Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 169K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Akimoto, T. Articles by Akira, S. Search for Related Content PubMed PubMed Citation Articles by Akimoto, T. Articles by Akira, S. Social Bookmarking                            What's this?

Brief Definitive Reports

Toshihiko Akimoto^*, Fumio Numata^*, Misato Tamura^*, Yoshimi Takata^*, Noriko Higashida^*, Tohru Takashi^*, Kiyoshi Takeda, and Shizuo Akira

From the ^* New Product Research Laboratories IV, Daiichi Pharmaceutical Co., Ltd., 1-16-13 Kitakasai, Edogawa, Tokyo 134, Japan; and the Department of Biochemistry, Hyogo College of Medicine, 1-1 Mukogawa, Nishinomiya, Hyogo 663, Japan

Signal transducers and activators of transcription 6 (STAT6) is essential for interleukin 4–mediated responses, including class switching to IgE and induction of type 2 T helper cells. To investigate the role of STAT6 in allergic asthma in vivo, we developed a murine model of allergen-induced airway inflammation. Repeated exposure of actively immunized C57BL/6 mice to ovalbumin (OVA) aerosol increased the level of serum IgE, the number of eosinophils in bronchoalveolar lavage (BAL) fluid, and airway reactivity. Histological analysis revealed peribronchial inflammation with pulmonary eosinophilia in OVA-treated mice. In STAT6-deficient (STAT6^–/–) C57BL/6 mice treated in the same fashion, there were no eosinophilia in BAL and significantly less peribronchial inflammation than in wild-type mice. Moreover STAT6^–/– mice had much less airway reactivity than wild-type mice. These findings suggest that STAT6 plays a crucial role in the pathogenesis of allergen-induced airway inflammation.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Chiba, Y., Todoroki, M., Nishida, Y., Tanabe, M., Misawa, M. (2009). A Novel STAT6 Inhibitor AS1517499 Ameliorates Antigen-Induced Bronchial Hypercontractility in Mice. Am. J. Respir. Cell Mol. Bio. 41: 516-524 [Abstract] [Full Text]  
• Wilson, R. H., Whitehead, G. S., Nakano, H., Free, M. E., Kolls, J. K., Cook, D. N. (2009). Allergic Sensitization through the Airway Primes Th17-dependent Neutrophilia and Airway Hyperresponsiveness. Am. J. Respir. Crit. Care Med. 180: 720-730 [Abstract] [Full Text]  
• Darcan-Nicolaisen, Y., Meinicke, H., Fels, G., Hegend, O., Haberland, A., Kuhl, A., Loddenkemper, C., Witzenrath, M., Kube, S., Henke, W., Hamelmann, E. (2009). Small Interfering RNA against Transcription Factor STAT6 Inhibits Allergic Airway Inflammation and Hyperreactivity in Mice. J. Immunol. 182: 7501-7508 [Abstract] [Full Text]  
• Zhou, B., Headley, M. B., Aye, T., Tocker, J., Comeau, M. R., Ziegler, S. F. (2008). Reversal of Thymic Stromal Lymphopoietin-Induced Airway Inflammation through Inhibition of Th2 Responses. J. Immunol. 181: 6557-6562 [Abstract] [Full Text]  
• Ueta, M., Hamuro, J., Ueda, E., Katoh, N., Yamamoto, M., Takeda, K., Akira, S., Kinoshita, S. (2008). Stat6-Independent Tissue Inflammation Occurs Selectively on the Ocular Surface and Perioral Skin of I{kappa}B{zeta}-/- Mice. IOVS 49: 3387-3394 [Abstract] [Full Text]  
• Cortes, J. R., Perez-G, M., Rivas, M. D., Zamorano, J. (2007). Kaempferol Inhibits IL-4-Induced STAT6 Activation by Specifically Targeting JAK3. J. Immunol. 179: 3881-3887 [Abstract] [Full Text]  
• Johnson, J. R., Swirski, F. K., Gajewska, B. U., Wiley, R. E., Fattouh, R., Pacitto, S. R., Wong, J. K., Stampfli, M. R., Jordana, M. (2007). Divergent immune responses to house dust mite lead to distinct structural-functional phenotypes. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L730-L739 [Abstract] [Full Text]  
• McCusker, C. T., Wang, Y., Shan, J., Kinyanjui, M. W., Villeneuve, A., Michael, H., Fixman, E. D. (2007). Inhibition of Experimental Allergic Airways Disease by Local Application of a Cell-Penetrating Dominant-Negative STAT-6 Peptide. J. Immunol. 179: 2556-2564 [Abstract] [Full Text]  
• Moller, M., Gravenor, M. B., Roberts, S. E., Sun, D., Gao, P., Hopkin, J. M. (2007). Genetic haplotypes of Th-2 immune signalling link allergy to enhanced protection to parasitic worms. Hum Mol Genet 16: 1828-1836 [Abstract] [Full Text]  
• Mishra, A., Wang, M., Schlotman, J., Nikolaidis, N. M., DeBrosse, C. W., Karow, M. L., Rothenberg, M. E. (2007). Resistin-like molecule-beta is an allergen-induced cytokine with inflammatory and remodeling activity in the murine lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 293: L305-L313 [Abstract] [Full Text]  
• Akiho, H., Khan, W. I., Al-Kaabi, A., Blennerhassett, P., Deng, Y., Collins, S. M (2007). Cytokine modulation of muscarinic receptors in the murine intestine. Am. J. Physiol. Gastrointest. Liver Physiol. 293: G250-G255 [Abstract] [Full Text]  
• Simeone-Penney, M. C., Severgnini, M., Tu, P., Homer, R. J., Mariani, T. J., Cohn, L., Simon, A. R. (2007). Airway Epithelial STAT3 Is Required for Allergic Inflammation in a Murine Model of Asthma. J. Immunol. 178: 6191-6199 [Abstract] [Full Text]  
• Maeda, Y., Dave, V., Whitsett, J. A. (2007). Transcriptional Control of Lung Morphogenesis. Physiol. Rev. 87: 219-244 [Abstract] [Full Text]  
• Temann, U.-A., Laouar, Y., Eynon, E. E., Homer, R., Flavell, R. A. (2007). IL9 leads to airway inflammation by inducing IL13 expression in airway epithelial cells. Int Immunol 19: 1-10 [Abstract] [Full Text]  
• Yang, M., Rangasamy, D., Matthaei, K. I., Frew, A. J., Zimmmermann, N., Mahalingam, S., Webb, D. C., Tremethick, D. J., Thompson, P. J., Hogan, S. P., Rothenberg, M. E., Cowden, W. B., Foster, P. S. (2006). Inhibition of Arginase I Activity by RNA Interference Attenuates IL-13-Induced Airways Hyperresponsiveness. J. Immunol. 177: 5595-5603 [Abstract] [Full Text]  
• Kataoka, T. R., Komazawa, N., Morii, E., Oboki, K., Nakano, T. (2005). Involvement of connective tissue-type mast cells in Th1 immune responses via Stat4 expression. Blood 105: 1016-1020 [Abstract] [Full Text]  
• Fulkerson, P. C., Zimmermann, N., Hassman, L. M., Finkelman, F. D., Rothenberg, M. E. (2004). Pulmonary Chemokine Expression Is Coordinately Regulated by STAT1, STAT6, and IFN-{gamma}. J. Immunol. 173: 7565-7574 [Abstract] [Full Text]  
• Hoshino, A., Tsuji, T., Matsuzaki, J., Jinushi, T., Ashino, S., Teramura, T., Chamoto, K., Tanaka, Y., Asakura, Y., Sakurai, T., Mita, Y., Takaoka, A., Nakaike, S., Takeshima, T., Ikeda, H., Nishimura, T. (2004). STAT6-mediated signaling in Th2-dependent allergic asthma: critical role for the development of eosinophilia, airway hyper-responsiveness and mucus hypersecretion, distinct from its role in Th2 differentiation. Int Immunol 16: 1497-1505 [Abstract] [Full Text]  
• Nagarkatti, R., B-Rao, C., Vijayan, V., Sharma, S. K., Ghosh, B. (2004). Signal Transducer and Activator of Transcription 6 Haplotypes and Asthma in the Indian Population. Am. J. Respir. Cell Mol. Bio. 31: 317-321 [Abstract] [Full Text]  
• Land, K. J., Moll, J. S., Kaplan, M. H., Seetharamaiah, G. S. (2004). Signal Transducer and Activator of Transcription (Stat)-6-Dependent, But Not Stat4-Dependent, Immunity Is Required for the Development of Autoimmunity in Graves' Hyperthyroidism. Endocrinology 145: 3724-3730 [Abstract] [Full Text]  
• Wang, Y., Malabarba, M. G., Nagy, Z. S., Kirken, R. A. (2004). Interleukin 4 Regulates Phosphorylation of Serine 756 in the Transactivation Domain of Stat6: ROLES FOR MULTIPLE PHOSPHORYLATION SITES AND Stat6 FUNCTION. J. Biol. Chem. 279: 25196-25203 [Abstract] [Full Text]  
• Kelly-Welch, A. E., Melo, M. E. F., Smith, E., Ford, A. Q., Haudenschild, C., Noben-Trauth, N., Keegan, A. D. (2004). Complex Role of the IL-4 Receptor {alpha} in a Murine Model of Airway Inflammation: Expression of the IL-4 Receptor {alpha} on Nonlymphoid Cells of Bone Marrow Origin Contributes to Severity of Inflammation. J. Immunol. 172: 4545-4555 [Abstract] [Full Text]  
• Peng, Q., Matsuda, T., Hirst, S. J. (2004). Signaling Pathways Regulating Interleukin-13-stimulated Chemokine Release from Airway Smooth Muscle. Am. J. Respir. Crit. Care Med. 169: 596-603 [Abstract] [Full Text]  
• Fulkerson, P. C., Zimmermann, N., Brandt, E. B., Muntel, E. E., Doepker, M. P., Kavanaugh, J. L., Mishra, A., Witte, D. P., Zhang, H., Farber, J. M., Yang, M., Foster, P. S., Rothenberg, M. E. (2004). Negative regulation of eosinophil recruitment to the lung by the chemokine monokine induced by IFN-{gamma} (Mig, CXCL9). Proc. Natl. Acad. Sci. USA 101: 1987-1992 [Abstract] [Full Text]  
• Zimmermann, N., Mishra, A., King, N. E., Fulkerson, P. C., Doepker, M. P., Nikolaidis, N. M., Kindinger, L. E., Moulton, E. A., Aronow, B. J., Rothenberg, M. E. (2004). Transcript Signatures in Experimental Asthma: Identification of STAT6-Dependent and -Independent Pathways. J. Immunol. 172: 1815-1824 [Abstract] [Full Text]  
• Monick, M. M., Samavati, L., Butler, N. S., Mohning, M., Powers, L. S., Yarovinsky, T., Spitz, D. R., Hunninghake, G. W. (2003). Intracellular Thiols Contribute to Th2 Function via a Positive Role in IL-4 Production. J. Immunol. 171: 5107-5115 [Abstract] [Full Text]  
• Taha, R., Hamid, Q., Cameron, L., Olivenstein, R. (2003). T Helper Type 2 Cytokine Receptors and Associated Transcription Factors GATA-3, c-MAF, and Signal Transducer and Activator of Transcription Factor-6 in Induced Sputum of Atopic Asthmatic Patients. Chest 123: 2074-2082 [Abstract] [Full Text]  
• Hadeiba, H., Locksley, R. M. (2003). Lung CD25 CD4 Regulatory T Cells Suppress Type 2 Immune Responses But Not Bronchial Hyperreactivity. J. Immunol. 170: 5502-5510 [Abstract] [Full Text]  
• Raman, K., Kaplan, M. H., Hogaboam, C. M., Berlin, A., Lukacs, N. W. (2003). STAT4 Signal Pathways Regulate Inflammation and Airway Physiology Changes in Allergic Airway Inflammation Locally Via Alteration of Chemokines. J. Immunol. 170: 3859-3865 [Abstract] [Full Text]  
• Herrick, C. A., Xu, L., McKenzie, A. N. J., Tigelaar, R. E., Bottomly, K. (2003). IL-13 Is Necessary, Not Simply Sufficient, for Epicutaneously Induced Th2 Responses to Soluble Protein Antigen. J. Immunol. 170: 2488-2495 [Abstract] [Full Text]  
• Stutz, A. M., Pickart, L. A., Trifilieff, A., Baumruker, T., Prieschl-Strassmayr, E., Woisetschlager, M. (2003). The Th2 Cell Cytokines IL-4 and IL-13 Regulate Found in Inflammatory Zone 1/Resistin-Like Molecule {alpha} Gene Expression by a STAT6 and CCAAT/Enhancer-Binding Protein-Dependent Mechanism. J. Immunol. 170: 1789-1796 [Abstract] [Full Text]  
• Welch, J. S., Escoubet-Lozach, L., Sykes, D. B., Liddiard, K., Greaves, D. R., Glass, C. K. (2002). TH2 Cytokines and Allergic Challenge Induce Ym1 Expression in Macrophages by a STAT6-dependent Mechanism. J. Biol. Chem. 277: 42821-42829 [Abstract] [Full Text]  
• Chang, H.-C., Zhang, S., Kaplan, M. H. (2002). Neonatal Tolerance in the Absence of Stat4- and Stat6- Dependent Th Cell Differentiation. J. Immunol. 169: 4124-4128 [Abstract] [Full Text]  
• Ritz, S. A., Cundall, M. J., Gajewska, B. U., Alvarez, D., Gutierrez-Ramos, J.-C., Coyle, A. J., McKenzie, A. N. J., Stampfli, M. R., Jordana, M. (2002). Granulocyte Macrophage Colony-Stimulating Factor-Driven Respiratory Mucosal Sensitization Induces Th2 Differentiation and Function Independently of Interleukin-4. Am. J. Respir. Cell Mol. Bio. 27: 428-435 [Abstract] [Full Text]  
• Haczku, A., Atochina, E. N., Tomer, Y., Cao, Y., Campbell, C., Scanlon, S. T., Russo, S. J., Enhorning, G., Beers, M. F. (2002). The late asthmatic response is linked with increased surface tension and reduced surfactant protein B in mice. Am. J. Physiol. Lung Cell. Mol. Physiol. 283: L755-L765 [Abstract] [Full Text]  
• Vicentini, L., Mazzi, P., Caveggion, E., Continolo, S., Fumagalli, L., Lapinet-Vera, J. A., Lowell, C. A., Berton, G. (2002). Fgr Deficiency Results in Defective Eosinophil Recruitment to the Lung During Allergic Airway Inflammation. J. Immunol. 168: 6446-6454 [Abstract] [Full Text]  
• Hirst, S. J., Hallsworth, M. P., Peng, Q., Lee, T. H. (2002). Selective Induction of Eotaxin Release by Interleukin-13 or Interleukin-4 in Human Airway Smooth Muscle Cells Is Synergistic with Interleukin-1beta and Is Mediated by the Interleukin-4 Receptor alpha -Chain. Am. J. Respir. Crit. Care Med. 165: 1161-1171 [Abstract] [Full Text]  
• Duetsch, G., Illig, T., Loesgen, S., Rohde, K., Klopp, N., Herbon, N., Gohlke, H., Altmueller, J., Wjst, M. (2002). STAT6 as an asthma candidate gene: polymorphism-screening, association and haplotype analysis in a Caucasian sib-pair study. Hum Mol Genet 11: 613-621 [Abstract] [Full Text]  
• Yagi, R., Nagai, H., Iigo, Y., Akimoto, T., Arai, T., Kubo, M. (2002). Development of Atopic Dermatitis-Like Skin Lesions in STAT6-Deficient NC/Nga Mice. J. Immunol. 168: 2020-2027 [Abstract] [Full Text]  
• Venkayya, R., Lam, M., Willkom, M., Grunig, G., Corry, D. B., Erle, D. J. (2002). The Th2 Lymphocyte Products IL-4 and IL-13 Rapidly Induce Airway Hyperresponsiveness Through Direct Effects on Resident Airway Cells. Am. J. Respir. Cell Mol. Bio. 26: 202-208 [Abstract] [Full Text]  
• Akiho, H., Blennerhassett, P., Deng, Y., Collins, S. M. (2002). Role of IL-4, IL-13, and STAT6 in inflammation-induced hypercontractility of murine smooth muscle cells. Am. J. Physiol. Gastrointest. Liver Physiol. 282: G226-G232 [Abstract] [Full Text]  
• Blease, K., Schuh, J. M., Jakubzick, C., Lukacs, N. W., Kunkel, S. L., Joshi, B. H., Puri, R. K., Kaplan, M. H., Hogaboam, C. M. (2002). Stat6-Deficient Mice Develop Airway Hyperresponsiveness and Peribronchial Fibrosis during Chronic Fungal Asthma. Am. J. Pathol. 160: 481-490 [Abstract] [Full Text]  
