The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1997/11/1763/ $5.00
The Journal of Experimental Medicine, Volume 186, Number 10, November 17, 1997 1763-1768

Brief Definitive Reports

Evidence that Singlet Oxygen-induced Human T Helper Cell Apoptosis Is the Basic Mechanism of Ultraviolet-A Radiation Phototherapy

Akimichi Morita*, Thomas Werfel{ddagger}, Helger Stege*, Constanze Ahrens*, Karin Karmann*, Markus Grewe*, Susanne Grether-Beck*, Thomas Ruzicka*, Alexander Kapp{ddagger}, Lars-Oliver Klotz§, Helmut Sies§, and Jean Krutmann*

From * Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University of Düsseldorf, D-40225 Düsseldorf; {ddagger} Department of Dermatology, Hannover Medical School, D-30625 Hannover; and § Institute of Physiological Chemistry I, Heinrich-Heine-University, D-40225 Düsseldorf, Germany

Ultraviolet A (UVA) irradiation is effectively used to treat patients with atopic dermatitis and other T cell mediated, inflammatory skin diseases. In the present study, successful phototherapy of atopic dermatitis was found to result from UVA radiation-induced apoptosis in skin-infiltrating T helper cells, leading to T cell depletion from eczematous skin. In vitro, UVA radiation-induced human T helper cell apoptosis was mediated through the FAS/FAS-ligand system, which was activated in irradiated T cells as a consequence of singlet oxygen generation. These studies demonstrate that singlet oxygen is a potent trigger for the induction of human T cell apoptosis. They also identify singlet oxygen generation as a fundamental mechanism of action operative in phototherapy.

Address correspondence to Prof. Dr. Jean Krutmann, Clinical and Experimental Photodermatology, Department of Dermatology, Heinrich-Heine-University Düsseldorf, Moorenstr. 5, D-40225 Düsseldorf. Phone: +49 211 8117627; FAX: +49 211 8118830; E-mail: krutmann{at}rz.uni-duesseldorf.de


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