Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 428K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Ngo, V. N. Articles by Cyster, J. G. Search for Related Content PubMed PubMed Citation Articles by Ngo, V. N. Articles by Cyster, J. G. Pubmed/NCBI databases Gene GEO Profiles HomoloGene Protein UniGene Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL Social Bookmarking                            What's this?

Articles

From the Department of Microbiology and Immunology, University of California at San Francisco, San Francisco, California 94143-0414

Movement of T and B lymphocytes through secondary lymphoid tissues is likely to involve multiple cues that help the cells navigate to appropriate compartments. Epstein-Barr virus– induced molecule 1 (EBI-1) ligand chemokine (ELC/MIP3β) is expressed constitutively within lymphoid tissues and may act as such a guidance cue. Here, we have isolated mouse ELC and characterized its expression pattern and chemotactic properties. ELC is expressed constitutively in dendritic cells within the T cell zone of secondary lymphoid tissues. Recombinant ELC was strongly chemotactic for naive (L-selectin^hi) CD4 T cells and for CD8 T cells and weakly attractive for resting B cells and memory (L-selectin^lo) CD4 T cells. After activation through the B cell receptor, the chemotactic response of B cells was enhanced. Like its human counterpart, murine ELC stimulated cells transfected with EBI-1/CC chemokine receptor 7 (CCR7). Our findings suggest a central role for ELC in promoting encounters between recirculating T cells and dendritic cells and in the migration of activated B cells into the T zone of secondary lymphoid tissues.

Key Words: chemokine • dendritic cells • lymphoid tissue • T zone • lymphocyte

Note added in proof. After submission of this manuscript, Kim et al. reported that human ELC is chemotactic for human T and B lymphocytes ( J. Immunol. 160:2418–2424), and Yoshida et al. demonstrated that SLC is a second ligand for CCR7 ( J. Biol. Chem. 273:7118–7122).

Abbreviations used: BLC, B lymphocyte chemoattractant; BLR, Burkitt's lymphoma receptor; CCR, CC chemokine receptor; DC, dendritic cell; DCCK, dendritic cell–derived CC chemokine; EBI-1, EBV-induced molecule 1; ELC, EBI-1 ligand chemokine; EF, elongation factor; EST, expressed sequence tag; HEV, high endothelial venules; MCP, monocyte chemoattractant protein; MIP, macrophage-inflammatory protein; PARC, pulmonary and activation–regulated chemokine; RT, reverse transcription; SDF, stromal cell–derived factor; SLC, secondary lymphoid tissue chemokine.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Dong, Y., Du, X., Ye, J., Han, M., Xu, T., Zhuang, Y., Tao, W. (2009). A Cell-Intrinsic Role for Mst1 in Regulating Thymocyte Egress. J. Immunol. 183: 3865-3872 [Abstract] [Full Text]  
• Kuwabara, T., Ishikawa, F., Yasuda, T., Aritomi, K., Nakano, H., Tanaka, Y., Okada, Y., Lipp, M., Kakiuchi, T. (2009). CCR 7 Ligands Are Required for Development of Experimental Autoimmune Encephalomyelitis through Generating IL-23-Dependent Th17 Cells. J. Immunol. 183: 2513-2521 [Abstract] [Full Text]  
• Zidar, D. A., Violin, J. D., Whalen, E. J., Lefkowitz, R. J. (2009). Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands. Proc. Natl. Acad. Sci. USA 106: 9649-9654 [Abstract] [Full Text]  
