The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article
Right arrow Full Text
Right arrow Full Text (PDF, 133K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Yang, L. P.
Right arrow Articles by Delespesse, G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Yang, L. P.
Right arrow Articles by Delespesse, G.
Social Bookmarking
 Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?

J. Exp. Med., Volume 187, Number 7, April 6, 1998 1139-1144

BRIEF DEFINITIVE REPORT:
Productive Infection of Neonatal CD8+ T Lymphocytes by HIV-1

By Liang Peng Yang,*par James L. Riley,§ Richard G. Carroll,Dagger Carl H. June,Dagger James Hoxie,Dagger Dagger Bruce K. Patterson,** Yusei Ohshima,* Richard J. Hodes, and Guy Delespesse*

From the * University of Montreal, Centre de Recherche Louis-Charles Simard, Hôpital Notre-Dame, Montreal, Quebec H2L 4M1, Canada; the Dagger  Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland 20889; the § Division of Retrovirology, Walter Reed Army Institute for Research, Rockville, Maryland 20850; the par  Experimental Immunology Branch, National Institutes of Health, Bethesda, Maryland 20892; the  National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892; the ** Department of Obstetrics/Gynecology and Medicine, Division of Infectious Diseases, Northwestern University Medical School, Chicago, Illinois 60611; and the Dagger Dagger  Hematology-Oncology Division, University of Pennsylvania, Philadelphia, Pennsylvania 19104

CD8+ T lymphocytes confer significant but ultimately insufficient protection against HIV infection. Here we report that activated neonatal CD8+ T cells can be productively infected in vitro by macrophage-tropic (M-tropic) HIV-1 isolates, which are responsible for disease transmission, whereas they are resistant to T cell-tropic (T-tropic) HIV strains. Physiological activation of CD8-alpha /beta + CD4- T cell receptor-alpha /beta + neonatal T cells, including activation by allogeneic dendritic cells, induces the accumulation of CD4 messenger RNA and the expression of CD4 Ag on the cell surface. The large majority of anti-CD3/B7.1-activated cord blood CD8+ T cells coexpress CD4, the primary HIV receptor, as well as CCR5 and CXCR4, the coreceptors used by M- and T-tropic HIV-1 strains, respectively, to enter target cells. These findings are relevant to the rapid progression of neonatal HIV infection. Infection of primary HIV-specific CD8+ T cells may compromise their survival and thus significantly contribute to the failure of the immune system to control the infection. Furthermore, these results indicate a previously unsuspected level of plasticity in the neonatal immune system in the regulation of CD4 expression by costimulation.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:



  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS