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From the Schering-Plough Laboratory for Immunological Research, 69571 Dardilly, France
To identify genes expressed by a specific subset of dendritic cells found in vivo a polymerase
chain reaction-based cDNA subtraction technique was applied to the recently described germinal center dendritic cells. A novel member of the disintegrin metalloproteinase family was
cloned which comprises a not typical zinc-chelating catalytic site most similar to a bacterial
metalloproteinase. Dendritic cell precursors or immature dendritic cells express no or low levels
of the message. It is induced to high levels upon spontaneous or CD40-dependent maturation
and in a mixed lymphocyte reaction. In situ hybridization showed distinct expression of this
gene in the germinal center. This, together with the findings that certain disintegrin metalloproteinases regulate the activity of tumor necrosis factor 
and that metalloproteinases have also been implicated in FasL processing, suggest that this novel molecule may play an important role
in dendritic cell function and their interactions with germinal center T cells.
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