Home | Help | Feedback | Subscriptions | Archive | Search | Table of Contents

This Article Full Text Full Text (PDF, 203K) PPT slides of all figures Alert me when this article is cited Citation Map Services Email this article Similar articles in this journal Similar articles in PubMed Alert me to new content in the JEM Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via CrossRef Citing Articles via Google Scholar Google Scholar Articles by Sutterwala, F. S. Articles by Mosser, D. M. Search for Related Content PubMed PubMed Citation Articles by Sutterwala, F. S. Articles by Mosser, D. M. Pubmed/NCBI databases Compound via MeSH Substance via MeSH Hazardous Substances DB CALCIUM COMPOUNDS CALCIUM, ELEMENTAL Social Bookmarking                            What's this?

Articles

Fayyaz S. Sutterwala^*, Gary J. Noel, Raphael Clynes, and David M. Mosser^*

From the ^* Department of Microbiology and Immunology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140; the Department of Pediatrics, Cornell University Medical College, New York,10021; and the Laboratory of Molecular Genetics and Immunology, Rockefeller University, New York, 10021

Interleukin (IL)-12 is a monocyte- and macrophage-derived cytokine that plays a crucial role in both the innate and the acquired immune response. In this study, we examined the effects that ligating specific macrophage receptors had on the induction of IL-12 by lipopolysaccharide (LPS). We report that ligation of the macrophage Fc, complement, or scavenger receptors inhibited the induction of IL-12 by LPS. Both mRNA synthesis and protein secretion were diminished to near-undetectable levels following receptor ligation. Suppression was specific to IL-12 since IL-10 and tumor necrosis factor- (TNF-) production were not inhibited by ligating macrophage receptors. The results of several different experimental approaches suggest that IL-12 downregulation was due to extracellular calcium influxes that resulted from receptor ligation. First, preventing extracellular calcium influxes, by performing the assays in EGTA, abrogated FcR-mediated IL-12(p40) mRNA suppression. Second, exposure of macrophages to the calcium ionophores, ionomycin or A23187, mimicked receptor ligation and inhibited IL-12(p40) mRNA induction by LPS. Finally, bone marrow–derived macrophages from FcR chain–deficient mice, which fail to flux calcium after receptor ligation, failed to inhibit IL-12(p40) mRNA induction. These results indicate that the calcium influxes that occur as a result of receptor ligation are responsible for inhibiting the induction of IL-12 by LPS. Hence, the ligation of phagocytic receptors on macrophages can lead to a dramatic decrease in IL-12 induction. This downregulation may be a way of limiting proinflammatory responses of macrophages to extracellular pathogens, or suppressing the development of cell-mediated immunity to intracellular pathogens.

F.S. Sutterwala was supported by the MD/PhD program at the Temple University School of Medicine. This work was supported by National Institutes of Health grant AI24313 (D.M. Mosser).

¹Abbreviations used in this paper: BMM, bone marrow–derived macrophages; E-C3bi, complement-opsonized erythrocytes; E-IgG, IgG-opsonized erythrocytes; E-ML-BSA, maleylated-BSA–coated erythrocytes; HI, heatinactivated; HPRT, hypoxanthine-guanine phosphoribosyltransferase; mBSA, maleylated-BSA.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Carter, C. R., Whitcomb, J. P., Campbell, J. A., Mukbel, R. M., McDowell, M. A. (2009). Complement Receptor 3 Deficiency Influences Lesion Progression during Leishmania major Infection in BALB/c Mice. Infect. Immun. 77: 5668-5675 [Abstract] [Full Text]  
• Jin, J.-O, Park, H.-Y., Xu, Q., Park, J.-I., Zvyagintseva, T., Stonik, V. A., Kwak, J.-Y. (2009). Ligand of scavenger receptor class A indirectly induces maturation of human blood dendritic cells via production of tumor necrosis factor-{alpha}. Blood 113: 5839-5847 [Abstract] [Full Text]  
• Shirey, K. A., Cole, L. E., Keegan, A. D., Vogel, S. N. (2008). Francisella tularensis Live Vaccine Strain Induces Macrophage Alternative Activation as a Survival Mechanism. J. Immunol. 181: 4159-4167 [Abstract] [Full Text]  
• Dower, K., Ellis, D. K., Saraf, K., Jelinsky, S. A., Lin, L.-L. (2008). Innate Immune Responses to TREM-1 Activation: Overlap, Divergence, and Positive and Negative Cross-Talk with Bacterial Lipopolysaccharide. J. Immunol. 180: 3520-3534 [Abstract] [Full Text]  
• Miyazaki, Y., Bunting, M., Stafforini, D. M., Harris, E. S., McIntyre, T. M., Prescott, S. M., Frutuoso, V. S., Amendoeira, F. C., de Oliveira Nascimento, D., Vieira-de-Abreu, A., Weyrich, A. S., Castro-Faria-Neto, H. C., Zimmerman, G. A. (2008). Integrin {alpha}D 2 Is Dynamically Expressed by Inflamed Macrophages and Alters the Natural History of Lethal Systemic Infections. J. Immunol. 180: 590-600 [Abstract] [Full Text]  
• Polumuri, S. K., Toshchakov, V. Y., Vogel, S. N. (2007). Role of Phosphatidylinositol-3 Kinase in Transcriptional Regulation of TLR-Induced IL-12 and IL-10 by Fc{gamma} Receptor Ligation in Murine Macrophages. J. Immunol. 179: 236-246 [Abstract] [Full Text]  
• Ma, W., Mishra, S., Gee, K., Mishra, J. P., Nandan, D., Reiner, N. E., Angel, J. B., Kumar, A. (2007). Cyclosporin A and FK506 Inhibit IL-12p40 Production through the Calmodulin/Calmodulin-dependent Protein Kinase-activated Phosphoinositide 3-Kinase in Lipopolysaccharide-stimulated Human Monocytic Cells. J. Biol. Chem. 282: 13351-13362 [Abstract] [Full Text]  
• Akilov, O. E., Kasuboski, R. E., Carter, C. R., McDowell, M. A. (2007). The role of mannose receptor during experimental leishmaniasis. J. Leukoc. Biol. 81: 1188-1196 [Abstract] [Full Text]  
• Conrad, S. M., Strauss-Ayali, D., Field, A. E., Mack, M., Mosser, D. M. (2007). Leishmania-Derived Murine Monocyte Chemoattractant Protein 1 Enhances the Recruitment of a Restrictive Population of CC Chemokine Receptor 2-Positive Macrophages. Infect. Immun. 75: 653-665 [Abstract] [Full Text]  
• Leon, F., Contractor, N., Fuss, I., Marth, T., Lahey, E., Iwaki, S., la Sala, A., Hoffmann, V., Strober, W., Kelsall, B. L. (2006). Antibodies to Complement Receptor 3 Treat Established Inflammation in Murine Models of Colitis and a Novel Model of Psoriasiform Dermatitis. J. Immunol. 177: 6974-6982 [Abstract] [Full Text]  
• Sutterwala, F. S., Ogura, Y., Zamboni, D. S., Roy, C. R., Flavell, R. A. (2006). NALP3: a key player in caspase-1 activation. Innate Immunity 12: 251-256 [Abstract]  
• Fraser, D. A., Bohlson, S. S., Jasinskiene, N., Rawal, N., Palmarini, G., Ruiz, S., Rochford, R., Tenner, A. J. (2006). C1q and MBL, components of the innate immune system, influence monocyte cytokine expression. J. Leukoc. Biol. 80: 107-116 [Abstract] [Full Text]  
• Fronhofer, V., Lennartz, M. R., Loegering, D. J. (2006). Role of PKC isoforms in the Fc{gamma}R-mediated inhibition of LPS-stimulated IL-12 secretion by macrophages. J. Leukoc. Biol. 79: 408-415 [Abstract] [Full Text]  
• Hamerman, J. A., Lanier, L. L. (2006). Inhibition of Immune Responses by ITAM-Bearing Receptors. Sci Signal 2006: re1-re1 [Abstract] [Full Text]  
• Mishra, S., Mishra, J. P., Gee, K., McManus, D. C., LaCasse, E. C., Kumar, A. (2005). Distinct Role of Calmodulin and Calmodulin-dependent Protein Kinase-II in Lipopolysaccharide and Tumor Necrosis Factor-{alpha}-mediated Suppression of Apoptosis and Antiapoptotic c-IAP2 Gene Expression in Human Monocytic Cells. J. Biol. Chem. 280: 37536-37546 [Abstract] [Full Text]  
• la Sala, A., Gadina, M., Kelsall, B. L. (2005). Gi-Protein-Dependent Inhibition of IL-12 Production Is Mediated by Activation of the Phosphatidylinositol 3-Kinase-Protein 3 Kinase B/Akt Pathway and JNK. J. Immunol. 175: 2994-2999 [Abstract] [Full Text]  
• Lucas, M., Zhang, X., Prasanna, V., Mosser, D. M. (2005). ERK Activation Following Macrophage Fc{gamma}R Ligation Leads to Chromatin Modifications at the IL-10 Locus. J. Immunol. 175: 469-477 [Abstract] [Full Text]  
• Olivier, M., Gregory, D. J., Forget, G. (2005). Subversion Mechanisms by Which Leishmania Parasites Can Escape the Host Immune Response: a Signaling Point of View. Clin. Microbiol. Rev. 18: 293-305 [Abstract] [Full Text]  
• Miles, S. A., Conrad, S. M., Alves, R. G., Jeronimo, S. M.B., Mosser, D. M. (2005). A role for IgG immune complexes during infection with the intracellular pathogen Leishmania. JEM 201: 747-754 [Abstract] [Full Text]  
• Smith, A. P., Paolucci, C., Di Lullo, G., Burastero, S. E., Santoro, F., Lusso, P. (2005). Viral Replication-Independent Blockade of Dendritic Cell Maturation and Interleukin-12 Production by Human Herpesvirus 6. J. Virol. 79: 2807-2813 [Abstract] [Full Text]  
• Scotton, C. J., Martinez, F. O., Smelt, M. J., Sironi, M., Locati, M., Mantovani, A., Sozzani, S. (2005). Transcriptional Profiling Reveals Complex Regulation of the Monocyte IL-1{beta} System by IL-13. J. Immunol. 174: 834-845 [Abstract] [Full Text]  
• Akamine, M., Higa, F., Arakaki, N., Kawakami, K., Takeda, K., Akira, S., Saito, A. (2005). Differential Roles of Toll-Like Receptors 2 and 4 in In Vitro Responses of Macrophages to Legionella pneumophila. Infect. Immun. 73: 352-361 [Abstract] [Full Text]  
• Kane, C. M., Cervi, L., Sun, J., McKee, A. S., Masek, K. S., Shapira, S., Hunter, C. A., Pearce, E. J. (2004). Helminth Antigens Modulate TLR-Initiated Dendritic Cell Activation. J. Immunol. 173: 7454-7461 [Abstract] [Full Text]  
• Raue, H.-P., Brien, J. D., Hammarlund, E., Slifka, M. K. (2004). Activation of Virus-Specific CD8+ T Cells by Lipopolysaccharide-Induced IL-12 and IL-18. J. Immunol. 173: 6873-6881 [Abstract] [Full Text]  
• Qin, H., Edberg, J. C., Gibson, A. W., Page, G. P., Teng, L., Kimberly, R. P. (2004). Differential Gene Expression Modulated by the Cytoplasmic Domain of Fc{gamma}RIa (CD64) {alpha}-Chain. J. Immunol. 173: 6211-6219 [Abstract] [Full Text]  
• Casadevall, A., Pirofski, L.-a. (2004). New Concepts in Antibody-Mediated Immunity. Infect. Immun. 72: 6191-6196 [Full Text]  
• Jozefowski, S., Kobzik, L. (2004). Scavenger receptor A mediates H2O2 production and suppression of IL-12 release in murine macrophages. J. Leukoc. Biol. 76: 1066-1074 [Abstract] [Full Text]  
• Xiong, H., Li, H., Chen, Y., Zhao, J., Unkeless, J. C. (2004). Interaction of TRAF6 with MAST205 Regulates NF-{kappa}B Activation and MAST205 Stability. J. Biol. Chem. 279: 43675-43683 [Abstract] [Full Text]  
• Darrah, P. A., Monaco, M. C. G., Jain, S., Hondalus, M. K., Golenbock, D. T., Mosser, D. M. (2004). Innate Immune Responses to Rhodococcus equi. J. Immunol. 173: 1914-1924 [Abstract] [Full Text]  
• Anderson, C. F., Lucas, M., Gutierrez-Kobeh, L., Field, A. E., Mosser, D. M. (2004). T Cell Biasing by Activated Dendritic Cells. J. Immunol. 173: 955-961 [Abstract] [Full Text]  
• Sulahian, T. H., Pioli, P. A., Wardwell, K., Guyre, P. M. (2004). Cross-linking of Fc{gamma}R triggers shedding of the hemoglobin-haptoglobin scavenger receptor CD163. J. Leukoc. Biol. 76: 271-277 [Abstract] [Full Text]  
• Ip, W.-K., Lau, Y.-L. (2004). Distinct Maturation of, but Not Migration between, Human Monocyte-Derived Dendritic Cells upon Ingestion of Apoptotic Cells of Early or Late Phases. J. Immunol. 173: 189-196 [Abstract] [Full Text]  
• Boule, M. W., Broughton, C., Mackay, F., Akira, S., Marshak-Rothstein, A., Rifkin, I. R. (2004). Toll-like Receptor 9-Dependent and -Independent Dendritic Cell Activation by Chromatin-Immunoglobulin G Complexes. JEM 199: 1631-1640 [Abstract] [Full Text]  
• Bodman-Smith, K. B., Gregory, R. E., Harrison, P. T., Raynes, J. G. (2004). Fc{gamma}RIIa expression with Fc{gamma}RI results in C-reactive protein- and IgG-mediated phagocytosis. J. Leukoc. Biol. 75: 1029-1035 [Abstract] [Full Text]  
• Zhou, H., Xiong, H., Li, H., Plevy, S. E., Walden, P. D., Sassaroli, M., Prestwich, G. D., Unkeless, J. C. (2004). Microtubule-Associated Serine/Threonine Kinase-205 kDa and Fc{gamma} Receptor Control IL-12 p40 Synthesis and NF-{kappa}B Activation. J. Immunol. 172: 2559-2568 [Abstract] [Full Text]  
• Morrison, A. C., Wilson, C. B., Ray, M., Correll, P. H. (2004). Macrophage-Stimulating Protein, the Ligand for the Stem Cell-Derived Tyrosine Kinase/RON Receptor Tyrosine Kinase, Inhibits IL-12 Production by Primary Peritoneal Macrophages Stimulated with IFN-{gamma} and Lipopolysaccharide. J. Immunol. 172: 1825-1832 [Abstract] [Full Text]  
• Zhu, C., Rao, K., Xiong, H., Gagnidze, K., Li, F., Horvath, C., Plevy, S. (2003). Activation of the Murine Interleukin-12 p40 Promoter by Functional Interactions between NFAT and ICSBP. J. Biol. Chem. 278: 39372-39382 [Abstract] [Full Text]  
• La Flamme, A. C., Ruddenklau, K., Backstrom, B. T. (2003). Schistosomiasis Decreases Central Nervous System Inflammation and Alters the Progression of Experimental Autoimmune Encephalomyelitis. Infect. Immun. 71: 4996-5004 [Abstract] [Full Text]  
• Gantner, B. N., Simmons, R. M., Canavera, S. J., Akira, S., Underhill, D. M. (2003). Collaborative Induction of Inflammatory Responses by Dectin-1 and Toll-like Receptor 2. JEM 197: 1107-1117 [Abstract] [Full Text]  
• Mosser, D. M. (2003). The many faces of macrophage activation. J. Leukoc. Biol. 73: 209-212 [Full Text]  
• Morelli, A. E., Larregina, A. T., Shufesky, W. J., Zahorchak, A. F., Logar, A. J., Papworth, G. D., Wang, Z., Watkins, S. C., Falo, L. D. Jr, Thomson, A. W. (2003). Internalization of circulating apoptotic cells by splenic marginal zone dendritic cells: dependence on complement receptors and effect on cytokine production. Blood 101: 611-620 [Abstract] [Full Text]  
• Anderson, C. F., Gerber, J. S., Mosser, D. M. (2002). Modulating macrophage function with IgG immune complexes. Innate Immunity 8: 477-481 [Abstract]  
• Drechsler, Y., Chavan, S., Catalano, D., Mandrekar, P., Szabo, G. (2002). Fc{gamma}R cross-linking mediates NF-{kappa}B activation, reduced antigen presentation capacity, and decreased IL-12 production in monocytes without modulation of myeloid dendritic cell development. J. Leukoc. Biol. 72: 657-667 [Abstract] [Full Text]  
• Butcher, B. A., Denkers, E. Y. (2002). Mechanism of Entry Determines the Ability of Toxoplasma gondii To Inhibit Macrophage Proinflammatory Cytokine Production. Infect. Immun. 70: 5216-5224 [Abstract] [Full Text]  
• Morehead, J., Coppens, I., Andrews, N. W. (2002). Opsonization Modulates Rac-1 Activation during Cell Entry by Leishmania amazonensis. Infect. Immun. 70: 4571-4580 [Abstract] [Full Text]  
• Purswani, M. U., Eckert, S. J., Arora, H. K., Noel, G. J. (2002). Effect of ciprofloxacin on lethal and sublethal challenge with endotoxin and on early cytokine responses in a murine in vivo model. J Antimicrob Chemother 50: 51-58 [Abstract] [Full Text]  
• Anderson, C. F., Mosser, D. M. (2002). A novel phenotype for an activated macrophage: the type 2 activated macrophage. J. Leukoc. Biol. 72: 101-106 [Abstract] [Full Text]  
• Indrigo, J., Hunter, R. L. Jr, Actor, J. K. (2002). Influence of trehalose 6,6'-dimycolate (TDM) during mycobacterial infection of bone marrow macrophages. Microbiology 148: 1991-1998 [Abstract] [Full Text]  
• Kanoh, M., Uetani, T., Sakan, H., Maruyama, S., Liu, F., Sumita, K., Asano, Y. (2002). A two-step model of T cell subset commitment: antigen-independent commitment of T cells before encountering nominal antigen during pathogenic infections. Int Immunol 14: 567-575 [Abstract] [Full Text]  
• Anderson, C. F., Mosser, D. M. (2002). Cutting Edge: Biasing Immune Responses by Directing Antigen to Macrophage Fc{gamma} Receptors. J. Immunol. 168: 3697-3701 [Abstract] [Full Text]  
• Wittmann, M., Kienlin, P., Mommert, S., Kapp, A., Werfel, T. (2002). Suppression of IL-12 Production by Soluble CD40 Ligand: Evidence for Involvement of the p44/42 Mitogen-Activated Protein Kinase Pathway. J. Immunol. 168: 3793-3800 [Abstract] [Full Text]  
• Stuart, L. M., Lucas, M., Simpson, C., Lamb, J., Savill, J., Lacy-Hulbert, A. (2002). Inhibitory Effects of Apoptotic Cell Ingestion upon Endotoxin-Driven Myeloid Dendritic Cell Maturation. J. Immunol. 168: 1627-1635 [Abstract] [Full Text]  
• Faries, M. B., Bedrosian, I., Xu, S., Koski, G., Roros, J. G., Moise, M. A., Nguyen, H. Q., Engels, F. H. C., Cohen, P. A., Czerniecki, B. J. (2001). Calcium signaling inhibits interleukin-12 production and activates CD83+ dendritic cells that induce Th2 cell development. Blood 98: 2489-2497 [Abstract] [Full Text]  
• Latour, S., Tanaka, H., Demeure, C., Mateo, V., Rubio, M., Brown, E. J., Maliszewski, C., Lindberg, F. P., Oldenborg, A., Ullrich, A., Delespesse, G., Sarfati, M. (2001). Bidirectional Negative Regulation of Human T and Dendritic Cells by CD47 and Its Cognate Receptor Signal-Regulator Protein-{alpha}: Down-Regulation of IL-12 Responsiveness and Inhibition of Dendritic Cell Activation. J. Immunol. 167: 2547-2554 [Abstract] [Full Text]  
• Das, G., Sheridan, S., Janeway, C. A. Jr. (2001). The Source of Early IFN-{gamma} That Plays a Role in Th1 Priming. J. Immunol. 167: 2004-2010 [Abstract] [Full Text]  
• Xu, X., Sumita, K., Feng, C., Xiong, X., Shen, H., Maruyama, S., Kanoh, M., Asano, Y. (2001). Down-Regulation of IL-12 p40 Gene in Plasmodium berghei-Infected Mice. J. Immunol. 167: 235-241 [Abstract] [Full Text]  
• Gerber, J. S., Mosser, D. M. (2001). Reversing Lipopolysaccharide Toxicity by Ligating the Macrophage Fc{{gamma}} Receptors. J. Immunol. 166: 6861-6868 [Abstract] [Full Text]  
• Chen, G., Darrah, P. A., Mosser, D. M. (2001). Vaccination against the Intracellular Pathogens Leishmania major and L. amazonensis by Directing CD40 Ligand to Macrophages. Infect. Immun. 69: 3255-3263 [Abstract] [Full Text]  
• Refici, M. L., Metzger, D. W., Arulanandam, B. P., Lennartz, M. R., Loegering, D. J. (2001). Fc{gamma}-receptor signaling augments the LPS-stimulated increase in serum tumor necrosis factor-{alpha} levels. Am. J. Physiol. Regul. Integr. Comp. Physiol. 280: R1037-R1044 [Abstract] [Full Text]  
• Grazia Cappiello, M., Sutterwala, F. S., Trinchieri, G., Mosser, D. M., Ma, X. (2001). Suppression of IL-12 Transcription in Macrophages Following Fc{{gamma}} Receptor Ligation. J. Immunol. 166: 4498-4506 [Abstract] [Full Text]  
• Calida, D. M., Constantinescu, C., Purev, E., Zhang, G.-X., Ventura, E. S., Lavi, E., Rostami, A. (2001). Cutting Edge: C3, a Key Component of Complement Activation, Is Not Required for the Development of Myelin Oligodendrocyte Glycoprotein Peptide-Induced Experimental Autoimmune Encephalomyelitis in Mice. J. Immunol. 166: 723-726 [Abstract] [Full Text]  
• Kane, M. M., Mosser, D. M. (2001). The Role of IL-10 in Promoting Disease Progression in Leishmaniasis. J. Immunol. 166: 1141-1147 [Abstract] [Full Text]  
• Lee, S. W., Song, M. K., Baek, K. H., Park, Y., Kim, J. K., Lee, C. H., Cheong, H.-K., Cheong, C., Sung, Y. C. (2000). Effects of a Hexameric Deoxyriboguanosine Run Conjugation into CpG Oligodeoxynucleotides on Their Immunostimulatory Potentials. J. Immunol. 165: 3631-3639 [Abstract] [Full Text]  
• Ma, X., Montaner, L. J. (2000). Proinflammatory response and IL-12 expression in HIV-1 infection. J. Leukoc. Biol. 68: 383-390 [Abstract] [Full Text]  
• Hu, C., Mayadas-Norton, T., Tanaka, K., Chan, J., Salgame, P. (2000). Mycobacterium tuberculosis Infection in Complement Receptor 3-Deficient Mice. J. Immunol. 165: 2596-2602 [Abstract] [Full Text]  
• Darrah, P. A., Hondalus, M. K., Chen, Q., Ischiropoulos, H., Mosser, D. M. (2000). Cooperation between Reactive Oxygen and Nitrogen Intermediates in Killing of Rhodococcus equi by Activated Macrophages. Infect. Immun. 68: 3587-3593 [Abstract] [Full Text]  
• Braun, M. C., Lahey, E., Kelsall, B. L. (2000). Selective Suppression of IL-12 Production by Chemoattractants. J. Immunol. 164: 3009-3017 [Abstract] [Full Text]  
• Ma, X., Sun, J., Papasavvas, E., Riemann, H., Robertson, S., Marshall, J., Bailer, R. T., Moore, A., Donnelly, R. P., Trinchieri, G., Montaner, L. J. (2000). Inhibition of IL-12 Production in Human Monocyte-Derived Macrophages by TNF. J. Immunol. 164: 1722-1729 [Abstract] [Full Text]  
• Demeure, C. E., Tanaka, H., Mateo, V., Rubio, M., Delespesse, G., Sarfati, M. (2000). CD47 Engagement Inhibits Cytokine Production and Maturation of Human Dendritic Cells. J. Immunol. 164: 2193-2199 [Abstract] [Full Text]  
• Shibata, Y., Foster, L. A., Bradfield, J. F., Myrvik, Q. N. (2000). Oral Administration of Chitin Down-Regulates Serum IgE Levels and Lung Eosinophilia in the Allergic Mouse. J. Immunol. 164: 1314-1321 [Abstract] [Full Text]  
• Singer, S. M., Nash, T. E. (2000). T-Cell-Dependent Control of Acute Giardia lamblia Infections in Mice. Infect. Immun. 68: 170-175 [Abstract] [Full Text]  
