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T Cells in
Lyme Arthritis
By
From the * Divisions of Immunobiology and Rheumatology, Department of Medicine, The University
of Vermont College of Medicine, Burlington, Vermont 05405-0068; The function of the minor subset of T lymphocytes bearing the Immunex Corporation, Seattle,
Washington 98101; § Institute of Biochemistry, University of Lausanne, Swiss Institute for Cancer
Research, Epalinges, Switzerland; Division of Rheumatology and Connective Tissue Research,
Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson
Medical School, New Brunswick, New Jersey 08903
T cell antigen receptor is
uncertain. Although some T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of
cells that proliferate in response to the causative spirochete, Borrelia burgdorferi. Furthermore,
synovial T cell clones express elevated and sustained levels of the ligand for Fas (APO-1,
CD95) compared to 
T cells, and induce apoptosis of Fashigh CD4+ synovial lymphocytes.
The findings suggest that T cells contribute to defense in human infections, as well as manifest an immunoregulatory function at inflammatory sites by a Fas-dependent process.
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