© The Rockefeller University Press, 0022-1007/1998/6/1839/ $5.00
The Journal of Experimental Medicine, Volume 187, Number 11, June 1, 1998 1839-1848
The Role of the Thymus and Recent Thymic Migrants in the Maintenance of the Adult Peripheral Lymphocyte Pool
S.P. Berzins*,
R.L. Boyd*, and
J.F.A.P. Miller
From the * Department of Pathology and Immunology, Monash Medical School, Prahran 3181, Victoria, Australia; and the
Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Victoria, Australia
The thymus is essential for the initial seeding of T cells to the periphery, but its role in maintaining the adult T cell pool remains poorly defined. We investigated whether changes to the rate of T cell export could form part of the mechanism(s) controlling the homeostatic regulation of the size and composition of the peripheral T cell pool. Using neonatal thymi grafted under the kidney capsule, we found that irrespective of whether the pool was oversupplied (by thymic grafts) or undersupplied (due to neonatal thymectomy), the thymic export rate was constant from both the host and graft thymus, and the periphery remained constant in size. Recent thymic emigrants (RTE) were also tracked to determine the extent of their acceptance into the T cell pool of a normal mouse. As a population, RTE are phenotypically mature, but were distinct from resident T cells in the periphery, being released in a CD4/CD8 ratio approximately twice that of established peripheral T cells. This export ratio is similar to that of T cells in the mature thymic compartment, but soon after entry into the periphery, the ratio falls, indicating separate thymic and peripheral regulation of the CD4/CD8 ratio. RTE may also be preferentially incorporated into the periphery, causing displacement of resident T cells, thus maintaining the size of the peripheral pool. Although not vital for the maintenance of a functional T cell pool, the acceptance of RTE in a "full" peripheral pool would ensure that the T cell receptor repertoire is kept diverse and that the T cell population encompasses a broad range of naive as well as memory T cells.
Key Words: thymus thymic emigration peripheral T cell pool T cell homeostasis thymus grafting
Address correspondence to Richard Boyd, Department of Pathology and Immunology, Monash Medical School, Commercial Rd., Prahran, Melbourne, Australia 3193. Phone: 61-3-9276-2738; Fax: 61-3-9529-6484; E-mail: richard.boyd{at}med.monash.edu.au
Abbreviations used: BrdU, bromo deoxyuridine; RAG-2, recombination activating gene-2; RTE, recent thymic emigrant(s).

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-
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-
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[Full Text]
-
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-
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[Abstract]
[Full Text]
-
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170: 4475-4482
[Abstract]
[Full Text]
-
O'Neill, R. M., Hassan, J., Reen, D. J.
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170: 4524-4531
[Abstract]
[Full Text]
-
Berzins, S. P., Venanzi, E. S., Benoist, C., Mathis, D.
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52: 327-334
[Abstract]
[Full Text]
-
Rodriguez-Barbosa, J.-I., Zhao, Y., Zhao, G., Ezquerra, A., Sykes, M.
(2002). Murine CD4 T Cells Selected in a Highly Disparate Xenogeneic Porcine Thymus Graft Do Not Show Rapid Decay in the Absence of Selecting MHC in the Periphery. J. Immunol.
169: 6697-6710
[Abstract]
[Full Text]
-
Almeida, A. R. M., Legrand, N., Papiernik, M., Freitas, A. A.
(2002). Homeostasis of Peripheral CD4+ T Cells: IL-2R{alpha} and IL-2 Shape a Population of Regulatory Cells That Controls CD4+ T Cell Numbers. J. Immunol.
169: 4850-4860
[Abstract]
[Full Text]
-
Davila, E., Velez, M. G., Heppelmann, C. J., Celis, E.
(2002). Creating space: an antigen-independent, CpG-induced peripheral expansion of naive and memory T lymphocytes in a full T-cell compartment. Blood
100: 2537-2545
[Abstract]
[Full Text]
-
Strobel, P., Helmreich, M., Menioudakis, G., Lewin, S. R., Rudiger, T., Bauer, A., Hoffacker, V., Gold, R., Nix, W., Schalke, B., Elert, O., Semik, M., Muller-Hermelink, H. K., Marx, A.
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100: 159-166
[Abstract]
[Full Text]
-
Ye, P., Kirschner, D. E.
(2002). Reevaluation of T Cell Receptor Excision Circles as a Measure of Human Recent Thymic Emigrants. J. Immunol.
168: 4968-4979
[Abstract]
[Full Text]
-
Hacein-Bey-Abina, S., Le Deist, F., Carlier, F., Bouneaud, C., Hue, C., De Villartay, J.-P., Thrasher, A. J., Wulffraat, N., Sorensen, R., Dupuis-Girod, S., Fischer, A., Davies, E. G., Kuis, W., Leiva, L., Cavazzana-Calvo, M.
(2002). Sustained Correction of X-Linked Severe Combined Immunodeficiency by ex Vivo Gene Therapy. NEJM
346: 1185-1193
[Abstract]
[Full Text]
-
Ge, Q., Hu, H., Eisen, H. N., Chen, J.
(2002). Different contributions of thymopoiesis and homeostasis-driven proliferation to the reconstitution of naive and memory T cell compartments. Proc. Natl. Acad. Sci. USA
99: 2989-2994
[Abstract]
[Full Text]
-
Dai, Z., Lakkis, F. G.
(2001). Cutting Edge: Secondary Lymphoid Organs Are Essential for Maintaining the CD4, But Not CD8, Naive T Cell Pool. J. Immunol.
167: 6711-6715
[Abstract]
[Full Text]
-
Mora, A. L., Stanley, S., Armistead, W., Chan, A. C., Boothby, M.
(2001). Inefficient ZAP-70 Phosphorylation and Decreased Thymic Selection In Vivo Result from Inhibition of NF-{kappa}B/Rel. J. Immunol.
167: 5628-5635
[Abstract]
[Full Text]
-
Cunningham, C. P., Kimpton, W. G., Fernando, A., Cahill, R. N. P.
(2001). Neonatal thymectomy identifies two major pools of sessile and recirculating peripheral T cells which appear to be under separate homeostatic control. Int Immunol
13: 1351-1359
[Abstract]
[Full Text]
-
Gudmundsdottir, H., Turka, L. A.
(2001). A Closer Look at Homeostatic Proliferation of CD4+ T Cells: Costimulatory Requirements and Role in Memory Formation. J. Immunol.
167: 3699-3707
[Abstract]
[Full Text]
-
Almeida, A. R.M., Borghans, J. A.M., Freitas, A. A.
(2001). T Cell Homeostasis: Thymus Regeneration and Peripheral T Cell Restoration in Mice with a Reduced Fraction of Competent Precursors. JEM
194: 591-600
[Abstract]
[Full Text]
-
Hassan, J., Reen, D. J.
(2001). Human Recent Thymic Emigrants-Identification, Expansion, And Survival Characteristics. J. Immunol.
167: 1970-1976
[Abstract]
[Full Text]
-
Fry, T. J., Connick, E., Falloon, J., Lederman, M. M., Liewehr, D. J., Spritzler, J., Steinberg, S. M., Wood, L. V., Yarchoan, R., Zuckerman, J., Landay, A., Mackall, C. L.
(2001). A potential role for interleukin-7 in T-cell homeostasis. Blood
97: 2983-2990
[Abstract]
[Full Text]
-
Mackall, C. L., Fry, T. J., Bare, C., Morgan, P., Galbraith, A., Gress, R. E.
(2001). IL-7 increases both thymic-dependent and thymic-independent T-cell regeneration after bone marrow transplantation. Blood
97: 1491-1497
[Abstract]
[Full Text]
-
Hoffacker, V., Schultz, A., Tiesinga, J. J., Gold, R., Schalke, B., Nix, W., Kiefer, R., Muller-Hermelink, H. K., Marx, A.
(2000). Thymomas alter the T-cell subset composition in the blood: a potential mechanism for thymoma-associated autoimmune disease. Blood
96: 3872-3879
[Abstract]
[Full Text]
-
Ferreira, C., Barthlott, T., Garcia, S., Zamoyska, R., Stockinger, B.
(2000). Differential Survival of Naive CD4 and CD8 T Cells. J. Immunol.
165: 3689-3694
[Abstract]
[Full Text]
-
Boileau, C., Houde, M., Dulude, G., Clegg, C. H., Perreault, C.
(2000). Regulation of Extrathymic T Cell Development and Turnover by Oncostatin M. J. Immunol.
164: 5713-5720
[Abstract]
[Full Text]
-
Annacker, O., Burlen-Defranoux, O., Pimenta-Araujo, R., Cumano, A., Bandeira, A.
(2000). Regulatory CD4 T Cells Control the Size of the Peripheral Activated/Memory CD4 T Cell Compartment. J. Immunol.
164: 3573-3580
[Abstract]
[Full Text]
-
Klug, D. B., Crouch, E., Carter, C., Coghlan, L., Conti, C. J., Richie, E. R.
(2000). Transgenic Expression of Cyclin D1 in Thymic Epithelial Precursors Promotes Epithelial and T Cell Development. J. Immunol.
164: 1881-1888
[Abstract]
[Full Text]
-
Arstila, T. P., Casrouge, A., Baron, V., Even, J., Kanellopoulos, J., Kourilsky, P.
(1999). A Direct Estimate of the Human T Cell Receptor Diversity. Science
286: 958-961
[Abstract]
[Full Text]
-
Damoiseaux, J. G. M. C., Cautain, B., Bernard, I., Mas, M., van Breda Vriesman, P. J. C., Druet, P., Fournie, G., Saoudi, A.
(1999). A Dominant Role for the Thymus and MHC Genes in Determining the Peripheral CD4/CD8 T Cell Ratio in the Rat. J. Immunol.
163: 2983-2989
[Abstract]
[Full Text]
-
Berzins, S. P., Godfrey, D. I., Miller, J. F. A. P., Boyd, R. L.
(1999). A central role for thymic emigrants in peripheral T cell homeostasis. Proc. Natl. Acad. Sci. USA
96: 9787-9791
[Abstract]
[Full Text]
-
Brochu, S., Rioux-Masse, B., Roy, J., Roy, D.-C., Perreault, C.
(1999). Massive Activation-Induced Cell Death of Alloreactive T Cells With Apoptosis of Bystander Postthymic T Cells Prevents Immune Reconstitution in Mice With Graft-Versus-Host Disease. Blood
94: 390-400
[Abstract]
[Full Text]
-
Berzins, S. P., Davey, G. M., Randle-Barrett, E. S., Malin, M. A., Classon, B. J., Fraser, S., Boyd, R. L.
(1999). Thymic Shared Antigen-2: A Novel Cell Surface Marker Associated with T Cell Differentiation and Activation. J. Immunol.
162: 5119-5126
[Abstract]
[Full Text]
-
Dulude, G., Roy, D.-C., Perreault, C.
(1999). The Effect of Graft-versus-Host Disease on T Cell Production and Homeostasis. JEM
189: 1329-1342
[Abstract]
[Full Text]
-
Dardalhon, V., Jaleco, S., Kinet, S., Herpers, B., Steinberg, M., Ferrand, C., Froger, D., Leveau, C., Tiberghien, P., Charneau, P., Noraz, N., Taylor, N.
(2001). IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells. Proc. Natl. Acad. Sci. USA
98: 9277-9282
[Abstract]
[Full Text]