The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF)

doi:10.1084/jem.184.3.1185

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The seven-span transmembrane receptor CD97 has a cellular ligand (CD55, DAF)

J Hamann, B Vogel, GM van Schijndel and RA van Lier
Department of Clinical Viro Immunology, Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, University of Austerdam, The Netherlands.

CD97 is an activation-induced antigen on leukocytes with a seven-span transmembrane (7-TM) region homologous to the secretin receptor superfamily. However, in contrast to this group of peptide hormone receptors, CD97 has an extended extracellular region with three EGF domains at the NH2 terminus, two of them with a calcium binding site. By demonstrating that lymphocytes and erythrocytes specifically adhere to CD97-transfected COS cells we here show that CD97 in parallel with its molecular evolution has acquired the ability to bind cellular ligands. A mAb selected on its capacity to block the adhesion between CD97 transfectants and red cells was found to be directed to the NH2- terminal short consensus repeat (SCR) of decay accelerating factor (DAF, CD55), a regulatory protein of the complement cascade. The specificity of the interaction of CD97 with CD55 was established by the observation that erythrocytes that lack CD55, obtained from patients with paroxysmal nocturnal hemoglobinuria (PNH) or the CD55, phenotype Inab, failed to adhere to CD97 transfectants. This is the first demonstration of a cellular ligand for a 7-TM receptor.
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Caragine, T. A., Imai, M., Frey, A. B., Tomlinson, S. (2002). Expression of rat complement control protein Crry on tumor cells inhibits rat natural killer cell-mediated cytotoxicity. Blood 100: 3304-3310 [Abstract] [Full Text]
Miwa, T., Maldonado, M. A., Zhou, L., Sun, X., Luo, H. Y., Cai, D., Werth, V. P., Madaio, M. P., Eisenberg, R. A., Song, W.-C. (2002). Deletion of Decay-Accelerating Factor (CD55) Exacerbates Autoimmune Disease Development in MRL/lpr Mice. Am. J. Pathol. 161: 1077-1086 [Abstract] [Full Text]
Stacey, M., Chang, G.-W., Sanos, S. L., Chittenden, L. R., Stubbs, L., Gordon, S., Lin, H.-H. (2002). EMR4, a Novel Epidermal Growth Factor (EGF)-TM7 Molecule Up-regulated in Activated Mouse Macrophages, Binds to a Putative Cellular Ligand on B Lymphoma Cell Line A20. J. Biol. Chem. 277: 29283-29293 [Abstract] [Full Text]
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Caminschi, I., Lucas, K. M., O'Keeffe, M. A., Hochrein, H., Laabi, Y., Kontgen, F., Lew, A. M., Shortman, K., Wright, M. D. (2001). Molecular Cloning of F4/80-Like-Receptor, a Seven-Span Membrane Protein Expressed Differentially by Dendritic Cell and Monocyte-Macrophage Subpopulations. J. Immunol. 167: 3570-3576 [Abstract] [Full Text]
Terskikh, A. V., Easterday, M. C., Li, L., Hood, L., Kornblum, H. I., Geschwind, D. H., Weissman, I. L. (2001). From the Cover: From hematopoiesis to neuropoiesis: Evidence of overlapping genetic programs. Proc. Natl. Acad. Sci. USA 98: 7934-7939 [Abstract] [Full Text]
Eichler, W. (2000). CD97 isoform expression in leukocytes. J. Leukoc. Biol. 68: 561-567 [Abstract] [Full Text]
Nikkila, H., McMillan, D. R., Nunez, B. S., Pascoe, L., Curnow, K. M., White, P. C. (2000). Sequence Similarities between a Novel Putative G Protein-Coupled Receptor and Na+/Ca2+ Exchangers Define a Cation Binding Domain. Mol. Endocrinol. 14: 1351-1364 [Abstract] [Full Text]
Perez de la Lastra, J. M., Harris, C. L., Hinchliffe, S. J., Holt, D. S., Rushmere, N. K., Morgan, B. P. (2000). Pigs Express Multiple Forms of Decay-Accelerating Factor (CD55), All of Which Contain Only Three Short Consensus Repeats. J. Immunol. 165: 2563-2573 [Abstract] [Full Text]
Hamann, J., van Zeventer, C., Bijl, A., Molenaar, C., Tesselaar, K., van Lier, R. A. W. (2000). Molecular cloning and characterization of mouse CD97. Int Immunol 12: 439-448 [Abstract] [Full Text]
Powell, R. M., Ward, T., Goodfellow, I., Almond, J. W., Evans, D. J. (1999). Mapping the binding domains on decay accelerating factor (DAF) for haemagglutinating enteroviruses: implications for the evolution of a DAF-binding phenotype. J. Gen. Virol. 80: 3145-3152 [Abstract] [Full Text]
Mason, J. C., Yarwood, H., Sugars, K., Morgan, B. P., Davies, K. A., Haskard, D. O. (1999). Induction of Decay-Accelerating Factor by Cytokines or the Membrane-Attack Complex Protects Vascular Endothelial Cells Against Complement Deposition. Blood 94: 1673-1682 [Abstract] [Full Text]
Spendlove, I., Li, L., Carmichael, J., Durrant, L. G. (1999). Decay Accelerating Factor (CD55): A Target for Cancer Vaccines?. Cancer Res. 59: 2282-2286 [Abstract] [Full Text]
Shafren, D. R. (1998). Viral Cell Entry Induced by Cross-Linked Decay-Accelerating Factor. J. Virol. 72: 9407-9412 [Abstract] [Full Text]
Wang, G., Nonaka, M., He, C., Okada, N., Nakashima, I., Okada, H. (1998). Functional Differences Among Multiple Isoforms of Guinea Pig Decay-Accelerating Factor. J. Immunol. 160: 3014-3022 [Abstract] [Full Text]
Shafren, D. R., Dorahy, D. J., Thorne, R. F., Kinoshita, T., Barry, R. D., Burns, G. F. (1998). Antibody Binding to Individual Short Consensus Repeats of Decay-Accelerating Factor Enhances Enterovirus Cell Attachment and Infectivity. J. Immunol. 160: 2318-2323 [Abstract] [Full Text]
Nechiporuk, T., Urness, L. D., Keating, M. T. (2001). ETL, a Novel Seven-transmembrane Receptor That Is Developmentally Regulated in the Heart. ETL IS A MEMBER OF THE SECRETIN FAMILY AND BELONGS TO THE EPIDERMAL GROWTH FACTOR-SEVEN-TRANSMEMBRANE SUBFAMILY. J. Biol. Chem. 276: 4150-4157 [Abstract] [Full Text]
Stacey, M., Lin, H.-H., Hilyard, K. L., Gordon, S., McKnight, A. J. (2001). Human Epidermal Growth Factor (EGF) Module-containing Mucin-like Hormone Receptor 3 Is a New Member of the EGF-TM7 Family That Recognizes a Ligand on Human Macrophages and Activated Neutrophils. J. Biol. Chem. 276: 18863-18870 [Abstract] [Full Text]
Lin, H.-H., Stacey, M., Saxby, C., Knott, V., Chaudhry, Y., Evans, D., Gordon, S., McKnight, A. J., Handford, P., Lea, S. (2001). Molecular Analysis of the Epidermal Growth Factor-like Short Consensus Repeat Domain-mediated Protein-Protein Interactions. DISSECTION OF THE CD97-CD55 COMPLEX. J. Biol. Chem. 276: 24160-24169 [Abstract] [Full Text]