J. Exp. Med., Volume 187, Number 2, January 19, 1998 259-264

BRIEF DEFINITIVE REPORT:
A Novel Mechanism for B Cell Repertoire Maturation Based on Response by B Cell Precursors to Pre-B Receptor Assembly

By R. Wasserman,^* Y.-S. Li,^* S.A. Shinton,^* C.E. Carmack,^* T. Manser, D.L. Wiest,^* K. Hayakawa,^* and R.R. Hardy^*

From the ^* Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111; and the  Kimmel Cancer Institute, Thomas Jefferson Medical College, Philadelphia, Pennsylvania 19107

The expression of different sets of immunoglobulin specificities by fetal and adult B lymphocytes is a long-standing puzzle in immunology. Recently it has become clear that production of immunoglobulin µ heavy chain and subsequent assembly with a surrogate light chain to form the pre-B cell receptor complex is critical for development of B cells. Here we show that instead of promoting pre-B cell progression as in adult bone marrow, this complex inhibits pre-B cell growth in fetal liver. Curiously, we identify a fetal-associated V_H11 µ heavy chain that allows continued pre-B proliferation in fetal liver. Interestingly, this heavy chain does not associate efficiently with a surrogate light chain, providing a previously unrecognized mechanism for skewing the expression of distinctive V_H genes toward fetal through early neonatal life.

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