• Tournadre, A, Miossec, P (2009). Chemokines and dendritic cells in inflammatory myopathies. Ann Rheum Dis 68: 300-304 [Abstract] [Full Text]  
• Britschgi, M. R., Link, A., Lissandrin, T. K. A., Luther, S. A. (2008). Dynamic Modulation of CCR7 Expression and Function on Naive T Lymphocytes In Vivo. J. Immunol. 181: 7681-7688 [Abstract] [Full Text]  
• Reichardt, W., Durr, C., von Elverfeldt, D., Juttner, E., Gerlach, U. V., Yamada, M., Smith, B., Negrin, R. S., Zeiser, R. (2008). Impact of Mammalian Target of Rapamycin Inhibition on Lymphoid Homing and Tolerogenic Function of Nanoparticle-Labeled Dendritic Cells following Allogeneic Hematopoietic Cell Transplantation. J. Immunol. 181: 4770-4779 [Abstract] [Full Text]  
• Matsumura, S., Wang, B., Kawashima, N., Braunstein, S., Badura, M., Cameron, T. O., Babb, J. S., Schneider, R. J., Formenti, S. C., Dustin, M. L., Demaria, S. (2008). Radiation-Induced CXCL16 Release by Breast Cancer Cells Attracts Effector T Cells. J. Immunol. 181: 3099-3107 [Abstract] [Full Text]  
• Anis, M. M., Fulton, S. A., Reba, S. M., Liu, Y., Harding, C. V., Boom, W. H. (2008). Modulation of Pulmonary Dendritic Cell Function during Mycobacterial Infection. Infect. Immun. 76: 671-677 [Abstract] [Full Text]  
• Arias, M. A., Jaramillo, G., Lopez, Y. P., Mejia, N., Mejia, C., Pantoja, A. E., Shattock, R. J., Garcia, L. F., Griffin, G. E. (2007). Mycobacterium tuberculosis Antigens Specifically Modulate CCR2 and MCP-1/CCL2 on Lymphoid Cells from Human Pulmonary Hilar Lymph Nodes. J. Immunol. 179: 8381-8391 [Abstract] [Full Text]  
• Yin, X., Ladi, E., Chan, S. W., Li, O., Killeen, N., Kappes, D. J., Robey, E. A. (2007). CCR7 Expression in Developing Thymocytes Is Linked to the CD4 versus CD8 Lineage Decision. J. Immunol. 179: 7358-7364 [Abstract] [Full Text]  
• Manzo, A., Bugatti, S., Caporali, R., Prevo, R., Jackson, D. G., Uguccioni, M., Buckley, C. D., Montecucco, C., Pitzalis, C. (2007). CCL21 Expression Pattern of Human Secondary Lymphoid Organ Stroma Is Conserved in Inflammatory Lesions with Lymphoid Neogenesis. Am. J. Pathol. 171: 1549-1562 [Abstract] [Full Text]  
• Unsoeld, H., Mueller, K., Schleicher, U., Bogdan, C., Zwirner, J., Voehringer, D., Pircher, H. (2007). Abrogation of CCL21 chemokine function by transgenic over-expression impairs T cell immunity to local infections. Int Immunol 19: 1281-1289 [Abstract] [Full Text]  
• Haynes, N. M., Allen, C. D. C., Lesley, R., Ansel, K. M., Killeen, N., Cyster, J. G. (2007). Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation. J. Immunol. 179: 5099-5108 [Abstract] [Full Text]  
• Kabashima, K., Shiraishi, N., Sugita, K., Mori, T., Onoue, A., Kobayashi, M., Sakabe, J.-i., Yoshiki, R., Tamamura, H., Fujii, N., Inaba, K., Tokura, Y. (2007). CXCL12-CXCR4 Engagement Is Required for Migration of Cutaneous Dendritic Cells. Am. J. Pathol. 171: 1249-1257 [Abstract] [Full Text]  
• Minges Wols, H. A., Ippolito, J. A., Yu, Z., Palmer, J. L., White, F. A., Le, P. T., Witte, P. L. (2007). The effects of microenvironment and internal programming on plasma cell survival. Int Immunol 0: dxm051v1- [Abstract] [Full Text]  
• Rangel-Moreno, J., Moyron-Quiroz, J. E., Hartson, L., Kusser, K., Randall, T. D. (2007). Pulmonary expression of CXC chemokine ligand 13, CC chemokine ligand 19, and CC chemokine ligand 21 is essential for local immunity to influenza. Proc. Natl. Acad. Sci. USA 104: 10577-10582 [Abstract] [Full Text]  
• Maeda, Y., Matsuyuki, H., Shimano, K., Kataoka, H., Sugahara, K., Chiba, K. (2007). Migration of CD4 T Cells and Dendritic Cells toward Sphingosine 1-Phosphate (S1P) Is Mediated by Different Receptor Subtypes: S1P Regulates the Functions of Murine Mature Dendritic Cells via S1P Receptor Type 3. J. Immunol. 178: 3437-3446 [Abstract] [Full Text]  
• Damas, J. K., Smith, C., Oie, E., Fevang, B., Halvorsen, B., Waehre, T., Boullier, A., Breland, U., Yndestad, A., Ovchinnikova, O., Robertson, A.-K. L., Sandberg, W. J., Kjekshus, J., Tasken, K., Froland, S. S., Gullestad, L., Hansson, G. K., Quehenberger, O., Aukrust, P. (2007). Enhanced Expression of the Homeostatic Chemokines CCL19 and CCL21 in Clinical and Experimental Atherosclerosis: Possible Pathogenic Role in Plaque Destabilization. Arterioscler. Thromb. Vasc. Bio. 27: 614-620 [Abstract] [Full Text]  
• Yasuda, T., Kuwabara, T., Nakano, H., Aritomi, K., Onodera, T., Lipp, M., Takahama, Y., Kakiuchi, T. (2007). Chemokines CCL19 and CCL21 promote activation-induced cell death of antigen-responding T cells. Blood 109: 449-456 [Abstract] [Full Text]  
• Kabashima, K., Haynes, N. M., Xu, Y., Nutt, S. L., Allende, M. L., Proia, R. L., Cyster, J. G. (2006). Plasma cell S1P1 expression determines secondary lymphoid organ retention versus bone marrow tropism. JEM 203: 2683-2690 [Abstract] [Full Text]  
• Kamphuis, E., Junt, T., Waibler, Z., Forster, R., Kalinke, U. (2006). Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood 108: 3253-3261 [Abstract] [Full Text]  
• Sancho, M., Vieira, J. M., Casalou, C., Mesquita, M., Pereira, T., Cavaco, B. M., Dias, S., Leite, V. (2006). Expression and function of the chemokine receptor CCR7 in thyroid carcinomas.. J Endocrinol 191: 229-238 [Abstract] [Full Text]  
• Annunziato, F, Cosmi, L, Liotta, F, Lazzeri, E, Romagnani, P, Angeli, R, Lasagni, L, Manetti, R, Marra, F, Gerard, C, Petrai, I, Dello Sbarba, P, Tonelli, F, Maggi, E, Romagnani, S (2006). CXCR3 and {alpha}E{beta}7 integrin identify a subset of CD8+ mature thymocytes that share phenotypic and functional properties with CD8+ gut intraepithelial lymphocytes. Gut 55: 961-968 [Abstract] [Full Text]  
• Ato, M., Maroof, A., Zubairi, S., Nakano, H., Kakiuchi, T., Kaye, P. M. (2006). Loss of Dendritic Cell Migration and Impaired Resistance to Leishmania donovani Infection in Mice Deficient in CCL19 and CCL21. J. Immunol. 176: 5486-5493 [Abstract] [Full Text]  
• Nacionales, D. C., Kelly, K. M., Lee, P. Y., Zhuang, H., Li, Y., Weinstein, J. S., Sobel, E., Kuroda, Y., Akaogi, J., Satoh, M., Reeves, W. H. (2006). Type I Interferon Production by Tertiary Lymphoid Tissue Developing in Response to 2,6,10,14-Tetramethyl-Pentadecane (Pristane). Am. J. Pathol. 168: 1227-1240 [Abstract] [Full Text]  
• Piqueras, B., Connolly, J., Freitas, H., Palucka, A. K., Banchereau, J. (2006). Upon viral exposure, myeloid and plasmacytoid dendritic cells produce 3 waves of distinct chemokines to recruit immune effectors. Blood 107: 2613-2618 [Abstract] [Full Text]  
• Rangel-Moreno, J., Moyron-Quiroz, J., Kusser, K., Hartson, L., Nakano, H., Randall, T. D. (2005). Role of CXC Chemokine Ligand 13, CC Chemokine Ligand (CCL) 19, and CCL21 in the Organization and Function of Nasal-Associated Lymphoid Tissue. J. Immunol. 175: 4904-4913 [Abstract] [Full Text]  
