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J. Exp. Med.,
Volume 187, Number 4, February 16, 1998 641-648
By


From the * Department of Cell Biology of the Albert Einstein College of Medicine, Bronx, New York,
10461, and the Coupling of an antibody response to effector cells through the Fc region of antibodies is a fundamental objective of effective vaccination. We have explored the role of the Fc receptor system in a murine model of Cryptococcus neoformans protection by infecting mice deleted for the
common
Lab of Molecular Genetics and Immunology, The Rockefeller University, New York
10021
chain of FcRs. Passive administration of an IgG1 mAb protects FcR
+/
mice infected with C. neoformans, but fails to protect FcR
/
mice, indicating that the
chain acting
through Fc
RI and/or III is essential for IgG1-mediated protection. In contrast, passive administration of an IgG3 mAb with identical specificity resulted in enhanced pathogenicity in
chain-deficient and wild-type mice. In vitro studies with isolated macrophages demonstrate
that IgG1-, IgG2a-, and IgG2b-opsonized C. neoformans are not phagocytosed or arrested in
their growth in the absence of the FcR
chain. In contrast, opsonization of C. neoformans by
IgG3 does not require the presence of the
chain or of FcRII, and the internalization of IgG3-treated organisms does not arrest fungal growth.
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