J. Exp. Med., Volume 187, Number 4, February 16, 1998 525-536

Subsets of Transgenic T Cells That Recognize CD1 Induce or Prevent Murine Lupus: Role of Cytokines

By Defu Zeng,^* Michael Dick,^* Lirong Cheng,^* Masahiko Amano,^* Sussan Dejbakhsh-Jones,^* Philip Huie, Richard Sibley, and Samuel Strober^*

From the Division of Immunology and Rheumatology, ^* Department of Medicine, and  Department of Pathology, Stanford University School of Medicine, Stanford, California 94305-5111

T cells with T cell receptor (TCR) transgenes that recognized CD1 on syngeneic B cells stimulated B cells to secrete immunoglobulins in vitro. The CD4⁺, CD8⁺, or CD4CD8 T cells from the spleen of the TCR transgenic BALB/c donors induced lupus with anti-double stranded DNA antibodies, proteinuria, and immune complex glomerulonephritis in irradiated BALB/c nude mice reconstituted with nude bone marrow. Injection of purified CD4CD8 T cells from the marrow of transgenic donors prevented the induction of lupus by the transgenic T cells. Transgenic T cells that induced lupus secreted large amounts of interferon (IFN)- and little interleukin (IL)-4, and those that prevented lupus secreted large amounts of IL-4 and little IFN- or IL-10.

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