• Chen, L.-C., Zhang, Z., Myers, A. C., Huang, S.-K. (2001). Cutting Edge: Altered Pulmonary Eosinophilic Inflammation in Mice Deficient for Clara Cell Secretory 10-kDa Protein. J. Immunol. 167: 3025-3028 [Abstract] [Full Text]  
• Hoeck, J., Woisetschlager, M. (2001). Activation of Eotaxin-3/CCL26 Gene Expression in Human Dermal Fibroblasts Is Mediated by STAT6. J. Immunol. 167: 3216-3222 [Abstract] [Full Text]  
• Takaoka, A., Tanaka, Y., Tsuji, T., Jinushi, T., Hoshino, A., Asakura, Y., Mita, Y., Watanabe, K., Nakaike, S., Togashi, Y., Koda, T., Matsushima, K., Nishimura, T. (2001). A Critical Role for Mouse CXC Chemokine(s) in Pulmonary Neutrophilia During Th Type 1-Dependent Airway Inflammation. J. Immunol. 167: 2349-2353 [Abstract] [Full Text]  
• Mattes, J., Yang, M., Siqueira, A., Clark, K., MacKenzie, J., McKenzie, A. N. J., Webb, D. C., Matthaei, K. I., Foster, P. S. (2001). IL-13 Induces Airways Hyperreactivity Independently of the IL-4R{alpha} Chain in the Allergic Lung. J. Immunol. 167: 1683-1692 [Abstract] [Full Text]  
• Kips, J.C. (2001). Cytokines in asthma. Eur Respir J 18: 24S-33s [Abstract] [Full Text]  
• Mathew, A., MacLean, J. A., DeHaan, E., Tager, A. M., Green, F. H.Y., Luster, A. D. (2001). Signal Transducer and Activator of Transcription 6 Controls Chemokine Production and T Helper Cell Type 2 Cell Trafficking in Allergic Pulmonary Inflammation. JEM 193: 1087-1096 [Abstract] [Full Text]  
• Hoeck, J., Woisetschlager, M. (2001). STAT6 Mediates Eotaxin-1 Expression in IL-4 or TNF-{{alpha}}-Induced Fibroblasts. J. Immunol. 166: 4507-4515 [Abstract] [Full Text]  
• Matsukawa, A., Kaplan, M. H., Hogaboam, C. M., Lukacs, N. W., Kunkel, S. L. (2001). Pivotal Role of Signal Transducer and Activator of Transcription (Stat)4 and Stat6 in the Innate Immune Response during Sepsis. JEM 193: 679-688 [Abstract] [Full Text]  
• Kips, J.C., Tournoy, K.G., Pauwels, R.A. (2001). New anti-asthma therapies: suppression of the effect of interleukin (IL)-4 and IL-5. Eur Respir J 17: 499-506 [Abstract] [Full Text]  
• Tekkanat, K. K., Maassab, H. F., Cho, D. S., Lai, J. J., John, A., Berlin, A., Kaplan, M. H., Lukacs, N. W. (2001). IL-13-Induced Airway Hyperreactivity During Respiratory Syncytial Virus Infection Is STAT6 Dependent. J. Immunol. 166: 3542-3548 [Abstract] [Full Text]  
• Sato, E., Nelson, D. K., Koyama, S., Hoyt, J. C., Robbins, R. A. (2001). Erythromycin Modulates Eosinophil Chemotactic Cytokine Production by Human Lung Fibroblasts in Vitro. Antimicrob. Agents Chemother. 45: 401-406 [Abstract] [Full Text]  
• Deng, J., Yeung, V. P., Tsitoura, D., DeKruyff, R. H., Umetsu, D. T., Levy, S. (2000). Allergen-Induced Airway Hyperreactivity Is Diminished in CD81-Deficient Mice. J. Immunol. 165: 5054-5061 [Abstract] [Full Text]  
• KIPS, J. C., TOURNOY, K. G., PAUWELS, R. A. (2000). Gene Knockout Models of Asthma. Am. J. Respir. Crit. Care Med. 162: S66-70 [Full Text]  
• Zhang, S., Lukacs, N. W., Lawless, V. A., Kunkel, S. L., Kaplan, M. H. (2000). Cutting Edge: Differential Expression of Chemokines in Th1 and Th2 Cells Is Dependent on Stat6 But Not Stat4. J. Immunol. 165: 10-14 [Abstract] [Full Text]  
• Webb, D. C., McKenzie, A. N. J., Koskinen, A. M. L., Yang, M., Mattes, J., Foster, P. S. (2000). Integrated Signals Between IL-13, IL-4, and IL-5 Regulate Airways Hyperreactivity. J. Immunol. 165: 108-113 [Abstract] [Full Text]  
