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© The Rockefeller University Press, 0022-1007/1997/5/1705/ $5.00
The Journal of Experimental Medicine, Volume 185, Number 9, May 5, 1997 1705-1710

Brief Definitive Reports

Resistance to Leishmania major is Linked to the H2 Region on Chromosome 17 and to Chromosome 9

Lynden J. Roberts, Tracey M. Baldwin, Joan M. Curtis, Emanuela Handman, and Simon J. Foote

From the The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia

In Leishmaniasis, as in many infectious diseases, clinical manifestations are determined by the interaction between the genetics of the host and of the parasite. Here we describe studies mapping two loci controlling resistance to murine cutaneous leishmaniasis. Mice infected with L. major show marked genetic differences in disease manifestations: BALB/c mice are susceptible, exhibiting enlarging lesions that progress to systemic disease and death, whereas C57BL/6 are resistant, developing small, self-healing lesions. F2 animals from a C57BL/6 x BALB/c cross showed a continuous distribution of lesion score. Quantitative trait loci (QTL) have been mapped after a non-parametric QTL analysis on a genome-wide scan on 199 animals. QTLs identified were confirmed in a second cross of 271 animals. Linkage was confirmed to a chromosome 9 locus (D9Mit67–D9Mit71) and to a region including the H2 locus on chromosome 17. These have been named lmr2 and lmr1, respectively.

Address correspondence to Dr. Simon J. Foote, The Walter and Eliza Hall Institute of Medical Research, Victoria 3050, Australia.


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