Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells

doi:10.1084/jem.184.3.863

This Article

Full Text (PDF, 875K)

Alert me when this article is cited

Citation Map

Services

Email this article

Similar articles in this journal

Similar articles in PubMed

Alert me to new content in the JEM

Download to citation manager

Citing Articles

Citing Articles via HighWire

Citing Articles via CrossRef

Citing Articles via Google Scholar

Google Scholar

Articles by Cardin, R. D.

Articles by Doherty, P. C.

Search for Related Content

PubMed

PubMed Citation

Articles by Cardin, R. D.

Articles by Doherty, P. C.

Pubmed/NCBI databases

Medline Plus Health Information
Substance via MeSH
Infectious Mononucleosis

Social Bookmarking

What's this?

ARTICLES

Progressive loss of CD8+ T cell-mediated control of a gamma-herpesvirus in the absence of CD4+ T cells

RD Cardin, JW Brooks, SR Sarawar and PC Doherty
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.

A unique experimental model has been developed for dissecting the integrity of CD8+ T cell-mediated immunity to a persistent gammaherpesvirus under conditions of CD4+ T cell deficiency. Respiratory challenge of major histocompatibility complex class II -/- and +/+ C57BL/6J mice with the murine gammaherpesvirus 68 (MHV-68) leads to productive infection of both lung and adrenal epithelial cells. Virus titers peak within 5-10 d, and are no longer detected after day 15. Persistent, latent infection is established concurrently in splenic and lymph node B cells, with higher numbers of MHV-68+ lymphocytes being found in all lymphoid sites analyzed from the +/+ mice concurrent with the massive, but transient splenomegaly that occurred only in this group. From day 17, however, the numbers of infected B lymphocytes were consistently higher in the -/- group, while the frequency of this population diminished progressively in the +/+ controls. Infectious MHV-68 was again detected in the respiratory tract and the adrenals of the -/- (but not the +/+) mice from day 22 after infection. The titers in these sites rose progressively, with the majority of the -/- mice dying between days 120 and 133. Even so, some CD8+ effectors were still functioning as late as 100 d after infection. Depletion of CD8+ T cells at this stage led to higher virus titers in the -/- lung, and to the development of wasting in some of the -/- mice. Elimination of the CD8+ T cells from the +/+ group (day 80) increased the numbers of MHV-68+ cells in the spleen, but did not reactivate the infection in the respiratory tract. The results are consistent with the interpretation that CD8+ T cell-mediated control of this persistent gammaherpesvirus is progressively lost in the absence of the CD4+ T cell subset. This parallels what may be happening in AIDS patients who develop Kaposi's sarcoma and various Epstein Barr virus associated disease processes.
Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Gredmark-Russ, S., Isaacson, M. K., Kattenhorn, L., Cheung, E. J., Watson, N., Ploegh, H. L. (2009). A Gammaherpesvirus Ubiquitin-Specific Protease Is Involved in the Establishment of Murine Gammaherpesvirus 68 Infection. J. Virol. 83: 10644-10652 [Abstract] [Full Text]
Stevenson, P. G., Simas, J. P., Efstathiou, S. (2009). Immune control of mammalian gamma-herpesviruses: lessons from murid herpesvirus-4. J. Gen. Virol. 90: 2317-2330 [Abstract] [Full Text]
Snyder, C. M., Loewendorf, A., Bonnett, E. L., Croft, M., Benedict, C. A., Hill, A. B. (2009). CD4+ T Cell Help Has an Epitope-Dependent Impact on CD8+ T Cell Memory Inflation during Murine Cytomegalovirus Infection. J. Immunol. 183: 3932-3941 [Abstract] [Full Text]
