The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 167K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Ujike, A.
Right arrow Articles by Takai, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ujike, A.
Right arrow Articles by Takai, T.
Right arrowPubmed/NCBI databases
*Gene*GEO Profiles
*HomoloGene*UniGene
*Substance via MeSH
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
© The Rockefeller University Press, 0022-1007/1999/5/1573/ $5.00
The Journal of Experimental Medicine, Volume 189, Number 10, May 17, 1999 1573-1579

Articles

Modulation of Immunoglobulin (Ig)E-mediated Systemic Anaphylaxis by Low-Affinity Fc Receptors for IgG

Azusa Ujike*,§, Yoko Ishikawa*, Masao Ono*,§, Takae Yuasa*,§, Tadashi Yoshino||, Manabu Fukumoto{ddagger}, Jeffrey V. Ravetch, and Toshiyuki Takai*,§

From the * Department of Experimental Immunology and the {ddagger} Department of Pathology, Institute of Development, Aging and Cancer, Tohoku University, Sendai 980-8575, Japan; § Core Research for Evolutional Science and Technology (CREST), Japan Science and Technology Corporation (JST), Tokyo 101-0062, Japan; || Second Department of Pathology, Okayama University Medical School, Okayama 700-8558, Japan; and Laboratory of Molecular Genetics and Immunology, The Rockefeller University, New York 10021

It is widely accepted that immunoglobulin (Ig)E triggers immediate hypersensitivity responses by activating a cognate high-affinity receptor, Fc{varepsilon}RI, leading to mast cell degranulation with release of vasoactive and proinflammatory mediators. This apparent specificity, however, is complicated by the ability of IgE to bind with low affinity to Fc receptors for IgG, Fc{gamma}RII and III. We have addressed the in vivo significance of this interaction by studying IgE-mediated passive systemic anaphylaxis in Fc{gamma}R-deficient mice. Mice deficient in the inhibitory receptor for IgG, Fc{gamma}RIIB, display enhanced IgE-mediated anaphylactic responses, whereas mice deficient in an IgG activation receptor, Fc{gamma}RIII, display a corresponding attenuation of IgE-mediated responses. Thus, in addition to modulating IgG-triggered hypersensitivity responses, Fc{gamma}RII and III on mast cells are potent regulators of IgE-mediated responses and reveal the existence of a regulatory pathway for IgE triggering of effector cells through IgG Fc receptors that could contribute to the etiology of the atopic response.

Key Words: systemic anaphylaxis • Fc receptor • immunoglobulin E • mast cell • gene targeting

Address correspondence to Toshiyuki Takai, Department of Experimental Immunology, Institute of Development, Aging and Cancer, Tohoku University, 4-1 Seiryo, Sendai 980-8575, Japan. Phone: 81-22-717-8501; Fax: 81-22-717-8505; E-mail: tostakai{at}idac.tohoku.ac.jp

Abbreviations used: BMMC, bone marrow–derived cultured mast cells; Fc{varepsilon}RI, high-affinity receptor for IgE; Fc{gamma}R, Fc receptor for IgG; FcR{gamma}, Fc receptor {gamma} subunit; Fc{gamma}RIIB and Fc{gamma}RIII, type IIB and type III low-affinity receptors for IgG, respectively.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS