Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 151K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sozzani, S. Articles by Mantovani, A. Search for Related Content PubMed PubMed Citation Articles by Sozzani, S. Articles by Mantovani, A. Social Bookmarking                            What's this?

Brief Definitive Reports

Silvano Sozzani^*, Silvia Ghezzi, Gioacchino Iannolo^*, Walter Luini^*, Alessandro Borsatti^*, Nadia Polentarutti^*, Antonio Sica^*, Massimo Locati^*, Charles Mackay^¶, Timothy N.C. Wells, Priscilla Biswas, Elisa Vicenzi, Guido Poli, and Alberto Mantovani^*,||

From the ^* Istituto di Ricerche Farmacologiche ‘Mario Negri', 20157 Milan, Italy; the AIDS Immunopathogenesis Unit, San Raffaele Scientific Institute, 20132 Milan, Italy; the Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Geneva, Switzerland; ^|| the Section of Pathology and Immunology, Department of Biotechnology, University of Brescia, 25123 Brescia, Italy; and ^¶ Millennium Biotherapeutics Inc., Cambridge, MA

The immunosuppressive and antiinflammatory cytokine interleukin (IL) 10 selectively upregulates the expression of the CC chemokine receptors CCR5, 2, and 1 in human monocytes by prolonging their mRNA half-life. IL-10–stimulated monocytes display an increased number of cell surface receptors for, and better chemotactic responsiveness to, relevant agonists than do control cells. In addition, IL-10–stimulated monocytes are more efficiently infected by HIV BaL. This effect was associated to the enhancement of viral entry through CCR5. These data add support to an emerging paradigm in which pro- and antiinflammatory molecules exert reciprocal and opposing influence on chemokine agonist production and receptor expression.

S. Sozzani and S. Ghezzi contributed equally to this work.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Cassol, E., Cassetta, L., Rizzi, C., Alfano, M., Poli, G. (2009). M1 and M2a Polarization of Human Monocyte-Derived Macrophages Inhibits HIV-1 Replication by Distinct Mechanisms. J. Immunol. 182: 6237-6246 [Abstract] [Full Text]  
• Frascaroli, G., Varani, S., Blankenhorn, N., Pretsch, R., Bacher, M., Leng, L., Bucala, R., Landini, M. P., Mertens, T. (2009). Human Cytomegalovirus Paralyzes Macrophage Motility through Down-Regulation of Chemokine Receptors, Reorganization of the Cytoskeleton, and Release of Macrophage Migration Inhibitory Factor. J. Immunol. 182: 477-488 [Abstract] [Full Text]  
• Nobile, C., Lind, M., Miro, F., Chemin, K., Tourret, M., Occhipinti, G., Dogniaux, S., Amigorena, S., Hivroz, C. (2008). Cognate CD4+ T-cell-dendritic cell interactions induce migration of immature dendritic cells through dissolution of their podosomes. Blood 111: 3579-3590 [Abstract] [Full Text]  
• Ferrandi, C., Ardissone, V., Ferro, P., Ruckle, T., Zaratin, P., Ammannati, E., Hauben, E., Rommel, C., Cirillo, R. (2007). Phosphoinositide 3-Kinase {gamma} Inhibition Plays a Crucial Role in Early Steps of Inflammation by Blocking Neutrophil Recruitment. J. Pharmacol. Exp. Ther. 322: 923-930 [Abstract] [Full Text]  
• Morrison, P. T., Thomas, L. H., Sharland, M., Friedland, J. S. (2007). RSV-infected airway epithelial cells cause biphasic up-regulation of CCR1 expression on human monocytes. J. Leukoc. Biol. 81: 1487-1495 [Abstract] [Full Text]  
