Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

doi:10.1084/jem.186.2.183

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© The Rockefeller University Press, 0022-1007/1997/7/183/ $5.00
The Journal of Experimental Medicine, Volume 186, Number 2, July 21, 1997 183-187

Article

Protective Immunity to Nematode Infection Is Induced by CTLA-4 Blockade

Kathy McCoy, Mali Camberis, and Graham Le Gros

From the Malaghan Institute for Medical Research, Wellington School of Medicine, Wellington, New Zealand

The recent observation that neutralization or genetic deletionof the T lymphocyte receptor CTLA-4 allows enhanced T cellreactivity offers new opportunities for immunotherapy against infectious agents. We used a neutralizing antibody to blockCTLA-4 interaction with its ligands CD80 and CD86 during infectionof mice with the nematode, Nippostrongylus brasiliensis. CTLA-4blockade greatly enhanced and accelerated the T cell immuneresponse to N. brasiliensis, resulting in a profound reductionin adult worm numbers and early termination of parasite eggproduction. The ability of CTLA-4 blockade to accelerate primaryimmune responses to a protective level during an acute infectionindicates its potential as an immunotherapeutic tool for dealingwith infectious agents.

Address correspondence to Dr. Graham Le Gros, Malaghan Instituteof Medical Research, PO Box 7060, Wellington South, New Zealand.Phone: 64-4-389-5096, ext. 822; FAX: 64-4-389-5095; E-mail:mimrglg{at}wnmeds.ac.nz

¹ Abbreviation used in this paper: Nb, Nippostrongylus brasiliensis.

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