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J. Exp. Med.,
Volume 189, Number 11, June 7, 1999 1765-1776
By
From the Vascular Research Division, Department of Pathology, Brigham and Women's Hospital and
Harvard Medical School, Boston, Massachusetts 02115
Different T cell subsets exhibit distinct capacities to migrate into peripheral sites of inflammation, and this may in part reflect differential expression of homing receptors and chemokine receptors. Using an adoptive transfer approach, we examined the ability of functionally distinct
subsets of T cells to home to a peripheral inflammatory site. The data directly demonstrate the
inability of naive T cells and the ability of effector cells to home to inflamed peritoneum. Furthermore, interleukin (IL)-12 directs the differentiation of either CD4+ or CD8+ T cells into
effector populations that expresses functional E- and P-selectin ligand and that are preferentially
recruited into the inflamed peritoneum compared with T cells differentiated in the presence of
IL-4. Recruitment can be blocked by anti-E- and -P-selectin antibodies. The presence of antigen in the peritoneum promotes local proliferation of recruited T cells, and significantly amplifies
the Th1 polarization of the lymphocytic infiltrate. Preferential recruitment of Th1 cells into the
peritoneum is also seen when cytokine response gene 2 (CRG-2)/interferon 
-inducible protein
10 (IP-10) is used as the sole inflammatory stimulus. We have also found that P-selectin binds
only to antigen-specific T cells in draining lymph nodes after immunization, implying that both
antigen- and cytokine-mediated signals are required for expression of functional selectin-ligand.
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