The Journal of Experimental Medicine
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Journal of Experimental Medicine, Vol 184, 1755-1768, Copyright © 1996 by Rockefeller University Press

ARTICLES

Immunization with soluble BDC 2.5 T cell receptor-immunoglobulin chimeric protein:antibody specificity and protection of nonobese diabetic mice against adoptive transfer of diabetes by maternal immunization

U McKeever, S Khandekar, J Newcomb, J Naylor, P Gregory, P Brauer, M Jesson, B Bettencourt, E Burke, A Alderson, J Banerji, K Haskins and B Jones
Procept Incorporated, Cambridge, Massachusetts 02139.

The BDC 2.5 T cell clone is specific for pancreatic beta-cell antigen presented by I-Ag7, and greatly accelerates diabetes when injected into 10-21-d-old nonobese diabetic (NOD) mice. The BDC 2.5 T cell receptor (TCR) has been solubilized as a TCR-IgG1 chimeric protein. All NOD mice immunized against BDC 2.5 TCR-IgG1 produced antibodies recognizing TCR C alpha/C beta epitopes that were inaccessible on the T cell surface. 56% of the mice produced antibodies against the BDC 2.5 clonotype that specifically blocked antigen activation of BDC 2.5 cells. We have used the adoptive transfer model of diabetes to demonstrate that maternal immunization with soluble TCR protects young mice from diabetes induced by the BDC 2.5 T cell clone.
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