The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1998/6/1813/ $5.00
The Journal of Experimental Medicine, Volume 187, Number 11, June 1, 1998 1813-1823

Articles

An Alternate Pathway for T Cell Development Supported by the Bone Marrow Microenvironment: Recapitulation of Thymic Maturation

Marcos E. García-Ojeda*, Sussan Dejbakhsh-Jones*, Irving L. Weissman{ddagger}, and Samuel Strober*

From the * Division of Immunology and Rheumatology, Department of Medicine, and the {ddagger} Department of Pathology, Stanford University School of Medicine, Stanford, California 94305

In the principal pathway of {alpha}/β T cell maturation, T cell precursors from the bone marrow migrate to the thymus and proceed through several well-characterized developmental stages into mature CD4+ and CD8+ T cells. This study demonstrates an alternative pathway in which the bone marrow microenvironment also supports the differentiation of T cell precursors into CD4+ and CD8+ T cells. The marrow pathway recapitulates developmental stages of thymic maturation including a CD4+CD8+ intermediary cell and positive and negative selection, and is strongly inhibited by the presence of mature T cells. The contribution of the marrow pathway in vivo requires further study in mice with normal and deficient thymic or immune function.

Key Words: extrathymic • bone marrow • T cell • development • thymus

Address correspondence to Samuel Strober, Division of Immunology and Rheumatology, Department of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, S105B, Stanford, California 94305-5111. Phone: 650-723-6500; Fax: 650-725-6104; E-mail: sstrober{at}leland.stanford.edu

M.E. García-Ojeda and S. Dejbakhsh-Jones contributed equally to the research described in this paper.

Abbreviations used: FBS, fetal bovine serum; HSA, heat-stable antigen.


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