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24+ CD4
CD8
T Cells
By

From the * Cancer Biology Program, Hematology/Oncology Division, Beth Israel Deaconess Medical
Center and Harvard Medical School, Boston, Massachusetts 02215; and A subset of human CD4
Lymphocyte Biology
Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and
Harvard Medical School, Boston, Massachusetts 02115
CD8
T cells that expresses an invariant V
24-J
Q T cell receptor
(TCR)-
chain, paired predominantly with V
11, has been identified. A series of these V
24
V
11 clones were shown to have TCR-
CDR3 diversity and express the natural killer (NK)
locus-encoded C-type lectins NKR-P1A, CD94, and CD69. However, in contrast to NK
cells, they did not express killer inhibitory receptors, CD16, CD56, or CD57. All invariant
V
24+ clones recognized the MHC class I-like CD16 molecule and discriminated between
CD1d and other closely related human CD1 proteins, indicating that recognition was TCR-mediated. Recognition was not dependent upon an endosomal targeting motif in the cytoplasmic tail of CD1d. Upon activation by anti-CD3 or CD1d, the clones produced both Th1 and
Th2 cytokines. These results demonstrate that human invariant V
24+ CD4
CD8
T cells,
and presumably the homologous murine NK1+ T cell population, are CD1d reactive and
functionally distinct from NK cells. The conservation of this cell population and of the CD1d
ligand across species indicates an important immunological function.
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