• Kawashima, D, Oshitani, N, Jinno, Y, Watanabe, K, Nakamura, S, Higuchi, K, Arakawa, T (2005). Augmented expression of secondary lymphoid tissue chemokine and EBI1 ligand chemokine in Crohn's disease. J. Clin. Pathol. 58: 1057-1063 [Abstract] [Full Text]  
• Hardtke, S., Ohl, L., Forster, R. (2005). Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help. Blood 106: 1924-1931 [Abstract] [Full Text]  
• Kaiser, A., Donnadieu, E., Abastado, J.-P., Trautmann, A., Nardin, A. (2005). CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate Antigen. J. Immunol. 175: 2349-2356 [Abstract] [Full Text]  
• Beilhack, A., Schulz, S., Baker, J., Beilhack, G. F., Wieland, C. B., Herman, E. I., Baker, E. M., Cao, Y.-A., Contag, C. H., Negrin, R. S. (2005). In vivo analyses of early events in acute graft-versus-host disease reveal sequential infiltration of T-cell subsets. Blood 106: 1113-1122 [Abstract] [Full Text]  
• Inamine, A., Takahashi, Y., Baba, N., Miyake, K., Tokuhisa, T., Takemori, T., Abe, R. (2005). Two waves of memory B-cell generation in the primary immune response. Int Immunol 17: 581-589 [Abstract] [Full Text]  
• Brittingham, K. C., Ruthel, G., Panchal, R. G., Fuller, C. L., Ribot, W. J., Hoover, T. A., Young, H. A., Anderson, A. O., Bavari, S. (2005). Dendritic Cells Endocytose Bacillus anthracis Spores: Implications for Anthrax Pathogenesis. J. Immunol. 174: 5545-5552 [Abstract] [Full Text]  
• McDonald, K. G., McDonough, J. S., Newberry, R. D. (2005). Adaptive Immune Responses Are Dispensable for Isolated Lymphoid Follicle Formation: Antigen-Naive, Lymphotoxin-Sufficient B Lymphocytes Drive the Formation of Mature Isolated Lymphoid Follicles. J. Immunol. 174: 5720-5728 [Abstract] [Full Text]  
• Chen, Y.-G., Choisy-Rossi, C.-M., Holl, T. M., Chapman, H. D., Besra, G. S., Porcelli, S. A., Shaffer, D. J., Roopenian, D., Wilson, S. B., Serreze, D. V. (2005). Activated NKT Cells Inhibit Autoimmune Diabetes through Tolerogenic Recruitment of Dendritic Cells to Pancreatic Lymph Nodes. J. Immunol. 174: 1196-1204 [Abstract] [Full Text]  
• Lo, C. G., Xu, Y., Proia, R. L., Cyster, J. G. (2005). Cyclical modulation of sphingosine-1-phosphate receptor 1 surface expression during lymphocyte recirculation and relationship to lymphoid organ transit. JEM 201: 291-301 [Abstract] [Full Text]  
• Ying, X., Chan, K., Shenoy, P., Hill, M., Ruddle, N. H. (2005). Lymphotoxin Plays a Crucial Role in the Development and Function of Nasal-Associated Lymphoid Tissue through Regulation of Chemokines and Peripheral Node Addressin. Am. J. Pathol. 166: 135-146 [Abstract] [Full Text]  
• Ott, T. R., Pahuja, A., Nickolls, S. A., Alleva, D. G., Struthers, R. S. (2004). Identification of CC Chemokine Receptor 7 Residues Important for Receptor Activation. J. Biol. Chem. 279: 42383-42392 [Abstract] [Full Text]  
• Pilkington, K. R., Clark-Lewis, I., McColl, S. R. (2004). Inhibition of Generation of Cytotoxic T Lymphocyte Activity by a CCL19/Macrophage Inflammatory Protein (MIP)-3{beta} Antagonist. J. Biol. Chem. 279: 40276-40282 [Abstract] [Full Text]  
• Witt, C. M., Robey, E. A. (2004). The Ins and Outs of CCR7 in the Thymus. JEM 200: 405-409 [Abstract] [Full Text]  
