Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 179K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Hamann, D. Articles by Lier, R. A.W. v. Search for Related Content PubMed PubMed Citation Articles by Hamann, D. Articles by Lier, R. A.W. v. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                            What's this?

Article

From the Department of Clinical Viro-Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, and Laboratory of Experimental and Clinical Immunology of the University of Amsterdam, 1066 CX Amsterdam, The Netherlands

Human CD8⁺ memory- and effector-type T cells are poorly defined. We show here that, next to a naive compartment, two discrete primed subpopulations can be found within the circulating human CD8⁺ T cell subset. First, CD45RA^–CD45R0⁺ cells are reminiscent of memory-type T cells in that they express elevated levels of CD95 (Fas) and the integrin family members CD11a, CD18, CD29, CD49d, and CD49e, compared to naive CD8⁺ T cells, and are able to secrete not only interleukin (IL) 2 but also interferon , tumor necrosis factor , and IL-4. This subset does not exert cytolytic activity without prior in vitro stimulation but does contain virus-specific cytotoxic T lymphocyte (CTL) precursors. A second primed population is characterized by CD45RA expression with concomitant absence of expression of the costimulatory molecules CD27 and CD28. The CD8⁺CD45RA⁺CD27^– population contains T cells expressing high levels of CD11a, CD11b, CD18, and CD49d, whereas CD62L (L-selectin) is not expressed. These T cells do not secrete IL-2 or -4 but can produce IFN- and TNF-. In accordance with this finding, cells contained within this subpopulation depend for proliferation on exogenous growth factors such as IL-2 and -15. Interestingly, CD8⁺CD45RA⁺CD27^– cells parallel effector CTLs, as they abundantly express Fas-ligand mRNA, contain perforin and granzyme B, and have high cytolytic activity without in vitro prestimulation. Based on both phenotypic and functional properties, we conclude that memory- and effector-type T cells can be separated as distinct entities within the human CD8⁺ T cell subset.

D. Hamann was supported by the Human Capital and Mobility Programme of the European Community, and P.A. Baars and M.H.G. Rep were supported by the Dutch Society for Support of Research on Multiple Sclerosis.

¹ Abbreviations used in this paper: B-LCL, B lymphoblastoid cell lines; p, precursors; RT, reverse transcriptase.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Kim, T. K., St. John, L. S., Wieder, E. D., Khalili, J., Ma, Q., Komanduri, K. V. (2009). Human Late Memory CD8+ T Cells Have a Distinct Cytokine Signature Characterized by CC Chemokine Production without IL-2 Production. J. Immunol. 183: 6167-6174 [Abstract] [Full Text]  
• Attig, S., Hennenlotter, J., Pawelec, G., Klein, G., Koch, S. D., Pircher, H., Feyerabend, S., Wernet, D., Stenzl, A., Rammensee, H.-G., Gouttefangeas, C. (2009). Simultaneous Infiltration of Polyfunctional Effector and Suppressor T Cells into Renal Cell Carcinomas. Cancer Res. 69: 8412-8419 [Abstract] [Full Text]  
• Le Dieu, R., Taussig, D. C., Ramsay, A. G., Mitter, R., Miraki-Moud, F., Fatah, R., Lee, A. M., Lister, T. A., Gribben, J. G. (2009). Peripheral blood T cells in acute myeloid leukemia (AML) patients at diagnosis have abnormal phenotype and genotype and form defective immune synapses with AML blasts. Blood 114: 3909-3916 [Abstract] [Full Text]  
• Wilkinson, K. A., Seldon, R., Meintjes, G., Rangaka, M. X., Hanekom, W. A., Maartens, G., Wilkinson, R. J. (2009). Dissection of Regenerating T-Cell Responses against Tuberculosis in HIV-infected Adults Sensitized by Mycobacterium tuberculosis. Am. J. Respir. Crit. Care Med. 180: 674-683 [Abstract] [Full Text]  
• Yin, L., Kou, Z. C., Rodriguez, C., Hou, W., Goodenow, M. M., Sleasman, J. W. (2009). Antiretroviral Therapy Restores Diversity in the T-Cell Receptor V{beta} Repertoire of CD4 T-Cell Subpopulations among Human Immunodeficiency Virus Type 1-Infected Children and Adolescents. CVI 16: 1293-1301 [Abstract] [Full Text]  
• Colleton, B. A., Huang, X.-L., Melhem, N. M., Fan, Z., Borowski, L., Rappocciolo, G., Rinaldo, C. R. (2009). Primary Human Immunodeficiency Virus Type 1-Specific CD8+ T-Cell Responses Induced by Myeloid Dendritic Cells. J. Virol. 83: 6288-6299 [Abstract] [Full Text]  
• Mack, D. G., Lanham, A. M., Palmer, B. E., Maier, L. A., Fontenot, A. P. (2009). CD27 Expression on CD4+ T Cells Differentiates Effector from Regulatory T Cell Subsets in the Lung. J. Immunol. 182: 7317-7324 [Abstract] [Full Text]  
• Nikolova, M., Lelievre, J.-D., Carriere, M., Bensussan, A., Levy, Y. (2009). Regulatory T cells differentially modulate the maturation and apoptosis of human CD8+ T-cell subsets. Blood 113: 4556-4565 [Abstract] [Full Text]  
• Kondo, T., Takiguchi, M. (2009). Human memory CCR4+CD8+ T cell subset has the ability to produce multiple cytokines. Int Immunol 21: 523-532 [Abstract] [Full Text]  
• Lecuroux, C., Girault, I., Urrutia, A., Doisne, J.-M., Deveau, C., Goujard, C., Meyer, L., Sinet, M., Venet, A. (2009). Identification of a particular HIV-specific CD8+ T-cell subset with a CD27+ CD45RO-/RA+ phenotype and memory characteristics after initiation of HAART during acute primary HIV infection. Blood 113: 3209-3217 [Abstract] [Full Text]  
• van Bergen, J., Kooy-Winkelaar, E. M. C., van Dongen, H., van Gaalen, F. A., Thompson, A., Huizinga, T. W. J., Feltkamp, M. C. W., Toes, R. E. M., Koning, F. (2009). Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus. J. Immunol. 182: 4175-4182 [Abstract] [Full Text]  
• Qu, C., Nguyen, V. A., Merad, M., Randolph, G. J. (2009). MHC Class I/Peptide Transfer between Dendritic Cells Overcomes Poor Cross-Presentation by Monocyte-Derived APCs That Engulf Dying Cells. J. Immunol. 182: 3650-3659 [Abstract] [Full Text]  
• Haluszczak, C., Akue, A. D., Hamilton, S. E., Johnson, L. D.S., Pujanauski, L., Teodorovic, L., Jameson, S. C., Kedl, R. M. (2009). The antigen-specific CD8+ T cell repertoire in unimmunized mice includes memory phenotype cells bearing markers of homeostatic expansion. JEM 206: 435-448 [Abstract] [Full Text]  
• Kondo, T., Takata, H., Matsuki, F., Takiguchi, M. (2009). Cutting Edge: Phenotypic Characterization and Differentiation of Human CD8+ T Cells Producing IL-17. J. Immunol. 182: 1794-1798 [Abstract] [Full Text]  
• Kuttruff, S., Koch, S., Kelp, A., Pawelec, G., Rammensee, H.-G., Steinle, A. (2009). NKp80 defines and stimulates a reactive subset of CD8 T cells. Blood 113: 358-369 [Abstract] [Full Text]  
• Zenhaeusern, G., Gubser, P., Eisele, P., Gasser, O., Steinhuber, A., Trampuz, A., Handschin, C., Luster, A. D., Hess, C. (2009). A high-mobility, low-cost phenotype defines human effector-memory CD8+ T cells. Blood 113: 95-99 [Abstract] [Full Text]  
• Libri, V., Schulte, D., van Stijn, A., Ragimbeau, J., Rogge, L., Pellegrini, S. (2008). Jakmip1 Is Expressed upon T Cell Differentiation and Has an Inhibitory Function in Cytotoxic T Lymphocytes. J. Immunol. 181: 5847-5856 [Abstract] [Full Text]  
• Zhang, R., Shah, M. V., Yang, J., Nyland, S. B., Liu, X., Yun, J. K., Albert, R., Loughran, T. P. Jr. (2008). Network model of survival signaling in large granular lymphocyte leukemia. Proc. Natl. Acad. Sci. USA 105: 16308-16313 [Abstract] [Full Text]  
• Das, A., Hoare, M., Davies, N., Lopes, A. R., Dunn, C., Kennedy, P. T.F., Alexander, G., Finney, H., Lawson, A., Plunkett, F. J., Bertoletti, A., Akbar, A. N., Maini, M. K. (2008). Functional skewing of the global CD8 T cell population in chronic hepatitis B virus infection. JEM 205: 2111-2124 [Abstract] [Full Text]  
• Caetano, J., Martinho, A., Paiva, A., Pais, B., Valente, C., Luxo, C. (2008). Differences in Hepatitis C Virus (HCV)-Specific CD8 T-Cell Phenotype during Pegylated Alpha Interferon and Ribavirin Treatment Are Related to Response to Antiviral Therapy in Patients Chronically Infected with HCV. J. Virol. 82: 7567-7577 [Abstract] [Full Text]  
• Pipeling, M. R., West, E. E., Osborne, C. M., Whitlock, A. B., Dropulic, L. K., Willett, M. H., Forman, M., Valsamakis, A., Orens, J. B., Moller, D. R., Lechtzin, N., Migueles, S. A., Connors, M., McDyer, J. F. (2008). Differential CMV-Specific CD8+ Effector T Cell Responses in the Lung Allograft Predominate over the Blood during Human Primary Infection. J. Immunol. 181: 546-556 [Abstract] [Full Text]  
• Ladell, K., Hellerstein, M. K., Cesar, D., Busch, R., Boban, D., McCune, J. M. (2008). Central Memory CD8+ T Cells Appear to Have a Shorter Lifespan and Reduced Abundance as a Function of HIV Disease Progression. J. Immunol. 180: 7907-7918 [Abstract] [Full Text]  
• Terabe, M., Tagaya, Y., Zhu, Q., Granger, L., Roederer, M., Waldmann, T. A., Berzofsky, J. A. (2008). IL-15 Expands Unconventional CD8{alpha}{alpha}NK1.1+ T Cells but Not V{alpha}14J{alpha}18+ NKT Cells. J. Immunol. 180: 7276-7286 [Abstract] [Full Text]  
• Waziri, A., Killory, B., Ogden, A. T. III, Canoll, P., Anderson, R. C. E., Kent, S. C., Anderson, D. E., Bruce, J. N. (2008). Preferential In Situ CD4+CD56+ T Cell Activation and Expansion within Human Glioblastoma. J. Immunol. 180: 7673-7680 [Abstract] [Full Text]  
• Lutsiak, M. E. C., Tagaya, Y., Adams, A. J., Schlom, J., Sabzevari, H. (2008). Tumor-Induced Impairment of TCR Signaling Results in Compromised Functionality of Tumor-Infiltrating Regulatory T Cells. J. Immunol. 180: 5871-5881 [Abstract] [Full Text]  
• Vrisekoop, N., den Braber, I., de Boer, A. B., Ruiter, A. F. C., Ackermans, M. T., van der Crabben, S. N., Schrijver, E. H. R., Spierenburg, G., Sauerwein, H. P., Hazenberg, M. D., de Boer, R. J., Miedema, F., Borghans, J. A. M., Tesselaar, K. (2008). Sparse production but preferential incorporation of recently produced naive T cells in the human peripheral pool. Proc. Natl. Acad. Sci. USA 105: 6115-6120 [Abstract] [Full Text]  
• Alves, N. L., van Leeuwen, E. M. M., Derks, I. A. M., van Lier, R. A. W. (2008). Differential Regulation of Human IL-7 Receptor {alpha} Expression by IL-7 and TCR Signaling. J. Immunol. 180: 5201-5210 [Abstract] [Full Text]  
• Wynn, K. K., Fulton, Z., Cooper, L., Silins, S. L., Gras, S., Archbold, J. K., Tynan, F. E., Miles, J. J., McCluskey, J., Burrows, S. R., Rossjohn, J., Khanna, R. (2008). Impact of clonal competition for peptide-MHC complexes on the CD8+ T-cell repertoire selection in a persistent viral infection. Blood 111: 4283-4292 [Abstract] [Full Text]  
• Vossen, M. T. M., Matmati, M., Hertoghs, K. M. L., Baars, P. A., Gent, M.-R., Leclercq, G., Hamann, J., Kuijpers, T. W., van Lier, R. A. W. (2008). CD27 Defines Phenotypically and Functionally Different Human NK Cell Subsets. J. Immunol. 180: 3739-3745 [Abstract] [Full Text]  
• Wlodarski, M. W., Nearman, Z., Jankowska, A., Babel, N., Powers, J., Leahy, P., Volk, H.-D., Maciejewski, J. P. (2008). Phenotypic differences between healthy effector CTL and leukemic LGL cells support the notion of antigen-triggered clonal transformation in T-LGL leukemia. J. Leukoc. Biol. 83: 589-601 [Abstract] [Full Text]  
• Dolfi, D. V., Boesteanu, A. C., Petrovas, C., Xia, D., Butz, E. A., Katsikis, P. D. (2008). Late Signals from CD27 Prevent Fas-Dependent Apoptosis of Primary CD8+ T Cells. J. Immunol. 180: 2912-2921 [Abstract] [Full Text]  
• Montes, C. L., Chapoval, A. I., Nelson, J., Orhue, V., Zhang, X., Schulze, D. H., Strome, S. E., Gastman, B. R. (2008). Tumor-Induced Senescent T Cells with Suppressor Function: A Potential Form of Tumor Immune Evasion. Cancer Res. 68: 870-879 [Abstract] [Full Text]  
• Uzel, G., Tng, E., Rosenzweig, S. D., Hsu, A. P., Shaw, J. M., Horwitz, M. E., Linton, G. F., Anderson, S. M., Kirby, M. R., Oliveira, J. B., Brown, M. R., Fleisher, T. A., Law, S. K. A., Holland, S. M. (2008). Reversion mutations in patients with leukocyte adhesion deficiency type-1 (LAD-1). Blood 111: 209-218 [Abstract] [Full Text]  
• Rezvani, K., Yong, A. S. M., Mielke, S., Savani, B. N., Musse, L., Superata, J., Jafarpour, B., Boss, C., Barrett, A. J. (2008). Leukemia-associated antigen-specific T-cell responses following combined PR1 and WT1 peptide vaccination in patients with myeloid malignancies. Blood 111: 236-242 [Abstract] [Full Text]  
• Waller, E. C. P., McKinney, N., Hicks, R., Carmichael, A. J., Sissons, J. G. P., Wills, M. R. (2007). Differential costimulation through CD137 (4 1BB) restores proliferation of human virus-specific "effector memory" (CD28 CD45RAHI) CD8+ T cells. Blood 110: 4360-4366 [Abstract] [Full Text]  
• Hovav, A.-H., Panas, M. W., Osuna, C. E., Cayabyab, M. J., Autissier, P., Letvin, N. L. (2007). The Impact of a Boosting Immunogen on the Differentiation of Secondary Memory CD8+ T Cells. J. Virol. 81: 12793-12802 [Abstract] [Full Text]  
• Racanelli, V., Frassanito, M. A., Leone, P., Brunetti, C., Ruggieri, S., Dammacco, F. (2007). Bone Marrow of Persistently Hepatitis C Virus-Infected Individuals Accumulates Memory CD8+ T Cells Specific for Current and Historical Viral Antigens: A Study in Patients with Benign Hematological Disorders. J. Immunol. 179: 5387-5398 [Abstract] [Full Text]  
• Winter, D., Moser, J., Kriehuber, E., Wiesner, C., Knobler, R., Trautinger, F., Bombosi, P., Stingl, G., Petzelbauer, P., Rot, A., Maurer, D. (2007). Down-Modulation of CXCR3 Surface Expression and Function in CD8+ T Cells from Cutaneous T Cell Lymphoma Patients. J. Immunol. 179: 4272-4282 [Abstract] [Full Text]  
• Rezvani, K., Yong, A. S. M., Savani, B. N., Mielke, S., Keyvanfar, K., Gostick, E., Price, D. A., Douek, D. C., Barrett, A. J. (2007). Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia. Blood 110: 1924-1932 [Abstract] [Full Text]  
• Pallikkuth, S., Wanchu, A., Bhatnagar, A., Sachdeva, R. K., Sharma, M. (2007). Human Immunodeficiency Virus (HIV) gag Antigen-Specific T-Helper and Granule-Dependent CD8 T-Cell Activities in Exposed but Uninfected Heterosexual Partners of HIV Type 1-Infected Individuals in North India. CVI 14: 1196-1202 [Abstract] [Full Text]  
• Lee, W.-W., Yang, Z.-Z., Li, G., Weyand, C. M., Goronzy, J. J. (2007). Unchecked CD70 Expression on T Cells Lowers Threshold for T Cell Activation in Rheumatoid Arthritis. J. Immunol. 179: 2609-2615 [Abstract] [Full Text]  
• Kordasti, S. Y., Ingram, W., Hayden, J., Darling, D., Barber, L., Afzali, B., Lombardi, G., Wlodarski, M. W., Maciejewski, J. P., Farzaneh, F., Mufti, G. J. (2007). CD4+CD25high Foxp3+ regulatory T cells in myelodysplastic syndrome (MDS). Blood 110: 847-850 [Abstract] [Full Text]  
• Jacobsen, M., Detjen, A. K., Mueller, H., Gutschmidt, A., Leitner, S., Wahn, U., Magdorf, K., Kaufmann, S. H. E. (2007). Clonal Expansion of CD8+ Effector T Cells in Childhood Tuberculosis. J. Immunol. 179: 1331-1339 [Abstract] [Full Text]  
• Hikono, H., Kohlmeier, J. E., Takamura, S., Wittmer, S. T., Roberts, A. D., Woodland, D. L. (2007). Activation phenotype, rather than central- or effector-memory phenotype, predicts the recall efficacy of memory CD8+ T cells. JEM 204: 1625-1636 [Abstract] [Full Text]  
• Marzo, A. L., Yagita, H., Lefrancois, L. (2007). Cutting Edge: Migration to Nonlymphoid Tissues Results in Functional Conversion of Central to Effector Memory CD8 T Cells. J. Immunol. 179: 36-40 [Abstract] [Full Text]  
• Alves, N. L., van Leeuwen, E. M. M., Remmerswaal, E. B. M., Vrisekoop, N., Tesselaar, K., Roosnek, E., ten Berge, I. J. M., van Lier, R. A. W. (2007). A New Subset of Human Naive CD8+ T Cells Defined by Low Expression of IL-7R{alpha}. J. Immunol. 179: 221-228 [Abstract] [Full Text]  
• Precopio, M. L., Betts, M. R., Parrino, J., Price, D. A., Gostick, E., Ambrozak, D. R., Asher, T. E., Douek, D. C., Harari, A., Pantaleo, G., Bailer, R., Graham, B. S., Roederer, M., Koup, R. A. (2007). Immunization with vaccinia virus induces polyfunctional and phenotypically distinctive CD8+ T cell responses. JEM 204: 1405-1416 [Abstract] [Full Text]  
• Smeltz, R. B. (2007). Profound Enhancement of the IL-12/IL-18 Pathway of IFN-{gamma} Secretion in Human CD8+ Memory T Cell Subsets via IL-15. J. Immunol. 178: 4786-4792 [Abstract] [Full Text]  
• Monteiro, M., Evaristo, C., Legrand, A., Nicoletti, A., Rocha, B. (2007). Cartography of gene expression in CD8 single cells: novel CCR7- subsets suggest differentiation independent of CD45RA expression. Blood 109: 2863-2870 [Abstract] [Full Text]  
• Barbey, C., Baumgaertner, P., Devevre, E., Rubio-Godoy, V., Derre, L., Bricard, G., Guillaume, P., Luescher, I. F., Lienard, D., Cerottini, J.-C., Romero, P., Rufer, N., Speiser, D. E. (2007). IL-12 Controls Cytotoxicity of a Novel Subset of Self-Antigen-Specific Human CD28+ Cytolytic T Cells. J. Immunol. 178: 3566-3574 [Abstract] [Full Text]  
• Liu, G.-Z., Fang, L.-B., Hjelmstrom, P., Gao, X.-G. (2007). Increased CD8+ central memory T cells in patients with multiple sclerosis. Mult Scler 13: 149-155 [Abstract]  
• Bengsch, B., Spangenberg, H. C., Kersting, N., Neumann-Haefelin, C., Panther, E., von Weizsacker, F., Blum, H. E., Pircher, H., Thimme, R. (2007). Analysis of CD127 and KLRG1 Expression on Hepatitis C Virus-Specific CD8+ T Cells Reveals the Existence of Different Memory T-Cell Subsets in the Peripheral Blood and Liver. J. Virol. 81: 945-953 [Abstract] [Full Text]  
• Kapina, M. A., Shepelkova, G. S., Mischenko, V. V., Sayles, P., Bogacheva, P., Winslow, G., Apt, A. S., Lyadova, I. V. (2007). CD27low CD4 T Lymphocytes That Accumulate in the Mouse Lungs during Mycobacterial Infection Differentiate from CD27high Precursors In Situ, Produce IFN-{gamma}, and Protect the Host against Tuberculosis Infection. J. Immunol. 178: 976-985 [Abstract] [Full Text]  
• Koch, A., Gaczkowski, M., Sturton, G., Staib, P., Schinkothe, T., Klein, E., Rubbert, A., Bacon, K., Wassermann, K., Erdmann, E. (2007). Modification of surface antigens in blood CD8+ T-lymphocytes in COPD: effects of smoking. Eur Respir J 29: 42-50 [Abstract] [Full Text]  
• Kreijveld, E., Koenen, H. J. P. M., Hilbrands, L. B., van Hooff, H. J. P., Joosten, I. (2007). The immunosuppressive drug FK778 induces regulatory activity in stimulated human CD4+CD25- T cells. Blood 109: 244-252 [Abstract] [Full Text]  
• Casazza, J. P., Betts, M. R., Price, D. A., Precopio, M. L., Ruff, L. E., Brenchley, J. M., Hill, B. J., Roederer, M., Douek, D. C., Koup, R. A. (2006). Acquisition of direct antiviral effector functions by CMV-specific CD4+ T lymphocytes with cellular maturation. JEM 203: 2865-2877 [Abstract] [Full Text]  
• Sun, Y., Schmitz, J. E., Buzby, A. P., Barker, B. R., Rao, S. S., Xu, L., Yang, Z.-y., Mascola, J. R., Nabel, G. J., Letvin, N. L. (2006). Virus-Specific Cellular Immune Correlates of Survival in Vaccinated Monkeys after Simian Immunodeficiency Virus Challenge. J. Virol. 80: 10950-10956 [Abstract] [Full Text]  
• Zhang, X., Dong, H., Lin, W., Voss, S., Hinkley, L., Westergren, M., Tian, G., Berry, D., Lewellen, D., Vile, R. G., Chen, L., Farber, D. L., Strome, S. E. (2006). Human Bone Marrow: A Reservoir for "Enhanced Effector Memory" CD8+ T Cells with Potent Recall Function. J. Immunol. 177: 6730-6737 [Abstract] [Full Text]  
• Fann, M., Godlove, J. M., Catalfamo, M., Wood, W. H. III, Chrest, F. J., Chun, N., Granger, L., Wersto, R., Madara, K., Becker, K., Henkart, P. A., Weng, N.-p. (2006). Histone acetylation is associated with differential gene expression in the rapid and robust memory CD8+ T-cell response. Blood 108: 3363-3370 [Abstract] [Full Text]  
• Takata, H., Takiguchi, M. (2006). Three Memory Subsets of Human CD8+ T Cells Differently Expressing Three Cytolytic Effector Molecules. J. Immunol. 177: 4330-4340 [Abstract] [Full Text]  
• Lee, S.-W., Park, Y., Song, A., Cheroutre, H., Kwon, B. S., Croft, M. (2006). Functional Dichotomy between OX40 and 4-1BB in Modulating Effector CD8 T Cell Responses. J. Immunol. 177: 4464-4472 [Abstract] [Full Text]  
• Peters, T., Bloch, W., Wickenhauser, C., Tawadros, S., Oreshkova, T., Kess, D., Krieg, T., Muller, W., Scharffetter-Kochanek, K. (2006). Terminal B cell differentiation is skewed by deregulated interleukin-6 secretion in {beta}2 integrin-deficient mice. J. Leukoc. Biol. 80: 599-607 [Abstract] [Full Text]  
• Kobayashi, N., Kondo, T., Takata, H., Yokota, S., Takiguchi, M. (2006). Functional and phenotypic analysis of human memory CD8+ T cells expressing CXCR3.. J. Leukoc. Biol. 80: 320-329 [Abstract] [Full Text]  
• Meng, Y., Harlin, H., O'Keefe, J. P., Gajewski, T. F. (2006). Induction of Cytotoxic Granules in Human Memory CD8+ T Cell Subsets Requires Cell Cycle Progression. J. Immunol. 177: 1981-1987 [Abstract] [Full Text]  
• Heydtmann, M., Hardie, D., Shields, P. L., Faint, J., Buckley, C. D., Campbell, J. J., Salmon, M., Adams, D. H. (2006). Detailed Analysis of Intrahepatic CD8 T Cells in the Normal and Hepatitis C-Infected Liver Reveals Differences in Specific Populations of Memory Cells with Distinct Homing Phenotypes. J. Immunol. 177: 729-738 [Abstract] [Full Text]  
• Lunemann, J. D., Edwards, N., Muraro, P. A., Hayashi, S., Cohen, J. I., Munz, C., Martin, R. (2006). Increased frequency and broadened specificity of latent EBV nuclear antigen-1-specific T cells in multiple sclerosis. Brain 129: 1493-1506 [Abstract] [Full Text]  
• Acierno, P. M., Schmitz, J. E., Gorgone, D. A., Sun, Y., Santra, S., Seaman, M. S., Newberg, M. H., Mascola, J. R., Nabel, G. J., Panicali, D., Letvin, N. L. (2006). Preservation of Functional Virus-Specific Memory CD8+ T Lymphocytes in Vaccinated, Simian Human Immunodeficiency Virus-Infected Rhesus Monkeys. J. Immunol. 176: 5338-5345 [Abstract] [Full Text]  
• Seddiki, N., Santner-Nanan, B., Tangye, S. G., Alexander, S. I., Solomon, M., Lee, S., Nanan, R., de Saint Groth, B. F. (2006). Persistence of naive CD45RA+ regulatory T cells in adult life. Blood 107: 2830-2838 [Abstract] [Full Text]  
• Serrano, L. M., Pfeiffer, T., Olivares, S., Numbenjapon, T., Bennitt, J., Kim, D., Smith, D., McNamara, G., Al-Kadhimi, Z., Rosenthal, J., Forman, S. J., Jensen, M. C., Cooper, L. J. N. (2006). Differentiation of naive cord-blood T cells into CD19-specific cytolytic effectors for posttransplantation adoptive immunotherapy. Blood 107: 2643-2652 [Abstract] [Full Text]  
• Ahmadzadeh, M., Rosenberg, S. A. (2006). IL-2 administration increases CD4+CD25hi Foxp3+ regulatory T cells in cancer patients. Blood 107: 2409-2414 [Abstract] [Full Text]  
• Migliaccio, M., Alves, P. M. S., Romero, P., Rufer, N. (2006). Distinct Mechanisms Control Human Naive and Antigen-Experienced CD8+ T Lymphocyte Proliferation. J. Immunol. 176: 2173-2182 [Abstract] [Full Text]  
• Galle, C., Schandene, L., Dereume, J.-P., Goldman, M., Duftner, C., Dejaco, C., Schirmer, M. (2006). CD8+ T-Cell Subpopulations in Human Abdominal Aortic Aneurysm Lesion. Arterioscler. Thromb. Vasc. Bio. 26: e19-e20 [Full Text]  
• Watanabe, Y., Nakayama, T., Nagakubo, D., Hieshima, K., Jin, Z., Katou, F., Hashimoto, K., Yoshie, O. (2006). Dopamine Selectively Induces Migration and Homing of Naive CD8+ T Cells via Dopamine Receptor D3. J. Immunol. 176: 848-856 [Abstract] [Full Text]  
• Luiten, R. M., Kueter, E. W.M., Mooi, W., Gallee, M. P.W., Rankin, E. M., Gerritsen, W. R., Clift, S. M., Nooijen, W. J., Weder, P., van de Kasteele, W. F., Sein, J., van den Berk, P. C.M., Nieweg, O. E., Berns, A. M., Spits, H., de Gast, G. C. (2005). Immunogenicity, Including Vitiligo, and Feasibility of Vaccination With Autologous GM-CSF-Transduced Tumor Cells in Metastatic Melanoma Patients. JCO 23: 8978-8991 [Abstract] [Full Text]  
• de Bree, G. J., van Leeuwen, E. M.M., Out, T. A., Jansen, H. M., Jonkers, R. E., van Lier, R. A.W. (2005). Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. JEM 202: 1433-1442 [Abstract] [Full Text]  
• Kaufmann, Y., Amariglio, N., Rosenthal, E., Hirsch, Y. J., Many, A., Rechavi, G. (2005). Proliferation Response of Leukemic Cells to CD70 Ligation Oscillates with Recurrent Remission and Relapse in a Low-Grade Lymphoma. J. Immunol. 175: 6940-6947 [Abstract] [Full Text]  
• Vossen, M. T. M., Gent, M.-R., Peters, K. M. C., Wertheim-van Dillen, P. M. E., Dolman, K. M., van Breda, A., van Lier, R. A. W., Kuijpers, T. W. (2005). Persistent Detection of Varicella-Zoster Virus DNA in a Previously Healthy Child after Severe Chickenpox. J. Clin. Microbiol. 43: 5614-5621 [Abstract] [Full Text]  
• Keating, S. M., Bejon, P., Berthoud, T., Vuola, J. M., Todryk, S., Webster, D. P., Dunachie, S. J., Moorthy, V. S., McConkey, S. J., Gilbert, S. C., Hill, A. V. S. (2005). Durable Human Memory T Cells Quantifiable by Cultured Enzyme-Linked Immunospot Assays Are Induced by Heterologous Prime Boost Immunization and Correlate with Protection against Malaria. J. Immunol. 175: 5675-5680 [Abstract] [Full Text]  
• Amyes, E., McMichael, A. J., Callan, M. F. C. (2005). Human CD4+ T Cells Are Predominantly Distributed among Six Phenotypically and Functionally Distinct Subsets. J. Immunol. 175: 5765-5773 [Abstract] [Full Text]  
• Willinger, T., Freeman, T., Hasegawa, H., McMichael, A. J., Callan, M. F. C. (2005). Molecular Signatures Distinguish Human Central Memory from Effector Memory CD8 T Cell Subsets. J. Immunol. 175: 5895-5903 [Abstract] [Full Text]  
• Ahn, J. K., Chung, H., Lee, D.-s., Yu, Y. S., Yu, H. G. (2005). CD8brightCD56+ T Cells Are Cytotoxic Effectors in Patients with Active Behcet's Uveitis. J. Immunol. 175: 6133-6142 [Abstract] [Full Text]  
• Bachmann, M. F., Wolint, P., Schwarz, K., Jager, P., Oxenius, A. (2005). Functional Properties and Lineage Relationship of CD8+ T Cell Subsets Identified by Expression of IL-7 Receptor {alpha} and CD62L. J. Immunol. 175: 4686-4696 [Abstract] [Full Text]  
• Elkord, E., Williams, P. E., Kynaston, H., Rowbottom, A. W. (2005). Differential CTLs specific for prostate-specific antigen in healthy donors and patients with prostate cancer. Int Immunol 17: 1315-1325 [Abstract] [Full Text]  
• Thimme, R., Appay, V., Koschella, M., Panther, E., Roth, E., Hislop, A. D., Rickinson, A. B., Rowland-Jones, S. L., Blum, H. E., Pircher, H. (2005). Increased Expression of the NK Cell Receptor KLRG1 by Virus-Specific CD8 T Cells during Persistent Antigen Stimulation. J. Virol. 79: 12112-12116 [Abstract] [Full Text]  
• van Leeuwen, E. M. M., de Bree, G. J., Remmerswaal, E. B. M., Yong, S.-L., Tesselaar, K., Berge, I. J. M. t., van Lier, R. A. W. (2005). IL-7 receptor {alpha} chain expression distinguishes functional subsets of virus-specific human CD8+ T cells. Blood 106: 2091-2098 [Abstract] [Full Text]  
• Salazar, J. C., Pope, C. D., Moore, M. W., Pope, J., Kiely, T. G., Radolf, J. D. (2005). Lipoprotein-Dependent and -Independent Immune Responses to Spirochetal Infection. CVI 12: 949-958 [Abstract] [Full Text]  
• Humphreys, T. L., Baldridge, L. A., Billings, S. D., Campbell, J. J., Spinola, S. M. (2005). Trafficking Pathways and Characterization of CD4 and CD8 Cells Recruited to the Skin of Humans Experimentally Infected with Haemophilus ducreyi. Infect. Immun. 73: 3896-3902 [Abstract] [Full Text]  
• Schilbach, K., Kerst, G., Walter, S., Eyrich, M., Wernet, D., Handgretinger, R., Xie, W., Rammensee, H.-G., Muller, I., Buhring, H.-J., Niethammer, D. (2005). Cytotoxic minor histocompatibility antigen HA-1-specific CD8+ effector memory T cells: artificial APCs pave the way for clinical application by potent primary in vitro induction. Blood 106: 144-149 [Abstract] [Full Text]  
• Sacre, K., Carcelain, G., Cassoux, N., Fillet, A.-M., Costagliola, D., Vittecoq, D., Salmon, D., Amoura, Z., Katlama, C., Autran, B. (2005). Repertoire, diversity, and differentiation of specific CD8 T cells are associated with immune protection against human cytomegalovirus disease. JEM 201: 1999-2010 [Abstract] [Full Text]  
• Ruprecht, C. R., Gattorno, M., Ferlito, F., Gregorio, A., Martini, A., Lanzavecchia, A., Sallusto, F. (2005). Coexpression of CD25 and CD27 identifies FoxP3+ regulatory T cells in inflamed synovia. JEM 201: 1793-1803 [Abstract] [Full Text]  
• Jiang, Y., Jolly, P. E., Ellis, W. O., Wang, J.-S., Phillips, T. D., Williams, J. H. (2005). Aflatoxin B1 albumin adduct levels and cellular immune status in Ghanaians. Int Immunol 17: 807-814 [Abstract] [Full Text]  
• Monceaux, V., Viollet, L., Petit, F., Fang, R. H. T., Cumont, M.-C., Zaunders, J., Hurtrel, B., Estaquier, J. (2005). CD8+ T Cell Dynamics during Primary Simian Immunodeficiency Virus Infection in Macaques: Relationship of Effector Cell Differentiation with the Extent of Viral Replication. J. Immunol. 174: 6898-6908 [Abstract] [Full Text]  
• Holmes, S., He, M., Xu, T., Lee, P. P. (2005). Memory T cells have gene expression patterns intermediate between naive and effector. Proc. Natl. Acad. Sci. USA 102: 5519-5523 [Abstract] [Full Text]  
• Rock, M. T., Yoder, S. M., Wright, P. F., Talbot, T. R., Edwards, K. M., Crowe, J. E. Jr (2005). Differential Regulation of Granzyme and Perforin in Effector and Memory T Cells following Smallpox Immunization. J. Immunol. 174: 3757-3764 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS