The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1998/2/433/ $5.00
The Journal of Experimental Medicine, Volume 187, Number 3, February 2, 1998 433-438

Brief Definitive Reports

Induction of an Antigen-specific, CD1-restricted Cytotoxic T Lymphocyte Response In vivo

Delphine J. Lee, Amila Abeyratne, Dennis A. Carson, and Maripat Corr

From the Department of Medicine and The Sam and Rose Stein Institute for Research on Aging, University of California, San Diego, La Jolla, California 92093-0663

The majority of T cell responses are restricted to peptide antigens bound by polymorphic major histocompatibility complex (MHC) molecules. However, peptide antigens can be presented to T cells by murine non-MHC–encoded CD1d (mCD1) molecules, and human T cell lines specific for nonpeptide antigens presented on CD1 isoforms have been identified. It is shown here that antigen-specific, mCD1-restricted lymphocytes can be generated in vivo by immunizing mice with a combination of plasmids encoding chicken ovalbumin, murine CD1d, and costimulatory molecules. Splenocytes from immunized mice have CD1d-restricted, MHC- unrestricted, ovalbumin-specific cytolytic activity that can be inhibited by anti-CD1 antibodies as well as a competing CD1-binding peptide. These results suggest a physiologic role for murine CD1d to present exogenous protein antigens.

Address correspondence to Maripat Corr, Department of Medicine, University of California, San Diego, Clinical Sciences Bldg., Rm. 140, 9500 Gilman Dr., La Jolla, CA 92093-0663. Phone: 619-534-7817; Fax: 619-534-5399.


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