J. Exp. Med.
© The Rockefeller University Press
0022-1007/97/06/1897/11 $2.00
Volume 185, Number 11, June 2, 1997 1897-1907

Perturbation of the T Lymphocyte Lineage In Transgenic Mice Expressing a Constitutive Repressor of Nuclear Factor (NF)-B

By Mark R. Boothby,^* Ana L. Mora,^* David C. Scherer,^*§ Jeffrey A. Brockman,^*§ and Dean W. Ballard^*§

From the ^* Department of Microbiology and Immunology;  Rheumatology Division, Department of Medicine; and the ^§ Howard Hughes Medical Institute, Vanderbilt University Medical Center, Nashville, Tennessee 37232

Members of the nuclear factor (NF)-B/Rel family transcription factors are induced during thymic selection and in mature T lymphocytes after ligation of the T cell antigen receptor (TCR). Despite these findings, disruption of individual NF-B/Rel genes has revealed no intrinsic defect in the development of mature T cells, perhaps reflecting functional redundancy. To circumvent this possibility, the T cell lineage was targeted to express a trans-dominant form of IB that constitutively represses the activity of multiple NF-B/Rel proteins. Transgenic cells expressing this inhibitor exhibit a significant proliferative defect, which is not reversed by the addition of exogenous interleukin-2. Moreover, mitogenic stimulation of splenocytes leads to increased apoptosis of transgenic T cells as compared with controls. In addition to deregulated T cell growth and survival, transgene expression impairs the development of normal T cell populations as evidenced by diminished numbers of TCR^hi CD8 single-positive thymocytes. This defect was significantly amplified in the periphery and was accompanied by a decrease in CD4⁺ T cells. Taken together, these in vivo findings indicate that the NF-B/Rel signaling pathway contains compensatory components that are essential for the establishment of normal T cell subsets.

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• Feuillard, J., Memet, S., Goudeau, B., Lilienbaum, A., Schmidt-Ullrich, R., Raphael, M., Israel, A. (2000). In vivo identification of lymphocyte subsets exhibiting transcriptionally active NF-{kappa}B/Rel complexes. Int Immunol 12: 613-621 [Abstract] [Full Text]  
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• Merritt, C., Enslen, H., Diehl, N., Conze, D., Davis, R. J., Rincón, M. (2000). Activation of p38 Mitogen-Activated Protein Kinase In Vivo Selectively Induces Apoptosis of CD8+ but Not CD4+ T Cells. Mol. Cell. Biol. 20: 936-946 [Abstract] [Full Text]  
• Memet, S., Laouini, D., Epinat, J.-C., Whiteside, S. T., Goudeau, B., Philpott, D., Kayal, S., Sansonetti, P. J., Berche, P., Kanellopoulos, J., Israel, A. (1999). I{kappa}B{epsilon}-Deficient Mice: Reduction of One T Cell Precursor Subspecies and Enhanced Ig Isotype Switching and Cytokine Synthesis. J. Immunol. 163: 5994-6005 [Abstract] [Full Text]  
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• Aronica, M. A., Mora, A. L., Mitchell, D. B., Finn, P. W., Johnson, J. E., Sheller, J. R., Boothby, M. R. (1999). Preferential Role for NF-{kappa}B/Rel Signaling in the Type 1 But Not Type 2 T Cell-Dependent Immune Response In Vivo. J. Immunol. 163: 5116-5124 [Abstract] [Full Text]  
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• Wang, C.-Y., Guttridge, D. C., Mayo, M. W., Baldwin, A. S. Jr. (1999). NF-kappa B Induces Expression of the Bcl-2 Homologue A1/Bfl-1 To Preferentially Suppress Chemotherapy-Induced Apoptosis. Mol. Cell. Biol. 19: 5923-5929 [Abstract] [Full Text]  
• Trushin, S. A., Pennington, K. N., Algeciras-Schimnich, A., Paya, C. V. (1999). Protein Kinase C and Calcineurin Synergize to Activate Ikappa B Kinase and NF-kappa B in T Lymphocytes. J. Biol. Chem. 274: 22923-22931 [Abstract] [Full Text]  
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• Mohan, C., Yu, Y., Morel, L., Yang, P., Wakeland, E. K. (1999). Genetic Dissection of Sle Pathogenesis: Sle3 on Murine Chromosome 7 Impacts T Cell Activation, Differentiation, and Cell Death. J. Immunol. 162: 6492-6502 [Abstract] [Full Text]  
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• Bakker, T. R., Renno, T., Jongeneel, C. V. (1999). Impaired Fetal Thymocyte Development After Efficient Adenovirus-Mediated Inhibition of NF-{kappa}B Activation. J. Immunol. 162: 3456-3462 [Abstract] [Full Text]  
• Devalaraja, M. N., Wang, D. Z., Ballard, D. W., Richmond, A. (1999). Elevated Constitutive I{{kappa}}B Kinase Activity and I{{kappa}}B-{{alpha}} Phosphorylation in Hs294T Melanoma Cells Lead to Increased Basal MGSA/GRO-{{alpha}} Transcription. Cancer Res. 59: 1372-1377 [Abstract] [Full Text]  
• Hettmann, T., DiDonato, J., Karin, M., Leiden, J. M. (1999). An Essential Role for Nuclear Factor kappa B in Promoting Double Positive Thymocyte Apoptosis. JEM 189: 145-158 [Abstract] [Full Text]  
• VOLL, R.E., GHOSH, S. (1999). Role of NF-{kappa}B in T-lymphocyte Development. Cold Spring Harb Symp Quant Biol 64: 485-490 [Abstract]  
• Wang, W., Wykrzykowska, J., Johnson, T., Sen, R., Sen, J. (1999). A NF-{kappa}B/c-myc-Dependent Survival Pathway Is Targeted by Corticosteroids in Immature Thymocytes. J. Immunol. 162: 314-322 [Abstract] [Full Text]  
• Maggirwar, S. B., Sarmiere, P. D., Dewhurst, S., Freeman, R. S. (1998). Nerve Growth Factor-Dependent Activation of NF-kappa B Contributes to Survival of Sympathetic Neurons. J. Neurosci. 18: 10356-10365 [Abstract] [Full Text]  
• Gabrilovich, D., Ishida, T., Oyama, T., Ran, S., Kravtsov, V., Nadaf, S., Carbone, D. P. (1998). Vascular Endothelial Growth Factor Inhibits the Development of Dendritic Cells and Dramatically Affects the Differentiation of Multiple Hematopoietic Lineages In Vivo. Blood 92: 4150-4166 [Abstract] [Full Text]  
• Youn, J., Chen, J., Goenka, S., Aronica, M. A., Mora, A. L., Correa, V., Sheller, J. R., Boothby, M. (1998). In Vivo Function of an Interleukin 2 Receptor beta  Chain (IL-2Rbeta )/IL-4Ralpha Cytokine Receptor Chimera Potentiates Allergic Airway Disease. JEM 188: 1803-1816 [Abstract] [Full Text]  
• Lee, S. Y., Kaufman, D. R., Mora, A. L., Santana, A., Boothby, M., Choi, Y. (1998). Stimulus-dependent Synergism of the Antiapoptotic Tumor Necrosis Factor Receptor-associated Factor 2 (TRAF2) and Nuclear Factor kappa B Pathways. JEM 188: 1381-1384 [Abstract] [Full Text]  
• Chu, Z.-L., DiDonato, J. A., Hawiger, J., Ballard, D. W. (1998). The Tax Oncoprotein of Human T-cell Leukemia Virus Type 1 Associates with and Persistently Activates Ikappa B Kinases Containing IKKalpha and IKKbeta. J. Biol. Chem. 273: 15891-15894 [Abstract] [Full Text]  
• Ochoa-Garay, J., Kaye, J., Coligan, J. E. (1998). Nuclear Factor {kappa}B Is Required for Peptide Antigen-Induced Differentiation of a CD4+CD8+ Thymocyte Line. J. Immunol. 160: 3835-3843 [Abstract] [Full Text]  
• Seitz, C. S., Lin, Q., Deng, H., Khavari, P. A. (1998). Alterations in NF-kappa B function in transgenic epithelial tissue demonstrate a growth inhibitory role for NF-kappa B. Proc. Natl. Acad. Sci. USA 95: 2307-2312 [Abstract] [Full Text]  
• Luque, I., Gélinas, C. (1998). Distinct Domains of Ikappa Balpha Regulate c-Rel in the Cytoplasm and in the Nucleus. Mol. Cell. Biol. 18: 1213-1224 [Abstract] [Full Text]  
• Attar, R. M., Macdonald-Bravo, H., Raventos-Suarez, C., Durham, S. K., Bravo, R. (1998). Expression of Constitutively Active Ikappa Bbeta in T Cells of Transgenic Mice: Persistent NF-kappa B Activity Is Required for T-Cell Immune Responses. Mol. Cell. Biol. 18: 477-487 [Abstract] [Full Text]  
• Franzoso, G., Carlson, L., Xing, L., Poljak, L., Shores, E. W., Brown, K. D., Leonardi, A., Tran, T., Boyce, B. F., Siebenlist, U. (1997). Requirement for NF-kappa B in osteoclast and B-cell development. Genes Dev. 11: 3482-3496 [Abstract] [Full Text]  
• Cheng, N., Chen, J. (2001). Tumor Necrosis Factor-alpha Induction of Endothelial Ephrin A1 Expression Is Mediated by a p38 MAPK- and SAPK/JNK-dependent but Nuclear Factor-kappa B-independent Mechanism. J. Biol. Chem. 276: 13771-13777 [Abstract] [Full Text]  
• Bour, S., Perrin, C., Akari, H., Strebel, K. (2001). The Human Immunodeficiency Virus Type 1 Vpu Protein Inhibits NF-kappa B Activation by Interfering with beta TrCP-mediated Degradation of Ikappa B. J. Biol. Chem. 276: 15920-15928 [Abstract] [Full Text]  
• Iwashima, M., Takamatsu, M., Yamagishi, H., Hatanaka, Y., Huang, Y.-Y., McGinty, C., Yamasaki, S., Koike, T. (2002). Genetic evidence for Shc requirement in TCR-induced c-Rel nuclear translocation and IL-2 expression. Proc. Natl. Acad. Sci. USA 99: 4544-4549 [Abstract] [Full Text]  
• Wan, Y. Y., Leon, R. P., Marks, R., Cham, C. M., Schaack, J., Gajewski, T. F., DeGregori, J. (2000). Transgenic expression of the coxsackie/adenovirus receptor enables adenoviral-mediated gene delivery in naive T cells. Proc. Natl. Acad. Sci. USA 97: 13784-13789 [Abstract] [Full Text]  

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