Sherrill, J. D., Stropes, M. P., Schneider, O. D., Koch, D. E., Bittencourt, F. M., Miller, J. L. C., Miller, W. E. (2009). Activation of Intracellular Signaling Pathways by the Murine Cytomegalovirus G Protein-Coupled Receptor M33 Occurs via PLC-{beta}/PKC-Dependent and -Independent Mechanisms. J. Virol. 83: 8141-8152 [Abstract] [Full Text]
Cardin, R. D., Schaefer, G. C., Allen, J. R., Davis-Poynter, N. J., Farrell, H. E. (2009). The M33 Chemokine Receptor Homolog of Murine Cytomegalovirus Exhibits a Differential Tissue-Specific Role during In Vivo Replication and Latency. J. Virol. 83: 7590-7601 [Abstract] [Full Text]
Kocks, J. R., Adler, H., Danzer, H., Hoffmann, K., Jonigk, D., Lehmann, U., Forster, R. (2009). Chemokine Receptor CCR7 Contributes to a Rapid and Efficient Clearance of Lytic Murine {gamma}-Herpes Virus 68 from the Lung, Whereas Bronchus-Associated Lymphoid Tissue Harbors Virus during Latency. J. Immunol. 182: 6861-6869 [Abstract] [Full Text]
Liu, J., Ruckwardt, T. J., Chen, M., Johnson, T. R., Graham, B. S. (2009). Characterization of Respiratory Syncytial Virus M- and M2-Specific CD4 T Cells in a Murine Model. J. Virol. 83: 4934-4941 [Abstract] [Full Text]
Krug, L. T., Collins, C. M., Gargano, L. M., Speck, S. H. (2009). NF-{kappa}B p50 Plays Distinct Roles in the Establishment and Control of Murine Gammaherpesvirus 68 Latency. J. Virol. 83: 4732-4748 [Abstract] [Full Text]
Molloy, M. J., Zhang, W., Usherwood, E. J. (2009). Cutting Edge: IL-2 Immune Complexes As a Therapy for Persistent Virus Infection. J. Immunol. 182: 4512-4515 [Abstract] [Full Text]
Fuse, S., Tsai, C.-Y., Molloy, M. J., Allie, S. R., Zhang, W., Yagita, H., Usherwood, E. J. (2009). Recall Responses by Helpless Memory CD8+ T Cells Are Restricted by the Up-Regulation of PD-1. J. Immunol. 182: 4244-4254 [Abstract] [Full Text]
Gehring, S., Gregory, S. H., Wintermeyer, P., Aloman, C., Wands, J. R. (2009). Generation of Immune Responses against Hepatitis C Virus by Dendritic Cells Containing NS5 Protein-Coated Microparticles. CVI 16: 163-171 [Abstract] [Full Text]
Gredmark-Russ, S., Cheung, E. J., Isaacson, M. K., Ploegh, H. L., Grotenbreg, G. M. (2008). The CD8 T-Cell Response against Murine Gammaherpesvirus 68 Is Directed toward a Broad Repertoire of Epitopes from both Early and Late Antigens. J. Virol. 82: 12205-12212 [Abstract] [Full Text]
Dow, C., Oseroff, C., Peters, B., Nance-Sotelo, C., Sidney, J., Buchmeier, M., Sette, A., Mothe, B. R. (2008). Lymphocytic Choriomeningitis Virus Infection Yields Overlapping CD4+ and CD8+ T-Cell Responses. J. Virol. 82: 11734-11741 [Abstract] [Full Text]
Dias, P., Shea, A. L., Inglis, C., Giannoni, F., Lee, L. N., Sarawar, S. R. (2008). Primary Clearance of Murine Gammaherpesvirus 68 by PKC{theta}-/- CD8 T Cells Is Compromised in the Absence of Help from CD4 T Cells. J. Virol. 82: 11970-11975 [Abstract] [Full Text]
Giannoni, F., Shea, A., Inglis, C., Lee, L. N., Sarawar, S. R. (2008). CD40 Engagement on Dendritic Cells, but Not on B or T Cells, Is Required for Long-Term Control of Murine Gammaherpesvirus 68. J. Virol. 82: 11016-11022 [Abstract] [Full Text]
DeZalia, M., Speck, S. H. (2008). Identification of Closely Spaced but Distinct Transcription Initiation Sites for the Murine Gammaherpesvirus 68 Latency-Associated M2 Gene. J. Virol. 82: 7411-7421 [Abstract] [Full Text]
Ito, H., Ando, K., Ishikawa, T., Nakayama, T., Taniguchi, M., Saito, K., Imawari, M., Moriwaki, H., Yokochi, T., Kakumu, S., Seishima, M. (2008). Role of V{alpha}14+ NKT cells in the development of Hepatitis B virus-specific CTL: activation of V{alpha}14+ NKT cells promotes the breakage of CTL tolerance. Int Immunol 20: 869-879 [Abstract] [Full Text]
Ford, M. L., Wagener, M. E., Hanna, S. S., Pearson, T. C., Kirk, A. D., Larsen, C. P. (2008). A Critical Precursor Frequency of Donor-Reactive CD4+ T Cell Help Is Required for CD8+ T Cell-Mediated CD28/CD154-Independent Rejection. J. Immunol. 180: 7203-7211 [Abstract] [Full Text]
Ptaschinski, C., Rochford, R. (2008). Infection of neonates with murine gammaherpesvirus 68 results in enhanced viral persistence in lungs and absence of infectious mononucleosis syndrome. J. Gen. Virol. 89: 1114-1121 [Abstract] [Full Text]
Evans, A. G., Moser, J. M., Krug, L. T., Pozharskaya, V., Mora, A. L., Speck, S. H. (2008). A gammaherpesvirus-secreted activator of V{beta}4+ CD8+ T cells regulates chronic infection and immunopathology. JEM 205: 669-684 [Abstract] [Full Text]
Li, H., Chien, P. C. Jr., Tuen, M., Visciano, M. L., Cohen, S., Blais, S., Xu, C.-F., Zhang, H.-T., Hioe, C. E. (2008). Identification of an N-Linked Glycosylation in the C4 Region of HIV-1 Envelope gp120 That Is Critical for Recognition of Neighboring CD4 T Cell Epitopes. J. Immunol. 180: 4011-4021 [Abstract] [Full Text]
Kemball, C. C., Szomolanyi-Tsuda, E., Lukacher, A. E. (2007). Allogeneic Differences in the Dependence on CD4+ T-Cell Help for Virus-Specific CD8+ T-Cell Differentiation. J. Virol. 81: 13743-13753 [Abstract] [Full Text]
Kayhan, B., Yager, E. J., Lanzer, K., Cookenham, T., Jia, Q., Wu, T.-T., Woodland, D. L., Sun, R., Blackman, M. A. (2007). A Replication-Deficient Murine {gamma}-Herpesvirus Blocked in Late Viral Gene Expression Can Establish Latency and Elicit Protective Cellular Immunity. J. Immunol. 179: 8392-8402 [Abstract] [Full Text]
Kupresanin, F., Chow, J., Mount, A., Smith, C. M., Stevenson, P. G., Belz, G. T. (2007). Dendritic Cells Present Lytic Antigens and Maintain Function throughout Persistent {gamma}-Herpesvirus Infection. J. Immunol. 179: 7506-7513 [Abstract] [Full Text]
Gredmark, S., Schlieker, C., Quesada, V., Spooner, E., Ploegh, H. L. (2007). A Functional Ubiquitin-Specific Protease Embedded in the Large Tegument Protein (ORF64) of Murine Gammaherpesvirus 68 Is Active during the Course of Infection. J. Virol. 81: 10300-10309 [Abstract] [Full Text]
Weslow-Schmidt, J. L., Jewell, N. A., Mertz, S. E., Simas, J. P., Durbin, J. E., Flano, E. (2007). Type I Interferon Inhibition and Dendritic Cell Activation during Gammaherpesvirus Respiratory Infection. J. Virol. 81: 9778-9789 [Abstract] [Full Text]
Mothe, B. R., Stewart, B. S., Oseroff, C., Bui, H.-H., Stogiera, S., Garcia, Z., Dow, C., Rodriguez-Carreno, M. P., Kotturi, M., Pasquetto, V., Botten, J., Crotty, S., Janssen, E., Buchmeier, M. J., Sette, A. (2007). Chronic Lymphocytic Choriomeningitis Virus Infection Actively Down-Regulates CD4+ T Cell Responses Directed against a Broad Range of Epitopes. J. Immunol. 179: 1058-1067 [Abstract] [Full Text]
Kemball, C. C., Pack, C. D., Guay, H. M., Li, Z.-N., Steinhauer, D. A., Szomolanyi-Tsuda, E., Lukacher, A. E. (2007). The Antiviral CD8+ T Cell Response Is Differentially Dependent on CD4+ T Cell Help Over the Course of Persistent Infection. J. Immunol. 179: 1113-1121 [Abstract] [Full Text]
Hochreiter, R., Ptaschinski, C., Kunkel, S. L., Rochford, R. (2007). Murine gammaherpesvirus-68 productively infects immature dendritic cells and blocks maturation. J. Gen. Virol. 88: 1896-1905 [Abstract] [Full Text]
Lunemann, J. D., Kamradt, T., Martin, R., Munz, C. (2007). Epstein-Barr Virus: Environmental Trigger of Multiple Sclerosis?. J. Virol. 81: 6777-6784 [Full Text]
Cush, S. S., Anderson, K. M., Ravneberg, D. H., Weslow-Schmidt, J. L., Flano, E. (2007). Memory Generation and Maintenance of CD8+ T Cell Function during Viral Persistence. J. Immunol. 179: 141-153 [Abstract] [Full Text]
Singh, A., Wuthrich, M., Klein, B., Suresh, M. (2007). Indirect Regulation of CD4 T-Cell Responses by Tumor Necrosis Factor Receptors in an Acute Viral Infection. J. Virol. 81: 6502-6512 [Abstract] [Full Text]
Wiertz, E. J., Devlin, R., Collins, H. L., Ressing, M. E. (2007). Herpesvirus Interference with Major Histocompatibility Complex Class II-Restricted T-Cell Activation. J. Virol. 81: 4389-4396 [Full Text]
Fuse, S., Bellfy, S., Yagita, H., Usherwood, E. J. (2007). CD8+ T Cell Dysfunction and Increase in Murine Gammaherpesvirus Latent Viral Burden in the Absence of 4-1BB Ligand. J. Immunol. 178: 5227-5236 [Abstract] [Full Text]
Tilton, J. C., Luskin, M. R., Johnson, A. J., Manion, M., Hallahan, C. W., Metcalf, J. A., McLaughlin, M., Davey, R. T. Jr., Connors, M. (2007). Changes in Paracrine Interleukin-2 Requirement, CCR7 Expression, Frequency, and Cytokine Secretion of Human Immunodeficiency Virus-Specific CD4+ T Cells Are a Consequence of Antigen Load. J. Virol. 81: 2713-2725 [Abstract] [Full Text]
Kim, I.-J., Burkum, C. E., Cookenham, T., Schwartzberg, P. L., Woodland, D. L., Blackman, M. A. (2007). Perturbation of B Cell Activation in SLAM-Associated Protein-Deficient Mice Is Associated with Changes in Gammaherpesvirus Latency Reservoirs. J. Immunol. 178: 1692-1701 [Abstract] [Full Text]
Kennedy, R., Celis, E. (2006). T Helper Lymphocytes Rescue CTL from Activation-Induced Cell Death.. J. Immunol. 177: 2862-2872 [Abstract] [Full Text]
Okazaki, T., Pendleton, C. D., Sarobe, P., Thomas, E. K., Iyengar, S., Harro, C., Schwartz, D., Berzofsky, J. A. (2006). Epitope Enhancement of a CD4 HIV Epitope toward the Development of the Next Generation HIV Vaccine. J. Immunol. 176: 3753-3759 [Abstract] [Full Text]
Steed, A. L., Barton, E. S., Tibbetts, S. A., Popkin, D. L., Lutzke, M. L., Rochford, R., Virgin, H. W. IV (2006). Gamma Interferon Blocks Gammaherpesvirus Reactivation from Latency. J. Virol. 80: 192-200 [Abstract] [Full Text]
Tarakanova, V. L., Suarez, F., Tibbetts, S. A., Jacoby, M. A., Weck, K. E., Hess, J. L., Speck, S. H., Virgin, H. W. IV (2005). Murine Gammaherpesvirus 68 Infection Is Associated with Lymphoproliferative Disease and Lymphoma in BALB {beta}2 Microglobulin-Deficient Mice. J. Virol. 79: 14668-14679 [Abstract] [Full Text]
Barton, E. S., Lutzke, M. L., Rochford, R., Virgin, H. W. IV (2005). Alpha/Beta Interferons Regulate Murine Gammaherpesvirus Latent Gene Expression and Reactivation from Latency. J. Virol. 79: 14149-14160 [Abstract] [Full Text]
Piriou, E., van Dort, K., Nanlohy, N. M., van Oers, M. H. J., Miedema, F., van Baarle, D. (2005). Loss of EBNA1-specific memory CD4+ and CD8+ T cells in HIV-infected patients progressing to AIDS-related non-Hodgkin lymphoma. Blood 106: 3166-3174 [Abstract] [Full Text]
Schulze zur Wiesch, J., Lauer, G. M., Day, C. L., Kim, A. Y., Ouchi, K., Duncan, J. E., Wurcel, A. G., Timm, J., Jones, A. M., Mothe, B., Allen, T. M., McGovern, B., Lewis-Ximenez, L., Sidney, J., Sette, A., Chung, R. T., Walker, B. D. (2005). Broad Repertoire of the CD4+ Th Cell Response in Spontaneously Controlled Hepatitis C Virus Infection Includes Dominant and Highly Promiscuous Epitopes. J. Immunol. 175: 3603-3613 [Abstract] [Full Text]
Brooks, D. G., Teyton, L., Oldstone, M. B. A., McGavern, D. B. (2005). Intrinsic Functional Dysregulation of CD4 T Cells Occurs Rapidly following Persistent Viral Infection. J. Virol. 79: 10514-10527 [Abstract] [Full Text]
Chen, G., Tai, A. K., Lin, M., Chang, F., Terhorst, C., Huber, B. T. (2005). Signaling Lymphocyte Activation Molecule-Associated Protein Is a Negative Regulator of the CD8 T Cell Response in Mice. J. Immunol. 175: 2212-2218 [Abstract] [Full Text]
Piriou, E., Jansen, C. A., Dort, K. v., De Cuyper, I., Nanlohy, N. M., Lange, J. M. A., van Oers, M. H. J., Miedema, F., van Baarle, D. (2005). Reconstitution of EBV Latent but Not Lytic Antigen-Specific CD4+ and CD8+ T Cells after HIV Treatment with Highly Active Antiretroviral Therapy. J. Immunol. 175: 2010-2017 [Abstract] [Full Text]
Lee, B. J., Giannoni, F., Lyon, A., Yada, S., Lu, B., Gerard, C., Sarawar, S. R. (2005). Role of CXCR3 in the Immune Response to Murine Gammaherpesvirus 68. J. Virol. 79: 9351-9355 [Abstract] [Full Text]
Steinaa, L., Rasmussen, P. B., Wegener, A. M., Sonderbye, L., Leach, D. R., Rygaard, J., Mouritsen, S., Gautam, A. M. (2005). Linked Foreign T-Cell Help Activates Self-Reactive CTL and Inhibits Tumor Growth. J. Immunol. 175: 329-334 [Abstract] [Full Text]
Giannoni, F., Lyon, A. B., Wareing, M. D., Dias, P. B., Sarawar, S. R. (2005). Protein Kinase C {theta} Is Not Essential for T-Cell-Mediated Clearance of Murine Gammaherpesvirus 68. J. Virol. 79: 6808-6813 [Abstract] [Full Text]
Flano, E., Jia, Q., Moore, J., Woodland, D. L., Sun, R., Blackman, M. A. (2005). Early Establishment of {gamma}-Herpesvirus Latency: Implications for Immune Control. J. Immunol. 174: 4972-4978 [Abstract] [Full Text]
May, J. S., Coleman, H. M., Boname, J. M., Stevenson, P. G. (2005). Murine gammaherpesvirus-68 ORF28 encodes a non-essential virion glycoprotein. J. Gen. Virol. 86: 919-928 [Abstract] [Full Text]
Gray, P. M., Arimilli, S., Palmer, E. M., Parks, G. D., Alexander-Miller, M. A. (2005). Altered Function in CD8+ T Cells following Paramyxovirus Infection of the Respiratory Tract. J. Virol. 79: 3339-3349 [Abstract] [Full Text]
Braaten, D. C., Sparks-Thissen, R. L., Kreher, S., Speck, S. H., Virgin, H. W. IV (2005). An Optimized CD8+ T-Cell Response Controls Productive and Latent Gammaherpesvirus Infection. J. Virol. 79: 2573-2583 [Abstract] [Full Text]
Bullock, T. N. J., Yagita, H. (2005). Induction of CD70 on Dendritic Cells through CD40 or TLR Stimulation Contributes to the Development of CD8+ T Cell Responses in the Absence of CD4+ T Cells. J. Immunol. 174: 710-717 [Abstract] [Full Text]
Loh, J., Thomas, D. A., Revell, P. A., Ley, T. J., Virgin, H. W. IV (2004). Granzymes and Caspase 3 Play Important Roles in Control of Gammaherpesvirus Latency. J. Virol. 78: 12519-12528 [Abstract] [Full Text]
Yarilin, D. A., Valiando, J., Posnett, D. N. (2004). A Mouse Herpesvirus Induces Relapse of Experimental Autoimmune Arthritis by Infection of the Inflammatory Target Tissue. J. Immunol. 173: 5238-5246 [Abstract] [Full Text]
Stewart, J. P., Silvia, O. J., Atkin, I. M. D., Hughes, D. J., Ebrahimi, B., Adler, H. (2004). In Vivo Function of a Gammaherpesvirus Virion Glycoprotein: Influence on B-Cell Infection and Mononucleosis. J. Virol. 78: 10449-10459 [Abstract] [Full Text]
Obar, J. J., Crist, S. G., Leung, E. K., Usherwood, E. J. (2004). IL-15-Independent Proliferative Renewal of Memory CD8+ T Cells in Latent Gammaherpesvirus Infection. J. Immunol. 173: 2705-2714 [Abstract] [Full Text]
Yao, Q., Zhang, R., Guo, L., Li, M., Chen, C. (2004). Th Cell-Independent Immune Responses to Chimeric Hemagglutinin/Simian Human Immunodeficiency Virus-Like Particles Vaccine. J. Immunol. 173: 1951-1958 [Abstract] [Full Text]
Sparks-Thissen, R. L., Braaten, D. C., Kreher, S., Speck, S. H., Virgin, H. W. IV (2004). An Optimized CD4 T-Cell Response Can Control Productive and Latent Gammaherpesvirus Infection. J. Virol. 78: 6827-6835 [Abstract] [Full Text]
McClellan, J. S., Tibbetts, S. A., Gangappa, S., Brett, K. A., Virgin, H. W. IV (2004). Critical Role of CD4 T Cells in an Antibody-Independent Mechanism of Vaccination against Gammaherpesvirus Latency. J. Virol. 78: 6836-6845 [Abstract] [Full Text]
Chen, Q., Jackson, H., Parente, P., Luke, T., Rizkalla, M., Tai, T. Y., Zhu, H.-C., Mifsud, N. A., Dimopoulos, N., Masterman, K.-A., Hopkins, W., Goldie, H., Maraskovsky, E., Green, S., Miloradovic, L., McCluskey, J., Old, L. J., Davis, I. D., Cebon, J., Chen, W. (2004). Immunodominant CD4+ responses identified in a patient vaccinated with full-length NY-ESO-1 formulated with ISCOMATRIX adjuvant. Proc. Natl. Acad. Sci. USA 101: 9363-9368 [Abstract] [Full Text]
Wherry, E. J., Ahmed, R. (2004). Memory CD8 T-Cell Differentiation during Viral Infection. J. Virol. 78: 5535-5545 [Full Text]
Suresh, M., Gao, X., Fischer, C., Miller, N. E., Tewari, K. (2004). Dissection of Antiviral and Immune Regulatory Functions of Tumor Necrosis Factor Receptors in a Chronic Lymphocytic Choriomeningitis Virus Infection. J. Virol. 78: 3906-3918 [Abstract] [Full Text]
Richards, D. M., Dalheimer, S. L., Ehst, B. D., Vanasek, T. L., Jenkins, M. K., Hertz, M. I., Mueller, D. L. (2004). Indirect Minor Histocompatibility Antigen Presentation by Allograft Recipient Cells in the Draining Lymph Node Leads to the Activation and Clonal Expansion of CD4+ T Cells That Cause Obliterative Airways Disease. J. Immunol. 172: 3469-3479 [Abstract] [Full Text]
Andreansky, S., Liu, H., Adler, H., Koszinowski, U. H., Efstathiou, S., Doherty, P. C. (2004). The limits of protection by "memory" T cells in Ig-/- mice persistently infected with a {gamma}-herpesvirus. Proc. Natl. Acad. Sci. USA 101: 2017-2022 [Abstract] [Full Text]
Landais, E., Saulquin, X., Scotet, E., Trautmann, L., Peyrat, M.-A., Yates, J. L., Kwok, W. W., Bonneville, M., Houssaint, E. (2004). Direct killing of Epstein-Barr virus (EBV)-infected B cells by CD4 T cells directed against the EBV lytic protein BHRF1. Blood 103: 1408-1416 [Abstract] [Full Text]
Shoukry, N. H., Sidney, J., Sette, A., Walker, C. M. (2004). Conserved Hierarchy of Helper T Cell Responses in a Chimpanzee during Primary and Secondary Hepatitis C Virus Infections. J. Immunol. 172: 483-492 [Abstract] [Full Text]
Elsawa, S. F., Bost, K. L. (2004). Murine {gamma}-Herpesvirus-68-Induced IL-12 Contributes to the Control of Latent Viral Burden, but Also Contributes to Viral-Mediated Leukocytosis. J. Immunol. 172: 516-524 [Abstract] [Full Text]
van den Broeke, L. T., Daschbach, E., Thomas, E. K., Andringa, G., Berzofsky, J. A. (2003). Dendritic Cell-Induced Activation of Adaptive and Innate Antitumor Immunity. J. Immunol. 171: 5842-5852 [Abstract] [Full Text]
Probst, H. C., Tschannen, K., Gallimore, A., Martinic, M., Basler, M., Dumrese, T., Jones, E., van den Broek, M. F. (2003). Immunodominance of an Antiviral Cytotoxic T Cell Response Is Shaped by the Kinetics of Viral Protein Expression. J. Immunol. 171: 5415-5422 [Abstract] [Full Text]
Iyasere, C., Tilton, J. C., Johnson, A. J., Younes, S., Yassine-Diab, B., Sekaly, R.-P., Kwok, W. W., Migueles, S. A., Laborico, A. C., Shupert, W. L., Hallahan, C. W., Davey, R. T. Jr., Dybul, M., Vogel, S., Metcalf, J., Connors, M. (2003). Diminished Proliferation of Human Immunodeficiency Virus-Specific CD4+ T Cells Is Associated with Diminished Interleukin-2 (IL-2) Production and Is Recovered by Exogenous IL-2. J. Virol. 77: 10900-10909 [Abstract] [Full Text]
Ressing, M. E., van Leeuwen, D., Verreck, F. A. W., Gomez, R., Heemskerk, B., Toebes, M., Mullen, M. M., Jardetzky, T. S., Longnecker, R., Schilham, M. W., Ottenhoff, T. H. M., Neefjes, J., Schumacher, T. N., Hutt-Fletcher, L. M., Wiertz, E. J. H. J. (2003). Interference with T cell receptor-HLA-DR interactions by Epstein-Barr virus gp42 results in reduced T helper cell recognition. Proc. Natl. Acad. Sci. USA 100: 11583-11588 [Abstract] [Full Text]
Macrae, A. I., Usherwood, E. J., Husain, S. M., Flano, E., Kim, I.-J., Woodland, D. L., Nash, A. A., Blackman, M. A., Sample, J. T., Stewart, J. P. (2003). Murid Herpesvirus 4 Strain 68 M2 Protein Is a B-Cell-Associated Antigen Important for Latency but Not Lymphocytosis. J. Virol. 77: 9700-9709 [Abstract] [Full Text]
Liu, H., Andreansky, S., Diaz, G., Turner, S. J., Wodarz, D., Doherty, P. C. (2003). Quantitative Analysis of Long-Term Virus-Specific CD8+-T-Cell Memory in Mice Challenged with Unrelated Pathogens. J. Virol. 77: 7756-7763 [Abstract] [Full Text]
Kim, I.-J., Flano, E., Woodland, D. L., Lund, F. E., Randall, T. D., Blackman, M. A. (2003). Maintenance of Long Term {gamma}-Herpesvirus B Cell Latency Is Dependent on CD40-Mediated Development of Memory B Cells. J. Immunol. 171: 886-892 [Abstract] [Full Text]
Marques, S., Efstathiou, S., Smith, K. G., Haury, M., Simas, J. P. (2003). Selective Gene Expression of Latent Murine Gammaherpesvirus 68 in B Lymphocytes. J. Virol. 77: 7308-7318 [Abstract] [Full Text]
Tibbetts, S. A., Loh, J., van Berkel, V., McClellan, J. S., Jacoby, M. A., Kapadia, S. B., Speck, S. H., Virgin, H. W. IV (2003). Establishment and Maintenance of Gammaherpesvirus Latency Are Independent of Infective Dose and Route of Infection. J. Virol. 77: 7696-7701 [Abstract] [Full Text]
Meij, P., van Esser, J. W. J., Niesters, H. G. M., van Baarle, D., Miedema, F., Blake, N., Rickinson, A. B., Leiner, I., Pamer, E., Lowenberg, B., Cornelissen, J. J., Gratama, J. W. (2003). Impaired recovery of Epstein-Barr virus (EBV)--specific CD8+ T lymphocytes after partially T-depleted allogeneic stem cell transplantation may identify patients at very high risk for progressive EBV reactivation and lymphoproliferative disease. Blood 101: 4290-4297 [Abstract] [Full Text]
Pavlova, I. V., Virgin, H. W. IV, Speck, S. H. (2003). Disruption of Gammaherpesvirus 68 Gene 50 Demonstrates that Rta Is Essential for Virus Replication. J. Virol. 77: 5731-5739 [Abstract] [Full Text]
van Dyk, L. F., Virgin, H. W. IV, Speck, S. H. (2003). Maintenance of Gammaherpesvirus Latency Requires Viral Cyclin in the Absence of B Lymphocytes. J. Virol. 77: 5118-5126 [Abstract] [Full Text]
Wherry, E. J., Blattman, J. N., Murali-Krishna, K., van der Most, R., Ahmed, R. (2003). Viral Persistence Alters CD8 T-Cell Immunodominance and Tissue Distribution and Results in Distinct Stages of Functional Impairment. J. Virol. 77: 4911-4927 [Abstract] [Full Text]
Flano, E., Kim, I.-J., Moore, J., Woodland, D. L., Blackman, M. A. (2003). Differential {gamma}-Herpesvirus Distribution in Distinct Anatomical Locations and Cell Subsets During Persistent Infection in Mice. J. Immunol. 170: 3828-3834 [Abstract] [Full Text]
Elsawa, S. F., Taylor, W., Petty, C. C., Marriott, I., Weinstock, J. V., Bost, K. L. (2003). Reduced CTL Response and Increased Viral Burden in Substance P Receptor-Deficient Mice Infected with Murine {gamma}-Herpesvirus 68. J. Immunol. 170: 2605-2612 [Abstract] [Full Text]
Welters, M. J. P., de Jong, A., van den Eeden, S. J. F., van der Hulst, J. M., Kwappenberg, K. M. C., Hassane, S., Franken, K. L. M. C., Drijfhout, J. W., Fleuren, G. J., Kenter, G., Melief, C. J. M., Offringa, R., van der Burg, S. H. (2003). Frequent Display of Human Papillomavirus Type 16 E6-specific Memory T-Helper Cells in the Healthy Population as Witness of Previous Viral Encounter. Cancer Res. 63: 636-641 [Abstract] [Full Text]
Ely, K. H., Cauley, L. S., Roberts, A. D., Brennan, J. W., Cookenham, T., Woodland, D. L. (2003). Nonspecific Recruitment of Memory CD8+ T Cells to the Lung Airways During Respiratory Virus Infections. J. Immunol. 170: 1423-1429 [Abstract] [Full Text]
Belz, G. T., Liu, H., Andreansky, S., Doherty, P. C., Stevenson, P. G. (2003). Absence of a functional defect in CD8+ T cells during primary murine gammaherpesvirus-68 infection of I-Ab-/- mice. J. Gen. Virol. 84: 337-341 [Abstract] [Full Text]
Flano, E., Kim, I.-J., Woodland, D. L., Blackman, M. A. (2002). {gamma}-Herpesvirus Latency Is Preferentially Maintained in Splenic Germinal Center and Memory B Cells. JEM 196: 1363-1372 [Abstract] [Full Text]
Day, C. L., Lauer, G. M., Robbins, G. K., McGovern, B., Wurcel, A. G., Gandhi, R. T., Chung, R. T., Walker, B. D. (2002). Broad Specificity of Virus-Specific CD4+ T-Helper-Cell Responses in Resolved Hepatitis C Virus Infection. J. Virol. 76: 12584-12595 [Abstract] [Full Text]
Belz, G. T., Wodarz, D., Diaz, G., Nowak, M. A., Doherty, P. C. (2002). Compromised Influenza Virus-Specific CD8+-T-Cell Memory in CD4+-T-Cell-Deficient Mice. J. Virol. 76: 12388-12393 [Abstract] [Full Text]
Schepers, K., Toebes, M., Sotthewes, G., Vyth-Dreese, F. A., Dellemijn, T. A. M., Melief, C. J. M., Ossendorp, F., Schumacher, T. N. M. (2002). Differential Kinetics of Antigen-Specific CD4+ and CD8+ T Cell Responses in the Regression of Retrovirus-Induced Sarcomas. J. Immunol. 169: 3191-3199 [Abstract] [Full Text]
Weinberg, J. B., Lutzke, M. L., Efstathiou, S., Kunkel, S. L., Rochford, R. (2002). Elevated Chemokine Responses Are Maintained in Lungs after Clearance of Viral Infection. J. Virol. 76: 10518-10523 [Abstract] [Full Text]
Shrikant, P., Mescher, M. F. (2002). Opposing Effects of IL-2 in Tumor Immunotherapy: Promoting CD8 T Cell Growth and Inducing Apoptosis. J. Immunol. 169: 1753-1759 [Abstract] [Full Text]
Kadin, M. E. (2002). T-Cell Clonality in Pityriasis Lichenoides: Evidence for a Premalignant or Reactive Immune Disorder?. Arch Dermatol 138: 1089-1090 [Full Text]
Paludan, C., Bickham, K., Nikiforow, S., Tsang, M. L., Goodman, K., Hanekom, W. A., Fonteneau, J.-F., Stevanovic, S., Munz, C. (2002). Epstein-Barr Nuclear Antigen 1-Specific CD4+ Th1 Cells Kill Burkitt's Lymphoma Cells. J. Immunol. 169: 1593-1603 [Abstract] [Full Text]
Tibbetts, S. A., van Dyk, L. F., Speck, S. H., Virgin, H. W. IV (2002). Immune Control of the Number and Reactivation Phenotype of Cells Latently Infected with a Gammaherpesvirus. J. Virol. 76: 7125-7132 [Abstract] [Full Text]
Clambey, E. T., Virgin, H. W. IV, Speck, S. H. (2002). Characterization of a Spontaneous 9.5-Kilobase-Deletion Mutant of Murine Gammaherpesvirus 68 Reveals Tissue-Specific Genetic Requirements for Latency. J. Virol. 76: 6532-6544 [Abstract] [Full Text]
Kim, I.-J., Flano, E., Woodland, D. L., Blackman, M. A. (2002). Antibody-Mediated Control of Persistent {gamma}-Herpesvirus Infection. J. Immunol. 168: 3958-3964 [Abstract] [Full Text]