The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1997/12/2075/ $5.00
The Journal of Experimental Medicine, Volume 186, Number 12, December 15, 1997 2075-2080

Brief Definitive Reports

TRANCE (Tumor Necrosis Factor [TNF]-related Activation-induced Cytokine), a New TNF Family Member Predominantly Expressed in T cells, Is a Dendritic Cell–specific Survival Factor

Brian R. Wong§, Régis Josien{ddagger}, Soo Young Lee§, Birthe Sauter{ddagger}, Hong-Li Li{ddagger}, Ralph M. Steinman{ddagger}, and Yongwon Choi*,§

From the * Howard Hughes Medical Insitute; the {ddagger} Laboratory of Cellular Physiology and Immunology; and the § Laboratory of Immunology, The Rockefeller University, New York 10021

TRANCE (tumor necrosis factor [TNF]–related activation-induced cytokine) is a new member of the TNF family that is induced upon T cell receptor engagement and activates c-Jun N-terminal kinase (JNK) after interaction with its putative receptor (TRANCE-R). In addition, TRANCE expression is restricted to lymphoid organs and T cells. Here, we show that high levels of TRANCE-R are detected on mature dendritic cells (DCs) but not on freshly isolated B cells, T cells, or macrophages. Signaling by TRANCE-R appears to be dependent on TNF receptor–associated factor 2 (TRAF2), since JNK induction is impaired in cells from transgenic mice overexpressing a dominant negative TRAF2 protein. TRANCE inhibits apoptosis of mouse bone marrow–derived DCs and human monocyte-derived DCs in vitro. The resulting increase in DC survival is accompanied by a proportional increase in DC-mediated T cell proliferation in a mixed leukocyte reaction. TRANCE upregulates Bcl-xL expression, suggesting a potential mechanism for enhanced DC survival. TRANCE does not induce the proliferation of or increase the survival of T or B cells. Therefore, TRANCE is a new DC-restricted survival factor that mediates T cell–DC communication and may provide a tool to selectively enhance DC activity.

Address correspondence to Dr. Yongwon Choi, HHMI, The Rockefeller University, 1230 York Ave., Box 295, New York, NY 10021. Phone: 212-327-7441; FAX: 212-327-7319; E-mail: choi{at}rockvax.rockefeller.edu

Brian R. Wong and Régis Josien contributed equally to this report.


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