The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1999/4/1355/ $5.00
The Journal of Experimental Medicine, Volume 189, Number 8, April 19, 1999 1355-1360

Brief Definitive Reports

Lineage-specific Requirement for Signal Transducer and Activator of Transcription (Stat)4 in Interferon {gamma} Production from CD4+ Versus CD8+ T Cells

Laura L. Carter and Kenneth M. Murphy

From the Department of Pathology and Center for Immunology, Howard Hughes Medical Institute, Washington University School of Medicine, St. Louis, Missouri 63110

CD4+ and CD8+ T cells exhibit important differences in their major effector functions. CD8+ T cells provide protection against pathogens through cytolytic activity, whereas CD4+ T cells exert important regulatory activity through production of cytokines. However, both lineages can produce interferon (IFN)-{gamma}, which can contribute to protective immunity. Here we show that CD4+ and CD8+ T cells differ in their regulation of IFN-{gamma} production. Both lineages require signal transducer and activator of transcription (Stat)4 activation for IFN-{gamma} induced by interleukin (IL)-12/IL-18 signaling, but only CD4+ T cells require Stat4 for IFN-{gamma} induction via the TCR pathway. In response to antigen, CD8+ T cells can produce IFN-{gamma} independently of IL-12, whereas CD4+ T cells require IL-12 and Stat4 activation. Thus, there is a lineage-specific requirement for Stat4 activation in antigen-induced IFN-{gamma} production based on differences in TCR signaling between CD4+ and CD8+ T cells.

Key Words: Stat4 • interferon {gamma} • T lymphocytes • interleukin 12 • interleukin 18

Address correspondence to Kenneth M. Murphy, Department of Pathology, Washington University School of Medicine, 660 South Euclid Ave., St. Louis, MO 63110. Phone: 314-362-2009; Fax: 314-747-4888; E-mail: murphy{at}immunology.wustl.edu


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