• Lopez-Giral, S., Quintana, N. E., Cabrerizo, M., Alfonso-Perez, M., Sala-Valdes, M., de Soria, V. G. G., Fernandez-Ranada, J. M., Fernandez-Ruiz, E., Munoz, C. (2004). Chemokine receptors that mediate B cell homing to secondary lymphoid tissues are highly expressed in B cell chronic lymphocytic leukemia and non-Hodgkin lymphomas with widespread nodular dissemination. J. Leukoc. Biol. 76: 462-471 [Abstract] [Full Text]  
• D'Amico, G., Vulcano, M., Bugarin, C., Bianchi, G., Pirovano, G., Bonamino, M., Marin, V., Allavena, P., Biagi, E., Biondi, A. (2004). CD40 activation of BCP-ALL cells generates IL-10-producing, IL-12-defective APCs that induce allogeneic T-cell anergy. Blood 104: 744-751 [Abstract] [Full Text]  
• Wysocki, C. A., Burkett, S. B., Panoskaltsis-Mortari, A., Kirby, S. L., Luster, A. D., McKinnon, K., Blazar, B. R., Serody, J. S. (2004). Differential Roles for CCR5 Expression on Donor T Cells during Graft-versus-Host Disease Based on Pretransplant Conditioning. J. Immunol. 173: 845-854 [Abstract] [Full Text]  
• Kwan, J., Killeen, N. (2004). CCR7 Directs the Migration of Thymocytes into the Thymic Medulla. J. Immunol. 172: 3999-4007 [Abstract] [Full Text]  
• Ghobrial, I. M., Bone, N. D., Stenson, M. J., Novak, A., Hedin, K. E., Kay, N. E., Ansell, S. M. (2004). Expression of the Chemokine Receptors CXCR4 and CCR7 and Disease Progression in B-Cell Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma. Mayo Clin Proc. 79: 318-325 [Abstract]  
• Miller, M. J., Hejazi, A. S., Wei, S. H., Cahalan, M. D., Parker, I. (2004). T cell repertoire scanning is promoted by dynamic dendritic cell behavior and random T cell motility in the lymph node. Proc. Natl. Acad. Sci. USA 101: 998-1003 [Abstract] [Full Text]  
• Hammad, H., de Heer, H. J., Soullie, T., Angeli, V., Trottein, F., Hoogsteden, H. C., Lambrecht, B. N. (2004). Activation of Peroxisome Proliferator-Activated Receptor-{gamma} in Dendritic Cells Inhibits the Development of Eosinophilic Airway Inflammation in a Mouse Model of Asthma. Am. J. Pathol. 164: 263-271 [Abstract] [Full Text]  
• Hillinger, S., Yang, S.-C., Zhu, L., Huang, M., Duckett, R., Atianzar, K., Batra, R. K., Strieter, R. M., Dubinett, S. M., Sharma, S. (2003). EBV-Induced Molecule 1 Ligand Chemokine (ELC/CCL19) Promotes IFN-{gamma}-Dependent Antitumor Responses in a Lung Cancer Model. J. Immunol. 171: 6457-6465 [Abstract] [Full Text]  
• Martin-Fontecha, A., Sebastiani, S., Hopken, U. E., Uguccioni, M., Lipp, M., Lanzavecchia, A., Sallusto, F. (2003). Regulation of Dendritic Cell Migration to the Draining Lymph Node: Impact on T Lymphocyte Traffic and Priming. JEM 198: 615-621 [Abstract] [Full Text]  
• Gibejova, A., Mrazek, F., Subrtova, D., Sekerova, V., Szotkowska, J., Kolek, V., du Bois, R. M., Petrek, M. (2003). Expression of Macrophage Inflammatory Protein-3{beta}/CCL19 in Pulmonary Sarcoidosis. Am. J. Respir. Crit. Care Med. 167: 1695-1703 [Abstract] [Full Text]  
• Annels, N. E., da Costa, C. E.T., Prins, F. A., Willemze, A., Hogendoorn, P. C.W., Egeler, R. M. (2003). Aberrant Chemokine Receptor Expression and Chemokine Production by Langerhans Cells Underlies the Pathogenesis of Langerhans Cell Histiocytosis. JEM 197: 1385-1390 [Abstract] [Full Text]  
• Vulcano, M., Struyf, S., Scapini, P., Cassatella, M., Bernasconi, S., Bonecchi, R., Calleri, A., Penna, G., Adorini, L., Luini, W., Mantovani, A., Van Damme, J., Sozzani, S. (2003). Unique Regulation of CCL18 Production by Maturing Dendritic Cells. J. Immunol. 170: 3843-3849 [Abstract] [Full Text]  
• Savinov, A. Y., Wong, F. S., Stonebraker, A. C., Chervonsky, A. V. (2003). Presentation of Antigen by Endothelial Cells and Chemoattraction Are Required for Homing of Insulin-specific CD8+ T Cells. JEM 197: 643-656 [Abstract] [Full Text]  
• Choi, Y. K., Fallert, B. A., Murphey-Corb, M. A., Reinhart, T. A. (2003). Simian immunodeficiency virus dramatically alters expression of homeostatic chemokines and dendritic cell markers during infection in vivo. Blood 101: 1684-1691 [Abstract] [Full Text]  
• Glodek, A. M., Honczarenko, M., Le, Y., Campbell, J. J., Silberstein, L. E. (2003). Sustained Activation of Cell Adhesion Is a Differentially Regulated Process in B Lymphopoiesis. JEM 197: 461-473 [Abstract] [Full Text]  
• Fillatreau, S., Gray, D. (2003). T Cell Accumulation in B Cell Follicles Is Regulated by Dendritic Cells and Is Independent of B Cell Activation. JEM 197: 195-206 [Abstract] [Full Text]  
• Sasaki, M., Hasegawa, H., Kohno, M., Inoue, A., Ito, M. R., Fujita, S. (2003). Antagonist of Secondary Lymphoid-Tissue Chemokine (CCR Ligand 21) Prevents the Development of Chronic Graft-Versus-Host Disease in Mice. J. Immunol. 170: 588-596 [Abstract] [Full Text]  
• Krug, A., Uppaluri, R., Facchetti, F., Dorner, B. G., Sheehan, K. C. F., Schreiber, R. D., Cella, M., Colonna, M. (2002). Cutting Edge: IFN-Producing Cells Respond to CXCR3 Ligands in the Presence of CXCL12 and Secrete Inflammatory Chemokines upon Activation. J. Immunol. 169: 6079-6083 [Abstract] [Full Text]  
• Fong, L., Mengozzi, M., Abbey, N. W., Herndier, B. G., Engleman, E. G. (2002). Productive Infection of Plasmacytoid Dendritic Cells with Human Immunodeficiency Virus Type 1 Is Triggered by CD40 Ligation. J. Virol. 76: 11033-11041 [Abstract] [Full Text]  
• Corcione, A., Tortolina, G., Bonecchi, R., Battilana, N., Taborelli, G., Malavasi, F., Sozzani, S., Ottonello, L., Dallegri, F., Pistoia, V. (2002). Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells. Int Immunol 14: 883-892 [Abstract] [Full Text]  
• Muller, G., Hopken, U. E., Stein, H., Lipp, M. (2002). Systemic immunoregulatory and pathogenic functions of homeostatic chemokine receptors. J. Leukoc. Biol. 72: 1-8 [Abstract] [Full Text]  
• Okada, T., Ngo, V. N., Ekland, E. H., Forster, R., Lipp, M., Littman, D. R., Cyster, J. G. (2002). Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches. JEM 196: 65-75 [Abstract] [Full Text]  
• Luther, S. A., Bidgol, A., Hargreaves, D. C., Schmidt, A., Xu, Y., Paniyadi, J., Matloubian, M., Cyster, J. G. (2002). Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis. J. Immunol. 169: 424-433 [Abstract] [Full Text]  
• Junt, T., Nakano, H., Dumrese, T., Kakiuchi, T., Odermatt, B., Zinkernagel, R. M., Hengartner, H., Ludewig, B. (2002). Antiviral Immune Responses in the Absence of Organized Lymphoid T Cell Zones in plt/plt Mice. J. Immunol. 168: 6032-6040 [Abstract] [Full Text]  
• Debes, G. F., Hopken, U. E., Hamann, A. (2002). In Vivo Differentiated Cytokine-Producing CD4+ T Cells Express Functional CCR7. J. Immunol. 168: 5441-5447 [Abstract] [Full Text]  
