J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/07/109/12 $2.00
Volume 186, Number 1, July 7, 1997 109-120

Requirements for CD1d Recognition by Human Invariant V24⁺ CD4CD8 T Cells

By Mark Exley,^* Jorge Garcia,^* Steven P. Balk,^* and Steven Porcelli

From the ^* Cancer Biology Program, Hematology/Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts 02215; and  Lymphocyte Biology Section, Division of Rheumatology, Immunology, and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115

A subset of human CD4CD8 T cells that expresses an invariant V24-JQ T cell receptor (TCR)- chain, paired predominantly with V11, has been identified. A series of these V24 V11 clones were shown to have TCR- CDR3 diversity and express the natural killer (NK) locus-encoded C-type lectins NKR-P1A, CD94, and CD69. However, in contrast to NK cells, they did not express killer inhibitory receptors, CD16, CD56, or CD57. All invariant V24⁺ clones recognized the MHC class I-like CD16 molecule and discriminated between CD1d and other closely related human CD1 proteins, indicating that recognition was TCR-mediated. Recognition was not dependent upon an endosomal targeting motif in the cytoplasmic tail of CD1d. Upon activation by anti-CD3 or CD1d, the clones produced both Th1 and Th2 cytokines. These results demonstrate that human invariant V24⁺ CD4CD8 T cells, and presumably the homologous murine NK1⁺ T cell population, are CD1d reactive and functionally distinct from NK cells. The conservation of this cell population and of the CD1d ligand across species indicates an important immunological function.

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• Kang, S.-J., Cresswell, P. (2002). Calnexin, Calreticulin, and ERp57 Cooperate in Disulfide Bond Formation in Human CD1d Heavy Chain. J. Biol. Chem. 277: 44838-44844 [Abstract] [Full Text]  
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• Sonoda, K.-H., Taniguchi, M., Stein-Streilein, J. (2002). Long-Term Survival of Corneal Allografts Is Dependent on Intact CD1d-Reactive NKT Cells. J. Immunol. 168: 2028-2034 [Abstract] [Full Text]  
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• Mempel, M., Ronet, C., Suarez, F., Gilleron, M., Puzo, G., Van Kaer, L., Lehuen, A., Kourilsky, P., Gachelin, G. (2002). Natural Killer T Cells Restricted by the Monomorphic MHC Class 1b CD1d1 Molecules Behave Like Inflammatory Cells. J. Immunol. 168: 365-371 [Abstract] [Full Text]  
• Singh, A. K., Wilson, M. T., Hong, S., Olivares-Villagomez, D., Du, C., Stanic, A. K., Joyce, S., Sriram, S., Koezuka, Y., Van Kaer, L. (2001). Natural Killer T Cell Activation Protects Mice Against Experimental Autoimmune Encephalomyelitis. JEM 194: 1801-1811 [Abstract] [Full Text]  
• Gui, M., Li, J., Wen, L.-J., Hardy, R. R., Hayakawa, K. (2001). TCR{beta} Chain Influences But Does Not Solely Control Autoreactivity of V{alpha}14J281T Cells. J. Immunol. 167: 6239-6246 [Abstract] [Full Text]  
• Exley, M. A., Tahir, S. M. A., Cheng, O., Shaulov, A., Joyce, R., Avigan, D., Sackstein, R., Balk, S. P. (2001). Cutting Edge: A Major Fraction of Human Bone Marrow Lymphocytes Are Th2-Like CD1d-Reactive T Cells That Can Suppress Mixed Lymphocyte Responses. J. Immunol. 167: 5531-5534 [Abstract] [Full Text]  
• Muhammad Ali Tahir, S., Cheng, O., Shaulov, A., Koezuka, Y., Bubley, G. J., Wilson, S. B., Balk, S. P., Exley, M. A. (2001). Loss of IFN-{gamma} Production by Invariant NK T Cells in Advanced Cancer. J. Immunol. 167: 4046-4050 [Abstract] [Full Text]  
• Metelitsa, L. S., Naidenko, O. V., Kant, A., Wu, H.-W., Loza, M. J., Perussia, B., Kronenberg, M., Seeger, R. C. (2001). Human NKT Cells Mediate Antitumor Cytotoxicity Directly by Recognizing Target Cell CD1d with Bound Ligand or Indirectly by Producing IL-2 to Activate NK Cells. J. Immunol. 167: 3114-3122 [Abstract] [Full Text]  
• Dunne, J., Lynch, S., O'Farrelly, C., Todryk, S., Hegarty, J. E., Feighery, C., Doherty, D. G. (2001). Selective Expansion and Partial Activation of Human NK Cells and NK Receptor-Positive T Cells by IL-2 and IL-15. J. Immunol. 167: 3129-3138 [Abstract] [Full Text]  
• Wang, B., Geng, Y.-B., Wang, C.-R. (2001). CD1-restricted NK T Cells Protect Nonobese Diabetic Mice from Developing Diabetes. JEM 194: 313-320 [Abstract] [Full Text]  
• Kamada, N., Iijima, H., Kimura, K., Harada, M., Shimizu, E., Motohashi, S.-i., Kawano, T., Shinkai, H., Nakayama, T., Sakai, T., Brossay, L., Kronenberg, M., Taniguchi, M. (2001). Crucial amino acid residues of mouse CD1d for glycolipid ligand presentation to V{{alpha}}14 NKT cells. Int Immunol 13: 853-861 [Abstract] [Full Text]  
• Campbell, J. J., Qin, S., Unutmaz, D., Soler, D., Murphy, K. E., Hodge, M. R., Wu, L., Butcher, E. C. (2001). Unique Subpopulations of CD56+ NK and NK-T Peripheral Blood Lymphocytes Identified by Chemokine Receptor Expression Repertoire. J. Immunol. 166: 6477-6482 [Abstract] [Full Text]  
• Kadowaki, N., Antonenko, S., Ho, S., Rissoan, M.-C., Soumelis, V., Porcelli, S. A., Lanier, L. L., Liu, Y.-J. (2001). Distinct Cytokine Profiles of Neonatal Natural Killer T Cells after Expansion with Subsets of Dendritic Cells. JEM 193: 1221-1226 [Abstract] [Full Text]  
• Exley, M. A., Bigley, N. J., Cheng, O., Tahir, S. M. A., Smiley, S. T., Carter, Q. L., Stills, H. F., Grusby, M. J., Koezuka, Y., Taniguchi, M., Balk, S. P. (2001). CD1d-reactive T-cell activation leads to amelioration of disease caused by diabetogenic encephalomyocarditis virus. J. Leukoc. Biol. 69: 713-718 [Abstract] [Full Text]  
• Yamazaki, K., Ohsawa, Y., Yoshie, H. (2001). Elevated Proportion of Natural Killer T Cells in Periodontitis Lesions : A Common Feature of Chronic Inflammatory Diseases. Am. J. Pathol. 158: 1391-1398 [Abstract] [Full Text]  
• Nieda, M., Nicol, A., Koezuka, Y., Kikuchi, A., Lapteva, N., Tanaka, Y., Tokunaga, K., Suzuki, K., Kayagaki, N., Yagita, H., Hirai, H., Juji, T. (2001). TRAIL expression by activated human CD4+V{alpha}24NKT cells induces in vitro and in vivo apoptosis of human acute myeloid leukemia cells. Blood 97: 2067-2074 [Abstract] [Full Text]  
• Wang, B., Chun, T., Rulifson, I. C., Exley, M., Balk, S. P., Wang, C.-R. (2001). Human CD1d Functions as a Transplantation Antigen and a Restriction Element in Mice. J. Immunol. 166: 3829-3836 [Abstract] [Full Text]  
• Karadimitris, A., Gadola, S., Altamirano, M., Brown, D., Woolfson, A., Klenerman, P., Chen, J.-L., Koezuka, Y., Roberts, I. A. G., Price, D. A., Dusheiko, G., Milstein, C., Fersht, A., Luzzatto, L., Cerundolo, V. (2001). From the Cover: Human CD1d-glycolipid tetramers generated by in vitro oxidative refolding chromatography. Proc. Natl. Acad. Sci. USA 98: 3294-3298 [Abstract] [Full Text]  
• Sonoda, K.-H., Faunce, D. E., Taniguchi, M., Exley, M., Balk, S., Stein-Streilein, J. (2001). NK T Cell-Derived IL-10 Is Essential for the Differentiation of Antigen-Specific T Regulatory Cells in Systemic Tolerance. J. Immunol. 166: 42-50 [Abstract] [Full Text]  
• Smith, A. L., Hayday, A. C. (2000). Genetic Dissection of Primary and Secondary Responses to a Widespread Natural Pathogen of the Gut, Eimeria vermiformis. Infect. Immun. 68: 6273-6280 [Abstract] [Full Text]  

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