Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

doi:10.1084/jem.184.3.963

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Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

M Loetscher, B Gerber, P Loetscher, SA Jones, L Piali, I Clark-Lewis, M Baggiolini and B Moser
Theodor Kocher Institute, University of Bern, Switzerland.

A human receptor that is selective for the CXC chemokines IP10 and Mig was cloned and characterized. The receptor cDNA has an open reading frame of 1104-bp encoding a protein of 368 amino acids with a molecular mass of 40,659 dalton. The sequence includes seven putative transmembrane segments characteristic of G-protein coupled receptors. It shares 40.9 and 40.3% identical amino acids with the two IL-8 receptors, and 34.2-36.9% identity with the five known CC chemokine receptors. The IP10/Mig receptor is highly expressed in IL-2-activated T lymphocytes, but is not detectable in resting T lymphocytes. B lymphocytes, monocytes and granulocytes. It mediates Ca2+ mobilization and chemotaxis in response to IP10 and Mig, but does not recognize the CXC-chemokines IL-8, GRO alpha, NAP-2, GCP-2. ENA78, PF4, the CC- chemokines MCP-1, MCP-2, MCP-3, MCP-4, MIP-1 alpha, MIP-1 beta. RANTES, 1309, eotaxin, nor lymphotactin. The exclusive expression in activated T-lymphocytes is of high interest since the receptors for chemokines which have been shown so far to attract lymphocytes, e.g., MCP-1, MCP- 2, MCP-3, MIP-1 alpha, MIP-1 beta, and RANTES, are also found in monocytes and granulocytes. The present observations suggest that the IP10/Mig receptor is involved in the selective recruitment of effector T cells.
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DE FOST, M., CHIERAKUL, W., PIMDA, K., DONDORP, A. M., WHITE, N. J., VAN DER POLL, T. (2005). ACTIVATION OF CYTOTOXIC LYMPHOCYTES IN PATIENTS WITH SCRUB TYPHUS. Am J Trop Med Hyg 72: 465-467 [Abstract] [Full Text]
Shimauchi, T., Imai, S., Hino, R., Tokura, Y. (2005). Production of Thymus and Activation-Regulated Chemokine and Macrophage-Derived Chemokine by CCR4+ Adult T-Cell Leukemia Cells. Clin. Cancer Res. 11: 2427-2435 [Abstract] [Full Text]
Ejrnaes, M., Videbaek, N., Christen, U., Cooke, A., Michelsen, B. K., von Herrath, M. (2005). Different Diabetogenic Potential of Autoaggressive CD8+ Clones Associated with IFN-{gamma}-Inducible Protein 10 (CXC Chemokine Ligand 10) Production but Not Cytokine Expression, Cytolytic Activity, or Homing Characteristics. J. Immunol. 174: 2746-2755 [Abstract] [Full Text]
Beisser, P. S., Verzijl, D., Gruijthuijsen, Y. K., Beuken, E., Smit, M. J., Leurs, R., Bruggeman, C. A., Vink, C. (2005). The Epstein-Barr Virus BILF1 Gene Encodes a G Protein-Coupled Receptor That Inhibits Phosphorylation of RNA-Dependent Protein Kinase. J. Virol. 79: 441-449 [Abstract] [Full Text]
Md Sheikh, A., Ochi, H., Manabe, A., Masuda, J. (2005). Lysophosphatidylcholine posttranscriptionally inhibits interferon-{gamma}-induced IP-10, Mig and I-Tac expression in endothelial cells. Cardiovasc Res 65: 263-271 [Abstract] [Full Text]
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Ehlert, J. E., Addison, C. A., Burdick, M. D., Kunkel, S. L., Strieter, R. M. (2004). Identification and Partial Characterization of a Variant of Human CXCR3 Generated by Posttranscriptional Exon Skipping. J. Immunol. 173: 6234-6240 [Abstract] [Full Text]
Deng, J. C., Zeng, X., Newstead, M., Moore, T. A., Tsai, W. C., Thannickal, V. J., Standiford, T. J. (2004). STAT4 Is a Critical Mediator of Early Innate Immune Responses against Pulmonary Klebsiella Infection. J. Immunol. 173: 4075-4083 [Abstract] [Full Text]
Petkovic, V., Moghini, C., Paoletti, S., Uguccioni, M., Gerber, B. (2004). I-TAC/CXCL11 is a natural antagonist for CCR5. J. Leukoc. Biol. 76: 701-708 [Abstract] [Full Text]
Hildebrandt, G. C., Corrion, L. A., Olkiewicz, K. M., Lu, B., Lowler, K., Duffner, U. A., Moore, B. B., Kuziel, W. A., Liu, C., Cooke, K. R. (2004). Blockade of CXCR3 Receptor:Ligand Interactions Reduces Leukocyte Recruitment to the Lung and the Severity of Experimental Idiopathic Pneumonia Syndrome. J. Immunol. 173: 2050-2059 [Abstract] [Full Text]
Colvin, R. A., Campanella, G. S. V., Sun, J., Luster, A. D. (2004). Intracellular Domains of CXCR3 That Mediate CXCL9, CXCL10, and CXCL11 Function. J. Biol. Chem. 279: 30219-30227 [Abstract] [Full Text]
Alatrash, G., Hutson, T. E., Molto, L., Richmond, A., Nemec, C., Mekhail, T., Elson, P., Tannenbaum, C., Olencki, T., Finke, J., Bukowski, R. M. (2004). Clinical and Immunologic Effects of Subcutaneously Administered Interleukin-12 and Interferon Alfa-2b: Phase I Trial of Patients With Metastatic Renal Cell Carcinoma or Malignant Melanoma. JCO 22: 2891-2900 [Abstract] [Full Text]
Whiting, D., Hsieh, G., Yun, J. J., Banerji, A., Yao, W., Fishbein, M. C., Belperio, J., Strieter, R. M., Bonavida, B., Ardehali, A. (2004). Chemokine Monokine Induced by IFN-{gamma}/CXC Chemokine Ligand 9 Stimulates T Lymphocyte Proliferation and Effector Cytokine Production. J. Immunol. 172: 7417-7424 [Abstract] [Full Text]
Delgado, M., Pozo, D., Ganea, D. (2004). The Significance of Vasoactive Intestinal Peptide in Immunomodulation. Pharmacol. Rev. 56: 249-290 [Abstract] [Full Text]
Christensen, J. E., Nansen, A., Moos, T., Lu, B., Gerard, C., Christensen, J. P., Thomsen, A. R. (2004). Efficient T-Cell Surveillance of the CNS Requires Expression of the CXC Chemokine Receptor 3. J. Neurosci. 24: 4849-4858 [Abstract] [Full Text]
Kitaya, K., Nakayama, T., Daikoku, N., Fushiki, S., Honjo, H. (2004). Spatial and Temporal Expression of Ligands for CXCR3 and CXCR4 in Human Endometrium. J. Clin. Endocrinol. Metab. 89: 2470-2476 [Abstract] [Full Text]
Proost, P., Verpoest, S., de Borne, K. V., Schutyser, E., Struyf, S., Put, W., Ronsse, I., Grillet, B., Opdenakker, G., Damme, J. V. (2004). Synergistic induction of CXCL9 and CXCL11 by Toll-like receptor ligands and interferon-{gamma} in fibroblasts correlates with elevated levels of CXCR3 ligands in septic arthritis synovial fluids. J. Leukoc. Biol. 75: 777-784 [Abstract] [Full Text]
Yang, S.-C., Hillinger, S., Riedl, K., Zhang, L., Zhu, L., Huang, M., Atianzar, K., Kuo, B. Y., Gardner, B., Batra, R. K., Strieter, R. M., Dubinett, S. M., Sharma, S. (2004). Intratumoral Administration of Dendritic Cells Overexpressing CCL21 Generates Systemic Antitumor Responses and Confers Tumor Immunity. Clin. Cancer Res. 10: 2891-2901 [Abstract] [Full Text]
Trifilo, M. J., Montalto-Morrison, C., Stiles, L. N., Hurst, K. R., Hardison, J. L., Manning, J. E., Masters, P. S., Lane, T. E. (2004). CXC Chemokine Ligand 10 Controls Viral Infection in the Central Nervous System: Evidence for a Role in Innate Immune Response through Recruitment and Activation of Natural Killer Cells. J. Virol. 78: 585-594 [Abstract] [Full Text]
Hillinger, S., Yang, S.-C., Zhu, L., Huang, M., Duckett, R., Atianzar, K., Batra, R. K., Strieter, R. M., Dubinett, S. M., Sharma, S. (2003). EBV-Induced Molecule 1 Ligand Chemokine (ELC/CCL19) Promotes IFN-{gamma}-Dependent Antitumor Responses in a Lung Cancer Model. J. Immunol. 171: 6457-6465 [Abstract] [Full Text]
Christen, U., McGavern, D. B., Luster, A. D., von Herrath, M. G., Oldstone, M. B. A. (2003). Among CXCR3 Chemokines, IFN-{gamma}-Inducible Protein of 10 kDa (CXC Chemokine Ligand (CXCL) 10) but Not Monokine Induced by IFN-{gamma} (CXCL9) Imprints a Pattern for the Subsequent Development of Autoimmune Disease. J. Immunol. 171: 6838-6845 [Abstract] [Full Text]
Richards, D. M., Dalheimer, S. L., Hertz, M. I., Mueller, D. L. (2003). Trachea Allograft Class I Molecules Directly Activate and Retain CD8+ T Cells That Cause Obliterative Airways Disease. J. Immunol. 171: 6919-6928 [Abstract] [Full Text]
Oikawa, Y., Shimada, A., Kasuga, A., Morimoto, J., Osaki, T., Tahara, H., Miyazaki, T., Tashiro, F., Yamato, E., Miyazaki, J.-i., Saruta, T. (2003). Systemic Administration of IL-18 Promotes Diabetes Development in Young Nonobese Diabetic Mice. J. Immunol. 171: 5865-5875 [Abstract] [Full Text]
Stanford, M. M., Issekutz, T. B. (2003). The relative activity of CXCR3 and CCR5 ligands in T lymphocyte migration: concordant and disparate activities in vitro and in vivo. J. Leukoc. Biol. 74: 791-799 [Abstract] [Full Text]
Belperio, J. A., Keane, M. P., Burdick, M. D., Lynch, J. P. III, Zisman, D. A., Xue, Y. Y., Li, K., Ardehali, A., Ross, D. J., Strieter, R. M. (2003). Role of CXCL9/CXCR3 Chemokine Biology during Pathogenesis of Acute Lung Allograft Rejection. J. Immunol. 171: 4844-4852 [Abstract] [Full Text]
Luker, G. D., Prior, J. L., Song, J., Pica, C. M., Leib, D. A. (2003). Bioluminescence Imaging Reveals Systemic Dissemination of Herpes Simplex Virus Type 1 in the Absence of Interferon Receptors. J. Virol. 77: 11082-11093 [Abstract] [Full Text]