J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/08/731/07 $2.00
Volume 186, Number 5, August 29, 1997 731-737

Epstein-Barr  Virus Binding to CD21 Activates the Initial Viral Promoter via NF-B Induction

By Naoyuki Sugano, Weiping Chen, M. Luisa Roberts, and Neil R. Cooper

From the Scripps Research Institute, Department of Immunology, La Jolla, California 92037

Epstein-Barr virus (EBV), an oncogenic human herpesvirus, binds to and infects normal human B lymphocytes via CD21, the CR2 complement receptor. Studies of the mechanisms that enable EBV to infect nonactivated, noncycling B cells provide compelling evidence for a sequence of events in which EBV binding to CD21 on purified resting human B cells rapidly activates the NF-B transcription factor, which, in turn, binds to and mediates transcriptional activation of Wp, the initial viral latent gene promoter. Thus, EBV binding to its cellular receptor on resting B cells triggers an NF-B-dependent intracellular signaling pathway which is required for infection.

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