The Journal of Experimental Medicine
CSHL 2010 Immunology Conference
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© The Rockefeller University Press, 0022-1007/1998/6/1839/ $5.00
The Journal of Experimental Medicine, Volume 187, Number 11, June 1, 1998 1839-1848

Articles

The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool

S.P. Berzins*, R.L. Boyd*, and J.F.A.P. Miller{ddagger}

From the * Department of Pathology and Immunology, Monash Medical School, Prahran 3181, Victoria, Australia; and the {ddagger} Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia

The thymus is essential for the initial seeding of T cells to the periphery, but its role in maintaining the adult T cell pool remains poorly defined. We investigated whether changes to the rate of T cell export could form part of the mechanism(s) controlling the homeostatic regulation of the size and composition of the peripheral T cell pool. Using neonatal thymi grafted under the kidney capsule, we found that irrespective of whether the pool was oversupplied (by thymic grafts) or undersupplied (due to neonatal thymectomy), the thymic export rate was constant from both the host and graft thymus, and the periphery remained constant in size. Recent thymic emigrants (RTE) were also tracked to determine the extent of their acceptance into the T cell pool of a normal mouse. As a population, RTE are phenotypically mature, but were distinct from resident T cells in the periphery, being released in a CD4/CD8 ratio approximately twice that of established peripheral T cells. This export ratio is similar to that of T cells in the mature thymic compartment, but soon after entry into the periphery, the ratio falls, indicating separate thymic and peripheral regulation of the CD4/CD8 ratio. RTE may also be preferentially incorporated into the periphery, causing displacement of resident T cells, thus maintaining the size of the peripheral pool. Although not vital for the maintenance of a functional T cell pool, the acceptance of RTE in a "full" peripheral pool would ensure that the T cell receptor repertoire is kept diverse and that the T cell population encompasses a broad range of naive as well as memory T cells.

Key Words: thymus • thymic emigration • peripheral T cell pool • T cell homeostasis • thymus grafting

Address correspondence to Richard Boyd, Department of Pathology and Immunology, Monash Medical School, Commercial Rd., Prahran, Melbourne, Australia 3193. Phone: 61-3-9276-2738; Fax: 61-3-9529-6484; E-mail: richard.boyd{at}med.monash.edu.au

Abbreviations used: BrdU, bromo deoxyuridine; RAG-2, recombination activating gene-2; RTE, recent thymic emigrant(s).


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