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J. Exp. Med.,
Volume 187, Number 3, February 2, 1998 297-306
By
From the * Department of Veterinary Clinic, and the Four full-thickness skin wounds made in normal mice led to the significant increase in levels of
nerve growth factor (NGF) in sera and in wounded skin tissues. Since sialoadenectomy before the wounds inhibited the rise in serum levels of NGF, the NGF may be released from the salivary gland into the blood stream after the wounds. In contrast, the fact that messenger RNA
and protein of NGF were detected in newly formed epithelial cells at the edge of the wound
and fibroblasts consistent with the granulation tissue produced in the wound space, suggests
that NGF was also produced at the wounded skin site. Topical application of NGF into the
wounds accelerated the rate of wound healing in normal mice and in healing-impaired diabetic
KK/Ta mice. This clinical effect of NGF was evaluated by histological examination; the increases in the degree of reepithelialization, the thickness of the granulation tissue, and the density of extracellular matrix were observed. NGF also increased the breaking strength of healing
linear wounds in normal and diabetic mice. These findings suggested that NGF immediately
and constitutively released in response to cutaneous injury may contribute to wound healing
through broader biological activities, and NGF improved the diabetic impaired response of wound healing.
Department of Veterinary Internal Medicine,
Faculty of Agriculture, Tokyo University of Agriculture and Technology, Fuchu, Tokyo 183, Japan
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