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Brief Definitive Reports |
and CD3
for Development of 
β and T Lymphocytes
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115
CD3
and CD3
are two highly related components of the T cell receptor (TCR)–CD3 complex which is essential for the assembly and signal transduction of the T cell receptor on mature T cells. In gene knockout mice deficient in either CD3 or CD3, early thymic development mediated by pre-TCR was either undisturbed or severely blocked, respectively, and small numbers of TCR-
β+ T cells were detected in the periphery of both mice. T cell development was either normal in CD3–/– mice or partially blocked in CD3–/– mice. To examine the collective role of CD3 and CD3 in the assembly and function of pre-TCR and in the development of T cells, we generated a mouse strain with a disruption in both CD3 and CD3 genes (CD3–/–). In contrast to mice deficient in either CD3 or CD3 chains, early thymic development mediated by pre-TCR is completely blocked, and TCR-β+ or TCR-+ T cells were absent in the CD3–/– mice. Taken together, these studies demonstrated that CD3 and CD3 play an essential, yet partially overlapping, role in the development of both β and T cell lineages.
Key Words: CD3 • CD3 • T cell receptor–CD3 complex • T cell development • knockout mouse
Dr. Salio's current address is Basel Institute of Immunology, Basel, Switzerland.
The first two authors contributed equally to this work.
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