The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1999/1/319/ $5.00
The Journal of Experimental Medicine, Volume 189, Number 2, January 18, 1999 319-330

Articles

Transfer of Small Resting B Cells into Immunodeficient Hosts Results in the Selection of a Self-renewing Activated B Cell Population

Fabien Agenès and António A. Freitas

From the Laboratoire des Dynamiques Lymphocytaires, Centre National de la Recherche Scientifique, Unité de Recherche Associée 1961, Institut Pasteur, 75724 Paris, cedex 15, France

We studied the role of bone marrow B cell production in the renewal of peripheral B cells and the feedback mechanisms that control the entry of newly formed B cells into the peripheral B cell pools. When resting lymph node B cells are injected into B cell–deficient hosts, a fraction of the transferred cells expands and constitutes a highly selected population that survives for prolonged periods of time by continuous cell renewal at the periphery. Although the number of donor B cells recovered is low, a significant fraction shows an activated phenotype, and the serum immunoglobulin (Ig)M levels are as in normal mice. This population of activated B cells is resistant to replacement by a new cohort of B cells and is able to feedback regulate both the entry of newly formed B cells into the peripheral pool and terminal differentiation. These findings suggest that peripheral B cell selection follows the first come, first served rule and that IgM-secreting cells are generated from a pool of stable activated B cells with an independent homeostasis.

Key Words: homeostasis • B cell renewal • lymphocyte competition • B cell lifespans • natural antibodies

Address correspondence to Fabien Agenès, Laboratoire des Dynamiques Lymphocytaires, CNRS URA1961, Institut Pasteur, 25-28 rue du Dr. Roux, 75724 Paris cedex 15, France. Phone: 33-1-45-68-85-82; Fax: 33-1-45-68-86-39; E-mail: fagenes{at}pasteur.fr

For additional information, please see http://www.pasteur.fr/units/Dynlym/Welcome.html

1 Abbreviations used in this paper: BM, bone marrow; BrdU, bromodeoxyuridine; LN, lymph node; SPL, spleen; Tg, transgenic.


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