• Hoek, K. L., Antony, P., Lowe, J., Shinners, N., Sarmah, B., Wente, S. R., Wang, D., Gerstein, R. M., Khan, W. N. (2006). Transitional B Cell Fate Is Associated with Developmental Stage-Specific Regulation of Diacylglycerol and Calcium Signaling upon B Cell Receptor Engagement. J. Immunol. 177: 5405-5413 [Abstract] [Full Text]  
• Wang, C., McDonald, K. G., McDonough, J. S., Newberry, R. D. (2006). Murine isolated lymphoid follicles contain follicular B lymphocytes with a mucosal phenotype. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G595-G604 [Abstract] [Full Text]  
• Rieken, S., Sassmann, A., Herroeder, S., Wallenwein, B., Moers, A., Offermanns, S., Wettschureck, N. (2006). G12/G13 family g proteins regulate marginal zone B cell maturation, migration, and polarization.. J. Immunol. 177: 2985-2993 [Abstract] [Full Text]  
• Melamed, D., Messika, O., Glass-Marmor, L., Miller, A. (2006). Modulation of matrix metalloproteinase-9 (MMP-9) secretion in B lymphopoiesis. Int Immunol 18: 1355-1362 [Abstract] [Full Text]  
• Acevedo-Suarez, C. A., Kilkenny, D. M., Reich, M. B., Thomas, J. W. (2006). Impaired Intracellular Calcium Mobilization and NFATc1 Availability in Tolerant Anti-Insulin B Cells. J. Immunol. 177: 2234-2241 [Abstract] [Full Text]  
• Tian, Q., Beardall, M., Xu, Y., Li, J., Parker, D. C., Casanova, N., Bakke, A. C., Chen, C. (2006). B Cells Expressing a Natural Polyreactive Autoantibody Have a Distinct Phenotype and Are Overrepresented in Immunoglobulin Heavy Chain Transgenic Mice. J. Immunol. 177: 2412-2422 [Abstract] [Full Text]  
• Mandik-Nayak, L., Racz, J., Sleckman, B. P., Allen, P. M. (2006). Autoreactive marginal zone B cells are spontaneously activated but lymph node B cells require T cell help. JEM 203: 1985-1998 [Abstract] [Full Text]  
• de la Fuente, M. A., Kumar, L., Lu, B., Geha, R. S. (2006). 3BP2 Deficiency Impairs the Response of B Cells, but Not T Cells, to Antigen Receptor Ligation. Mol. Cell. Biol. 26: 5214-5225 [Abstract] [Full Text]  
• Bussiere, F. I., Chaturvedi, R., Asim, M., Hoek, K. L., Cheng, Y., Gainor, J., Scholz, A., Khan, W. N., Wilson, K. T. (2006). Low Multiplicity of Infection of Helicobacter pylori Suppresses Apoptosis of B Lymphocytes.. Cancer Res. 66: 6834-6842 [Abstract] [Full Text]  
• Ippolito, G. C., Schelonka, R. L., Zemlin, M., Ivanov, I. I., Kobayashi, R., Zemlin, C., Gartland, G. L., Nitschke, L., Pelkonen, J., Fujihashi, K., Rajewsky, K., Schroeder, H. W. Jr. (2006). Forced usage of positively charged amino acids in immunoglobulin CDR-H3 impairs B cell development and antibody production. JEM 203: 1567-1578 [Abstract] [Full Text]  
• Yu, X., Siegel, R., Roeder, R. G. (2006). Interaction of the B Cell-specific Transcriptional Coactivator OCA-B and Galectin-1 and a Possible Role in Regulating BCR-mediated B Cell Proliferation. J. Biol. Chem. 281: 15505-15516 [Abstract] [Full Text]  
• Miller, J. P., Stadanlick, J. E., Cancro, M. P. (2006). Space, Selection, and Surveillance: Setting Boundaries with BLyS.. J. Immunol. 176: 6405-6410 [Abstract] [Full Text]  
• Huang, H., Kearney, J. F., Grusby, M. J., Benoist, C., Mathis, D. (2006). Induction of tolerance in arthritogenic B cells with receptors of differing affinity for self-antigen. Proc. Natl. Acad. Sci. USA 103: 3734-3739 [Abstract] [Full Text]  
• Grimaldi, C. M., Jeganathan, V., Diamond, B. (2006). Hormonal Regulation of B Cell Development: 17beta-Estradiol Impairs Negative Selection of High-Affinity DNA-Reactive B Cells at More Than One Developmental Checkpoint.. J. Immunol. 176: 2703-2710 [Abstract] [Full Text]  
• Cuss, A. K., Avery, D. T., Cannons, J. L., Yu, L. J., Nichols, K. E., Shaw, P. J., Tangye, S. G. (2006). Expansion of Functionally Immature Transitional B Cells Is Associated with Human-Immunodeficient States Characterized by Impaired Humoral Immunity. J. Immunol. 176: 1506-1516 [Abstract] [Full Text]  
• Dai, X., Chen, Y., Schuman, J., Hua, Z., Adamson, J. W., Wen, R., Wang, D. (2006). Distinct Roles of Phosphoinositide-3 Kinase and Phospholipase C{gamma}2 in B-Cell Receptor-Mediated Signal Transduction. Mol. Cell. Biol. 26: 88-99 [Abstract] [Full Text]  
• Skalet, A. H., Isler, J. A., King, L. B., Harding, H. P., Ron, D., Monroe, J. G. (2005). Rapid B Cell Receptor-induced Unfolded Protein Response in Nonsecretory B Cells Correlates with Pro- Versus Antiapoptotic Cell Fate. J. Biol. Chem. 280: 39762-39771 [Abstract] [Full Text]  
• Viau, M., Longo, N. S., Lipsky, P. E., Zouali, M. (2005). Staphylococcal Protein A Deletes B-1a and Marginal Zone B Lymphocytes Expressing Human Immunoglobulins: An Immune Evasion Mechanism. J. Immunol. 175: 7719-7727 [Abstract] [Full Text]  
• Craxton, A., Draves, K. E., Gruppi, A., Clark, E. A. (2005). BAFF regulates B cell survival by downregulating the BH3-only family member Bim via the ERK pathway. JEM 202: 1363-1374 [Abstract] [Full Text]  
• Schelonka, R. L., Ivanov, I. I., Jung, D. H., Ippolito, G. C., Nitschke, L., Zhuang, Y., Gartland, G. L., Pelkonen, J., Alt, F. W., Rajewsky, K., Schroeder, H. W. Jr (2005). A Single DH Gene Segment Creates Its Own Unique CDR-H3 Repertoire and Is Sufficient for B cell Development and Immune Function. J. Immunol. 175: 6624-6632 [Abstract] [Full Text]  
• Srivastava, B., Quinn, W. J. III, Hazard, K., Erikson, J., Allman, D. (2005). Characterization of marginal zone B cell precursors. JEM 202: 1225-1234 [Abstract] [Full Text]  
• Dube, N., Bourdeau, A., Heinonen, K. M., Cheng, A., Lee Loy, A., Tremblay, M. L. (2005). Genetic Ablation of Protein Tyrosine Phosphatase 1B Accelerates Lymphomagenesis of p53-Null Mice through the Regulation of B-Cell Development. Cancer Res. 65: 10088-10095 [Abstract] [Full Text]  
• Valerie Pasqualetto, , Florence Vasseur, , Flora Zavala, , Elke Schneider, , Sophie Ezine, (2005). Fas receptor signaling is requisite for B cell differentiation. J. Leukoc. Biol. 78: 1106-1117 [Abstract] [Full Text]  
• Zheng, Y., Gallucci, S., Gaughan, J. P., Gross, J. A., Monestier, M. (2005). A Role for B Cell-Activating Factor of the TNF Family in Chemically Induced Autoimmunity. J. Immunol. 175: 6163-6168 [Abstract] [Full Text]  
• Heltemes-Harris, L., Liu, X., Manser, T. (2005). An antibody VH gene that promotes marginal zone B cell development and heavy chain allelic inclusion. Int Immunol 17: 1447-1461 [Abstract] [Full Text]  
• Hart, G., Flaishon, L., Becker-Herman, S., Shachar, I. (2005). Tight Regulation of IFN-{gamma} Transcription and Secretion in Immature and Mature B cells by the Inhibitory MHC Class I Receptor, Ly49G2. J. Immunol. 175: 5034-5042 [Abstract] [Full Text]  
• Kroll, J., Shi, X., Caprioli, A., Liu, H.-H., Waskow, C., Lin, K.-M., Miyazaki, T., Rodewald, H.-R., Sato, T. N. (2005). The BTB-kelch Protein KLHL6 Is Involved in B-Lymphocyte Antigen Receptor Signaling and Germinal Center Formation. Mol. Cell. Biol. 25: 8531-8540 [Abstract] [Full Text]  
• Vigorito, E., Gambardella, L., Colucci, F., McAdam, S., Turner, M. (2005). Vav proteins regulate peripheral B-cell survival. Blood 106: 2391-2398 [Abstract] [Full Text]  
• Peeva, E., Venkatesh, J., Diamond, B. (2005). Tamoxifen Blocks Estrogen-Induced B Cell Maturation but Not Survival. J. Immunol. 175: 1415-1423 [Abstract] [Full Text]  
• Subramanian, S., Yim, Y.-S., Liu, K., Tus, K., Zhou, X. J., Wakeland, E. K. (2005). Epistatic Suppression of Systemic Lupus Erythematosus: Fine Mapping of Sles1 to Less Than 1 Mb. J. Immunol. 175: 1062-1072 [Abstract] [Full Text]  
• Sims, G. P., Ettinger, R., Shirota, Y., Yarboro, C. H., Illei, G. G., Lipsky, P. E. (2005). Identification and characterization of circulating human transitional B cells. Blood 105: 4390-4398 [Abstract] [Full Text]  
• Hillion, S., Saraux, A., Youinou, P., Jamin, C. (2005). Expression of RAGs in Peripheral B Cells outside Germinal Centers Is Associated with the Expression of CD5. J. Immunol. 174: 5553-5561 [Abstract] [Full Text]  
• Samanta, D. N., Palmetshofer, A., Marinkovic, D., Wirth, T., Serfling, E., Nitschke, L. (2005). B Cell Hyperresponsiveness and Expansion of Mature Follicular B Cells but Not of Marginal Zone B Cells in NFATc2/c3 Double-Deficient Mice. J. Immunol. 174: 4797-4802 [Abstract] [Full Text]  
• Rolf, J., Motta, V., Duarte, N., Lundholm, M., Berntman, E., Bergman, M.-L., Sorokin, L., Cardell, S. L., Holmberg, D. (2005). The Enlarged Population of Marginal Zone/CD1dhigh B Lymphocytes in Nonobese Diabetic Mice Maps to Diabetes Susceptibility Region Idd11. J. Immunol. 174: 4821-4827 [Abstract] [Full Text]  
• Hamaguchi, Y., Uchida, J., Cain, D. W., Venturi, G. M., Poe, J. C., Haas, K. M., Tedder, T. F. (2005). The Peritoneal Cavity Provides a Protective Niche for B1 and Conventional B Lymphocytes during Anti-CD20 Immunotherapy in Mice. J. Immunol. 174: 4389-4399 [Abstract] [Full Text]  
• Yurasov, S., Wardemann, H., Hammersen, J., Tsuiji, M., Meffre, E., Pascual, V., Nussenzweig, M. C. (2005). Defective B cell tolerance checkpoints in systemic lupus erythematosus. JEM 201: 703-711 [Abstract] [Full Text]  
• Storck, S., Delbos, F., Stadler, N., Thirion-Delalande, C., Bernex, F., Verthuy, C., Ferrier, P., Weill, J.-C., Reynaud, C.-A. (2005). Normal Immune System Development in Mice Lacking the Deltex-1 RING Finger Domain. Mol. Cell. Biol. 25: 1437-1445 [Abstract] [Full Text]  
• Grimaldi, C. M., Hicks, R., Diamond, B. (2005). B Cell Selection and Susceptibility to Autoimmunity. J. Immunol. 174: 1775-1781 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS