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J. Exp. Med.,
Volume 189, Number 4, February 15, 1999 693-700
By
From the * Department of Immunology and Cell Biology, and the CD34+ hematopoietic stem cells, which circulate in peripheral blood with very low frequency,
exert essential accessory function during lipopolysaccharide (LPS)-induced human T lymphocyte activation, resulting in interferon Department of Immunochemistry and
Biochemical Microbiology, Research Center Borstel, 23845 Borstel, Germany
production and proliferation. In contrast, stimulation
of T cells by "conventional" recall antigens is not controlled by blood stem cells. These conclusions are based on the observation that depletion of CD34+ blood stem cells results in a loss
of LPS-induced T cell stimulation as well as reduced expression of CD80 antigen on monocytes. The addition of CD34-enriched blood stem cells resulted in a recovery of reactivity of T
cells and monocytes to LPS. Blood stem cells could be replaced by the hematopoietic stem cell
line KG-1a. These findings may be of relevance for high risk patients treated with stem cells or
stem cell recruiting compounds and for patients suffering from endotoxin-mediated diseases.
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