© The Rockefeller University Press, 0022-1007/1998/6/2065/ $5.00
The Journal of Experimental Medicine, Volume 187, Number 12, June 15, 1998 2065-2072
NKp44, a Novel Triggering Surface Molecule Specifically Expressed by Activated Natural Killer Cells, Is Involved in Non–Major Histocompatibility Complex–restricted Tumor Cell Lysis
Massimo Vitale*,
Cristina Bottino*,
Simona Sivori
,
Lorenza Sanseverino
,
Roberta Castriconi
,
Emanuela Marcenaro
,
Raffaella Augugliaro
,
Lorenzo Moretta
, and
Alessandro Moretta
From the * Istituto Nazionale per la Ricerca sul Cancro and Centro Biotecnologie Avanzate, 16132 Genova, Italy; and the
Dipartimento di Medicina Sperimentale, Università degli Studi di Genova, 16132 Genova, Italy
After culture in interleukin (IL)-2, natural killer (NK) cells acquire an increased capability of mediating non–major histocompatibility complex (MHC)–restricted tumor cell lysis. This may reflect, at least in part, the de novo expression by NK cells of triggering receptors involved in cytolysis. In this study we identified a novel 44-kD surface molecule (NKp44) that is absent in freshly isolated peripheral blood lymphocytes but is progressively expressed by all NK cells in vitro after culture in IL-2. Different from other markers of cell activation such as CD69 or VLA.2, NKp44 is absent in activated T lymphocytes or T cell clones. Since NKp44 was not detected in any of the other cell lineages analyzed, it appears as the first marker specific for activated human NK cells. Monoclonal antibody (mAb)–mediated cross-linking of NKp44 in cloned NK cells resulted in strong activation of target cell lysis in a redirected killing assay. This data indicated that NKp44 can mediate triggering of NK cell cytotoxicity. mAb-mediated masking of NKp44 resulted in partial inhibition of cytolytic activity against certain (Fc
R-negative) NK-susceptible target cells. This inhibition was greatly increased by the simultaneous masking of p46, another recently identified NK-specific triggering surface molecule. These data strongly suggest that NKp44 functions as a triggering receptor selectively expressed by activated NK cells that, together with p46, may be involved in the process of non-MHC-restricted lysis. Finally, we show that p46 and NKp44 are coupled to the intracytoplasmic transduction machinery via the association with CD3
or KARAP/DAP12, respectively; these associated molecules are tyrosine phosphorylated upon NK cell stimulation.
Key Words: natural killer cells cell-mediated cytotoxicity activating receptors subset-specific markers tumor target cells
Address correspondence to Lorenzo Moretta, Centro Biotecnologie Avanzate, Largo R. Benzi 10, 16132 Genova, Italy. Phone: 39-10-57-37-217; FAX: 39-10-35-41-23; E-mail: miriello{at}sirio.cba.unige.it

CiteULike
Complore
Connotea
Del.icio.us
Digg
Facebook
Reddit
Technorati
Twitter What's this?
This article has been cited by other articles:
-
Carlsten, M., Norell, H., Bryceson, Y. T., Poschke, I., Schedvins, K., Ljunggren, H.-G., Kiessling, R., Malmberg, K.-J.
(2009). Primary Human Tumor Cells Expressing CD155 Impair Tumor Targeting by Down-Regulating DNAM-1 on NK Cells. J. Immunol.
183: 4921-4930
[Abstract]
[Full Text]
-
Hershkovitz, O., Rosental, B., Rosenberg, L. A., Navarro-Sanchez, M. E., Jivov, S., Zilka, A., Gershoni-Yahalom, O., Brient-Litzler, E., Bedouelle, H., Ho, J. W., Campbell, K. S., Rager-Zisman, B., Despres, P., Porgador, A.
(2009). NKp44 Receptor Mediates Interaction of the Envelope Glycoproteins from the West Nile and Dengue Viruses with NK Cells. J. Immunol.
183: 2610-2621
[Abstract]
[Full Text]
-
Roda-Navarro, P., Reyburn, H. T.