• Silva, T.A., Garlet, G.P., Fukada, S.Y., Silva, J.S., Cunha, F.Q. (2007). Chemokines in Oral Inflammatory Diseases: Apical Periodontitis and Periodontal Disease. JDR 86: 306-319 [Abstract] [Full Text]  
• Mocellin, S., Marincola, F. M., Young, H. A. (2005). Interleukin-10 and the immune response against cancer: a counterpoint. J. Leukoc. Biol. 78: 1043-1051 [Abstract] [Full Text]  
• Pettersson, A., Sabirsh, A., Bristulf, J., Kidd-Ljunggren, K., Ljungberg, B., Owman, C., Karlsson, U. (2005). Pro- and anti-inflammatory substances modulate expression of the leukotriene B4 receptor, BLT1, in human monocytes. J. Leukoc. Biol. 77: 1018-1025 [Abstract] [Full Text]  
• Yang, C.-H., Fang, I-M., Lin, C.-P., Yang, C.-M., Chen, M.-S. (2005). Effects of the NF-{kappa}B Inhibitor Pyrrolidine Dithiocarbamate on Experimentally Induced Autoimmune Anterior Uveitis. IOVS 46: 1339-1347 [Abstract] [Full Text]  
• Teixeira, M. J., Fernandes, J. D., Teixeira, C. R., Andrade, B. B., Pompeu, M. L., Santana da Silva, J., Brodskyn, C. I., Barral-Netto, M., Barral, A. (2005). Distinct Leishmania braziliensis Isolates Induce Different Paces of Chemokine Expression Patterns. Infect. Immun. 73: 1191-1195 [Abstract] [Full Text]  
• Choudhary, S. K., Choudhary, N. R., Kimbrell, K. C., Colasanti, J., Ziogas, A., Kwa, D., Schuitemaker, H., Camerini, D. (2005). R5 Human Immunodeficiency Virus Type 1 Infection of Fetal Thymic Organ Culture Induces Cytokine and CCR5 Expression. J. Virol. 79: 458-471 [Abstract] [Full Text]  
• Chang, W. L. W., Baumgarth, N., Yu, D., Barry, P. A. (2004). Human Cytomegalovirus-Encoded Interleukin-10 Homolog Inhibits Maturation of Dendritic Cells and Alters Their Functionality. J. Virol. 78: 8720-8731 [Abstract] [Full Text]  
• Perrier, P., Martinez, F. O., Locati, M., Bianchi, G., Nebuloni, M., Vago, G., Bazzoni, F., Sozzani, S., Allavena, P., Mantovani, A. (2004). Distinct Transcriptional Programs Activated by Interleukin-10 with or without Lipopolysaccharide in Dendritic Cells: Induction of the B Cell-Activating Chemokine, CXC Chemokine Ligand 13. J. Immunol. 172: 7031-7042 [Abstract] [Full Text]  
• Granelli-Piperno, A., Golebiowska, A., Trumpfheller, C., Siegal, F. P., Steinman, R. M. (2004). HIV-1-infected monocyte-derived dendritic cells do not undergo maturation but can elicit IL-10 production and T cell regulation. Proc. Natl. Acad. Sci. USA 101: 7669-7674 [Abstract] [Full Text]  
• Secor, W. E., Shah, A., Mwinzi, P. M. N., Ndenga, B. A., Watta, C. O., Karanja, D. M. S. (2003). Increased Density of Human Immunodeficiency Virus Type 1 Coreceptors CCR5 and CXCR4 on the Surfaces of CD4+ T Cells and Monocytes of Patients with Schistosoma mansoni Infection. Infect. Immun. 71: 6668-6671 [Abstract] [Full Text]  
• Moriuchi, M., Moriuchi, H. (2003). YY1 Transcription Factor Down-regulates Expression of CCR5, a Major Coreceptor for HIV-1. J. Biol. Chem. 278: 13003-13007 [Abstract] [Full Text]  
• Perez-Bercoff, D., David, A., Sudry, H., Barre-Sinoussi, F., Pancino, G. (2003). Fc{gamma} Receptor-Mediated Suppression of Human Immunodeficiency Virus Type 1 Replication in Primary Human Macrophages. J. Virol. 77: 4081-4094 [Abstract] [Full Text]  
• Trabattoni, D., Saresella, M., Biasin, M., Boasso, A., Piacentini, L., Ferrante, P., Dong, H., Maserati, R., Shearer, G. M., Chen, L., Clerici, M. (2003). B7-H1 is up-regulated in HIV infection and is a novel surrogate marker of disease progression. Blood 101: 2514-2520 [Abstract] [Full Text]  
• Cui, Y., Le, Y., Yazawa, H., Gong, W., Wang, J. M. (2002). Potential role of the formyl peptide receptor-like 1 (FPRL1) in inflammatory aspects of Alzheimer's disease. J. Leukoc. Biol. 72: 628-635 [Abstract] [Full Text]  
• Lee, C. G., Homer, R. J., Cohn, L., Link, H., Jung, S., Craft, J. E., Graham, B. S., Johnson, T. R., Elias, J. A. (2002). Transgenic Overexpression of Interleukin (IL)-10 in the Lung Causes Mucus Metaplasia, Tissue Inflammation, and Airway Remodeling via IL-13-dependent and -independent Pathways. J. Biol. Chem. 277: 35466-35474 [Abstract] [Full Text]  
• Cui, Y.-H., Le, Y., Gong, W., Proost, P., Van Damme, J., Murphy, W. J., Wang, J. M. (2002). Bacterial Lipopolysaccharide Selectively Up-Regulates the Function of the Chemotactic Peptide Receptor Formyl Peptide Receptor 2 in Murine Microglial Cells. J. Immunol. 168: 434-442 [Abstract] [Full Text]  
• Hase, K., Tani, K., Shimizu, T., Ohmoto, Y., Matsushima, K., Sone, S. (2001). Increased CCR4 expression in active systemic lupus erythematosus. J. Leukoc. Biol. 70: 749-755 [Abstract] [Full Text]  
• Tchou, I., Misery, L., Sabido, O., Dezutter-Dambuyant, C., Bourlet, T., Moja, P., Hamzeh, H., Peguet-Navarro, J., Schmitt, D., Genin, C. (2001). Functional HIV CXCR4 coreceptor on human epithelial Langerhans cells and infection by HIV strain X4. J. Leukoc. Biol. 70: 313-321 [Abstract] [Full Text]  
• Takayama, T., Morelli, A. E., Onai, N., Hirao, M., Matsushima, K., Tahara, H., Thomson, A. W. (2001). Mammalian and Viral IL-10 Enhance C-C Chemokine Receptor 5 but Down-Regulate C-C Chemokine Receptor 7 Expression by Myeloid Dendritic Cells: Impact on Chemotactic Responses and In Vivo Homing Ability. J. Immunol. 166: 7136-7143 [Abstract] [Full Text]  
• Xu, K., Yen, T., Geczy, C. L. (2001). IL-10 Up-Regulates Macrophage Expression of the S100 Protein S100A8. J. Immunol. 166: 6358-6366 [Abstract] [Full Text]  
• Crawley, E., Kon, S., Woo, P. (2001). Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis. Rheumatology (Oxford) 40: 574-578 [Abstract] [Full Text]  
• Kito, K., Morishita, K., Nishida, K. (2001). MCP-1 receptor binding affinity is up-regulated by pre-stimulation with MCP-1 in an actin polymerization-dependent manner. J. Leukoc. Biol. 69: 666-674 [Abstract] [Full Text]  
• Ancuta, P., Bakri, Y., Chomont, N., Hocini, H., Gabuzda, D., Haeffner-Cavaillon, N. (2001). Opposite Effects of IL-10 on the Ability of Dendritic Cells and Macrophages to Replicate Primary CXCR4-Dependent HIV-1 Strains. J. Immunol. 166: 4244-4253 [Abstract] [Full Text]  
• Mohan, V. P., Scanga, C. A., Yu, K., Scott, H. M., Tanaka, K. E., Tsang, E., Tsai, M. C., Flynn, J. L., Chan, J. (2001). Effects of Tumor Necrosis Factor Alpha on Host Immune Response in Chronic Persistent Tuberculosis: Possible Role for Limiting Pathology. Infect. Immun. 69: 1847-1855 [Abstract] [Full Text]  
• Bruhl, H., Cihak, J., Stangassinger, M., Schlondorff, D., Mack, M. (2001). Depletion of CCR5-Expressing Cells with Bispecific Antibodies and Chemokine Toxins: A New Strategy in the Treatment of Chronic Inflammatory Diseases and HIV. J. Immunol. 166: 2420-2426 [Abstract] [Full Text]  
• Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., Takahashi, T. A. (2001). Signaling events following chemokine receptor ligation in human dendritic cells at different developmental stages. Int Immunol 13: 167-179 [Abstract] [Full Text]  
• Cheng, S. S., Lai, J. J., Lukacs, N. W., Kunkel, S. L. (2001). Granulocyte-Macrophage Colony Stimulating Factor Up-Regulates CCR1 in Human Neutrophils. J. Immunol. 166: 1178-1184 [Abstract] [Full Text]  
• Nardelli, B., Belvedere, O., Roschke, V., Moore, P. A., Olsen, H. S., Migone, T. S., Sosnovtseva, S., Carrell, J. A., Feng, P., Giri, J. G., Hilbert, D. M. (2001). Synthesis and release of B-lymphocyte stimulator from myeloid cells. Blood 97: 198-204 [Abstract] [Full Text]  
• Doms, R. W., Trono, D. (2000). The plasma membrane as a combat zone in the HIV battlefield. Genes Dev. 14: 2677-2688 [Full Text]  
• Juffermans, N. P., Paxton, W. A., Dekkers, P. E. P., Verbon, A., de Jonge, E., Speelman, P., van Deventer, S. J. H., van der Poll, T. (2000). Up-regulation of HIV coreceptors CXCR4 and CCR5 on CD4+ T cells during human endotoxemia and after stimulation with (myco)bacterial antigens: the role of cytokines. Blood 96: 2649-2654 [Abstract] [Full Text]  
• Jinquan, T., Jing, C., Jacobi, H. H., Reimert, C. M., Millner, A., Quan, S., Hansen, J. B., Dissing, S., Malling, H.-J., Skov, P. S., Poulsen, L. K. (2000). CXCR3 Expression and Activation of Eosinophils: Role of IFN-{gamma}-Inducible Protein-10 and Monokine Induced by IFN-{gamma}. J. Immunol. 165: 1548-1556 [Abstract] [Full Text]  
• Zhang, L., Rogers, T. J. (2000). {kappa}-Opioid Regulation of Thymocyte IL-7 Receptor and C-C Chemokine Receptor 2 Expression. J. Immunol. 164: 5088-5093 [Abstract] [Full Text]  
• Murdoch, C., Finn, A. (2000). Chemokine receptors and their role in inflammation and infectious diseases. Blood 95: 3032-3043 [Abstract] [Full Text]  
• Bonecchi, R., Facchetti, F., Dusi, S., Luini, W., Lissandrini, D., Simmelink, M., Locati, M., Bernasconi, S., Allavena, P., Brandt, E., Rossi, F., Mantovani, A., Sozzani, S. (2000). Induction of Functional IL-8 Receptors by IL-4 and IL-13 in Human Monocytes. J. Immunol. 164: 3862-3869 [Abstract] [Full Text]  
• Saccani, A., Saccani, S., Orlando, S., Sironi, M., Bernasconi, S., Ghezzi, P., Mantovani, A., Sica, A. (2000). Redox regulation of chemokine receptor expression. Proc. Natl. Acad. Sci. USA 97: 2761-2766 [Abstract] [Full Text]  
• Graziani-Bowering, G. M., Filion, L. G. (2000). Down Regulation of CD4 Expression following Isolation and Culture of Human Monocytes. CVI 7: 182-191 [Abstract] [Full Text]  
• Sato, K., Kawasaki, H., Nagayama, H., Enomoto, M., Morimoto, C., Tadokoro, K., Juji, T., Takahashi, T. A. (2000). TGF-{beta}1 Reciprocally Controls Chemotaxis of Human Peripheral Blood Monocyte-Derived Dendritic Cells Via Chemokine Receptors. J. Immunol. 164: 2285-2295 [Abstract] [Full Text]  
• Khanna, K. V., Yu, X.-F., Ford, D. H., Ratner, L., Hildreth, J. K., Markham, R. B. (2000). Differences Among HIV-1 Variants in Their Ability to Elicit Secretion of TNF-{alpha}. J. Immunol. 164: 1408-1415 [Abstract] [Full Text]  
• Sica, A., Saccani, A., Bottazzi, B., Bernasconi, S., Allavena, P., Gaetano, B., Fei, F., LaRosa, G., Scotton, C., Balkwill, F., Mantovani, A. (2000). Defective Expression of the Monocyte Chemotactic Protein-1 Receptor CCR2 in Macrophages Associated with Human Ovarian Carcinoma. J. Immunol. 164: 733-738 [Abstract] [Full Text]  
• Proudfoot, A. E. I., Buser, R., Borlat, F., Alouani, S., Soler, D., Offord, R. E., Schroder, J.-M., Power, C. A., Wells, T. N. C. (1999). Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors. J. Biol. Chem. 274: 32478-32485 [Abstract] [Full Text]  
• Penton-Rol, G., Cota, M., Polentarutti, N., Luini, W., Bernasconi, S., Borsatti, A., Sica, A., LaRosa, G. J., Sozzani, S., Poli, G., Mantovani, A. (1999). Up-Regulation of CCR2 Chemokine Receptor Expression and Increased Susceptibility to the Multitropic HIV Strain 89.6 in Monocytes Exposed to Glucocorticoid Hormones. J. Immunol. 163: 3524-3529 [Abstract] [Full Text]  
• Weiss, J. M., Nath, A., Major, E. O., Berman, J. W. (1999). HIV-1 Tat Induces Monocyte Chemoattractant Protein-1-Mediated Monocyte Transmigration Across a Model of the Human Blood-Brain Barrier and Up-Regulates CCR5 Expression on Human Monocytes. J. Immunol. 163: 2953-2959 [Abstract] [Full Text]  
• Fantuzzi, L., Borghi, P., Ciolli, V., Pavlakis, G., Belardelli, F., Gessani, S. (1999). Loss of CCR2 Expression and Functional Response to Monocyte Chemotactic Protein (MCP-1) During the Differentiation of Human Monocytes: Role of Secreted MCP-1 in the Regulation of the Chemotactic Response. Blood 94: 875-883 [Abstract] [Full Text]  
• Maréchal, V., Arenzana-Seisdedos, F., Heard, J.-M., Schwartz, O. (1999). Opposite Effects of SDF-1 on Human Immunodeficiency Virus Type 1 Replication. J. Virol. 73: 3608-3615 [Abstract] [Full Text]  
• Sato, K., Nagayama, H., Tadokoro, K., Juji, T., Takahashi, T. A. (1999). Extracellular Signal-Regulated Kinase, Stress-Activated Protein Kinase/c-Jun N-Terminal Kinase, and p38mapk Are Involved in IL-10-Mediated Selective Repression of TNF-{alpha}-Induced Activation and Maturation of Human Peripheral Blood Monocyte-Derived Dendritic Cells. J. Immunol. 162: 3865-3872 [Abstract] [Full Text]  
• Thivierge, M., Parent, J.-L., Stankova, J., Rola-Pleszczynski, M. (1999). Modulation of Formyl Peptide Receptor Expression by IL-10 in Human Monocytes and Neutrophils. J. Immunol. 162: 3590-3595 [Abstract] [Full Text]  
• Karlas, J., Siebelink, K., Peer, M., Huisman, W, Cuisinier, A., Rimmelzwaan, G., Osterhaus, A. (1999). Vaccination with experimental feline immunodeficiency virus vaccines, based on autologous infected cells, elicits enhancement of homologous challenge infection. J. Gen. Virol. 80: 761-765 [Abstract]  
• Rahimpour, R., Mitchell, G., Khandaker, M. H., Kong, C., Singh, B., Xu, L., Ochi, A., Feldman, R. D., Pickering, J. G., Gill, B. M., Kelvin, D. J. (1999). Bacterial Superantigens Induce Down-Modulation of CC Chemokine Responsiveness in Human Monocytes Via an Alternative Chemokine Ligand-Independent Mechanism. J. Immunol. 162: 2299-2307 [Abstract] [Full Text]  
• Secchiero, P., Zella, D., Capitani, S., Gallo, R. C., Zauli, G. (1999). Extracellular HIV-1 Tat Protein Up-Regulates the Expression of Surface CXC-Chemokine Receptor 4 in Resting CD4+ T Cells. J. Immunol. 162: 2427-2431 [Abstract] [Full Text]  
