J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/10/1357/08 $2.00
Volume 186, Number 8, October 20, 1997 1357-1364

Neutrophil Emigration in the Skin, Lungs, and Peritoneum: Different Requirements for CD11/CD18 Revealed by CD18-deficient Mice

By Joseph P. Mizgerd,^* Hiroshi Kubo,^* Gregory J. Kutkoski,^* Sabrina D. Bhagwan,^* Karin Scharffetter-Kochanek, Arthur L. Beaudet, and Claire M. Doerschuk^*

From the ^* Physiology Program, Harvard School of Public Health, Boston, Massachusetts 02115; and  Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas 77030

To determine the role of CD11/CD18 complexes in neutrophil emigration, inflammation was induced in the skin, lungs, or peritoneum of mutant mice deficient in CD18 (CD18^/ mutants). Peripheral blood of CD18^/ mutants contained 11-fold more neutrophils than did blood of wild-type (WT) mice. During irritant dermatitis induced by topical application of croton oil, the number of emigrated neutrophils in histological sections of dermis was 98% less in CD18^/ mutants than in WT mice. During Streptococcus pneumoniae pneumonia, neutrophil emigration in CD18^/ mutants was not reduced. These data are consistent with expectations based on studies using blocking antibodies to inhibit CD11/CD18 complexes, and on observations of humans lacking CD11/CD18 complexes. The number of emigrated neutrophils in lung sections during Escherichia coli pneumonia, or in peritoneal lavage fluid after 4 h of S. pneumoniae peritonitis, was not reduced in CD18^/ mutants, but rather was greater than the WT values (240 ± 30 and 220 ± 30% WT, respectively). Also, there was no inhibition of neutrophil emigration during sterile peritonitis induced by intraperitoneal injection of thioglycollate (90 ± 20% WT). These data contrast with expectations. Whereas CD11/CD18 complexes are essential to the dermal emigration of neutrophils during acute dermatitis, CD18^/ mutant mice demonstrate surprising alternative pathways for neutrophil emigration during pneumonia or peritonitis.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• Smith, E., Stark, M. A., Zarbock, A., Burcin, T. L., Bruce, A. C., Vaswani, D., Foley, P., Ley, K. (2008). IL-17A Inhibits the Expansion of IL-17A-Producing T Cells in Mice through "Short-Loop" Inhibition via IL-17 Receptor. J. Immunol. 181: 1357-1364 [Abstract] [Full Text]  
• Kaynar, A. M., Houghton, A. M., Lum, E. H., Pitt, B. R., Shapiro, S. D. (2008). Neutrophil Elastase Is Needed for Neutrophil Emigration into Lungs in Ventilator-Induced Lung Injury. Am. J. Respir. Cell Mol. Bio. 39: 53-60 [Abstract] [Full Text]  
• Quinton, L. J., Jones, M. R., Robson, B. E., Simms, B. T., Whitsett, J. A., Mizgerd, J. P. (2008). Alveolar Epithelial STAT3, IL-6 Family Cytokines, and Host Defense during Escherichia coli Pneumonia. Am. J. Respir. Cell Mol. Bio. 38: 699-706 [Abstract] [Full Text]  
• Cullere, X., Lauterbach, M., Tsuboi, N., Mayadas, T. N. (2008). Neutrophil-selective CD18 silencing using RNA interference in vivo. Blood 111: 3591-3598 [Abstract] [Full Text]  
• Mizgerd, J. P., Skerrett, S. J. (2008). Animal models of human pneumonia. Am. J. Physiol. Lung Cell. Mol. Physiol. 294: L387-L398 [Abstract] [Full Text]  
• Nieminen, J., St-Pierre, C., Bhaumik, P., Poirier, F., Sato, S. (2008). Role of Galectin-3 in Leukocyte Recruitment in a Murine Model of Lung Infection by Streptococcus pneumoniae. J. Immunol. 180: 2466-2473 [Abstract] [Full Text]  
• Wu, X., Guo, R., Wang, Y., Cunningham, P. N. (2007). The role of ICAM-1 in endotoxin-induced acute renal failure. Am. J. Physiol. Renal Physiol. 293: F1262-F1271 [Abstract] [Full Text]  
• Ostanin, D. V., Furr, K. L., Pavlick, K. P., Gray, L., Kevil, C. G., Shukla, D., D'Souza, D., Hoffman, J. M., Grisham, M. B. (2007). T cell-associated CD18 but not CD62L, ICAM-1, or PSGL-1 is required for the induction of chronic colitis. Am. J. Physiol. Gastrointest. Liver Physiol. 292: G1706-G1714 [Abstract] [Full Text]  
• Mathew, B., Park, G. Y., Cao, H., Azim, A. C., Wang, X., Van Breemen, R. B., Sadikot, R. T., Christman, J. W. (2007). Inhibitory {kappa}B Kinase 2 Activates Airway Epithelial Cells to Stimulate Bone Marrow Macrophages. Am. J. Respir. Cell Mol. Bio. 36: 562-572 [Abstract] [Full Text]  
• Gregory, A. D., Hogue, L. A., Ferkol, T. W., Link, D. C. (2007). Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection. Blood 109: 3235-3243 [Abstract] [Full Text]  
• Wang, T., Tian, L., Haino, M., Gao, J.-L., Lake, R., Ward, Y., Wang, H., Siebenlist, U., Murphy, P. M., Kelly, K. (2007). Improved Antibacterial Host Defense and Altered Peripheral Granulocyte Homeostasis in Mice Lacking the Adhesion Class G Protein Receptor CD97. Infect. Immun. 75: 1144-1153 [Abstract] [Full Text]  
• Quinton, L. J., Jones, M. R., Simms, B. T., Kogan, M. S., Robson, B. E., Skerrett, S. J., Mizgerd, J. P. (2007). Functions and Regulation of NF-{kappa}B RelA during Pneumococcal Pneumonia. J. Immunol. 178: 1896-1903 [Abstract] [Full Text]  
• Mullaly, S. C., Kubes, P. (2006). The Role of TLR2 In Vivo following Challenge with Staphylococcus aureus and Prototypic Ligands. J. Immunol. 177: 8154-8163 [Abstract] [Full Text]  
• Li, Z., Burns, A. R., Smith, C. W. (2006). Lymphocyte Function-Associated Antigen-1-Dependent Inhibition of Corneal Wound Healing. Am. J. Pathol. 169: 1590-1600 [Abstract] [Full Text]  
• Hale, J. S., Dahlem, T. J., Margraf, R. L., Debnath, I., Weis, J. J., Weis, J. H. (2006). Transcriptional control of Pactolus: evidence of a negative control region and comparison with its evolutionary paralogue, CD18 ({beta}2 integrin). J. Leukoc. Biol. 80: 383-398 [Abstract] [Full Text]  
• Kodali, P., Wu, P., Lahiji, P. A., Brown, E. J., Maher, J. J. (2006). ANIT toxicity toward mouse hepatocytes in vivo is mediated primarily by neutrophils via CD18. Am. J. Physiol. Gastrointest. Liver Physiol. 291: G355-G363 [Abstract] [Full Text]  
• Francis, S. A., Shen, X., Young, J. B., Kaul, P., Lerner, D. J. (2006). Rho GEF Lsc is required for normal polarization, migration, and adhesion of formyl-peptide-stimulated neutrophils. Blood 107: 1627-1635 [Abstract] [Full Text]  
• Jones, M. R., Simms, B. T., Lupa, M. M., Kogan, M. S., Mizgerd, J. P. (2005). Lung NF-{kappa}B Activation and Neutrophil Recruitment Require IL-1 and TNF Receptor Signaling during Pneumococcal Pneumonia. J. Immunol. 175: 7530-7535 [Abstract] [Full Text]  
• Jia, W., Li, H., He, Y.-W. (2005). The extracellular matrix protein mindin serves as an integrin ligand and is critical for inflammatory cell recruitment. Blood 106: 3854-3859 [Abstract] [Full Text]  
• Kallapur, S. G., Moss, T. J. M., Ikegami, M., Jasman, R. L., Newnham, J. P., Jobe, A. H. (2005). Recruited Inflammatory Cells Mediate Endotoxin-induced Lung Maturation in Preterm Fetal Lambs. Am. J. Respir. Crit. Care Med. 172: 1315-1321 [Abstract] [Full Text]  
• Nieminen, J., St-Pierre, C., Sato, S. (2005). Galectin-3 interacts with naive and primed neutrophils, inducing innate immune responses. J. Leukoc. Biol. 78: 1127-1135 [Abstract] [Full Text]  
• Tasaka, S., Koh, H., Yamada, W., Shimizu, M., Ogawa, Y., Hasegawa, N., Yamaguchi, K., Ishii, Y., Richer, S. E., Doerschuk, C. M., Ishizaka, A. (2005). Attenuation of Endotoxin-Induced Acute Lung Injury by the Rho-Associated Kinase Inhibitor, Y-27632. Am. J. Respir. Cell Mol. Bio. 32: 504-510 [Abstract] [Full Text]  
• Aurrand-Lions, M., Lamagna, C., Dangerfield, J. P., Wang, S., Herrera, P., Nourshargh, S., Imhof, B. A. (2005). Junctional Adhesion Molecule-C Regulates the Early Influx of Leukocytes into Tissues during Inflammation. J. Immunol. 174: 6406-6415 [Abstract] [Full Text]  
• Gao, X.-P., Liu, Q., Broman, M., Predescu, D., Frey, R. S., Malik, A. B. (2005). Inactivation of CD11b in a mouse transgenic model protects against sepsis-induced lung PMN infiltration and vascular injury. Physiol. Genomics 21: 230-242 [Abstract] [Full Text]  
• Watts, G. M., Beurskens, F. J. M., Martin-Padura, I., Ballantyne, C. M., Klickstein, L. B., Brenner, M. B., Lee, D. M. (2005). Manifestations of Inflammatory Arthritis Are Critically Dependent on LFA-1. J. Immunol. 174: 3668-3675 [Abstract] [Full Text]  
• Adair-Kirk, T. L., Atkinson, J. J., Kelley, D. G., Arch, R. H., Miner, J. H., Senior, R. M. (2005). A Chemotactic Peptide from Laminin {alpha}5 Functions as a Regulator of Inflammatory Immune Responses via TNF{alpha}-mediated Signaling. J. Immunol. 174: 1621-1629 [Abstract] [Full Text]  
• Wang, J., Barke, R. A., Charboneau, R., Roy, S. (2005). Morphine Impairs Host Innate Immune Response and Increases Susceptibility to Streptococcus pneumoniae Lung Infection. J. Immunol. 174: 426-434 [Abstract] [Full Text]  
• Ariga, M., Neitzert, B., Nakae, S., Mottin, G., Bertrand, C., Pruniaux, M. P., Jin, S.-L. C., Conti, M. (2004). Nonredundant Function of Phosphodiesterases 4D and 4B in Neutrophil Recruitment to the Site of Inflammation. J. Immunol. 173: 7531-7538 [Abstract] [Full Text]  
• Humlicek, A. L., Pang, L., Look, D. C. (2004). Modulation of airway inflammation and bacterial clearance by epithelial cell ICAM-1. Am. J. Physiol. Lung Cell. Mol. Physiol. 287: L598-L607 [Abstract] [Full Text]  
• Gakidis, M. A. M., Cullere, X., Olson, T., Wilsbacher, J. L., Zhang, B., Moores, S. L., Ley, K., Swat, W., Mayadas, T., Brugge, J. S. (2004). Vav GEFs are required for {beta}2 integrin-dependent functions of neutrophils. JCB 166: 273-282 [Abstract] [Full Text]  
• Beck-Schimmer, B., Schimmer, R.C., Pasch, T. (2004). The Airway Compartment: Chambers of Secrets. Physiology 19: 129-132 [Abstract] [Full Text]  
• Pluskota, E., Soloviev, D. A., Bdeir, K., Cines, D. B., Plow, E. F. (2004). Integrin {alpha}M{beta}2 Orchestrates and Accelerates Plasminogen Activation and Fibrinolysis by Neutrophils. J. Biol. Chem. 279: 18063-18072 [Abstract] [Full Text]  
• Garrison, S., Hojgaard, A., Margraf, R., Weis, J. J., Weis, J. H. (2003). Surface Translocation of Pactolus Is Induced by Cell Activation and Death, but Is Not Required for Neutrophil Migration and Function. J. Immunol. 171: 6795-6806 [Abstract] [Full Text]  
• Ong, E. S., Gao, X.-P., Xu, N., Predescu, D., Rahman, A., Broman, M. T., Jho, D. H., Malik, A. B. (2003). E. coli pneumonia induces CD18-independent airway neutrophil migration in the absence of increased lung vascular permeability. Am. J. Physiol. Lung Cell. Mol. Physiol. 285: L879-L888 [Abstract] [Full Text]  
• Tasaka, S., Ishizaka, A., Yamada, W., Shimizu, M., Koh, H., Hasegawa, N., Adachi, Y., Yamaguchi, K. (2003). Effect of CD14 Blockade on Endotoxin-Induced Acute Lung Injury in Mice. Am. J. Respir. Cell Mol. Bio. 29: 252-258 [Abstract] [Full Text]  
• Sakurai, E., Taguchi, H., Anand, A., Ambati, B. K., Gragoudas, E. S., Miller, J. W., Adamis, A. P., Ambati, J. (2003). Targeted Disruption of the CD18 or ICAM-1 Gene Inhibits Choroidal Neovascularization. IOVS 44: 2743-2749 [Abstract] [Full Text]  
• Borjesson, D. L., Simon, S. I., Hodzic, E., DeCock, H. E. V., Ballantyne, C. M., Barthold, S. W. (2003). Roles of neutrophil beta 2 integrins in kinetics of bacteremia, extravasation, and tick acquisition of Anaplasma phagocytophila in mice. Blood 101: 3257-3264 [Abstract] [Full Text]  
• Pluskota, E., Soloviev, D. A., Plow, E. F. (2003). Convergence of the adhesive and fibrinolytic systems: recognition of urokinase by integrin alpha Mbeta 2 as well as by the urokinase receptor regulates cell adhesion and migration. Blood 101: 1582-1590 [Abstract] [Full Text]  
• Manitz, M.-P., Horst, B., Seeliger, S., Strey, A., Skryabin, B. V., Gunzer, M., Frings, W., Schonlau, F., Roth, J., Sorg, C., Nacken, W. (2003). Loss of S100A9 (MRP14) Results in Reduced Interleukin-8-Induced CD11b Surface Expression, a Polarized Microfilament System, and Diminished Responsiveness to Chemoattractants In Vitro. Mol. Cell. Biol. 23: 1034-1043 [Abstract] [Full Text]  
• Mizgerd, J. P., Scott, M. L., Spieker, M. R., Doerschuk, C. M. (2002). Functions of I{kappa}B Proteins in Inflammatory Responses to Escherichia coli LPS in Mouse Lungs. Am. J. Respir. Cell Mol. Bio. 27: 575-582 [Abstract] [Full Text]  
• Moreland, J. G., Fuhrman, R. M., Pruessner, J. A., Schwartz, D. A. (2002). CD11b and Intercellular Adhesion Molecule-1 Are Involved in Pulmonary Neutrophil Recruitment in Lipopolysaccharide-Induced Airway Disease. Am. J. Respir. Cell Mol. Bio. 27: 474-480 [Abstract] [Full Text]  
• FORLOW, S. B., FOLEY, P. L., LEY, K. (2002). Severely reduced neutrophil adhesion and impaired host defense against fecal and commensal bacteria in CD18-/-P-selectin-/- double null mice. FASEB J. 16: 1488-1496 [Abstract] [Full Text]  
• Lu, Y.-T., Chen, P.-G., Liu, S. F. (2002). Time course of lung ischemia-reperfusion-induced ICAM-1 expression and its role in ischemia-reperfusion lung injury. J. Appl. Physiol. 93: 620-628 [Abstract] [Full Text]  
• Tasaka, S., Richer, S. E., Mizgerd, J. P., Doerschuk, C. M. (2002). Very Late Antigen-4 in CD18-Independent Neutrophil Emigration during Acute Bacterial Pneumonia in Mice. Am. J. Respir. Crit. Care Med. 166: 53-60 [Abstract] [Full Text]  
• Edens, H. A., Levi, B. P., Jaye, D. L., Walsh, S., Reaves, T. A., Turner, J. R., Nusrat, A., Parkos, C. A. (2002). Neutrophil Transepithelial Migration: Evidence for Sequential, Contact-Dependent Signaling Events and Enhanced Paracellular Permeability Independent of Transjunctional Migration. J. Immunol. 169: 476-486 [Abstract] [Full Text]  
• Kubes, P., Payne, D., Woodman, R. C. (2002). Molecular mechanisms of leukocyte recruitment in postischemic liver microcirculation. Am. J. Physiol. Gastrointest. Liver Physiol. 283: G139-G147 [Abstract] [Full Text]  
• Bowden, R. A., Ding, Z.-M., Donnachie, E. M., Petersen, T. K., Michael, L. H., Ballantyne, C. M., Burns, A. R. (2002). Role of {alpha}4 Integrin and VCAM-1 in CD18-Independent Neutrophil Migration Across Mouse Cardiac Endothelium. Circ. Res. 90: 562-569 [Abstract] [Full Text]  
• Sato, S., Ouellet, N., Pelletier, I., Simard, M., Rancourt, A., Bergeron, M. G. (2002). Role of Galectin-3 as an Adhesion Molecule for Neutrophil Extravasation During Streptococcal Pneumonia. J. Immunol. 168: 1813-1822 [Abstract] [Full Text]  
• CHAVAKIS, T., KANSE, S. M., PIXLEY, R. A., MAY, A. E., ISORDIA-SALAS, I., COLMAN, R. W., PREISSNER, K. T. (2001). Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen. FASEB J. 15: 2365-2376 [Abstract] [Full Text]  
• D'AMBROSIO, D., MARIANI, M., PANINA-BORDIGNON, P., SINIGAGLIA, F. (2001). Chemokines and Their Receptors Guiding T Lymphocyte Recruitment in Lung Inflammation. Am. J. Respir. Crit. Care Med. 164: 1266-1275 [Full Text]  
• Gao, X.-p., Xu, N., Sekosan, M., Mehta, D., Ma, S. Y., Rahman, A., Malik, A. B. (2001). Differential Role of CD18 Integrins in Mediating Lung Neutrophil Sequestration and Increased Microvascular Permeability Induced by Escherichia coli in Mice. J. Immunol. 167: 2895-2901 [Abstract] [Full Text]  
• Cotter, M. J., Norman, K. E., Hellewell, P. G., Ridger, V. C. (2001). A Novel Method for Isolation of Neutrophils from Murine Blood Using Negative Immunomagnetic Separation. Am. J. Pathol. 159: 473-481 [Abstract] [Full Text]  
• Alcamo, E., Mizgerd, J. P., Horwitz, B. H., Bronson, R., Beg, A. A., Scott, M., Doerschuk, C. M., Hynes, R. O., Baltimore, D. (2001). Targeted Mutation of TNF Receptor I Rescues the RelA-Deficient Mouse and Reveals a Critical Role for NF-{kappa}B in Leukocyte Recruitment. J. Immunol. 167: 1592-1600 [Abstract] [Full Text]  
• Bouvard, D., Brakebusch, C., Gustafsson, E., Aszodi, A., Bengtsson, T., Berna, A., Fassler, R. (2001). Functional Consequences of Integrin Gene Mutations in Mice. Circ. Res. 89: 211-223 [Abstract] [Full Text]  
• Henderson, R. B., Lim, L. H.K., Tessier, P. A., Gavins, F. N.E., Mathies, M., Perretti, M., Hogg, N. (2001). The Use of Lymphocyte Function-associated Antigen (LFA)-1-deficient Mice to Determine the Role of LFA-1, Mac-1, and {alpha}4 Integrin in the Inflammatory Response of Neutrophils. JEM 194: 219-226 [Abstract] [Full Text]  
• Fillion, I., Ouellet, N., Simard, M., Bergeron, Y., Sato, S., Bergeron, M. G. (2001). Role of Chemokines and Formyl Peptides in Pneumococcal Pneumonia-Induced Monocyte/Macrophage Recruitment. J. Immunol. 166: 7353-7361 [Abstract] [Full Text]  
• Prince, J. E., Brayton, C. F., Fossett, M. C., Durand, J. A., Kaplan, S. L., Smith, C. W., Ballantyne, C. M. (2001). The Differential Roles of LFA-1 and Mac-1 in Host Defense Against Systemic Infection with Streptococcus pneumoniae. J. Immunol. 166: 7362-7369 [Abstract] [Full Text]  
• Burns, J. A., Issekutz, T. B., Yagita, H., Issekutz, A. C. (2001). The {{alpha}}4{{beta}}1 (Very Late Antigen (VLA)-4, CD49d/CD29) and {{alpha}}5{{beta}}1 (VLA-5, CD49e/CD29) Integrins Mediate {{beta}}2 (CD11/CD18) Integrin-Independent Neutrophil Recruitment to Endotoxin-Induced Lung Inflammation. J. Immunol. 166: 4644-4649 [Abstract] [Full Text]  
• Mizgerd, J. P., Spieker, M. R., Doerschuk, C. M. (2001). Early Response Cytokines and Innate Immunity: Essential Roles for TNF Receptor 1 and Type I IL-1 Receptor During Escherichia coli Pneumonia in Mice. J. Immunol. 166: 4042-4048 [Abstract] [Full Text]  
• Horwitz, B. H., Mizgerd, J. P., Scott, M. L., Doerschuk, C. M. (2001). Mechanisms of granulocytosis in the absence of CD18. Blood 97: 1578-1583 [Abstract] [Full Text]  
• Car, B. D., Eng, V. M. (2001). Special Considerations in the Evaluation of the Hematology and Hemostasis of Mutant Mice. Vet Pathol 38: 20-30 [Abstract] [Full Text]  
• Doerschuk, C. M., Tasaka, S., Wang, Q. (2000). CD11/CD18-Dependent and -Independent Neutrophil Emigration in the Lungs . How Do Neutrophils Know Which Route to Take?. Am. J. Respir. Cell Mol. Bio. 23: 133-136 [Full Text]  
• Gyetko, M. R., Sud, S., Kendall, T., Fuller, J. A., Newstead, M. W., Standiford, T. J. (2000). Urokinase Receptor-Deficient Mice Have Impaired Neutrophil Recruitment in Response to Pulmonary Pseudomonas aeruginosa Infection. J. Immunol. 165: 1513-1519 [Abstract] [Full Text]  
• GARDINALI, M., BORRELLI, E., CHIARA, O., LUNDBERG, C., PADALINO, P., CONCIATO, L., CAFARO, C., LAZZI, S., LUZI, P., GIOMARELLI, P. P., AGOSTONI, A. (2000). Inhibition of CD11-CD18 Complex Prevents Acute Lung Injury and Reduces Mortality after Peritonitis in Rabbits. Am. J. Respir. Crit. Care Med. 161: 1022-1029 [Abstract] [Full Text]  
• Mizgerd, J. P., Peschon, J. J., Doerschuk, C. M. (2000). Roles of Tumor Necrosis Factor Receptor Signaling during Murine Escherichia coli Pneumonia. Am. J. Respir. Cell Mol. Bio. 22: 85-91 [Abstract] [Full Text]  
• Hyde, D. M., Miller, L. A., McDonald, R. J., Stovall, M. Y., Wong, V., Pinkerton, K. E., Wegner, C. D., Rothlein, R., Plopper, C. G. (1999). Neutrophils enhance clearance of necrotic epithelial cells in ozone-induced lung injury in rhesus monkeys. Am. J. Physiol. Lung Cell. Mol. Physiol. 277: L1190-L1198 [Abstract] [Full Text]  
• Etzioni, A., Doerschuk, C. M., Harlan, J. M. (1999). Of Man and Mouse: Leukocyte and Endothelial Adhesion Molecule Deficiencies. Blood 94: 3281-3288 [Full Text]  
• Ding, Z.-M., Babensee, J. E., Simon, S. I., Lu, H., Perrard, J. L., Bullard, D. C., Dai, X. Y., Bromley, S. K., Dustin, M. L., Entman, M. L., Smith, C. W., Ballantyne, C. M. (1999). Relative Contribution of LFA-1 and Mac-1 to Neutrophil Adhesion and Migration. J. Immunol. 163: 5029-5038 [Abstract] [Full Text]  
• Wang, J., Brown, E. J. (1999). Immune Complex-induced Integrin Activation and L-plastin Phosphorylation Require Protein Kinase A. J. Biol. Chem. 274: 24349-24356 [Abstract] [Full Text]  
• Rizoli, S. B., Rotstein, O. D., Kapus, A. (1999). Cell Volume-dependent Regulation of L-selectin Shedding in Neutrophils. A ROLE FOR p38 MITOGEN-ACTIVATED PROTEIN KINASE. J. Biol. Chem. 274: 22072-22080 [Abstract] [Full Text]  
• Mizgerd, J. P., Horwitz, B. H., Quillen, H. C., Scott, M. L., Doerschuk, C. M. (1999). Effects of CD18 Deficiency on the Emigration of Murine Neutrophils During Pneumonia. J. Immunol. 163: 995-999 [Abstract] [Full Text]  
• Doerschuk, C. M., Mizgerd, J. P., Kubo, H., Qin, L., Kumasaka, T. (1999). Adhesion Molecules and Cellular Biomechanical Changes in Acute Lung Injury: Giles F. Filley Lecture. Chest 116: 37S-43S [Full Text]  
• Downey, G. P., Dong, Q., Kruger, J., Dedhar, S., Cherapanov, V. (1999). Regulation of Neutrophil Activation in Acute Lung Injury. Chest 116: 46S-54S [Full Text]  
• Betsuyaku, T., Michael Shipley, J., Liu, Z., Senior, R. M. (1999). Neutrophil Emigration in the Lungs, Peritoneum, and Skin Does Not Require Gelatinase B. Am. J. Respir. Cell Mol. Bio. 20: 1303-1309 [Abstract] [Full Text]  
• Walzog, B., Scharffetter-Kochanek, K., Gaehtgens, P. (1999). Impairment of neutrophil emigration in CD18-null mice. Am. J. Physiol. Gastrointest. Liver Physiol. 276: G1125-G1130 [Abstract] [Full Text]  
• Mizgerd, J. P., Bullard, D. C., Hicks, M. J., Beaudet, A. L., Doerschuk, C. M. (1999). Chronic Inflammatory Disease Alters Adhesion Molecule Requirements for Acute Neutrophil Emigration in Mouse Skin. J. Immunol. 162: 5444-5448 [Abstract] [Full Text]  
• Taooka, Y., Chen, J., Yednock, T., Sheppard, D. (1999). The Integrin alpha 9beta 1 Mediates Adhesion to Activated Endothelial Cells and Transendothelial Neutrophil Migration through Interaction with Vascular Cell Adhesion Molecule-1. JCB 145: 413-420 [Abstract] [Full Text]  
• May, A. E., Kanse, S. M., Lund, L. R., Gisler, R. H., Imhof, B. A., Preissner, K. T. (1998). Urokinase Receptor (CD87) Regulates Leukocyte Recruitment via beta 2 Integrins In Vivo. JEM 188: 1029-1037 [Abstract] [Full Text]  
• Jones, S. L., Wang, J., Turck, C. W., Brown, E. J. (1998). A role for the actin-bundling protein L-plastin in the regulation of leukocyte integrin function. Proc. Natl. Acad. Sci. USA 95: 9331-9336 [Abstract] [Full Text]  
• Scharffetter-Kochanek, K., Lu, H., Norman, K., van Nood, N., Munoz, F., Grabbe, S., McArthur, M., Lorenzo, I., Kaplan, S., Ley, K., Wayne Smith, C., Montgomery, C. A., Rich, S., Beaudet, A. L. (1998). Spontaneous Skin Ulceration and Defective T Cell Function in CD18 Null Mice. JEM 188: 119-131 [Abstract] [Full Text]  
• Huang, C., De Sanctis, G. T., O'Brien, P. J., Mizgerd, J. P., Friend, D. S., Drazen, J. M., Brass, L. F., Stevens, R. L. (2001). Evaluation of the Substrate Specificity of Human Mast Cell Tryptase beta I and Demonstration of Its Importance in Bacterial Infections of the Lung. J. Biol. Chem. 276: 26276-26284 [Abstract] [Full Text]  
• Harris, E. S., McIntyre, T. M., Prescott, S. M., Zimmerman, G. A. (2000). The Leukocyte Integrins. J. Biol. Chem. 275: 23409-23412 [Full Text]  
• Bowden, R. A., Ding, Z.-M., Donnachie, E. M., Petersen, T. K., Michael, L. H., Ballantyne, C. M., Burns, A. R. (2002). Role of {alpha}4 Integrin and VCAM-1 in CD18-Independent Neutrophil Migration Across Mouse Cardiac Endothelium. Circ. Res. 90: 562-569 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS