Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases

doi:10.1084/jem.184.3.981

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Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases

DA Arenberg, SL Kunkel, PJ Polverini, SB Morris, MD Burdick, MC Glass, DT Taub, MD Iannettoni, RI Whyte and RM Strieter
Department of Internal Medicine, University of Michigan Medical School, Ann Arbor 48109-0360, USA.

The success of solid tumor growth and metastasis is dependent upon angiogenesis. Neovascularization within the tumor is regulated, in part, by a dual and opposing system of angiogenic and angiostatic factors. We now report that IP-10, a recently described angiostatic factor, as a potent angiostatic factor that regulates non-small cell lung cancer (NSCLC)-derived angiogenesis, tumor growth, and spontaneous metastasis. We initially found significantly elevated levels of IP-10 in freshly isolated human NSCLC samples of squamous cell carcinoma (SCCA). In contrast, levels of IP-10 were equivalent in either normal lung tissue or adenocarcinoma specimens. The neoplastic cells in specimens of SCCA were the predominant cells that appeared to express IP-10 by immunolocalization. Neutralization of IP-10 in SCCA tumor specimens resulted in enhanced tumor-derived angiogenic activity. Using a model of human NSCLC tumorigenesis in SCID mice, we found that NSCLC tumor growth was inversely correlated with levels of plasma or tumor- associated IP-10. IP-10 in vitro functioned as neither an autocrine growth factor nor as an inhibitor of proliferation of the NSCLC cell lines. Reconstitution of intratumor IP-10 for a period of 8 wk resulted in a significant inhibition of tumor growth, tumor-associated angiogenic activity and neovascularization, and spontaneous lung metastases, whereas, neutralization of IP-10 for 10 wk augmented tumor growth. These findings support the notion that tumor-derived IP-10 is an important endogenous angiostatic factor in NSCLC.
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Bodnar, R. J., Yates, C. C., Wells, A. (2006). IP-10 Blocks Vascular Endothelial Growth Factor-Induced Endothelial Cell Motility and Tube Formation via Inhibition of Calpain. Circ. Res. 98: 617-625 [Abstract] [Full Text]
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Phillips, R. J., Burdick, M. D., Lutz, M., Belperio, J. A., Keane, M. P., Strieter, R. M. (2003). The Stromal Derived Factor-1/CXCL12-CXC Chemokine Receptor 4 Biological Axis in Non-Small Cell Lung Cancer Metastases. Am. J. Respir. Crit. Care Med. 167: 1676-1686 [Abstract] [Full Text]
Lasagni, L., Francalanci, M., Annunziato, F., Lazzeri, E., Giannini, S., Cosmi, L., Sagrinati, C., Mazzinghi, B., Orlando, C., Maggi, E., Marra, F., Romagnani, S., Serio, M., Romagnani, P. (2003). An Alternatively Spliced Variant of CXCR3 Mediates the Inhibition of Endothelial Cell Growth Induced by IP-10, Mig, and I-TAC, and Acts as Functional Receptor for Platelet Factor 4. JEM 197: 1537-1549 [Abstract] [Full Text]
