A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

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A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1)

CC Bleul, RC Fuhlbrigge, JM Casasnovas, A Aiuti and TA Springer
The Center for Blood Research, Harvard Medical School, Department of Pathology, Boston, Massachusetts 02115, USA.

Chemotactic factors are postulated to direct emigration of lymphocytes from the blood stream into sites of inflammation. Members of a family of chemotactic cytokines, termed chemokines, have been shown to attract lymphocytes but efficacy, i.e., the maximal percentage of attracted cells, has been low. We have identified a highly efficacious lymphocyte chemotactic activity in the supernatants of the murine bone marrow stroma cell line MS-5 which attracts 10-fold more lymphocytes in vitro than currently described lymphocyte chemoattractants. Purification of this chemotactic activity revealed identity to stromal cell-derived factor 1 (SDF-1). SDF-1 acts on lymphocytes and monocytes but not neutrophils in vitro and is both a highly efficacious and highly potent mononuclear cell attractant in vivo. In addition, SDF-1 induces intracellular actin polymerization in lymphocytes, a process that is thought to be a prerequisite for cell motility. Since SDF-1 is expressed constitutively in a broad range of tissues it may have a role in immune surveillance and in basal extravasation of lymphocytes and monocytes rather than in inflammation.
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Zhang, X., Dong, H., Lin, W., Voss, S., Hinkley, L., Westergren, M., Tian, G., Berry, D., Lewellen, D., Vile, R. G., Chen, L., Farber, D. L., Strome, S. E. (2006). Human Bone Marrow: A Reservoir for "Enhanced Effector Memory" CD8+ T Cells with Potent Recall Function. J. Immunol. 177: 6730-6737 [Abstract] [Full Text]
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Goda, S., Inoue, H., Umehara, H., Miyaji, M., Nagano, Y., Harakawa, N., Imai, H., Lee, P., MaCarthy, J. B., Ikeo, T., Domae, N., Shimizu, Y., Iida, J. (2006). Matrix Metalloproteinase-1 Produced by Human CXCL12-Stimulated Natural Killer Cells. Am. J. Pathol. 169: 445-458 [Abstract] [Full Text]
Humpert, P. M., Battista, M. J., Lammert, A., Reismann, P., Djuric, Z., Rudofsky, G. Jr, Zorn, M., Morcos, M., Hammes, H.-P., Nawroth, P. P., Bierhaus, A. (2006). Association of stromal cell-derived factor 1 genotype with diabetic foot syndrome and macrovascular disease in patients with type 2 diabetes.. Clin. Chem. 52: 1206-1208 [Full Text]
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Richardson, S. J., Matthews, C., Catherwood, M. A., Alexander, H. D., Carey, B. S., Farrugia, J., Gardiner, A., Mould, S., Oscier, D., Copplestone, J. A., Prentice, A. G. (2006). ZAP-70 expression is associated with enhanced ability to respond to migratory and survival signals in B-cell chronic lymphocytic leukemia (B-CLL). Blood 107: 3584-3592 [Abstract] [Full Text]
Fushimi, T., O'Connor, T. P., Crystal, R. G. (2006). Adenoviral gene transfer of stromal cell-derived factor-1 to murine tumors induces the accumulation of dendritic cells and suppresses tumor growth.. Cancer Res. 66: 3513-3522 [Abstract] [Full Text]
Vianello, F., Papeta, N., Chen, T., Kraft, P., White, N., Hart, W. K., Kircher, M. F., Swart, E., Rhee, S., Palu, G., Irimia, D., Toner, M., Weissleder, R., Poznansky, M. C. (2006). Murine B16 Melanomas Expressing High Levels of the Chemokine Stromal-Derived Factor-1/CXCL12 Induce Tumor-Specific T Cell Chemorepulsion and Escape from Immune Control.. J. Immunol. 176: 2902-2914 [Abstract] [Full Text]
Goichberg, P., Kalinkovich, A., Borodovsky, N., Tesio, M., Petit, I., Nagler, A., Hardan, I., Lapidot, T. (2006). cAMP-induced PKC{zeta} activation increases functional CXCR4 expression on human CD34+ hematopoietic progenitors. Blood 107: 870-879 [Abstract] [Full Text]
Narducci, M. G., Scala, E., Bresin, A., Caprini, E., Picchio, M. C., Remotti, D., Ragone, G., Nasorri, F., Frontani, M., Arcelli, D., Volinia, S., Lombardo, G. A., Baliva, G., Napolitano, M., Russo, G. (2006). Skin homing of Sezary cells involves SDF-1-CXCR4 signaling and down-regulation of CD26/dipeptidylpeptidase IV. Blood 107: 1108-1115 [Abstract] [Full Text]
Gerli, G., Vanelli, C., Turri, O., Erario, M., Gardellini, A., Pugliano, M., Biondi, M. L. (2005). SDF1-3'A Gene Polymorphism Is Associated with Chronic Myeloproliferative Disease and Thrombotic Events. Clin. Chem. 51: 2411-2414 [Full Text]
Vianello, F., Kraft, P., Mok, Y. T., Hart, W. K., White, N., Poznansky, M. C. (2005). A CXCR4-Dependent Chemorepellent Signal Contributes to the Emigration of Mature Single-Positive CD4 Cells from the Fetal Thymus. J. Immunol. 175: 5115-5125 [Abstract] [Full Text]
Rosu-Myles, M., Stewart, E., Trowbridge, J., Ito, C. Y., Zandstra, P., Bhatia, M. (2005). A unique population of bone marrow cells migrates to skeletal muscle via hepatocyte growth factor/c-met axis. J. Cell Sci. 118: 4343-4352 [Abstract] [Full Text]
Vasyutina, E., Stebler, J., Brand-Saberi, B., Schulz, S., Raz, E., Birchmeier, C. (2005). CXCR4 and Gab1 cooperate to control the development of migrating muscle progenitor cells. Genes Dev. 19: 2187-2198 [Abstract] [Full Text]
Seo, S., Asai, T., Saito, T., Suzuki, T., Morishita, Y., Nakamoto, T., Ichikawa, M., Yamamoto, G., Kawazu, M., Yamagata, T., Sakai, R., Mitani, K., Ogawa, S., Kurokawa, M., Chiba, S., Hirai, H. (2005). Crk-Associated Substrate Lymphocyte Type Is Required for Lymphocyte Trafficking and Marginal Zone B Cell Maintenance. J. Immunol. 175: 3492-3501 [Abstract] [Full Text]
Vermaelen, K., Pauwels, R. (2005). Pulmonary Dendritic Cells. Am. J. Respir. Crit. Care Med. 172: 530-551 [Abstract] [Full Text]
Burger, M., Hartmann, T., Krome, M., Rawluk, J., Tamamura, H., Fujii, N., Kipps, T. J., Burger, J. A. (2005). Small peptide inhibitors of the CXCR4 chemokine receptor (CD184) antagonize the activation, migration, and antiapoptotic responses of CXCL12 in chronic lymphocytic leukemia B cells. Blood 106: 1824-1830 [Abstract] [Full Text]
Dalakas, E., Newsome, P. N., Harrison, D. J., Plevris, J. N. (2005). Hematopoietic stem cell trafficking in liver injury. FASEB J. 19: 1225-1231 [Abstract] [Full Text]
Zanin-Zhorov, A., Tal, G., Shivtiel, S., Cohen, M., Lapidot, T., Nussbaum, G., Margalit, R., Cohen, I. R., Lider, O. (2005). Heat Shock Protein 60 Activates Cytokine-Associated Negative Regulator Suppressor of Cytokine Signaling 3 in T Cells: Effects on Signaling, Chemotaxis, and Inflammation. J. Immunol. 175: 276-285 [Abstract] [Full Text]
Kimura, R., Nishioka, T., Soemantri, A., Ishida, T. (2005). Allele-specific transcript quantification detects haplotypic variation in the levels of the SDF-1 transcripts. Hum Mol Genet 14: 1579-1585 [Abstract] [Full Text]
Davis, D. A., Singer, K. E., De La Luz Sierra, M., Narazaki, M., Yang, F., Fales, H. M., Yarchoan, R., Tosato, G. (2005). Identification of carboxypeptidase N as an enzyme responsible for C-terminal cleavage of stromal cell-derived factor-1{alpha} in the circulation. Blood 105: 4561-4568 [Abstract] [Full Text]
