|
|
|
|
|
|
|
||
J. Exp. Med.,
Volume 189, Number 2, January 18, 1999 319-330
By
From the Laboratoire des Dynamiques Lymphocytaires, Centre National de la Recherche Scientifique,
Unité de Recherche Associée 1961, Institut Pasteur, 75724 Paris, cedex 15, France
We studied the role of bone marrow B cell production in the renewal of peripheral B cells and
the feedback mechanisms that control the entry of newly formed B cells into the peripheral B
cell pools. When resting lymph node B cells are injected into B cell-deficient hosts, a fraction
of the transferred cells expands and constitutes a highly selected population that survives for prolonged periods of time by continuous cell renewal at the periphery. Although the number
of donor B cells recovered is low, a significant fraction shows an activated phenotype, and the
serum immunoglobulin (Ig)M levels are as in normal mice. This population of activated B cells
is resistant to replacement by a new cohort of B cells and is able to feedback regulate both the
entry of newly formed B cells into the peripheral pool and terminal differentiation. These findings suggest that peripheral B cell selection follows the first come, first served rule and that
IgM-secreting cells are generated from a pool of stable activated B cells with an independent homeostasis.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
| TABLE OF CONTENTS |
|
