J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/04/1371/10 $2.00
Volume 185, Number 7, April 7, 1997 1371-1380

RANTES and Monocyte Chemoattractant Protein-1 (MCP-1) Play an Important Role in the Inflammatory Phase of Crescentic Nephritis, but Only MCP-1 Is Involved in Crescent Formation and Interstitial Fibrosis

By Clare M. Lloyd,^*¶ Andrew W. Minto,^* Martin E. Dorf,^§ Amanda Proudfoot, Timothy N.C. Wells, David J. Salant,^* and Jose-Carlos Gutierrez-Ramos^¶

From the ^* Department of Medicine, Boston University Medical Center, Boston, Massachusetts 02118;  The Center for Blood Research, Incorporated and Department of Genetics and the ^§ Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115;  Glaxo Institute for Molecular Biology, Geneva, CH1228 Switzerland; and ^¶ Millennium Pharmaceuticals Inc., Cambridge Massachusets 02139

The involvement of chemokines in inflammation is well established, but their functional role in disease progression, and particularly in the development of fibrosis, is not yet understood. To investigate the functional role that the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES play in inflammation and the progression to fibrosis during crescentic nephritis we have developed and characterized a murine model for this syndrome. Significant increases in T-lymphocytes and macrophages were observed within glomeruli and interstitium, paralleled by an induction of mRNA expression of MCP-1 and RANTES, early after disease initiation. Blocking the function of MCP-1 or RANTES resulted in significant decreases in proteinuria as well as in numbers of infiltrating leukocytes, indicating that both MCP-1 and RANTES (regulated upon activation in normal T cells expressed and secreted) play an important role in the inflammatory phase of crescentic nephritis. In addition, neutralization of MCP-1 resulted in a dramatic decrease in both glomerular crescent formation and deposition of type I collagen. These results highlight a novel role for MCP-1 in crescent formation and development of interstitial fibrosis, and indicate that in addition to recruiting inflammatory cells this chemokine is critically involved in irreversible tissue damage.

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• Liu, Z.-H., Chen, S.-F., Zhou, H., Chen, H.-P., Li, L.-S. (2003). Glomerular expression of C-C chemokines in different types of human crescentic glomerulonephritis. Nephrol Dial Transplant 18: 1526-1534 [Abstract] [Full Text]  
• Liu, Z.-H., Chen, S.-F., Zhou, H., Chen, H.-P., Li, L.-S. (2003). Glomerular expression of C-C chemokines in different types of human crescentic glomerulonephritis. Nephrol Dial Transplant 18: 1526-1534 [Abstract] [Full Text]  
• Pocock, J., Gomez-Guerrero, C., Harendza, S., Ayoub, M., Hernandez-Vargas, P., Zahner, G., Stahl, R. A. K., Thaiss, F. (2003). Differential Activation of NF-{kappa}B, AP-1, and C/EBP in Endotoxin-Tolerant Rats: Mechanisms for In Vivo Regulation of Glomerular RANTES/CCL5 Expression. J. Immunol. 170: 6280-6291 [Abstract] [Full Text]  
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• Takaya, K., Koya, D., Isono, M., Sugimoto, T., Sugaya, T., Kashiwagi, A., Haneda, M. (2003). Involvement of ERK pathway in albumin-induced MCP-1 expression in mouse proximal tubular cells. Am. J. Physiol. Renal Physiol. 284: F1037-F1045 [Abstract] [Full Text]  
• Kawashima, H., Watanabe, N., Hirose, M., Sun, X., Atarashi, K., Kimura, T., Shikata, K., Matsuda, M., Ogawa, D., Heljasvaara, R., Rehn, M., Pihlajaniemi, T., Miyasaka, M. (2003). Collagen XVIII, a Basement Membrane Heparan Sulfate Proteoglycan, Interacts with L-selectin and Monocyte Chemoattractant Protein-1. J. Biol. Chem. 278: 13069-13076 [Abstract] [Full Text]  
• Chen, K., Wei, Y., Sharp, G. C., Braley-Mullen, H. (2002). Inhibition of TGF{beta}1 by Anti-TGF{beta}1 Antibody or Lisinopril Reduces Thyroid Fibrosis in Granulomatous Experimental Autoimmune Thyroiditis. J. Immunol. 169: 6530-6538 [Abstract] [Full Text]  
• Wolf, G., Jocks, T., Zahner, G., Panzer, U., Stahl, R. A. K. (2002). Existence of a regulatory loop between MCP-1 and TGF-beta in glomerular immune injury. Am. J. Physiol. Renal Physiol. 283: F1075-F1084 [Abstract] [Full Text]  
• Tanaka, T., Kuroiwa, T., Ikeuchi, H., Ota, F., Kaneko, Y., Ueki, K., Tsukada, Y., McInnes, I. B., Boumpas, D. T., Nojima, Y. (2002). Human Platelets Stimulate Mesangial Cells to Produce Monocyte Chemoattractant Protein-1 via the CD40/CD40 Ligand Pathway and May Amplify Glomerular Injury. J. Am. Soc. Nephrol. 13: 2488-2496 [Abstract] [Full Text]  
• Olson, T. S., Ley, K. (2002). Chemokines and chemokine receptors in leukocyte trafficking. Am. J. Physiol. Regul. Integr. Comp. Physiol. 283: R7-R28 [Abstract] [Full Text]  
• Huber, T. B., Reinhardt, H. C., Exner, M., Burger, J. A., Kerjaschki, D., Saleem, M. A., Pavenstadt, H. (2002). Expression of Functional CCR and CXCR Chemokine Receptors in Podocytes. J. Immunol. 168: 6244-6252 [Abstract] [Full Text]  
• Remuzzi, G., Ruggenenti, P., Perico, N. (2002). Chronic Renal Diseases: Renoprotective Benefits of Renin-Angiotensin System Inhibition. ANN INTERN MED 136: 604-615 [Abstract] [Full Text]  
• Suganami, T., Mukoyama, M., Sugawara, A., Mori, K., Nagae, T., Kasahara, M., Yahata, K., Makino, H., Fujinaga, Y., Ogawa, Y., Tanaka, I., Nakao, K. (2001). Overexpression of Brain Natriuretic Peptide in Mice Ameliorates Immune-Mediated Renal Injury. J. Am. Soc. Nephrol. 12: 2652-2663 [Abstract] [Full Text]  
• Miura, M., Fu, X., Zhang, Q.-W., Remick, D. G., Fairchild, R. L. (2001). Neutralization of Gro{alpha} and Macrophage Inflammatory Protein-2 Attenuates Renal Ischemia/Reperfusion Injury. Am. J. Pathol. 159: 2137-2145 [Abstract] [Full Text]  
• Moore, B. B., Paine, R. III, Christensen, P. J., Moore, T. A., Sitterding, S., Ngan, R., Wilke, C. A., Kuziel, W. A., Toews, G. B. (2001). Protection from Pulmonary Fibrosis in the Absence of CCR2 Signaling. J. Immunol. 167: 4368-4377 [Abstract] [Full Text]  
