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© The Rockefeller University Press, 0022-1007/1999/7/75/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 1, July 1, 1999 75-90

Original Article

B Cell Development in the Spleen Takes Place in Discrete Steps and Is Determined by the Quality of B Cell Receptor–Derived Signals

By Florienne Lodera, Bettina Mutschlera, Robert J. Rayc, Christopher J. Paigec, Paschalis Siderasd, Raul Torrese, Marinus C. Lamersb, and Rita Carsettia

a From the Department of Molecular Immunology, Institute of Biology III, University of Freiburg, and the Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany
b Department of Developmental Immunology, Max-Planck-Institute for Immunobiology, D-79108 Freiburg, Germany
c Wellesley Hospital Research Institute, Toronto, Ontario M4Y 1J3, Canada
d Department of Applied Cellular and Molecular Biology, Umeå University, S-901 87 Umeå, Sweden
e Basel Institute for Immunology, 4005 Basel, Switzerland

Only mature B lymphocytes can enter the lymphoid follicles of spleen and lymph nodes and thus efficiently participate in the immune response. Mature, long-lived B lymphocytes derive from short-lived precursors generated in the bone marrow. We show that selection into the mature pool is an active process and takes place in the spleen. Two populations of splenic B cells were identified as precursors for mature B cells. Transitional B cells of type 1 (T1) are recent immigrants from the bone marrow. They develop into the transitional B cells of type 2 (T2), which are cycling and found exclusively in the primary follicles of the spleen. Mature B cells can be generated from T1 or T2 B cells.

Key Words: B cell development • transitional B cells • spleen • CD45 • Bruton's tyrosine kinase

1used in this paper: BCR, B cell antigen receptor; BrdU, bromodeoxyuridine; Btk, Bruton's tyrosine kinase; HSA, heat-stable antigen; MAP, mitogen-activated protein; MZ, marginal zone; PALS, periarteriolar lymphoid sheath; PH, plekstrin homology; PKC, protein kinase C; T1, transitional type 1; T2, transitional type 2

© 1999 The Rockefeller University Press


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