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Lars Rogge^*, Luisella Barberis-Maino^*, Mauro Biffi^*, Nadia Passini^*, David H. Presky, Ueli Gubler, and Francesco Sinigaglia^*

From ^* Roche Milano Ricerche, I-20132 Milan, Italy; and Department of Inflammation/ Autoimmune Diseases, Hoffmann-La Roche Inc., Nutley, New Jersey 07110

Interleukin-12 (IL-12), a heterodimeric cytokine produced by activated monocytes and dendritic cells, plays a crucial role in regulating interferon (IFN)- production and in the generation of IFN––producing T helper 1 (Th1) cells. Here we show that the IL-12 receptor (IL12R) β2 subunit, a recently cloned binding and signal transducing component of the IL-12R, is expressed on human Th1 but not Th2 clones and is induced during differentiation of human naive cells along the Th1 but not the Th2 pathway. IL-12 and type I but not type II interferons induce expression of the IL-12R β2 chain during in vitro T cell differentiation after antigen receptor triggering. The selective expression and regulation of the IL-12R β2 subunit may help to understand the basis of Th1/Th2 differentiation and may provide therapeutic options for altering the Th1/Th2 balance in several immuno-pathological conditions such as autoimmune diseases and allergies.

¹Abbreviations used in this paper: IL-12R, IL-12 receptor; Stat, signal transducers and activators of transcription.

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