van Leeuwen, E. M. M., van Buul, J. D., Remmerswaal, E. B. M., Hordijk, P. L., ten Berge, I. J. M., van Lier, R. A. W. (2005). Functional re-expression of CCR7 on CMV-specific CD8+ T cells upon antigenic stimulation. Int Immunol 17: 713-719 [Abstract] [Full Text]
Wysocki, C. A., Panoskaltsis-Mortari, A., Blazar, B. R., Serody, J. S. (2005). Leukocyte migration and graft-versus-host disease. Blood 105: 4191-4199 [Abstract] [Full Text]
Huber, C., Thielen, C., Seeger, H., Schwarz, P., Montrasio, F., Wilson, M. R., Heinen, E., Fu, Y.-X., Miele, G., Aguzzi, A. (2005). Lymphotoxin-{beta} Receptor-Dependent Genes in Lymph Node and Follicular Dendritic Cell Transcriptomes. J. Immunol. 174: 5526-5536 [Abstract] [Full Text]
McDonald, K. G., McDonough, J. S., Newberry, R. D. (2005). Adaptive Immune Responses Are Dispensable for Isolated Lymphoid Follicle Formation: Antigen-Naive, Lymphotoxin-Sufficient B Lymphocytes Drive the Formation of Mature Isolated Lymphoid Follicles. J. Immunol. 174: 5720-5728 [Abstract] [Full Text]
Bendall, L. J., Baraz, R., Juarez, J., Shen, W., Bradstock, K. F. (2005). Defective p38 Mitogen-Activated Protein Kinase Signaling Impairs Chemotaxic but not Proliferative Responses to Stromal-Derived Factor-1{alpha} in Acute Lymphoblastic Leukemia. Cancer Res. 65: 3290-3298 [Abstract] [Full Text]
Diamant, E., Keren, Z., Melamed, D. (2005). CD19 regulates positive selection and maturation in B lymphopoiesis: lack of CD19 imposes developmental arrest of immature B cells and consequential stimulation of receptor editing. Blood 105: 3247-3254 [Abstract] [Full Text]
Saeed, R. W., Varma, S., Peng-Nemeroff, T., Sherry, B., Balakhaneh, D., Huston, J., Tracey, K. J., Al-Abed, Y., Metz, C. N. (2005). Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation. JEM 201: 1113-1123 [Abstract] [Full Text]
Mori, T., Kim, J., Yamano, T., Takeuchi, H., Huang, S., Umetani, N., Koyanagi, K., Hoon, D. S.B. (2005). Epigenetic Up-regulation of C-C Chemokine Receptor 7 and C-X-C Chemokine Receptor 4 Expression in Melanoma Cells. Cancer Res. 65: 1800-1807 [Abstract] [Full Text]
Busso, N., Wagtmann, N., Herling, C., Chobaz-Peclat, V., Bischof-Delaloye, A., So, A., Grouzmann, E. (2005). Circulating CD26 Is Negatively Associated with Inflammation in Human and Experimental Arthritis. Am. J. Pathol. 166: 433-442 [Abstract] [Full Text]
Kryczek, I., Lange, A., Mottram, P., Alvarez, X., Cheng, P., Hogan, M., Moons, L., Wei, S., Zou, L., Machelon, V., Emilie, D., Terrassa, M., Lackner, A., Curiel, T. J., Carmeliet, P., Zou, W. (2005). CXCL12 and Vascular Endothelial Growth Factor Synergistically Induce Neoangiogenesis in Human Ovarian Cancers. Cancer Res. 65: 465-472 [Abstract] [Full Text]
Li, S. S., Forslow, A., Sundqvist, K.-G. (2005). Autocrine Regulation of T Cell Motility by Calreticulin-Thrombospondin-1 Interaction. J. Immunol. 174: 654-661 [Abstract] [Full Text]
Perissinotto, E., Cavalloni, G., Leone, F., Fonsato, V., Mitola, S., Grignani, G., Surrenti, N., Sangiolo, D., Bussolino, F., Piacibello, W., Aglietta, M. (2005). Involvement of Chemokine Receptor 4/Stromal Cell-Derived Factor 1 System during Osteosarcoma Tumor Progression. Clin. Cancer Res. 11: 490-497 [Abstract] [Full Text]
Okabe, S., Fukuda, S., Kim, Y.-J., Niki, M., Pelus, L. M., Ohyashiki, K., Pandolfi, P. P., Broxmeyer, H. E. (2005). Stromal cell-derived factor-1{alpha}/CXCL12-induced chemotaxis of T cells involves activation of the RasGAP-associated docking protein p62Dok-1. Blood 105: 474-480 [Abstract] [Full Text]
