The Journal of Experimental Medicine
ELISpot, FluoroSpot and ELISA kits from Mabtech
  Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents
This Article
Right arrow Full Text
Right arrow Full Text (PDF, 1884K)
Right arrow PPT slides of all figures
Right arrow Alert me when this article is cited
Right arrow Citation Map
Services
Right arrow Email this article
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new content in the JEM
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via CrossRef
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Wykrzykowska, J. J.
Right arrow Articles by Lackner, A. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Wykrzykowska, J. J.
Right arrow Articles by Lackner, A. A.
Right arrowPubmed/NCBI databases
Medline Plus Health Information
*Stem Cells
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Facebook   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?
© The Rockefeller University Press, 0022-1007/1998/6/1767/ $5.00
The Journal of Experimental Medicine, Volume 187, Number 11, June 1, 1998 1767-1778

Articles

Early Regeneration of Thymic Progenitors in Rhesus Macaques Infected with Simian Immunodeficiency Virus

Joanna J. Wykrzykowska*, Michael Rosenzweig*, Ronald S. Veazey*, Meredith A. Simon*, Katherine Halvorsen{ddagger}, Ronald C. Desrosiers*, R. Paul Johnson*, and Andrew A. Lackner*

From the * New England Regional Primate Research Center, Harvard Medical School, Southborough, Massachusetts 01772; and the {ddagger} Department of Mathematics, Smith College, Northampton, Massachusetts 01063

The thymus plays a critical role in the maturation and production of T lymphocytes and is a target of infection by human immunodeficiency virus (HIV) and the related simian immunodeficiency virus (SIV). Using the SIV/macaque model of AIDS, we examined the early effects of SIV on the thymus. We found that thymic infection by SIV resulted in increased apoptosis 7–14 d after infection, followed by depletion of thymocyte progenitors by day 21. A marked rebound in thymocyte progenitors occurred by day 50 and was accompanied by increased levels of cell proliferation in the thymus. Our results demonstrate a marked increase in thymic progenitor activity very early in the course of SIV infection, long before marked declines in peripheral CD4+ T cell counts.

Key Words: AIDS • T cell homeostasis • apoptosis • animal model • pathogenesis

Address correspondence to Andrew A. Lackner, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Dr., PO Box 9102, Southborough, MA 01772. Phone: 508-624-8018; Fax: 508-624-8181; E mail: alackner{at}warren.med.harvard.edu

Abbreviations used: dpi, days after infection; SIV, simian immunodeficiency virus.


Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Facebook Facebook   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?




  Home | Help | Feedback | Subscriptions | Archive | Search
TABLE OF CONTENTS