• Yu, P., Wang, Y., Chin, R. K., Martinez-Pomares, L., Gordon, S., Kosco-Vibois, M. H., Cyster, J., Fu, Y.-X. (2002). B Cells Control the Migration of a Subset of Dendritic Cells into B Cell Follicles Via CXC Chemokine Ligand 13 in a Lymphotoxin-Dependent Fashion. J. Immunol. 168: 5117-5123 [Abstract] [Full Text]  
• Page, G., Lebecque, S., Miossec, P. (2002). Anatomic Localization of Immature and Mature Dendritic Cells in an Ectopic Lymphoid Organ: Correlation with Selective Chemokine Expression in Rheumatoid Synovium. J. Immunol. 168: 5333-5341 [Abstract] [Full Text]  
• Zimmer, M. I., Larregina, A. T., Castillo, C. M., Capuano, S. III, Falo, L. D. Jr, Murphey-Corb, M., Reinhart, T. A., Barratt-Boyes, S. M. (2002). Disrupted homeostasis of Langerhans cells and interdigitating dendritic cells in monkeys with AIDS. Blood 99: 2859-2868 [Abstract] [Full Text]  
• Till, K. J., Lin, K., Zuzel, M., Cawley, J. C. (2002). The chemokine receptor CCR7 and alpha 4 integrin are important for migration of chronic lymphocytic leukemia cells into lymph nodes. Blood 99: 2977-2984 [Abstract] [Full Text]  
• Casamayor-Palleja, M., Mondiere, P., Verschelde, C., Bella, C., Defrance, T. (2002). BCR ligation reprograms B cells for migration to the T zone and B-cell follicle sequentially. Blood 99: 1913-1921 [Abstract] [Full Text]  
• Foxman, E. F., Zhang, M., Hurst, S. D., Muchamuel, T., Shen, D., Wawrousek, E. F., Chan, C.-C., Gery, I. (2002). Inflammatory Mediators in Uveitis: Differential Induction of Cytokines and Chemokines in Th1- Versus Th2-Mediated Ocular Inflammation. J. Immunol. 168: 2483-2492 [Abstract] [Full Text]  
• Lipscomb, M. F., Masten, B. J. (2002). Dendritic Cells: Immune Regulators in Health and Disease. Physiol. Rev. 82: 97-130 [Abstract] [Full Text]  
• Ploix, C., Lo, D., Carson, M. J. (2001). A Ligand for the Chemokine Receptor CCR7 Can Influence the Homeostatic Proliferation of CD4 T Cells and Progression of Autoimmunity. J. Immunol. 167: 6724-6730 [Abstract] [Full Text]  
• Ngo, V. N., Cornall, R. J., Cyster, J. G. (2001). Splenic T Zone Development Is B Cell Dependent. JEM 194: 1649-1660 [Abstract] [Full Text]  
• Kirk, C. J., Hartigan-O'Connor, D., Mule, J. J. (2001). The Dynamics of the T-Cell Antitumor Response: Chemokine-secreting Dendritic Cells Can Prime Tumor-reactive T Cells Extranodally. Cancer Res. 61: 8794-8802 [Abstract] [Full Text]  
• Lambrecht, B.N., Prins, J-;B., Hoogsteden, H.C. (2001). Lung dendritic cells and host immunity to infection. Eur Respir J 18: 692-704 [Abstract] [Full Text]  
• Dubois, B., Massacrier, C., Caux, C. (2001). Selective attraction of naive and memory B cells by dendritic cells. J. Leukoc. Biol. 70: 633-641 [Abstract] [Full Text]  
• Hawiger, D., Inaba, K., Dorsett, Y., Guo, M., Mahnke, K., Rivera, M., Ravetch, J. V., Steinman, R. M., Nussenzweig, M. C. (2001). Dendritic Cells Induce Peripheral T Cell Unresponsiveness under Steady State Conditions in Vivo. JEM 194: 769-780 [Abstract] [Full Text]  
• Pilette, C., Ouadrhiri, Y., Godding, V., Vaerman, J-P., Sibille, Y. (2001). Lung mucosal immunity: immunoglobulin-A revisited. Eur Respir J 18: 571-588 [Abstract] [Full Text]  
• Weyand, C. M., Kurtin, P. J., Goronzy, J. J. (2001). Ectopic Lymphoid Organogenesis : A Fast Track for Autoimmunity. Am. J. Pathol. 159: 787-793 [Full Text]  
• Weih, D. S., Yilmaz, Z. B., Weih, F. (2001). Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines. J. Immunol. 167: 1909-1919 [Abstract] [Full Text]  
• Mandik-Nayak, L., Huang, G., Sheehan, K. C. F., Erikson, J., Chaplin, D. D. (2001). Signaling Through TNF Receptor p55 in TNF-{alpha}-Deficient Mice Alters the CXCL13/CCL19/CCL21 Ratio in the Spleen and Induces Maturation and Migration of Anergic B Cells into the B Cell Follicle. J. Immunol. 167: 1920-1928 [Abstract] [Full Text]  
• Kellermann, S.-A., McEvoy, L. M. (2001). The Peyer's Patch Microenvironment Suppresses T Cell Responses to Chemokines and Other Stimuli. J. Immunol. 167: 682-690 [Abstract] [Full Text]  
• Hargreaves, D. C., Hyman, P. L., Lu, T. T., Ngo, V. N., Bidgol, A., Suzuki, G., Zou, Y.-R., Littman, D. R., Cyster, J. G. (2001). A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements. JEM 194: 45-56 [Abstract] [Full Text]  
• Stumbles, P. A., Strickland, D. H., Pimm, C. L., Proksch, S. F., Marsh, A. M., McWilliam, A. S., Bosco, A., Tobagus, I., Thomas, J. A., Napoli, S., Proudfoot, A. E. I., Wells, T. N. C., Holt, P. G. (2001). Regulation of Dendritic Cell Recruitment into Resting and Inflamed Airway Epithelium: Use of Alternative Chemokine Receptors as a Function of Inducing Stimulus. J. Immunol. 167: 228-234 [Abstract] [Full Text]  
• Kim, C. H., Rott, L. S., Clark-Lewis, I., Campbell, D. J., Wu, L., Butcher, E. C. (2001). Subspecialization of Cxcr5+ T Cells: B Helper Activity Is Focused in a Germinal Center-Localized Subset of Cxcr5+ T Cells. JEM 193: 1373-1382 [Abstract] [Full Text]  
• Manz, M. G., Traver, D., Miyamoto, T., Weissman, I. L., Akashi, K. (2001). Dendritic cell potentials of early lymphoid and myeloid progenitors. Blood 97: 3333-3341 [Abstract] [Full Text]  
• Finke, D., Baribaud, F., Diggelmann, H., Acha-Orbea, H. (2001). Extrafollicular Plasmablast B Cells Play a Key Role in Carrying Retroviral Infection to Peripheral Organs. J. Immunol. 166: 6266-6275 [Abstract] [Full Text]  
• Baekkevold, E. S., Yamanaka, T., Palframan, R. T., Carlsen, H. S., Reinholt, F. P., von Andrian, U. H., Brandtzaeg, P., Haraldsen, G. (2001). The Ccr7 Ligand ELC (Ccl19) Is Transcytosed in High Endothelial Venules and Mediates T Cell Recruitment. JEM 193: 1105-1112 [Abstract] [Full Text]  
• Katou, F., Ohtani, H., Nakayama, T., Ono, K., Matsushima, K., Saaristo, A., Nagura, H., Yoshie, O., Motegi, K. (2001). Macrophage-Derived Chemokine (MDC/CCL22) and CCR4 Are Involved in the Formation of T Lymphocyte-Dendritic Cell Clusters in Human Inflamed Skin and Secondary Lymphoid Tissue. Am. J. Pathol. 158: 1263-1270 [Abstract] [Full Text]  
• Seo, S.-j., Buckler, J., Erikson, J. (2001). Novel Roles for Lyn in B Cell Migration and Lipopolysaccharide Responsiveness Revealed Using Anti-Double-Stranded DNA Ig Transgenic Mice. J. Immunol. 166: 3710-3716 [Abstract] [Full Text]  
• Honda, K., Nakano, H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., Nishikawa, S.-I. (2001). Molecular Basis for Hematopoietic/Mesenchymal Interaction during Initiation of Peyer's Patch Organogenesis. JEM 193: 621-630 [Abstract] [Full Text]  
• Mori, S., Nakano, H., Aritomi, K., Wang, C.-R., Gunn, M. D., Kakiuchi, T. (2001). Mice Lacking Expression of the Chemokines Ccl21-Ser and Ccl19 (plt Mice) Demonstrate Delayed but Enhanced T Cell Immune Responses. JEM 193: 207-218 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS