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J. Exp. Med.,
Volume 187, Number 5, March 2, 1998 703-709
By


From the * Department of Cell and Molecular Biology, Umeå University, S-901 87 Umeå, Sweden;
and the The development of B lymphocytes from progenitor cells is dependent on the expression of a
pre-B cell-specific receptor made up by a µ heavy chain associated with the surrogate light
chains, immunoglobulin (Ig)
Department of Immunology, Institut Pasteur, 750 15 Paris, Cedex 15, France
, and Ig
. A variant pre-B cell receptor can be formed in which
the µ heavy chain is exchanged for a truncated µ chain denoted Dµ. To investigate the role of
this receptor in the development of B cells, we have generated transgenic mice that express the
Dµ protein in cells of the B lineage. Analysis of these mice reveal that Dµ expression leads to a
partial block in B cell development at the early pre-B cell stage, probably by inhibiting VH to
DHJH rearrangement. Furthermore, we provide evidence that Dµ induces VL to JL rearrangements.
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