(2009). The Traffic of the NKG2D/Dap10 Receptor Complex during Natural Killer (NK) Cell Activation. J. Biol. Chem.
284: 16463-16472
[Abstract]
[Full Text]
-
De Maria, A., Ugolotti, E., Rutjens, E., Mazza, S., Radic, L., Faravelli, A., Koopman, G., Di Marco, E., Costa, P., Ensoli, B., Cafaro, A., Mingari, M. C., Moretta, L., Heeney, J., Biassoni, R.
(2009). NKp44 expression, phylogenesis and function in non-human primate NK cells. Int Immunol
21: 245-255
[Abstract]
[Full Text]
-
Halfteck, G. G., Elboim, M., Gur, C., Achdout, H., Ghadially, H., Mandelboim, O.
(2009). Enhanced In Vivo Growth of Lymphoma Tumors in the Absence of the NK-Activating Receptor NKp46/NCR1. J. Immunol.
182: 2221-2230
[Abstract]
[Full Text]
-
Giustiniani, J., Bensussan, A., Marie-Cardine, A.
(2009). Identification and Characterization of a Transmembrane Isoform of CD160 (CD160-TM), a Unique Activating Receptor Selectively Expressed upon Human NK Cell Activation. J. Immunol.
182: 63-71
[Abstract]
[Full Text]
-
Moretta, L, Locatelli, F, Moretta, A
(2008). Alloreactive natural killer cells in targeting high-risk leukaemias. Ann Rheum Dis
67: iii39-iii43
[Abstract]
[Full Text]
-
Vacca, P., Cantoni, C., Prato, C., Fulcheri, E., Moretta, A., Moretta, L., Mingari, M. C.
(2008). Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells. Int Immunol
20: 1395-1405
[Abstract]
[Full Text]
-
Tang, Q., Grzywacz, B., Wang, H., Kataria, N., Cao, Q., Wagner, J. E., Blazar, B. R., Miller, J. S., Verneris, M. R.
(2008). Umbilical Cord Blood T Cells Express Multiple Natural Cytotoxicity Receptors after IL-15 Stimulation, but Only NKp30 Is Functional. J. Immunol.
181: 4507-4515
[Abstract]
[Full Text]
-
Guo, H., Samarakoon, A., Vanhaesebroeck, B., Malarkannan, S.
(2008). The p110{delta} of PI3K plays a critical role in NK cell terminal maturation and cytokine/chemokine generation. JEM
205: 2419-2435
[Abstract]
[Full Text]
-
El Costa, H., Casemayou, A., Aguerre-Girr, M., Rabot, M., Berrebi, A., Parant, O., Clouet-Delannoy, M., Lombardelli, L., Jabrane-Ferrat, N., Rukavina, D., Bensussan, A., Piccinni, M.-P., Le Bouteiller, P., Tabiasco, J.
(2008). Critical and Differential Roles of NKp46- and NKp30-Activating Receptors Expressed by Uterine NK Cells in Early Pregnancy. J. Immunol.
181: 3009-3017
[Abstract]
[Full Text]
-
Le Maux Chansac, B., Misse, D., Richon, C., Vergnon, I., Kubin, M., Soria, J.-C., Moretta, A., Chouaib, S., Mami-Chouaib, F.
(2008). Potentiation of NK cell-mediated cytotoxicity in human lung adenocarcinoma: role of NKG2D-dependent pathway. Int Immunol
20: 801-810
[Abstract]
[Full Text]
-
Marcenaro, E., Ferranti, B., Falco, M., Moretta, L., Moretta, A.
(2008). Human NK cells directly recognize Mycobacterium bovis via TLR2 and acquire the ability to kill monocyte-derived DC. Int Immunol
0: dxn073v1-dxn073
[Abstract]
[Full Text]
-
Esin, S., Batoni, G., Counoupas, C., Stringaro, A., Brancatisano, F. L., Colone, M., Maisetta, G., Florio, W., Arancia, G., Campa, M.
(2008). Direct Binding of Human NK Cell Natural Cytotoxicity Receptor NKp44 to the Surfaces of Mycobacteria and Other Bacteria. Infect. Immun.
76: 1719-1727
[Abstract]
[Full Text]
-
van Stijn, A., Rowshani, A. T., Yong, S. L., Baas, F., Roosnek, E., ten Berge, I. J. M., van Lier, R. A. W.
(2008). Human Cytomegalovirus Infection Induces a Rapid and Sustained Change in the Expression of NK Cell Receptors on CD8+ T Cells. J. Immunol.
180: 4550-4560
[Abstract]
[Full Text]
-
Coudert, J. D., Scarpellino, L., Gros, F., Vivier, E., Held, W.
(2008). Sustained NKG2D engagement induces cross-tolerance of multiple distinct NK cell activation pathways. Blood
111: 3571-3578
[Abstract]
[Full Text]
-
Vossen, M. T. M., Matmati, M., Hertoghs, K. M. L., Baars, P. A., Gent, M.-R., Leclercq, G., Hamann, J., Kuijpers, T. W., van Lier, R. A. W.
(2008). CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets. J. Immunol.
180: 3739-3745
[Abstract]
[Full Text]
-
Shi, J., Tricot, G. J., Garg, T. K., Malaviarachchi, P. A., Szmania, S. M., Kellum, R. E., Storrie, B., Mulder, A., Shaughnessy, J. D. Jr, Barlogie, B., van Rhee, F.
(2008). Bortezomib down-regulates the cell-surface expression of HLA class I and enhances natural killer cell-mediated lysis of myeloma. Blood
111: 1309-1317
[Abstract]
[Full Text]
-
Fink, L. N., Zeuthen, L. H., Christensen, H. R., Morandi, B., Frokiaer, H., Ferlazzo, G.
(2007). Distinct gut-derived lactic acid bacteria elicit divergent dendritic cell-mediated NK cell responses. Int Immunol
19: 1319-1327
[Abstract]
[Full Text]
-
Mizrahi, S., Yefenof, E., Gross, M., Attal, P., Ben Yaakov, A., Goldman-Wohl, D., Maly, B., Stern, N., Katz, G., Gazit, R., Sionov, R. V., Mandelboim, O., Chaushu, S.
(2007). A phenotypic and functional characterization of NK cells in adenoids. J. Leukoc. Biol.
82: 1095-1105
[Abstract]
[Full Text]
-
Harlin, H., Hanson, M., Johansson, C. C., Sakurai, D., Poschke, I., Norell, H., Malmberg, K.-J., Kiessling, R.
(2007). The CD16 CD56bright NK Cell Subset Is Resistant to Reactive Oxygen Species Produced by Activated Granulocytes and Has Higher Antioxidative Capacity Than the CD16+CD56dim Subset. J. Immunol.
179: 4513-4519
[Abstract]
[Full Text]
-
Ward, J., Bonaparte, M., Sacks, J., Guterman, J., Fogli, M., Mavilio, D., Barker, E.
(2007). HIV modulates the expression of ligands important in triggering natural killer cell cytotoxic responses on infected primary T-cell blasts. Blood
110: 1207-1214
[Abstract]
[Full Text]
-
Roberts, J. L., Lauritsen, J. P. H., Cooney, M., Parrott, R. E., Sajaroff, E. O., Win, C. M., Keller, M. D., Carpenter, J. H., Carabana, J., Krangel, M. S., Sarzotti, M., Zhong, X.-P., Wiest, D. L., Buckley, R. H.
(2007). T-B+NK+ severe combined immunodeficiency caused by complete deficiency of the CD3{zeta} subunit of the T-cell antigen receptor complex. Blood
109: 3198-3206
[Abstract]
[Full Text]
-
Draghi, M., Pashine, A., Sanjanwala, B., Gendzekhadze, K., Cantoni, C., Cosman, D., Moretta, A., Valiante, N. M., Parham, P.
(2007). NKp46 and NKG2D Recognition of Infected Dendritic Cells Is Necessary for NK Cell Activation in the Human Response to Influenza Infection. J. Immunol.
178: 2688-2698
[Abstract]
[Full Text]
-
Tessarz, A. S., Weiler, S., Zanzinger, K., Angelisova, P., Horejsi, V., Cerwenka, A.
(2007). Non-T Cell Activation Linker (NTAL) Negatively Regulates TREM-1/DAP12-Induced Inflammatory Cytokine Production in Myeloid Cells. J. Immunol.
178: 1991-1999
[Abstract]
[Full Text]
-
Carlsten, M., Bjorkstrom, N. K., Norell, H., Bryceson, Y., van Hall, T., Baumann, B. C., Hanson, M., Schedvins, K., Kiessling, R., Ljunggren, H.-G., Malmberg, K.-J.
(2007). DNAX Accessory Molecule-1 Mediated Recognition of Freshly Isolated Ovarian Carcinoma by Resting Natural Killer Cells. Cancer Res.
67: 1317-1325
[Abstract]
[Full Text]
-
Chiesa, M. D., Carlomagno, S., Frumento, G., Balsamo, M., Cantoni, C., Conte, R., Moretta, L., Moretta, A., Vitale, M.
(2006). The tryptophan catabolite L-kynurenine inhibits the surface expression of NKp46- and NKG2D-activating receptors and regulates NK-cell function. Blood
108: 4118-4125
[Abstract]
[Full Text]
-
Vacca, P., Pietra, G., Falco, M., Romeo, E., Bottino, C., Bellora, F., Prefumo, F., Fulcheri, E., Venturini, P. L., Costa, M., Moretta, A., Moretta, L., Mingari, M. C.
(2006). Analysis of natural killer cells isolated from human decidua: evidence that 2B4 (CD244) functions as an inhibitory receptor and blocks NK-cell function. Blood
108: 4078-4085
[Abstract]
[Full Text]
-
Martinez-Barriocanal, A., Sayos, J.
(2006). Molecular and Functional Characterization of CD300b, a New Activating Immunoglobulin Receptor Able to Transduce Signals through Two Different Pathways.. J. Immunol.
177: 2819-2830
[Abstract]
[Full Text]
-
Lilienfeld, B. G., Garcia-Borges, C., Crew, M. D., Seebach, J. D.
(2006). Porcine UL16-Binding Protein 1 Expressed on the Surface of Endothelial Cells Triggers Human NK Cytotoxicity through NKG2D. J. Immunol.
177: 2146-2152
[Abstract]
[Full Text]
-
Joerink, M., Ribeiro, C. M. S., Stet, R. J. M., Hermsen, T., Savelkoul, H. F. J., Wiegertjes, G. F.
(2006). Head Kidney-Derived Macrophages of Common Carp (Cyprinus carpio L.) Show Plasticity and Functional Polarization upon Differential Stimulation. J. Immunol.
177: 61-69
[Abstract]
[Full Text]
-
Nattermann, J, Feldmann, G, Ahlenstiel, G, Langhans, B, Sauerbruch, T, Spengler, U
(2006). Surface expression and cytolytic function of natural killer cell receptors is altered in chronic hepatitis C. Gut
55: 869-877
[Abstract]
[Full Text]
-
Meresse, B., Curran, S. A., Ciszewski, C., Orbelyan, G., Setty, M., Bhagat, G., Lee, L., Tretiakova, M., Semrad, C., Kistner, E., Winchester, R. J., Braud, V., Lanier, L. L., Geraghty, D. E., Green, P. H., Guandalini, S., Jabri, B.
(2006). Reprogramming of CTLs into natural killer-like cells in celiac disease. JEM
203: 1343-1355
[Abstract]
[Full Text]
-
Cebo, C., Da Rocha, S., Wittnebel, S., Turhan, A. G., Abdelali, J., Caillat-Zucman, S., Bourhis, J. H., Chouaib, S., Caignard, A.
(2006). The Decreased Susceptibility of Bcr/Abl Targets to NK Cell-Mediated Lysis in Response to Imatinib Mesylate Involves Modulation of NKG2D Ligands, GM1 Expression, and Synapse Formation. J. Immunol.
176: 864-872
[Abstract]
[Full Text]
-
Bryceson, Y. T., March, M. E., Ljunggren, H.-G., Long, E. O.
(2006). Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion. Blood
107: 159-166
[Abstract]
[Full Text]
-
Karimi, M., Cao, T. M., Baker, J. A., Verneris, M. R., Soares, L., Negrin, R. S.
(2005). Silencing Human NKG2D, DAP10, and DAP12 Reduces Cytotoxicity of Activated CD8+ T Cells and NK Cells. J. Immunol.
175: 7819-7828
[Abstract]
[Full Text]
-
Le Maux Chansac, B., Moretta, A., Vergnon, I., Opolon, P., Lecluse, Y., Grunenwald, D., Kubin, M., Soria, J.-C., Chouaib, S., Mami-Chouaib, F.
(2005). NK Cells Infiltrating a MHC Class I-Deficient Lung Adenocarcinoma Display Impaired Cytotoxic Activity toward Autologous Tumor Cells Associated with Altered NK Cell-Triggering Receptors. J. Immunol.
175: 5790-5798
[Abstract]
[Full Text]
-
Woll, P. S., Martin, C. H., Miller, J. S., Kaufman, D. S.
(2005). Human Embryonic Stem Cell-Derived NK Cells Acquire Functional Receptors and Cytolytic Activity. J. Immunol.
175: 5095-5103
[Abstract]
[Full Text]
-
Forte, P., Lilienfeld, B. G., Baumann, B. C., Seebach, J. D.
(2005). Human NK Cytotoxicity against Porcine Cells Is Triggered by NKp44 and NKG2D. J. Immunol.
175: 5463-5470
[Abstract]
[Full Text]
-
Fuchs, A., Cella, M., Kondo, T., Colonna, M.
(2005). Paradoxic inhibition of human natural interferon-producing cells by the activating receptor NKp44. Blood
106: 2076-2082
[Abstract]
[Full Text]
-
Maghazachi, A. A.
(2005). Insights into Seven and Single Transmembrane-Spanning Domain Receptors and Their Signaling Pathways in Human Natural Killer Cells. Pharmacol. Rev.
57: 339-357
[Abstract]
[Full Text]
-
Zhang, T., Lemoi, B. A., Sentman, C. L.
(2005). Chimeric NK-receptor-bearing T cells mediate antitumor immunotherapy. Blood
106: 1544-1551
[Abstract]
[Full Text]
-
Williams, A. P., Bateman, A. R., Khakoo, S. I.
(2005). HANGING IN THE BALANCE: KIR and Their Role in Disease. Mol. Interv.
5: 226-240
[Abstract]
[Full Text]
-
Brando, C., Mukhopadhyay, S., Kovacs, E., Medina, R., Patel, P., Catina, T. L., Campbell, K. S., Santoli, D.
(2005). Receptors and lytic mediators regulating anti-tumor activity by the leukemic killer T cell line TALL-104. J. Leukoc. Biol.
78: 359-371
[Abstract]
[Full Text]
-
Hollyoake, M., Campbell, R. D., Aguado, B.
(2005). NKp30 (NCR3) is a Pseudogene in 12 Inbred and Wild Mouse Strains, but an Expressed Gene in Mus caroli. Mol Biol Evol
22: 1661-1672
[Abstract]
[Full Text]
-
Viertlboeck, B. C., Habermann, F. A., Schmitt, R., Groenen, M. A. M., Du Pasquier, L., Gobel, T. W.
(2005). The Chicken Leukocyte Receptor Complex: A Highly Diverse Multigene Family Encoding at Least Six Structurally Distinct Receptor Types. J. Immunol.
175: 385-393
[Abstract]
[Full Text]
-
Westgaard, I. H., Berg, S. F., Vaage, J. T., Wang, L. L., Yokoyama, W. M., Dissen, E., Fossum, S.
(2004). Rat NKp46 activates natural killer cell cytotoxicity and is associated with Fc{varepsilon}RI{gamma} and CD3{zeta}. J. Leukoc. Biol.
76: 1200-1206
[Abstract]
[Full Text]
-
Ferlazzo, G., Munz, C.
(2004). NK Cell Compartments and Their Activation by Dendritic Cells. J. Immunol.
172: 1333-1339
[Full Text]
-
Campbell, K. S., Yusa, S.-i., Kikuchi-Maki, A., Catina, T. L.
(2004). NKp44 Triggers NK Cell Activation through DAP12 Association That Is Not Influenced by a Putative Cytoplasmic Inhibitory Sequence. J. Immunol.
172: 899-906
[Abstract]
[Full Text]
-
Arnon, T. I., Achdout, H., Lieberman, N., Gazit, R., Gonen-Gross, T., Katz, G., Bar-Ilan, A., Bloushtain, N., Lev, M., Joseph, A., Kedar, E., Porgador, A., Mandelboim, O.
(2004). The mechanisms controlling the recognition of tumor- and virus-infected cells by NKp46. Blood
103: 664-672
[Abstract]
[Full Text]
-
Loza, M. J., Perussia, B.
(2004). The IL-12 Signature: NK Cell Terminal CD56+high Stage and Effector Functions. J. Immunol.
172: 88-96
[Abstract]
[Full Text]
-
Foster, C. E., Colonna, M., Sun, P. D.
(2003). Crystal Structure of the Human Natural Killer (NK) Cell Activating Receptor NKp46 Reveals Structural Relationship to Other Leukocyte Receptor Complex Immunoreceptors. J. Biol. Chem.
278: 46081-46086
[Abstract]
[Full Text]
-
Zambello, R., Falco, M., Chiesa, M. D., Trentin, L., Carollo, D., Castriconi, R., Cannas, G., Carlomagno, S., Cabrelle, A., Lamy, T., Agostini, C., Moretta, A., Semenzato, G., Vitale, M.
(2003). Expression and function of KIR and natural cytotoxicity receptors in NK-type lymphoproliferative diseases of granular lymphocytes. Blood
102: 1797-1805
[Abstract]
[Full Text]
-
Zhao, Y., Ohdan, H., Manilay, J. O., Sykes, M.
(2003). NK Cell Tolerance in Mixed Allogeneic Chimeras. J. Immunol.
170: 5398-5405
[Abstract]
[Full Text]
-
McCann, F. E., Vanherberghen, B., Eleme, K., Carlin, L. M., Newsam, R. J., Goulding, D., Davis, D. M.
(2003). The Size of the Synaptic Cleft and Distinct Distributions of Filamentous Actin, Ezrin, CD43, and CD45 at Activating and Inhibitory Human NK Cell Immune Synapses. J. Immunol.
170: 2862-2870
[Abstract]
[Full Text]
-
Watzl, C., Long, E. O.
(2003). Natural Killer Cell Inhibitory Receptors Block Actin Cytoskeleton-dependent Recruitment of 2B4 (CD244) to Lipid Rafts. JEM
197: 77-85
[Abstract]
[Full Text]
-
Le Bouteiller, P., Barakonyi, A., Giustiniani, J., Lenfant, F., Marie-Cardine, A., Aguerre-Girr, M., Rabot, M., Hilgert, I., Mami-Chouaib, F., Tabiasco, J., Boumsell, L., Bensussan, A.
(2002). Engagement of CD160 receptor by HLA-C is a triggering mechanism used by circulating natural killer (NK) cells to mediate cytotoxicity. Proc. Natl. Acad. Sci. USA
99: 16963-16968
[Abstract]
[Full Text]
-
Pende, D., Rivera, P., Marcenaro, S., Chang, C.-C., Biassoni, R., Conte, R., Kubin, M., Cosman, D., Ferrone, S., Moretta, L., Moretta, A.
(2002). Major Histocompatibility Complex Class I-related Chain A and UL16-Binding Protein Expression on Tumor Cell Lines of Different Histotypes: Analysis of Tumor Susceptibility to NKG2D-dependent Natural Killer Cell Cytotoxicity. Cancer Res.
62: 6178-6186
[Abstract]
[Full Text]
-
Farag, S. S., Fehniger, T. A., Ruggeri, L., Velardi, A., Caligiuri, M. A.
(2002). Natural killer cell receptors: new biology and insights into the graft-versus-leukemia effect. Blood
100: 1935-1947
[Abstract]
[Full Text]
-
Wang, E. C. Y., McSharry, B., Retiere, C., Tomasec, P., Williams, S., Borysiewicz, L. K., Braud, V. M., Wilkinson, G. W. G.
(2002). From the Cover: UL40-mediated NK evasion during productive infection with human cytomegalovirus. Proc. Natl. Acad. Sci. USA
99: 7570-7575
[Abstract]
[Full Text]
-
Yusa, S.-i., Catina, T. L., Campbell, K. S.
(2002). SHP-1- and Phosphotyrosine-Independent Inhibitory Signaling by a Killer Cell Ig-Like Receptor Cytoplasmic Domain in Human NK Cells. J. Immunol.
168: 5047-5057
[Abstract]
[Full Text]
-
Briard, D., Brouty-Boye, D., Azzarone, B., Jasmin, C.
(2002). Fibroblasts from Human Spleen Regulate NK Cell Differentiation from Blood CD34+ Progenitors Via Cell Surface IL-15. J. Immunol.
168: 4326-4332
[Abstract]
[Full Text]
-
Sivori, S., Falco, M., Marcenaro, E., Parolini, S., Biassoni, R., Bottino, C., Moretta, L., Moretta, A.
(2002). Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl. Acad. Sci. USA
99: 4526-4531
[Abstract]
[Full Text]
-
Vankayalapati, R., Wizel, B., Weis, S. E., Safi, H., Lakey, D. L., Mandelboim, O., Samten, B., Porgador, A., Barnes, P. F.
(2002). The NKp46 Receptor Contributes to NK Cell Lysis of Mononuclear Phagocytes Infected with an Intracellular Bacterium. J. Immunol.
168: 3451-3457
[Abstract]
[Full Text]
-
Vitale, M., Zimmer, J., Castriconi, R., Hanau, D., Donato, L., Bottino, C., Moretta, L., de la Salle, H., Moretta, A.
(2002). Analysis of natural killer cells in TAP2-deficient patients: expression of functional triggering receptors and evidence for the existence of inhibitory receptor(s) that prevent lysis of normal autologous cells. Blood
99: 1723-1729
[Abstract]
[Full Text]
-
Ferlazzo, G., Tsang, M. L., Moretta, L., Melioli, G., Steinman, R. M., Munz, C.
(2002). Human Dendritic Cells Activate Resting Natural Killer (NK) Cells and Are Recognized via the NKp30 Receptor by Activated NK Cells. JEM
195: 343-351
[Abstract]
[Full Text]
-
Bottino, C., Falco, M., Parolini, S., Marcenaro, E., Augugliaro, R., Sivori, S., Landi, E., Biassoni, R., Notarangelo, L. D., Moretta, L., Moretta, A.
(2001). Gntb-A, a Novel Sh2d1a-Associated Surface Molecule Contributing to the Inability of Natural Killer Cells to Kill Epstein-Barr Virus-Infected B Cells in X-Linked Lymphoproliferative Disease. JEM
194: 235-246
[Abstract]
[Full Text]
-
Wu, J., Cherwinski, H., Spies, T., Phillips, J. H., Lanier, L. L.
(2000). Dap10 and Dap12 Form Distinct, but Functionally Cooperative, Receptor Complexes in Natural Killer Cells. JEM
192: 1059-1068
[Abstract]
[Full Text]
-
Parolini, S., Bottino, C., Falco, M., Augugliaro, R., Giliani, S., Franceschini, R., Ochs, H. D., Wolf, H., Bonnefoy, J.-Y., Biassoni, R., Moretta, L., Notarangelo, L. D., Moretta, A.
(2000). X-Linked Lymphoproliferative Disease: 2b4 Molecules Displaying Inhibitory Rather than Activating Function Are Responsible for the Inability of Natural Killer Cells to Kill Epstein-Barr Virus-Infected Cells. JEM
192: 337-346
[Abstract]
[Full Text]
-
Yu, T.-K., Caudell, E. G., Smid, C., Grimm, E. A.
(2000). IL-2 Activation of NK Cells: Involvement of MKK1/2/ERK But Not p38 Kinase Pathway. J. Immunol.
164: 6244-6251
[Abstract]
[Full Text]
-
Gays, F., Unnikrishnan, M., Shrestha, S., Fraser, K. P., Brown, A. R., Tristram, C. M. G., Chrzanowska-Lightowlers, Z. M. A., Brooks, C. G.
(2000). The Mouse Tumor Cell Lines EL4 and RMA Display Mosaic Expression of NK-Related and Certain Other Surface Molecules and Appear to Have a Common Origin. J. Immunol.
164: 5094-5102
[Abstract]
[Full Text]
-
Lanier, L. L.
(2000). Turning on Natural Killer Cells. JEM
191: 1259-1262
[Full Text]
-
Glas, R., Franksson, L., Une, C., Eloranta, M.-L., Ohlen, C., Orn, A., Karre, K.
(2000). Recruitment and Activation of Natural Killer (Nk) Cells in Vivo Determined by the Target Cell Phenotype: An Adaptive Component of Nk Cell-Mediated Responses. JEM
191: 129-138
[Abstract]
[Full Text]
-
Pende, D., Parolini, S., Pessino, A., Sivori, S., Augugliaro, R., Morelli, L., Marcenaro, E., Accame, L., Malaspina, A., Biassoni, R., Bottino, C., Moretta, L., Moretta, A.
(1999). Identification and Molecular Characterization of Nkp30, a Novel Triggering Receptor Involved in Natural Cytotoxicity Mediated by Human Natural Killer Cells. JEM
190: 1505-1516
[Abstract]
[Full Text]
-
Lutz, C. T., Kurago, Z. B.
(1999). Human Leukocyte Antigen Class I Expression on Squamous Cell Carcinoma Cells Regulates Natural Killer Cell Activity. Cancer Res.
59: 5793-5799
[Abstract]
[Full Text]
-
Palmieri, G., Tullio, V., Zingoni, A., Piccoli, M., Frati, L., Lopez-Botet, M., Santoni, A.
(1999). CD94/NKG2-A Inhibitory Complex Blocks CD16-Triggered Syk and Extracellular Regulated Kinase Activation, Leading to Cytotoxic Function of Human NK Cells. J. Immunol.
162: 7181-7188
[Abstract]
[Full Text]
-
Martin-Fontecha, A., Assarsson, E., Carbone, E., Karre, K., Ljunggren, H.-G.
(1999). Triggering of Murine NK Cells by CD40 and CD86 (B7-2). J. Immunol.
162: 5910-5916
[Abstract]
[Full Text]
-
Mandelboim, O., Malik, P., Davis, D. M., Jo, C. H., Boyson, J. E., Strominger, J. L.
(1999). Human CD16 as a lysis receptor mediating direct natural killer cell cytotoxicity. Proc. Natl. Acad. Sci. USA
96: 5640-5644
[Abstract]
[Full Text]
-
Bernard, K., Cambiaggi, A., Guia, S., Bertucci, F., Granjeaud, S., Tagett, R., N'Guyen, C., Jordan, B. R., Vivier, E.
(1999). Engagement of Natural Cytotoxicity Programs Regulates AP-1 Expression in the NKL Human NK Cell Line. J. Immunol.
162: 4062-4068
[Abstract]
[Full Text]
-
Cantoni, C., Bottino, C., Vitale, M., Pessino, A., Augugliaro, R., Malaspina, A., Parolini, S., Moretta, L., Moretta, A., Biassoni, R.
(1999). NKp44, A Triggering Receptor Involved in Tumor Cell Lysis by Activated Human Natural Killer Cells, Is a Novel Member of the Immunoglobulin Superfamily. JEM
189: 787-796
[Abstract]
[Full Text]
-
Sivori, S., Falco, M., Marcenaro, E., Parolini, S., Biassoni, R., Bottino, C., Moretta, L., Moretta, A.
(2002). Early expression of triggering receptors and regulatory role of 2B4 in human natural killer cell precursors undergoing in vitro differentiation. Proc. Natl. Acad. Sci. USA
99: 4526-4531
[Abstract]
[Full Text]