• Lee, B., Ratajczak, J., Doms, R. W., Gewirtz, A. M., Ratajczak, M. Z. (1999). Coreceptor/Chemokine Receptor Expression on Human Hematopoietic Cells: Biological Implications for Human Immunodeficiency Virus-Type 1 Infection. Blood 93: 1145-1156 [Abstract] [Full Text]  
• Cole, S. W., Jamieson, B. D., Zack, J. A. (1999). cAMP Up-Regulates Cell Surface Expression of Lymphocyte CXCR4: Implications for Chemotaxis and HIV-1 Infection. J. Immunol. 162: 1392-1400 [Abstract] [Full Text]  
• Bonecchi, R., Polentarutti, N., Luini, W., Borsatti, A., Bernasconi, S., Locati, M., Power, C., Proudfoot, A., Wells, T. N. C., Mackay, C., Mantovani, A., Sozzani, S. (1999). Up-Regulation of CCR1 and CCR3 and Induction of Chemotaxis to CC Chemokines by IFN-{gamma} in Human Neutrophils. J. Immunol. 162: 474-479 [Abstract] [Full Text]  
• Pedroza-Martins, L., Gurney, K. B., Torbett, B. E., Uittenbogaart, C. H. (1998). Differential Tropism and Replication Kinetics of Human Immunodeficiency Virus Type 1 Isolates in Thymocytes: Coreceptor Expression Allows Viral Entry, but Productive Infection of Distinct Subsets Is Determined at the Postentry Level. J. Virol. 72: 9441-9452 [Abstract] [Full Text]  
• Huang, L., Bosch, I., Hofmann, W., Sodroski, J., Pardee, A. B. (1998). Tat Protein Induces Human Immunodeficiency Virus Type 1 (HIV-1) Coreceptors and Promotes Infection with both Macrophage-Tropic and T-Lymphotropic HIV-1 Strains. J. Virol. 72: 8952-8960 [Abstract] [Full Text]  
• Bonecchi, R., Sozzani, S., Stine, J. T., Luini, W., D'Amico, G., Allavena, P., Chantry, D., Mantovani, A. (1998). Divergent Effects of Interleukin-4 and Interferon-gamma on Macrophage-Derived Chemokine Production: An Amplification Circuit of Polarized T Helper 2 Responses. Blood 92: 2668-2671 [Abstract] [Full Text]  
• Zoeteweij, J. P., Golding, H., Mostowski, H., Blauvelt, A. (1998). Cutting Edge: Cytokines Regulate Expression and Function of the HIV Coreceptor CXCR4 on Human Mature Dendritic Cells. J. Immunol. 161: 3219-3223 [Abstract] [Full Text]  
• Wang, J., Roderiquez, G., Oravecz, T., Norcross, M. A. (1998). Cytokine Regulation of Human Immunodeficiency Virus Type 1 Entry and Replication in Human Monocytes/Macrophages through Modulation of CCR5 Expression. J. Virol. 72: 7642-7647 [Abstract] [Full Text]  
• Sozzani, S., Allavena, P., D'Amico, G., Luini, W., Bianchi, G., Kataura, M., Imai, T., Yoshie, O., Bonecchi, R., Mantovani, A. (1998). Cutting Edge: Differential Regulation of Chemokine Receptors During Dendritic Cell Maturation: A Model for Their Trafficking Properties. J. Immunol. 161: 1083-1086 [Abstract] [Full Text]  
• Moriuchi, M., Moriuchi, H. (2001). Octamer Transcription Factors Up-regulate the Expression of CCR5, a Coreceptor for HIV-1 Entry. J. Biol. Chem. 276: 8639-8642 [Abstract] [Full Text]  
• Cota, M., Mengozzi, M., Vicenzi, E., Panina-Bordignon, P., Sinigaglia, F., Transidico, P., Sozzani, S., Mantovani, A., Poli, G. (2000). Selective inhibition of HIV replication in primary macrophages but not T lymphocytes by macrophage-derived chemokine. Proc. Natl. Acad. Sci. USA 97: 9162-9167 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS