|
|
|
|
|
|
|
||
J. Exp. Med.,
Volume 187, Number 5, March 2, 1998 703-709
By
From the * Department of Cell and Molecular Biology, Umeå University, S-901 87 Umeå, Sweden;
and the The development of B lymphocytes from progenitor cells is dependent on the expression of a
pre-B cell-specific receptor made up by a µ heavy chain associated with the surrogate light
chains, immunoglobulin (Ig) Department of Immunology, Institut Pasteur, 750 15 Paris, Cedex 15, France
, and Ig
. A variant pre-B cell receptor can be formed in which
the µ heavy chain is exchanged for a truncated µ chain denoted Dµ. To investigate the role of
this receptor in the development of B cells, we have generated transgenic mice that express the
Dµ protein in cells of the B lineage. Analysis of these mice reveal that Dµ expression leads to a
partial block in B cell development at the early pre-B cell stage, probably by inhibiting VH to
DHJH rearrangement. Furthermore, we provide evidence that Dµ induces VL to JL rearrangements.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
| TABLE OF CONTENTS |
|
