The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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© The Rockefeller University Press, 0022-1007/1999/7/141/ $5.00
The Journal of Experimental Medicine, Volume 190, Number 1, July 1, 1999 141-144

Brief Definitive Report

Early T Cell Receptor β Gene Expression Is Regulated by the Pre-T Cell Receptor–CD3 Complex

Iannis Aifantisa, Jacqueline Feinberga, Hans Jörg Fehlingc, James P. Di Santob, and Harald von Boehmera

a From the Institut National de la Santé et de la Recherche Médicale (INSERM) U373, Hôpital Necker-Enfants Malades, F-75730 Paris, France
b INSERM U429, CH-4005 Basel, Switzerland
c Basel Institute for Immunology, CH-4005 Basel, Switzerland

We have examined the question of whether there is an additional checkpoint in T cell development that regulates T cell receptor (TCR)-β expression in CD25+44– thymocytes by mechanisms that are independent of the pre-TCR. Our analysis in various mutant mice indicates that all changes in cytoplasmic TCR-β expression can be accounted for by pre-TCR–dependent signal mediation, putting into question the function of a putative pro-TCR.

Key Words: lymphocyte development • pre-T cell receptor • cytoplasmic T cell receptor β • clonotype-independent CD3 complex

© 1999 The Rockefeller University Press


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