The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1999/5/1679/ $5.00
The Journal of Experimental Medicine, Volume 189, Number 10, May 17, 1999 1679-1684

Brief Definitive Reports

T Cell Receptor β Chain Lacking the Large Solvent-exposed Cβ FG Loop Supports Normal {alpha}/β T Cell Development and Function in Transgenic Mice

Sylvie Degermann, Giuseppina Sollami, and Klaus Karjalainen

From the Basel Institute for Immunology, CH-4005 Basel, Switzerland

The striking and unique structural feature of the T cell receptor (TCR) β chain is the bulky solvent-exposed FG loop on the Cβ domain, the size of almost half an immunoglobulin domain. The location and size of this loop suggested immediately that it could be a crucial structural link between the invariant CD3 subunits and antigen-recognizing {alpha}/β chains during TCR signaling. However, functional analysis does not support the above notion, since transgene coding for TCR β chain lacking the complete FG loop supports normal {alpha}/β T cell development and function.

Key Words: T cell receptor • Cβ domain • mutagenesis • transgenic mice • T cell development and function

Address correspondence to Sylvie Degermann or Klaus Karjalainen, Basel Institute for Immunology, Grenzacherstrasse 487, CH-4005 Basel, Switzerland. Phone: 41-61-605-1249; Fax: 41-61-605-1364; E-mail: degermann{at}bii.ch, or karjalainen{at}bii.ch

The Basel Institute for Immunology was founded and is supported by F. Hoffmann-La Roche Ltd., Basel, Switzerland.


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