• Hadeiba, H., Corry, D. B., Locksley, R. M. (2000). Baseline Airway Hyperreactivity in A/J Mice Is not Mediated by Cells of the Adaptive Immune System. J. Immunol. 164: 4933-4940 [Abstract] [Full Text]  
• Yokozeki, H., Ghoreishi, M., Takagawa, S., Takayama, K., Satoh, T., Katayama, I., Takeda, K., Akira, S., Nishioka, K. (2000). Signal Transducer and Activator of Transcription 6 Is Essential in the Induction of Contact Hypersensitivity. JEM 191: 995-1004 [Abstract] [Full Text]  
• Koglin, J., Glysing-Jensen, T., Gadiraju, S., Russell, M. E. (2000). Attenuated Cardiac Allograft Vasculopathy in Mice With Targeted Deletion of the Transcription Factor STAT4. Circulation 101: 1034-1039 [Abstract] [Full Text]  
• Wang, L. H., Yang, X. Y., Kirken, R. A., Resau, J. H., Farrar, W. L. (2000). Targeted disruption of Stat6 DNA binding activity by an oligonucleotide decoy blocks IL-4-driven TH2 cell response. Blood 95: 1249-1257 [Abstract] [Full Text]  
• Kagami, S.-i., Nakajima, H., Kumano, K., Suzuki, K., Suto, A., Imada, K., Davey, H. W., Saito, Y., Takatsu, K., Leonard, W. J., Iwamoto, I. (2000). Both Stat5a and Stat5b are required for antigen-induced eosinophil and T-cell recruitment into the tissue. Blood 95: 1370-1377 [Abstract] [Full Text]  
• Conrad, D. J., Lu, M. (2000). Regulation of Human 12/15-Lipoxygenase by Stat6-Dependent Transcription. Am. J. Respir. Cell Mol. Bio. 22: 226-234 [Abstract] [Full Text]  
• Hayashi, N., Matsui, K., Tsutsui, H., Osada, Y., Mohamed, R. T., Nakano, H., Kashiwamura, S.-i., Hyodo, Y., Takeda, K., Akira, S., Hada, T., Higashino, K., Kojima, S., Nakanishi3, K. (1999). Kupffer Cells from Schistosoma mansoni-Infected Mice Participate in the Prompt Type 2 Differentiation of Hepatic T Cells in Response to Worm Antigens. J. Immunol. 163: 6702-6711 [Abstract] [Full Text]  
• Matsukura, S., Stellato, C., Plitt, J. R., Bickel, C., Miura, K., Georas, S. N., Casolaro, V., Schleimer, R. P. (1999). Activation of Eotaxin Gene Transcription by NF-{kappa}B and STAT6 in Human Airway Epithelial Cells. J. Immunol. 163: 6876-6883 [Abstract] [Full Text]  
• TOMKINSON, A., KANEHIRO, A., RABINOVITCH, N., JOETHAM, A., CIESLEWICZ, G., GELFAND, E. W. (1999). The Failure of STAT6-deficient Mice to Develop Airway Eosinophilia and Airway Hyperresponsiveness Is Overcome by Interleukin-5. Am. J. Respir. Crit. Care Med. 160: 1283-1291 [Abstract] [Full Text]  
• Dickensheets, H. L., Venkataraman, C., Schindler, U., Donnelly, R. P. (1999). Interferons inhibit activation of STAT6 by interleukin 4 in human monocytes by inducing SOCS-1 gene expression. Proc. Natl. Acad. Sci. USA 96: 10800-10805 [Abstract] [Full Text]  
• Levings, M. K., Schrader, J. W. (1999). IL-4 Inhibits the Production of TNF-{alpha} and IL-12 by STAT6-Dependent and -Independent Mechanisms. J. Immunol. 162: 5224-5229 [Abstract] [Full Text]  
• Dent, A. L., Hu-Li, J., Paul, W. E., Staudt, L. M. (1998). T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc. Natl. Acad. Sci. USA 95: 13823-13828 [Abstract] [Full Text]  
• Cohn, L., Tepper, J. S., Bottomly, K. (1998). Cutting Edge: IL-4-Independent Induction of Airway Hyperresponsiveness by Th2, But Not Th1, Cells. J. Immunol. 161: 3813-3816 [Abstract] [Full Text]  
• Daniel, C., Salvekar, A., Schindler, U. (2000). A Gain-of-function Mutation in STAT6. J. Biol. Chem. 275: 14255-14259 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS