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© The Rockefeller University Press, 0022-1007/1997/5/1541/ $5.00
The Journal of Experimental Medicine, Volume 185, Number 9, May 5, 1997 1541-1548

Articles

Role of Different T Cell Receptors in the Development of Pre–T Cells

Jan Buer*, Iannis Aifantis*, James P. DiSanto{ddagger}, Hans Joerg Fehling§, and Harald von Boehmer*

From the * Institut Necker, Institut National de la Santé et de la Recherche Médicale, 373, F-75730 Paris, Cedex 15, France; {ddagger} Hôpital Necker-Enfants Malades, Institut National de la Santé et de la Recherche Médicale, 429, F-75743 Paris, France; and § Basel Institute for Immunology, CH-4005 Basel, Switzerland

The development of pre–T cells with productive TCR-β rearrangements can be mediated by each the pre–T cell receptor (pre-TCR), the TCR-{alpha}β as well as the TCR-{gamma}{delta}, albeit by distinct mechanisms. Although the TCR-{gamma}{delta} affects CD4–8– precursor cells irrespective of their rearrangement status by TCR-β mechanisms not involving TCR-β selection, both the preTCR and the TCR-{alpha}β select only cells with productive TCR-β genes for expansion and maturation. The TCR-{alpha}β appears to be much less effective than the pre-TCR because of the paucity of TCR-{alpha} proteins in TCR-β–positive precursors since an early expressed transgenic TCR-{alpha}β can largely substitute for the pre-TCR. Thus, the TCR-{alpha}β can assume a role not only in the rescue from programmed cell death of CD4+8+ but also of CD4–8– thymocytes. In evolution this double function of the TCR-{alpha}β may have been responsible for the maturation of {alpha}β T cells before the advent of the pre–TCR-{alpha} chain.

Address correspondence to Harald von Boehmer, Institut Necker, INSERM 373, 156, rue de Vaugirad, F-75730 Paris, Cedex 15, France.

1 Abbreviations used in this paper: DP, double positive; pT{alpha}, pre-TCR-{alpha}.


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