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J. Exp. Med.,
Volume 188, Number 7, October 5, 1998 1375-1380
and
CD3
for Development of 
and T Lymphocytes
By
From the * Division of Immunology, Beth Israel Deaconess Medical Center, Harvard Medical School,
Boston, Massachusetts 02215; and the CD3
Department of Pathology, Brigham and Women's Hospital,
Harvard Medical School, Boston, Massachusetts 02115
and CD3
are two highly related components of the T cell receptor (TCR)-CD3 complex which is essential for the assembly and signal transduction of the T cell receptor on mature
T cells. In gene knockout mice deficient in either CD3 or CD3, early thymic development
mediated by pre-TCR was either undisturbed or severely blocked, respectively, and small
numbers of TCR-
+ T cells were detected in the periphery of both mice. T cell development was either normal in CD3
/ mice or partially blocked in CD3/ mice. To examine
the collective role of CD3 and CD3 in the assembly and function of pre-TCR and in the
development of T cells, we generated a mouse strain with a disruption in both CD3 and
CD3 genes (CD3/). In contrast to mice deficient in either CD3 or CD3 chains, early
thymic development mediated by pre-TCR is completely blocked, and TCR-+ or TCR-+ T cells were absent in the CD3/ mice. Taken together, these studies demonstrated
that CD3 and CD3 play an essential, yet partially overlapping, role in the development of
both and T cell lineages.
;
CD3;
T cell receptor-CD3 complex;
T cell development;
knockout
mouse
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