• Miura, M., Morita, K., Kobayashi, H., Hamilton, T. A., Burdick, M. D., Strieter, R. M., Fairchild, R. L. (2001). Monokine Induced by IFN-{gamma} Is a Dominant Factor Directing T Cells into Murine Cardiac Allografts During Acute Rejection. J. Immunol. 167: 3494-3504 [Abstract] [Full Text]  
• Fillion, I., Ouellet, N., Simard, M., Bergeron, Y., Sato, S., Bergeron, M. G. (2001). Role of Chemokines and Formyl Peptides in Pneumococcal Pneumonia-Induced Monocyte/Macrophage Recruitment. J. Immunol. 166: 7353-7361 [Abstract] [Full Text]  
• VIELHAUER, V., ANDERS, H.-J., MACK, M., CIHAK, J., STRUTZ, F., STANGASSINGER, M., LUCKOW, B., GRÖNE, H.-J., SCHLÖNDORFF, D. (2001). Obstructive Nephropathy in the Mouse: Progressive Fibrosis Correlates with Tubulointerstitial Chemokine Expression and Accumulation of CC Chemokine Receptor 2- and 5-Positive Leukocytes. J. Am. Soc. Nephrol. 12: 1173-1187 [Abstract] [Full Text]  
• ANDERS, H.-J., VIELHAUER, V., KRETZLER, M., COHEN, C. D., SEGERER, S., LUCKOW, B., WELLER, L., GRÖNE, H.-J., SCHLÖNDORFF, D. (2001). Chemokine and Chemokine Receptor Expression during Initiation and Resolution of Immune Complex Glomerulonephritis. J. Am. Soc. Nephrol. 12: 919-931 [Abstract] [Full Text]  
• Ni, W., Egashira, K., Kitamoto, S., Kataoka, C., Koyanagi, M., Inoue, S., Imaizumi, K., Akiyama, C., Nishida, K.-i., Takeshita, A. (2001). New Anti-Monocyte Chemoattractant Protein-1 Gene Therapy Attenuates Atherosclerosis in Apolipoprotein E-Knockout Mice. Circulation 103: 2096-2101 [Abstract] [Full Text]  
• Mack, M., Cihak, J., Simonis, C., Luckow, B., Proudfoot, A. E. I., Bruhl, H., Frink, M., Anders, H.-J., Vielhauer, V., Pfirstinger, J., Stangassinger, M., Schlondorff, D. (2001). Expression and Characterization of the Chemokine Receptors CCR2 and CCR5 in Mice. J. Immunol. 166: 4697-4704 [Abstract] [Full Text]  
• Blease, K., Mehrad, B., Lukacs, N. W., Kunkel, S. L., Standiford, T. J., Hogaboam, C. M. (2001). Antifungal and Airway Remodeling Roles for Murine Monocyte Chemoattractant Protein-1/CCL2 During Pulmonary Exposure to Asperigillus fumigatus Conidia. J. Immunol. 166: 1832-1842 [Abstract] [Full Text]  
• SEGERER, S., CUI, Y., HUDKINS, K. L., GOODPASTER, T., EITNER, F., MACK, M., SCHLÖNDORFF, D., ALPERS, C. E. (2000). Expression of the Chemokine Monocyte Chemoattractant Protein-1 and Its Receptor Chemokine Receptor 2 in Human Crescentic Glomerulonephritis. J. Am. Soc. Nephrol. 11: 2231-2242 [Abstract] [Full Text]  
• Kitching, A. R., Tipping, P. G., Kurimoto, M., Holdsworth, S. R. (2000). IL-18 Has IL-12-Independent Effects in Delayed-Type Hypersensitivity: Studies in Cell-Mediated Crescentic Glomerulonephritis. J. Immunol. 165: 4649-4657 [Abstract] [Full Text]  
• Schadde, E., Kretzler, M., Banas, B., Luckow, B., Assmann, K., Schlondorff, D. (2000). Expression of chemokines and their receptors in nephrotoxic serum nephritis. Nephrol Dial Transplant 15: 1046-1053 [Abstract] [Full Text]  
• Yamamoto, T., Eckes, B., Mauch, C., Hartmann, K., Krieg, T. (2000). Monocyte Chemoattractant Protein-1 Enhances Gene Expression and Synthesis of Matrix Metalloproteinase-1 in Human Fibroblasts by an Autocrine IL-1{alpha} Loop. J. Immunol. 164: 6174-6179 [Abstract] [Full Text]  
• Watarai, Y., Koga, S., Paolone, D. R., Engeman, T. M., Tannenbaum, C., Hamilton, T. A., Fairchild, R. L. (2000). Intraallograft Chemokine RNA and Protein During Rejection of MHC-Matched/Multiple Minor Histocompatibility-Disparate Skin Grafts. J. Immunol. 164: 6027-6033 [Abstract] [Full Text]  
• Engeman, T. M., Gorbachev, A. V., Gladue, R. P., Heeger, P. S., Fairchild, R. L. (2000). Inhibition of Functional T Cell Priming and Contact Hypersensitivity Responses by Treatment with Anti-Secondary Lymphoid Chemokine Antibody During Hapten Sensitization. J. Immunol. 164: 5207-5214 [Abstract] [Full Text]  
• Kuroiwa, T., Schlimgen, R., Illei, G. G., McInnes, I. B., Boumpas, D. T. (2000). Distinct T Cell/Renal Tubular Epithelial Cell Interactions Define Differential Chemokine Production: Implications for Tubulointerstitial Injury in Chronic Glomerulonephritides. J. Immunol. 164: 3323-3329 [Abstract] [Full Text]  
• Elsner, J., Mack, M., Bruhl, H., Dulkys, Y., Kimmig, D., Simmons, G., Clapham, P. R., Schlondorff, D., Kapp, A., Wells, T. N. C., Proudfoot, A. E. I. (2000). Differential Activation of CC Chemokine Receptors by AOP-RANTES. J. Biol. Chem. 275: 7787-7794 [Abstract] [Full Text]  
• Marchand, P., Resch, K., Radeke, H. H. (2000). Selective Inhibition of Monocyte Chemoattractant Protein-1 Gene Expression in Human Embryonal Kidney Cells by Specific Triple Helix-Forming Oligonucleotides. J. Immunol. 164: 2070-2076 [Abstract] [Full Text]  
• HUANG, X. R., KITCHING, A. R., TIPPING, P. G., HOLDSWORTH, S. R. (2000). Interleukin-10 Inhibits Macrophage-Induced Glomerular Injury. J. Am. Soc. Nephrol. 11: 262-269 [Abstract] [Full Text]  
• SEGERER, S., NELSON, P. J., SCHLÖNDORFF, D. (2000). Chemokines, Chemokine Receptors, and Renal Disease: From Basic ScienceTo Pathophysiologic and Therapeutic Studies. J. Am. Soc. Nephrol. 11: 152-176 [Abstract] [Full Text]  
• Tesch, G. H., Maifert, S., Schwarting, A., Rollins, B. J., Kelley, V. R. (1999). Monocyte Chemoattractant Protein 1-dependent Leukocytic Infiltrates Are Responsible for Autoimmune Disease in MRL-Faslpr Mice. JEM 190: 1813-1824 [Abstract] [Full Text]  
• Francki, A., Bradshaw, A. D., Bassuk, J. A., Howe, C. C., Couser, W. G., Sage, E. H. (1999). SPARC Regulates the Expression of Collagen Type I and Transforming Growth Factor-beta 1 in Mesangial Cells. J. Biol. Chem. 274: 32145-32152 [Abstract] [Full Text]  
• Proudfoot, A. E. I., Buser, R., Borlat, F., Alouani, S., Soler, D., Offord, R. E., Schroder, J.-M., Power, C. A., Wells, T. N. C. (1999). Amino-terminally Modified RANTES Analogues Demonstrate Differential Effects on RANTES Receptors. J. Biol. Chem. 274: 32478-32485 [Abstract] [Full Text]  
• Koga, S., Auerbach, M. B., Engeman, T. M., Novick, A. C., Toma, H., Fairchild, R. L. (1999). T Cell Infiltration into Class II MHC-Disparate Allografts and Acute Rejection Is Dependent on the IFN-{gamma}-Induced Chemokine Mig. J. Immunol. 163: 4878-4885 [Abstract] [Full Text]  
• ISHIKAWA, Y., SUGIYAMA, H., STYLIANOU, E., KITAMURA, M. (1999). Bioflavonoid Quercetin Inhibits Interleukin-1-Induced Transcriptional Expression of Monocyte Chemoattractant Protein-1 in Glomerular Cells via Suppression of Nuclear Factor-{kappa}B. J. Am. Soc. Nephrol. 10: 2290-2296 [Abstract] [Full Text]  
• BANAS, B., LUCKOW, B., MÖLLER, M., KLIER, C., NELSON, P. J., SCHADDE, E., BRIGL, M., HALEVY, D., HOLTHÖFER, H., REINHART, B., SCHLÖNDORFF, D. (1999). Chemokine and Chemokine Receptor Expression in a Novel Human Mesangial Cell Line. J. Am. Soc. Nephrol. 10: 2314-2322 [Abstract] [Full Text]  
• Luo, Y., Lloyd, C., Gutierrez-Ramos, J.-C., Dorf, M. E. (1999). Chemokine Amplification in Mesangial Cells. J. Immunol. 163: 3985-3992 [Abstract] [Full Text]  
• Kuroiwa, T., Lee, E. G., Danning, C. L., Illei, G. G., McInnes, I. B., Boumpas, D. T. (1999). CD40 Ligand-Activated Human Monocytes Amplify Glomerular Inflammatory Responses Through Soluble and Cell-to-Cell Contact-Dependent Mechanisims. J. Immunol. 163: 2168-2175 [Abstract] [Full Text]  
• Hogaboam, C. M., Bone-Larson, C. L., Lipinski, S., Lukacs, N. W., Chensue, S. W., Strieter, R. M., Kunkel, S. L. (1999). Differential Monocyte Chemoattractant Protein-1 and Chemokine Receptor 2 Expression by Murine Lung Fibroblasts Derived from Th1- and Th2-Type Pulmonary Granuloma Models. J. Immunol. 163: 2193-2201 [Abstract] [Full Text]  
• GRÖNE, H.-J., WEBER, C., WEBER, K. S. C., GRÖNE, E. F., RABELINK, T., KLIER, C. M., WELLS, T. N. C., PROUDFOOT, A. E., SCHLÖNDORFF, D., NELSON, P. J. (1999). Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment. FASEB J. 13: 1371-1383 [Abstract] [Full Text]  
• Gonzalo, J.-A., Pan, Y., Lloyd, C. M., Jia, G.-Q., Yu, G., Dussault, B., Powers, C. A., Proudfoot, A. E. I., Coyle, A. J., Gearing, D., Gutierrez-Ramos, J.-C. (1999). Mouse Monocyte-Derived Chemokine Is Involved in Airway Hyperreactivity and Lung Inflammation. J. Immunol. 163: 403-411 [Abstract] [Full Text]  
• WANG, Y., RANGAN, G. K., TAY, Y.-C., WANG, Y., HARRIS, D. C. H. (1999). Induction of Monocyte Chemoattractant Protein-1 by Albumin Is Mediated by Nuclear Factor {kappa}B in Proximal Tubule Cells. J. Am. Soc. Nephrol. 10: 1204-1213 [Abstract] [Full Text]  
• Rodriguez-Frade, J. M., Vila-Coro, A. J., Martin de Ana, A., Albar, J. P., Martinez-A., C., Mellado, M. (1999). The chemokine monocyte chemoattractant protein-1 induces functional responses through dimerization of its receptor CCR2. Proc. Natl. Acad. Sci. USA 96: 3628-3633 [Abstract] [Full Text]  
• Yu, X. Q., Fan, J.-M., Nikolic-Paterson, D. J., Yang, N., Mu, W., Pichler, R., Johnson, R. J., Atkins, R. C., Lan, H. Y. (1999). IL-1 Up-Regulates Osteopontin Expression in Experimental Crescentic Glomerulonephritis in the Rat. Am. J. Pathol. 154: 833-841 [Abstract] [Full Text]  
• Hogaboam, C. M., Gallinat, C. S., Bone-Larson, C., Chensue, S. W., Lukacs, N. W., Strieter, R. M., Kunkel, S. L. (1998). Collagen Deposition in a Non-Fibrotic Lung Granuloma Model after Nitric Oxide Inhibition. Am. J. Pathol. 153: 1861-1872 [Abstract] [Full Text]  
• Remuzzi, G., Bertani, T. (1998). Pathophysiology of Progressive Nephropathies. NEJM 339: 1448-1456 [Full Text]  
• Kuroiwa, T, Lee, E G (1998). Cellular interactions in the pathogenesis of lupus nephritis: The role of T cells and macrophages in the amplification of the inflammatory process in the kidney. Lupus 7: 597-603 [Abstract]  
• Youssef, S., Wildbaum, G., Maor, G., Lanir, N., Gour-Lavie, A., Grabie, N., Karin, N. (1998). Long-Lasting Protective Immunity to Experimental Autoimmune Encephalomyelitis Following Vaccination with Naked DNA Encoding C-C Chemokines. J. Immunol. 161: 3870-3879 [Abstract] [Full Text]  
• Quigg, R. J., He, C., Lim, A., Berthiaume, D., Alexander, J. J., Kraus, D., Michael Holers, V. (1998). Transgenic Mice Overexpressing the Complement Inhibitor Crry as a Soluble Protein Are Protected from Antibody-induced Glomerular Injury. JEM 188: 1321-1331 [Abstract] [Full Text]  
• Maher, J. J., Lozier, J. S., Scott, M. K. (1998). Rat hepatic stellate cells produce cytokine-induced neutrophil chemoattractant in culture and in vivo. Am. J. Physiol. Gastrointest. Liver Physiol. 275: G847-G853 [Abstract] [Full Text]  
• Gonzalo, J.-A., Lloyd, C. M., Wen, D., Albar, J. P., Wells, T. N.C., Proudfoot, A., Martinez-A, C., Dorf, M., Bjerke, T., Coyle, A. J., Gutierrez-Ramos, J.-C. (1998). The Coordinated Action of CC Chemokines in the Lung Orchestrates Allergic Inflammation and Airway Hyperresponsiveness. JEM 188: 157-167 [Abstract] [Full Text]  
• Chen, S., Bacon, K. B., Li, L., Garcia, G. E., Xia, Y., Lo, D., Thompson, D. A., Siani, M. A., Yamamoto, T., Harrison, J. K., Feng, L. (1998). In Vivo Inhibition of CC and CX3C Chemokine-induced Leukocyte Infiltration and Attenuation of Glomerulonephritis in Wistar-Kyoto (WKY) Rats by vMIP-II. JEM 188: 193-198 [Abstract] [Full Text]  
• Quigg, R. J., Kozono, Y., Berthiaume, D., Lim, A., Salant, D. J., Weinfeld, A., Griffin, P., Kremmer, E., Holers, V. M. (1998). Blockade of Antibody-Induced Glomerulonephritis with Crry-Ig, a Soluble Murine Complement Inhibitor. J. Immunol. 160: 4553-4560 [Abstract] [Full Text]  
• Kalled, S. L., Cutler, A. H., Datta, S. K., Thomas, D. W. (1998). Anti-CD40 Ligand Antibody Treatment of SNF1 Mice with Established Nephritis: Preservation of Kidney Function. J. Immunol. 160: 2158-2165 [Abstract] [Full Text]  
• Shioi, T., Matsumori, A., Kihara, Y., Inoko, M., Ono, K., Iwanaga, Y., Yamada, T., Iwasaki, A., Matsushima, K., Sasayama, S. (1997). Increased Expression of Interleukin-1ß and Monocyte Chemotactic and Activating Factor/Monocyte Chemoattractant Protein-1 in the Hypertrophied and Failing Heart With Pressure Overload. Circ. Res. 81: 664-671 [Abstract] [Full Text]  

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