• Huang, L.-Y., Krieg, A. M., Eller, N., Scott, D. E. (1999). Induction and Regulation of Th1-Inducing Cytokines by Bacterial DNA, Lipopolysaccharide, and Heat-Inactivated Bacteria. Infect. Immun. 67: 6257-6263 [Abstract] [Full Text]  
• Armant, M., Avice, M.-N., Hermann, P., Rubio, M., Kiniwa, M., Delespesse, G., Sarfati, M. (1999). Cd47 Ligation Selectively Downregulates Human Interleukin 12 Production. JEM 190: 1175-1182 [Abstract] [Full Text]  
• Wittmann, M., Larsson, V.-A., Schmidt, P., Begemann, G., Kapp, A., Werfel, T. (1999). Suppression of Interleukin-12 Production by Human Monocytes After Preincubation With Lipopolysaccharide. Blood 94: 1717-1726 [Abstract] [Full Text]  
• Segel, L. A., Bar-Or, R. L. (1999). On the Role of Feedback in Promoting Conflicting Goals of the Adaptive Immune System. J. Immunol. 163: 1342-1349 [Abstract] [Full Text]  
• Bhat, N., Perera, P.-Y., Carboni, J. M., Blanco, J., Golenbock, D. T., Mayadas, T. N., Vogel, S. N. (1999). Use of a Photoactivatable Taxol Analogue to Identify Unique Cellular Targets in Murine Macrophages: Identification of Murine CD18 as a Major Taxol-Binding Protein and a Role for Mac-1 in Taxol-Induced Gene Expression. J. Immunol. 162: 7335-7342 [Abstract] [Full Text]  
• Wittmann, M., Zwirner, J., Larsson, V.-A., Kirchhoff, K., Begemann, G., Kapp, A., Gotze, O., Werfel, T. (1999). C5a Suppresses the Production of IL-12 by IFN-{gamma}-Primed and Lipopolysaccharide-Challenged Human Monocytes. J. Immunol. 162: 6763-6769 [Abstract] [Full Text]  
• Conboy, I. M., Manoli, D., Mhaiskar, V., Jones, P. P. (1999). Calcineurin and vacuolar-type H+-ATPase modulate macrophage effector functions. Proc. Natl. Acad. Sci. USA 96: 6324-6329 [Abstract] [Full Text]  
• Braun, M. C., He, J., Wu, C.-Y., Kelsall, B. L. (1999). Cholera Toxin Suppresses Interleukin (IL)-12 Production and IL-12 Receptor {beta}1 and {beta}2 Chain Expression. JEM 189: 541-552 [Abstract] [Full Text]  
• Mevorach, D., Mascarenhas, J. O., Gershov, D., Elkon, K. B. (1998). Complement-dependent Clearance of Apoptotic Cells by Human Macrophages. JEM 188: 2313-2320 [Abstract] [Full Text]  
• Yoshida, Y., Kang, K., Berger, M., Chen, G., Gilliam, A. C., Moser, A., Wu, L., Hammerberg, C., Cooper, K. D. (1998). Monocyte Induction of IL-10 and Down-Regulation of IL-12 by iC3b Deposited in Ultraviolet-Exposed Human Skin. J. Immunol. 161: 5873-5879 [Abstract] [Full Text]  
• Hensler, T., Heidecke, C.-D., Hecker, H., Heeg, K., Bartels, H., Zantl, N., Wagner, H., Siewert, J.-R., Holzmann, B. (1998). Increased Susceptibility to Postoperative Sepsis in Patients with Impaired Monocyte IL-12 Production. J. Immunol. 161: 2655-2659 [Abstract] [Full Text]  
• Sutterwala, F. S., Noel, G. J., Salgame, P., Mosser, D. M. (1998). Reversal of Proinflammatory Responses by Ligating the Macrophage Fc{gamma} Receptor Type I. JEM 188: 217-222 [Abstract] [Full Text]  
• Singh, N., Bhatia, S., Abraham, R., Basu, S. K., George, A., Bal, V., Rath, S. (1998). Modulation of T Cell Cytokine Profiles and Peptide-MHC Complex Availability In Vivo by Delivery to Scavenger Receptors via Antigen Maleylation. J. Immunol. 160: 4869-4880 [Abstract] [Full Text]  
• Hammerberg, C., Katiyar, S. K., Carroll, M. C., Cooper, K. D. (1998). Activated Complement Component 3 (C3) Is Required for Ultraviolet Induction of Immunosuppression and Antigenic Tolerance. JEM 187: 1133-1138 [Abstract] [Full Text]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS