The Journal of Experimental Medicine
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© The Rockefeller University Press, 0022-1007/1996/12/2079/ $5.00
The Journal of Experimental Medicine, Volume 184, Number 6, December 1, 1996 2079-2084

Articles

Counterselection against Dµ Is Mediated through Immunoglobulin (Ig){alpha}-Igβ

Shiaoching Gong, Mercedes Sanchez, and Michel C. Nussenzweig

From the Laboratory of Molecular Immunology, The Howard Hughes Medical Institute, The Rockefeller University, New York 10021

The pre-B cell receptor is a key checkpoint regulator in developing B cells. Early events that are controlled by the pre-B cell receptor include positive selection for cells express membrane immunoglobulin heavy chains and negative selection against cells expressing truncated immunoglobulins that lack a complete variable region (Dµ). Positive selection is known to be mediated by membrane immunoglobulin heavy chains through Ig{alpha}-Igβ, whereas the mechanism for counterselection against Dµ has not been determined. We have examined the role of the Ig{alpha}-Igβ signal transducers in counterselection against Dµ using mice that lack Igβ. We found that Dµ expression is not selected against in developing B cells in Igβ mutant mice. Thus, the molecular mechanism for counterselection against Dµ in pre-B cells resembles positive selection in that it requires interaction between mDµ and Ig{alpha}-Igβ.

Address correspondence to Dr. Michel Nussenzweig, The Rockefeller University, Howard Hughes Medical Institute, 1230 York Ave., New York, NY 10021.

This work was supported by the Howard Hughes Medical Institute, and by National Institutes of Health grants to Dr. Nussenzweig.

1Abbreviations used in this paper: BCR, B cell receptor; mIgµ, membrane immunoglobulin heavy chain; RF, reading frame.


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