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J. Exp. Med.,
Volume 188, Number 7, October 5, 1998 1359-1368
v
5 and CD36, and Cross-present Antigens to
Cytotoxic T Lymphocytes
By
From the * Laboratory of Cellular Physiology and Immunology, The Rockefeller University,
New York 10021; and the Dendritic cells, but not macrophages, efficiently phagocytose apoptotic cells and cross-present
viral, tumor, and self-antigens to CD8+ T cells. This in vitro pathway corresponds to the in
vivo phenomena of cross-priming and cross-tolerance. Here, we demonstrate that phagocytosis
of apoptotic cells is restricted to the immature stage of dendritic cell (DC) development, and
that this process is accompanied by the expression of a unique profile of receptors, in particular
the Division of Hematology-Oncology, Cornell University Medical
College, New York 10021
v
5 integrin and CD36. Upon maturation, these receptors and, in turn, the phagocytic capacity of DCs, are downmodulated. Macrophages engulf apoptotic cells more efficiently than
DCs, and although they express many receptors that mediate this uptake, they lack the v5 integrin. Furthermore, in contrast to DCs, macrophages fail to cross-present antigenic material
contained within the engulfed apoptotic cells. Thus, DCs use unique pathways for the phagocytosis, processing, and presentation of antigen derived from apoptotic cells on class I major
histocompatibility complex. We suggest that the v5 integrin plays a critical role in the trafficking of exogenous antigen by immature DCs in this cross-priming pathway.
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