GlyCAM-1, a physiologic ligand for L-selectin, activates beta 2 integrins on naive peripheral lymphocytes

doi:10.1084/jem.184.4.1343

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GlyCAM-1, a physiologic ligand for L-selectin, activates beta 2 integrins on naive peripheral lymphocytes

ST Hwang, MS Singer, PA Giblin, TA Yednock, KB Bacon, SI Simon and SD Rosen
Department of Anatomy and Program in Immunology, University of California, San Francisco 94143, USA.

Naive T cells are selectively recruited from the blood into peripheral lymph nodes during lymphocyte recirculation. L-selectin, a lectin-like receptor, mediates the initial attachment of lymphocytes to high endothelial venules (HEV) in lymph nodes. A subsequent step involving the activation of beta 2 integrins has been proposed to facilitate firm adhesion, but the activating signals are poorly understood. We report here that either antibody-mediated cross-linking of L-selectin on human lymphocytes or treatment of the cells with GlyCAM-1, an HEV-derived, secreted ligand for L-selectin, stimulates their binding to ICAM-1 through the beta 2 integrin pathway. Furthermore, GlyCAM-1 causes the rapid expression of a neoepitope on beta 2 integrins associated with a high-avidity state. Naive (CD45RA+), but not memory (CD45R0+) lymphocytes, respond to L-selectin cross-linking or GlyCAM-1 treatment. Thus, the complexing of L-selectin by specific ligands may provide key signals to naive lymphocytes, contributing to their selective recruitment into peripheral lymphoid organs.
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Chan, J. R., Hyduk, S. J., Cybulsky, M. I. (2000). {alpha}4{beta}1 Integrin/VCAM-1 Interaction Activates {alpha}L{beta}2 Integrin-Mediated Adhesion to ICAM-1 in Human T Cells. J. Immunol. 164: 746-753 [Abstract] [Full Text]
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Rosen, S. D. (1999). Endothelial Ligands for L-Selectin : From Lymphocyte Recirculation to Allograft Rejection. Am. J. Pathol. 155: 1013-1020 [Full Text]
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Mehta, P., Cummings, R. D., McEver, R. P. (1998). Affinity and Kinetic Analysis of P-selectin Binding to P-selectin Glycoprotein Ligand-1. J. Biol. Chem. 273: 32506-32513 [Abstract] [Full Text]
Tangemann, K., Gunn, M. D., Giblin, P., Rosen, S. D. (1998). A High Endothelial Cell-Derived Chemokine Induces Rapid, Efficient, and Subset-Selective Arrest of Rolling T Lymphocytes on a Reconstituted Endothelial Substrate. J. Immunol. 161: 6330-6337 [Abstract] [Full Text]
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Frey, M., Packianathan, N. B., Fehniger, T. A., Ross, M. E., Wang, W.-C., Stewart, C. C., Caligiuri, M. A., Evans, S. S. (1998). Differential Expression and Function of L-Selectin on CD56bright and CD56dim Natural Killer Cell Subsets. J. Immunol. 161: 400-408 [Abstract] [Full Text]
Sassetti, C., Tangemann, K., Singer, M. S., Kershaw, D. B., Rosen, S. D. (1998). Identification of Podocalyxin-like Protein as a High Endothelial Venule Ligand for L-selectin: Parallels to CD34. JEM 187: 1965-1975 [Abstract] [Full Text]
Aplin, A. E., Howe, A., Alahari, S. K., Juliano, R. L. (1998). Signal Transduction and Signal Modulation by Cell Adhesion Receptors: The Role of Integrins, Cadherins, Immunoglobulin-Cell Adhesion Molecules, and Selectins. Pharmacol. Rev. 50: 197-264 [Abstract] [Full Text]
Chiba, K., Yanagawa, Y., Masubuchi, Y., Kataoka, H., Kawaguchi, T., Ohtsuki, M., Hoshino, Y. (1998). FTY720, a Novel Immunosuppressant, Induces Sequestration of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing in Rats. I. FTY720 Selectively Decreases the Number of Circulating Mature Lymphocytes by Acceleration of Lymphocyte Homing. J. Immunol. 160: 5037-5044 [Abstract] [Full Text]
Tang, M. L. K., Steeber, D. A., Zhang, X.-Q., Tedder, T. F. (1998). Intrinsic Differences in L-Selectin Expression Levels Affect T and B Lymphocyte Subset-Specific Recirculation Pathways. J. Immunol. 160: 5113-5121 [Abstract] [Full Text]
Kushnir, N., Liu, L., MacPherson, G. G. (1998). Dendritic Cells and Resting B Cells Form Clusters In Vitro and In Vivo: T Cell Independence, Partial LFA-1 Dependence, and Regulation by Cross-Linking Surface Molecules. J. Immunol. 160: 1774-1781 [Abstract] [Full Text]
Newton, R. A., Hogg, N. (1998). The Human S100 Protein MRP-14 Is a Novel Activator of the {beta}2 Integrin Mac-1 on Neutrophils. J. Immunol. 160: 1427-1435 [Abstract] [Full Text]
Diacovo, T. G., Catalina, M. D., Siegelman, M. H., Andrian, U. H. v. (1998). Circulating Activated Platelets Reconstitute Lymphocyte Homing and Immunity in L-selectin-Deficient Mice. JEM 187: 197-204 [Abstract] [Full Text]
Warnock, R. A., Askari, S., Butcher, E. C., Andrian, U. H. v. (1998). Molecular Mechanisms of Lymphocyte Homing to Peripheral Lymph Nodes. JEM 187: 205-216 [Abstract] [Full Text]
Nicholson, M. W., Barclay, A. N., Singer, M. S., Rosen, S. D., van der Merwe, P. A. (1998). Affinity and Kinetic Analysis of L-selectin (CD62L) Binding to Glycosylation-dependent Cell-adhesion Molecule-1. J. Biol. Chem. 273: 763-770 [Abstract] [Full Text]
Gunn, M. D., Tangemann, K., Tam, C., Cyster, J. G., Rosen, S. D., Williams, L. T. (1998). A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T�lymphocytes. Proc. Natl. Acad. Sci. USA 95: 258-263 [Abstract] [Full Text]
Hidari, K. I.-P. J., Weyrich, A. S., Zimmerman, G. A., McEver, R. P. (1997). Engagement of P-selectin Glycoprotein Ligand-1 Enhances Tyrosine Phosphorylation and Activates Mitogen-activated Protein Kinases in Human Neutrophils. J. Biol. Chem. 272: 28750-28756 [Abstract] [Full Text]
Kawashima, H., Hirose, M., Hirose, J., Nagakubo, D., Plaas, A. H. K., Miyasaka, M. (2000). Binding of a Large Chondroitin Sulfate/Dermatan Sulfate Proteoglycan, Versican, to L-selectin, P-selectin, and CD44. J. Biol. Chem. 275: 35448-35456 [Abstract] [Full Text]
Zhao, L.-c., Shey, M., Farnsworth, M., Dailey, M. O. (2001). Regulation of Membrane Metalloproteolytic Cleavage of L-selectin (CD62L) by the Epidermal Growth Factor Domain. J. Biol. Chem. 276: 30631-30640 [Abstract] [Full Text]
Smolen, J. E., Petersen, T. K., Koch, C., O'Keefe, S. J., Hanlon, W. A., Seo, S., Pearson, D., Fossett, M. C., Simon, S. I. (2000). L-Selectin Signaling of Neutrophil Adhesion and Degranulation Involves p38 Mitogen-activated Protein Kinase. J. Biol. Chem. 275: 15876-15884 [Abstract] [Full Text]