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From the * Department of Immunology, Research Institute, Osaka Medical Center for Maternal and
Child Health, Osaka 590-02, Japan; Since some murine cells expressing human CD4 fail to internalize HIV-1, another block was
thought to be located at the level of viral entry in addition to CD4. Recently, CXCR4 was
shown to function as a coreceptor for T cell line-tropic HIV-1 entry. Here we demonstrated
that cells expressing murine CXCR4 and human CD4 fused with cells expressing the env proteins derived from T cell line-tropic HIV-1 and were infected with T cell line-tropic HIV-1 strains. In contrast, the same cells were not infected with chimeric clones constructed by substitution of monocyte- or macrophage-tropic strain-derived env region or V3 region into T cell
line-tropic HIV-1, indicating V3 loop of envelope protein is required for murine CXCR4mediated HIV-1 entry. We conclude that murine CXCR4 is not a species specific barrier to
the entry of T cell line-tropic HIV-1.
Shionogi Institute for Medical Science, Osaka 566, Japan; § Institute for Virus Research, Kyoto University, Kyoto 606-01, Japan; Department of Molecular
Preventive Medicine, Division of Social Medicine, Graduate School of Medicine, University of Tokyo,
Tokyo 113, Japan; and ¶ Department of Medicine III, Osaka University Medical School, Osaka
565, Japan
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