Dabrosin, C. (2003). Variability of Vascular Endothelial Growth Factor in Normal Human Breast Tissue in Vivo during the Menstrual Cycle. J. Clin. Endocrinol. Metab. 88: 2695-2698 [Abstract] [Full Text]
Flynn, S., Stockinger, B. (2003). Tumor and CD4 T-cell interactions: tumor escape as result of reciprocal inactivation. Blood 101: 4472-4478 [Abstract] [Full Text]
Campanella, G. S. V., Lee, E. M. J., Sun, J., Luster, A. D. (2003). CXCR3 and Heparin Binding Sites of the Chemokine IP-10 (CXCL10). J. Biol. Chem. 278: 17066-17074 [Abstract] [Full Text]
Wolf, M., Clark-Lewis, I., Buri, C., Langen, H., Lis, M., Mazzucchelli, L. (2003). Cathepsin D Specifically Cleaves the Chemokines Macrophage Inflammatory Protein-1{alpha}, Macrophage Inflammatory Protein-1{beta}, and SLC That Are Expressed in Human Breast Cancer. Am. J. Pathol. 162: 1183-1190 [Abstract] [Full Text]
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Keane, M. P., Donnelly, S. C., Belperio, J. A., Goodman, R. B., Dy, M., Burdick, M. D., Fishbein, M. C., Strieter, R. M. (2002). Imbalance in the Expression of CXC Chemokines Correlates with Bronchoalveolar Lavage Fluid Angiogenic Activity and Procollagen Levels in Acute Respiratory Distress Syndrome. J. Immunol. 169: 6515-6521 [Abstract] [Full Text]
Belperio, J. A., Dy, M., Burdick, M. D., Xue, Y. Y., Li, K., Elias, J. A., Keane, M. P. (2002). Interaction of IL-13 and C10 in the Pathogenesis of Bleomycin-Induced Pulmonary Fibrosis. Am. J. Respir. Cell Mol. Bio. 27: 419-427 [Abstract] [Full Text]
Dhawan, P., Richmond, A. (2002). Role of CXCL1 in tumorigenesis of melanoma. J. Leukoc. Biol. 72: 9-18 [Abstract] [Full Text]
Wakasugi, K., Slike, B. M., Hood, J., Ewalt, K. L., Cheresh, D. A., Schimmel, P. (2002). Induction of Angiogenesis by a Fragment of Human Tyrosyl-tRNA Synthetase. J. Biol. Chem. 277: 20124-20126 [Abstract] [Full Text]
Padovan, E., Spagnoli, G. C., Ferrantini, M., Heberer, M. (2002). IFN-{alpha}2a induces IP-10/CXCL10 and MIG/CXCL9 production in monocyte-derived dendritic cells and enhances their capacity to attract and stimulate CD8+ effector T cells. J. Leukoc. Biol. 71: 669-676 [Abstract] [Full Text]
Cheng, S. S., Lukacs, N. W., Kunkel, S. L. (2002). Eotaxin/CCL11 Suppresses IL-8/CXCL8 Secretion from Human Dermal Microvascular Endothelial Cells. J. Immunol. 168: 2887-2894 [Abstract] [Full Text]
Maxion, H. K., Kelly, K. A. (2002). Chemokine Expression Patterns Differ within Anatomically Distinct Regions of the Genital Tract during Chlamydia trachomatis Infection. Infect. Immun. 70: 1538-1546 [Abstract] [Full Text]
KEANE, M. P., BELPERIO, J. A., BURDICK, M. D., LYNCH, J. P. III, FISHBEIN, M. C., STRIETER, R. M. (2001). ENA-78 Is an Important Angiogenic Factor in Idiopathic Pulmonary Fibrosis. Am. J. Respir. Crit. Care Med. 164: 2239-2242 [Abstract] [Full Text]
Bone-Larson, C. L., Hogaboam, C. M., Evanhoff, H., Strieter, R. M., Kunkel, S. L. (2001). IFN-{gamma}-Inducible Protein-10 (CXCL10) Is Hepatoprotective During Acute Liver Injury Through the Induction of CXCR2 on Hepatocytes. J. Immunol. 167: 7077-7083 [Abstract] [Full Text]
White, E. S., Livant, D. L., Markwart, S., Arenberg, D. A. (2001). Monocyte-Fibronectin Interactions, Via {alpha}5{beta}1 Integrin, Induce Expression of CXC Chemokine-Dependent Angiogenic Activity. J. Immunol. 167: 5362-5366 [Abstract] [Full Text]
Sharma, S., Stolina, M., Zhu, L., Lin, Y., Batra, R., Huang, M., Strieter, R., Dubinett, S. M. (2001). Secondary Lymphoid Organ Chemokine Reduces Pulmonary Tumor Burden in Spontaneous Murine Bronchoalveolar Cell Carcinoma. Cancer Res. 61: 6406-6412 [Abstract] [Full Text]
Detjen, K M, Farwig, K, Welzel, M, Wiedenmann, B, Rosewicz, S (2001). Interferon {gamma} inhibits growth of human pancreatic carcinoma cells via caspase-1 dependent induction of apoptosis. Gut 49: 251-262 [Abstract] [Full Text]
Gruys, M. E., Back, T. C., Subleski, J., Wiltrout, T. A., Lee, J.-K., Schmidt, L., Watanabe, M., Stanyon, R., Ward, J. M., Wigginton, J. M., Wiltrout, R. H. (2001). Induction of Transplantable Mouse Renal Cell Cancers by Streptozotocin: In Vivo Growth, Metastases, and Angiogenic Phenotype. Cancer Res. 61: 6255-6263 [Abstract] [Full Text]
Cole, A. M., Ganz, T., Liese, A. M., Burdick, M. D., Liu, L., Strieter, R. M. (2001). Cutting Edge: IFN-Inducible ELR- CXC Chemokines Display Defensin-Like Antimicrobial Activity. J. Immunol. 167: 623-627 [Abstract] [Full Text]
Keane, M. P., Belperio, J. A., Burdick, M. D., Strieter, R. M. (2001). IL-12 attenuates bleomycin-induced pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol. 281: L92-L97 [Abstract] [Full Text]
White, E. S., Strom, S. R. B., Wys, N. L., Arenberg, D. A. (2001). Non-Small Cell Lung Cancer Cells Induce Monocytes to Increase Expression of Angiogenic Activity. J. Immunol. 166: 7549-7555 [Abstract] [Full Text]
Fife, B. T., Kennedy, K. J., Paniagua, M. C., Lukacs, N. W., Kunkel, S. L., Luster, A. D., Karpus, W. J. (2001). CXCL10 (IFN-{{gamma}}-Inducible Protein-10) Control of Encephalitogenic CD4+ T Cell Accumulation in the Central Nervous System During Experimental Autoimmune Encephalomyelitis. J. Immunol. 166: 7617-7624 [Abstract] [Full Text]
Park, J.-W., Gruys, M. E., McCormick, K., Lee, J.-K., Subleski, J., Wigginton, J. M., Fenton, R. G., Wang, J.-M., Wiltrout, R. H. (2001). Primary Hepatocytes from Mice Treated with IL-2/IL-12 Produce T Cell Chemoattractant Activity that Is Dependent on Monokine Induced by IFN-{{gamma}} (Mig) and Chemokine Responsive to {{gamma}}-2 (Crg-2). J. Immunol. 166: 3763-3770 [Abstract] [Full Text]
Beatty, G. L., Paterson, Y. (2001). IFN-{{gamma}}-Dependent Inhibition of Tumor Angiogenesis by Tumor-Infiltrating CD4+ T Cells Requires Tumor Responsiveness to IFN-{{gamma}}. J. Immunol. 166: 2276-2282 [Abstract] [Full Text]
Itakura, M., Tokuda, A., Kimura, H., Nagai, S., Yoneyama, H., Onai, N., Ishikawa, S., Kuriyama, T., Matsushima, K. (2001). Blockade of Secondary Lymphoid Tissue Chemokine Exacerbates Propionibacterium acnes-Induced Acute Lung Inflammation. J. Immunol. 166: 2071-2079 [Abstract] [Full Text]
Ueno, T., Toi, M., Saji, H., Muta, M., Bando, H., Kuroi, K., Koike, M., Inadera, H., Matsushima, K. (2000). Significance of Macrophage Chemoattractant Protein-1 in Macrophage Recruitment, Angiogenesis, and Survival in Human Breast Cancer. Clin. Cancer Res. 6: 3282-3289 [Abstract] [Full Text]
Belperio, J. A., Keane, M. P., Arenberg, D. A., Addison, C. L., Ehlert, J. E., Burdick, M. D., Strieter, R. M. (2000). CXC chemokines in angiogenesis. J. Leukoc. Biol. 68: 1-8 [Abstract] [Full Text]
Frederick, M. J., Henderson, Y., Xu, X., Deavers, M. T., Sahin, A. A., Wu, H., Lewis, D. E., El-Naggar, A. K., Clayman, G. L. (2000). In Vivo Expression of the Novel CXC Chemokine BRAK in Normal and Cancerous Human Tissue. Am. J. Pathol. 156: 1937-1950 [Abstract] [Full Text]
Sharma, S., Stolina, M., Luo, J., Strieter, R. M., Burdick, M., Zhu, L. X., Batra, R. K., Dubinett, S. M. (2000). Secondary Lymphoid Tissue Chemokine Mediates T Cell-Dependent Antitumor Responses In Vivo. J. Immunol. 164: 4558-4563 [Abstract] [Full Text]
Simonini, A., Moscucci, M., Muller, D. W. M., Bates, E. R., Pagani, F. D., Burdick, M. D., Strieter, R. M. (2000). IL-8 Is an Angiogenic Factor in Human Coronary Atherectomy Tissue. Circulation 101: 1519-1526 [Abstract] [Full Text]
Fong, K. M., Sekido, Y., Minna, J. D. (1999). MOLECULAR PATHOGENESIS OF LUNG CANCER. J. Thorac. Cardiovasc. Surg. 118: 1136-1152 [Abstract] [Full Text]
CAO, R., FARNEBO, J., KURIMOTO, M., CAO, Y. (1999). Interleukin-18 acts as an angiogenesis and tumor suppressor. FASEB J. 13: 2195-2202 [Abstract] [Full Text]
Peoples, G. E., Anderson, B. W., Lee, T. V., Murray, J. L., Kudelka, A. P., Wharton, J. T., Ioannides, C. G. (1999). Vaccine Implications of Folate Binding Protein, a Novel Cytotoxic T Lymphocyte-recognized Antigen System in Epithelial Cancers. Clin. Cancer Res. 5: 4214-4223 [Abstract] [Full Text]
Keane, M. P., Belperio, J. A., Arenberg, D. A., Burdick, M. D., Xu, Z. J., Xue, Y. Y., Strieter, R. M. (1999). IFN-{gamma}-Inducible Protein-10 Attenuates Bleomycin-Induced Pulmonary Fibrosis Via Inhibition of Angiogenesis. J. Immunol. 163: 5686-5692 [Abstract] [Full Text]
Keane, M. P., Wilke, C. A., Burdick, M. D., Morris, S. B., Glass, M. C., Strieter, R. M. (1999). CXC Chemokines Regulate Angiogenic Activity in Acute Lung Injury. Chest 116 : 93S-94S [Full Text]
Keane, M. P., Belperio, J. A., Moore, T. A., Moore, B. B., Arenberg, D. A., Smith, R. E., Burdick, M. D., Kunkel, S. L., Strieter, R. M. (1999). Neutralization of the CXC Chemokine, Macrophage Inflammatory Protein-2, Attenuates Bleomycin-Induced Pulmonary Fibrosis. J. Immunol. 162: 5511-5518 [Abstract] [Full Text]
Moore, B. B., Arenberg, D. A., Stoy, K., Morgan, T., Addison, C. L., Morris, S. B., Glass, M., Wilke, C., Xue, Y. Y., Sitterding, S., Kunkel, S. L., Burdick, M. D., Strieter, R. M. (1999). Distinct CXC Chemokines Mediate Tumorigenicity of Prostate Cancer Cells. Am. J. Pathol. 154: 1503-1512 [Abstract] [Full Text]
Gasperini, S., Marchi, M., Calzetti, F., Laudanna, C., Vicentini, L., Olsen, H., Murphy, M., Liao, F., Farber, J., Cassatella, M. A. (1999). Gene Expression and Production of the Monokine Induced by IFN-{gamma} (MIG), IFN-Inducible T Cell {alpha} Chemoattractant (I-TAC), and IFN-{gamma}-Inducible Protein-10 (IP-10) Chemokines by Human Neutrophils. J. Immunol. 162: 4928-4937 [Abstract] [Full Text]
Elner, S. G., Strieter, R., Bian, Z. M., Kunkel, S., Mokhtarzaden, L., Johnson, M., Lukacs, N., Elner, V. M. (1998). Interferon-Induced Protein 10 and Interleukin 8: C-X-C Chemokines Present in Proliferative Diabetic Retinopathy. Arch Ophthalmol 116: 1597-1601 [Abstract] [Full Text]
Tannenbaum, C. S., Tubbs, R., Armstrong, D., Finke, J. H., Bukowski, R. M., Hamilton, T. A. (1998). The CXC Chemokines IP-10 and Mig Are Necessary for IL-12-Mediated Regression of the Mouse RENCA Tumor. J. Immunol. 161: 927-932 [Abstract] [Full Text]
Soto, H., Wang, W., Strieter, R. M., Copeland, N. G., Gilbert, D. J., Jenkins, N. A., Hedrick, J., Zlotnik, A. (1998). The CC chemokine 6Ckine binds the CXC chemokine receptor CXCR3. Proc. Natl. Acad. Sci. USA 95: 8205-8210 [Abstract] [Full Text]
Gangur, V., R. Simons, F. E., Hayglass, K. T. (1998). Human IP-10 selectively promotes dominance of polyclonally activated and environmental antigen-driven IFN-{gamma} over IL-4 responses. FASEB J. 12: 705-713 [Abstract] [Full Text]
Cherney, B. W., Sgadari, C., Kanegane, C., Wang, F., Tosato, G. (1998). Expression of the Epstein-Barr Virus Protein LMP1 Mediates Tumor Regression In Vivo. Blood 91: 2491-2500 [Abstract] [Full Text]
Osaki, T., Peron, J.-M., Cai, Q., Okamura, H., Robbins, P. D., Kurimoto, M., Lotze, M. T., Tahara, H. (1998). IFN-{gamma}-Inducing Factor/IL-18 Administration Mediates IFN-{gamma}- and IL-12-Independent Antitumor Effects. J. Immunol. 160: 1742-1749 [Abstract] [Full Text]
Teruya-Feldstein, J., Jaffe, E. S., Burd, P. R., Kanegane, H., Kingma, D. W., Wilson, W. H., Longo, D. L., Tosato, G. (1997). The Role of Mig, the Monokine Induced by Interferon-gamma , and IP-10, the Interferon-gamma -Inducible Protein-10, in Tissue Necrosis and Vascular Damage Associated With Epstein-Barr Virus-Positive Lymphoproliferative Disease. Blood 90: 4099-4105 [Abstract] [Full Text]
Chang, M.-s., McNinch, J., Elias III, C., Manthey, C. L., Grosshans, D., Meng, T., Boone, T., Andrew, D. P. (1997). Molecular Cloning and Functional Characterization of a Novel CC Chemokine, Stimulated T Cell Chemotactic Protein (STCP-1) That Specifically Acts on Activated T Lymphocytes. J. Biol. Chem. 272: 25229-25237 [Abstract] [Full Text]
Sgadari, C., Farber, J. M., Angiolillo, A. L., Liao, F., Teruya-Feldstein, J., Burd, P. R., Yao, L., Gupta, G., Kanegane, C., Tosato, G. (1997). Mig, the Monokine Induced By Interferon-gamma , Promotes Tumor Necrosis In Vivo. Blood 89: 2635-2643 [Abstract] [Full Text]