Fulkerson, P. C., Zimmermann, N., Hassman, L. M., Finkelman, F. D., Rothenberg, M. E. (2004). Pulmonary Chemokine Expression Is Coordinately Regulated by STAT1, STAT6, and IFN-{gamma}. J. Immunol. 173: 7565-7574 [Abstract] [Full Text]
Princen, K., Hatse, S., Vermeire, K., Aquaro, S., De Clercq, E., Gerlach, L.-O., Rosenkilde, M., Schwartz, T. W., Skerlj, R., Bridger, G., Schols, D. (2004). Inhibition of Human Immunodeficiency Virus Replication by a Dual CCR5/CXCR4 Antagonist. J. Virol. 78: 12996-13006 [Abstract] [Full Text]
Jaleel, M. A., Tsai, A. C., Sarkar, S., Freedman, P. V., Rubin, L. P. (2004). Stromal cell-derived factor-1 (SDF-1) signalling regulates human placental trophoblast cell survival. Mol Hum Reprod 10: 901-909 [Abstract] [Full Text]
Kohrgruber, N., Groger, M., Meraner, P., Kriehuber, E., Petzelbauer, P., Brandt, S., Stingl, G., Rot, A., Maurer, D. (2004). Plasmacytoid Dendritic Cell Recruitment by Immobilized CXCR3 Ligands. J. Immunol. 173: 6592-6602 [Abstract] [Full Text]
LeCouter, J., Zlot, C., Tejada, M., Peale, F., Ferrara, N. (2004). Bv8 and endocrine gland-derived vascular endothelial growth factor stimulate hematopoiesis and hematopoietic cell mobilization. Proc. Natl. Acad. Sci. USA 101: 16813-16818 [Abstract] [Full Text]
Saeed, R. W., Varma, S., Peng, T., Tracey, K. J., Sherry, B., Metz, C. N. (2004). Ethanol Blocks Leukocyte Recruitment and Endothelial Cell Activation In Vivo and In Vitro. J. Immunol. 173: 6376-6383 [Abstract] [Full Text]
Sakihama, H., Masunaga, T., Yamashita, K., Hashimoto, T., Inobe, M., Todo, S., Uede, T. (2004). Stromal Cell-Derived Factor-1 and CXCR4 Interaction Is Critical for Development of Transplant Arteriosclerosis. Circulation 110: 2924-2930 [Abstract] [Full Text]
Niiro, H., Allam, A., Stoddart, A., Brodsky, F. M., Marshall, A. J., Clark, E. A. (2004). The B Lymphocyte Adaptor Molecule of 32 Kilodaltons (Bam32) Regulates B Cell Antigen Receptor Internalization. J. Immunol. 173: 5601-5609 [Abstract] [Full Text]
Garzon, R., Soriano, S. F., Rodriguez-Frade, J. M., Gomez, L., Martin de Ana, A., Sanchez-Gomez, M., Martinez-A, C., Mellado, M. (2004). CXCR4-mediated Suppressor of Cytokine Signaling Up-regulation Inactivates Growth Hormone Function. J. Biol. Chem. 279: 44460-44466 [Abstract] [Full Text]
Huang, M.-B., Jin, L. L., James, C. O., Khan, M., Powell, M. D., Bond, V. C. (2004). Characterization of Nef-CXCR4 Interactions Important for Apoptosis Induction. J. Virol. 78: 11084-11096 [Abstract] [Full Text]
Sadir, R., Imberty, A., Baleux, F., Lortat-Jacob, H. (2004). Heparan Sulfate/Heparin Oligosaccharides Protect Stromal Cell-derived Factor-1 (SDF-1)/CXCL12 against Proteolysis Induced by CD26/Dipeptidyl Peptidase IV. J. Biol. Chem. 279: 43854-43860 [Abstract] [Full Text]
Trentin, L., Cabrelle, A., Facco, M., Carollo, D., Miorin, M., Tosoni, A., Pizzo, P., Binotto, G., Nicolardi, L., Zambello, R., Adami, F., Agostini, C., Semenzato, G. (2004). Homeostatic chemokines drive migration of malignant B cells in patients with non-Hodgkin lymphomas. Blood 104: 502-508 [Abstract] [Full Text]
Rombouts, E. J. C., Pavic, B., Lowenberg, B., Ploemacher, R. E. (2004). Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia. Blood 104: 550-557 [Abstract] [Full Text]
Suratt, B. T., Petty, J. M., Young, S. K., Malcolm, K. C., Lieber, J. G., Nick, J. A., Gonzalo, J.-A., Henson, P. M., Worthen, G. S. (2004). Role of the CXCR4/SDF-1 chemokine axis in circulating neutrophil homeostasis. Blood 104: 565-571 [Abstract] [Full Text]
Fischer, A. M., Mercer, J. C., Iyer, A., Ragin, M. J., August, A. (2004). Regulation of CXC Chemokine Receptor 4-mediated Migration by the Tec Family Tyrosine Kinase ITK. J. Biol. Chem. 279: 29816-29820 [Abstract] [Full Text]
Salvucci, O., Basik, M., Yao, L., Bianchi, R., Tosato, G. (2004). Evidence for the involvement of SDF-1 and CXCR4 in the disruption of endothelial cell-branching morphogenesis and angiogenesis by TNF-{alpha} and IFN-{gamma}. J. Leukoc. Biol. 76: 217-226 [Abstract] [Full Text]
Han, K. H., Hong, K. H., Ko, J., Rhee, K. S., Hong, M. K., Kim, J. J., Kim, Y. H., Park, S. J. (2004). Lysophosphatidylcholine up-regulates CXCR4 chemokine receptor expression in human CD4 T cells. J. Leukoc. Biol. 76: 195-202 [Abstract] [Full Text]
Kuwabara, K., Nakaoka, T., Sato, K., Nishishita, T., Sasaki, T., Yamashita, N. (2004). Differential Regulation of Cell Migration and Proliferation through Proline-Rich Tyrosine Kinase 2 in Endothelial Cells. Endocrinology 145: 3324-3330 [Abstract] [Full Text]
Iqbal, J., Sanger, W. G., Horsman, D. E., Rosenwald, A., Pickering, D. L., Dave, B., Dave, S., Xiao, L., Cao, K., Zhu, Q., Sherman, S., Hans, C. P., Weisenburger, D. D., Greiner, T. C., Gascoyne, R. D., Ott, G., Muller-Hermelink, H. K., Delabie, J., Braziel, R. M., Jaffe, E. S., Campo, E., Lynch, J. C., Connors, J. M., Vose, J. M., Armitage, J. O., Grogan, T. M., Staudt, L. M., Chan, W. C. (2004). BCL2 Translocation Defines a Unique Tumor Subset within the Germinal Center B-Cell-Like Diffuse Large B-Cell Lymphoma. Am. J. Pathol. 165: 159-166 [Abstract] [Full Text]
Kimura, T., Boehmler, A. M., Seitz, G., Kuci, S., Wiesner, T., Brinkmann, V., Kanz, L., Mohle, R. (2004). The sphingosine 1-phosphate receptor agonist FTY720 supports CXCR4-dependent migration and bone marrow homing of human CD34+ progenitor cells. Blood 103: 4478-4486 [Abstract] [Full Text]
Kawada, K., Sonoshita, M., Sakashita, H., Takabayashi, A., Yamaoka, Y., Manabe, T., Inaba, K., Minato, N., Oshima, M., Taketo, M. M. (2004). Pivotal Role of CXCR3 in Melanoma Cell Metastasis to Lymph Nodes. Cancer Res. 64: 4010-4017 [Abstract] [Full Text]
Lee, B.-C., Lee, T.-H., Avraham, S., Avraham, H. K. (2004). Involvement of the Chemokine Receptor CXCR4 and Its Ligand Stromal Cell-Derived Factor 1{alpha} in Breast Cancer Cell Migration Through Human Brain Microvascular Endothelial Cells. Mol Cancer Res 2: 327-338 [Abstract] [Full Text]
Lenoir, M., Djerdjouri, B., Perianin, A. (2004). Stroma Cell-Derived Factor 1{alpha} Mediates Desensitization of Human Neutrophil Respiratory Burst in Synovial Fluid from Rheumatoid Arthritic Patients. J. Immunol. 172: 7136-7143 [Abstract] [Full Text]
Brainard, D. M., Tharp, W. G., Granado, E., Miller, N., Trocha, A. K., Ren, X.-H., Conrad, B., Terwilliger, E. F., Wyatt, R., Walker, B. D., Poznansky, M. C. (2004). Migration of Antigen-Specific T Cells Away from CXCR4-Binding Human Immunodeficiency Virus Type 1 gp120. J. Virol. 78: 5184-5193 [Abstract] [Full Text]
Evans, C. A., Tonge, R., Blinco, D., Pierce, A., Shaw, J., Lu, Y., Hamzah, H. G., Gray, A., Downes, C. P., Gaskell, S. J., Spooncer, E., Whetton, A. D. (2004). Comparative proteomics of primitive hematopoietic cell populations reveals differences in expression of proteins regulating motility. Blood 103: 3751-3759 [Abstract] [Full Text]