A mutated HLA-A2 molecule recognized by autologous cytotoxic T lymphocytes on a human renal cell carcinoma

doi:10.1084/jem.183.6.2501

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A mutated HLA-A2 molecule recognized by autologous cytotoxic T lymphocytes on a human renal cell carcinoma

D Brandle, F Brasseur, P Weynants, T Boon and B Van den Eynde
Ludwig Institute for Cancer Research, Universite Catholique de Louvain, Brussels, Belgium.

Many human tumor cells have been shown to express antigens that are recognized by autologous cytotoxic T lymphocytes (CTL) and the molecular nature of a number of melanoma antigens has been defined recently. Here we describe the characterization of an antigen recognized on a renal cell carcinoma by autologous CTL clones. This antigen is encoded by the HLA-A2 gene present in the tumor cells. The sequence of this gene differs from the HLA-A2 sequence found in autologous peripheral blood lymphocytes by a point mutation that results in an arginine to isoleucine exchange at residue 170, which is located on the alpha-helix of the alpha 2 domain. Transfection experiments with the normal and mutated HLA-A2 cDNA demonstrated that this amino acid replacement was responsible for the recognition of the HLA-A2 molecule expressed on the tumor cells. The mutant HLA-A2 gene was also detected in the original tumor tissue from the patient, excluding the possibility that the mutation had appeared in vitro. Thus, HLA class I molecules carrying a tumor-specific mutation can be involved in the recognition of tumor cells by autologous CTL.
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Kausche, S., Wehler, T., Schnurer, E., Lennerz, V., Brenner, W., Melchior, S., Grone, M., Nonn, M., Strand, S., Meyer, R., Ranieri, E., Huber, C., Falk, C. S., Herr, W. (2006). Superior Antitumor In vitro Responses of Allogeneic Matched Sibling Compared with Autologous Patient CD8+ T Cells. Cancer Res. 66: 11447-11454 [Abstract] [Full Text]
Sensi, M., Anichini, A. (2006). Unique Tumor Antigens: Evidence for Immune Control of Genome Integrity and Immunogenic Targets for T Cell-Mediated Patient-Specific Immunotherapy. Clin. Cancer Res. 12: 5023-5032 [Abstract] [Full Text]
Tassi, E., Facchinetti, V., Seresini, S., Borri, A., Dell'Antonio, G., Garavaglia, C., Casorati, G., Protti, M. P. (2006). Peptidome from Renal Cell Carcinoma Contains Antigens Recognized by CD4+ T Cells and Shared among Tumors of Different Histology.. Clin. Cancer Res. 12: 4949-4957 [Abstract] [Full Text]
Frey, A. B., Monu, N. (2006). Effector-phase tolerance: another mechanism of how cancer escapes antitumor immune response. J. Leukoc. Biol. 79: 652-662 [Abstract] [Full Text]
Zhou, X., Jun, D. Y., Thomas, A. M., Huang, X., Huang, L.-Q., Mautner, J., Mo, W., Robbins, P. F., Pardoll, D. M., Jaffee, E. M. (2005). Diverse CD8+ T-Cell Responses to Renal Cell Carcinoma Antigens in Patients Treated with an Autologous Granulocyte-Macrophage Colony-Stimulating Factor Gene-Transduced Renal Tumor Cell Vaccine. Cancer Res. 65: 1079-1088 [Abstract] [Full Text]
Tykodi, S. S., Warren, E. H., Thompson, J. A., Riddell, S. R., Childs, R. W., Otterud, B. E., Leppert, M. F., Storb, R., Sandmaier, B. M. (2004). Allogeneic Hematopoietic Cell Transplantation for Metastatic Renal Cell Carcinoma after Nonmyeloablative Conditioning: Toxicity, Clinical Response, and Immunological Response to Minor Histocompatibility Antigens. Clin. Cancer Res. 10: 7799-7811 [Abstract] [Full Text]
Huang, J., El-Gamil, M., Dudley, M. E., Li, Y. F., Rosenberg, S. A., Robbins, P. F. (2004). T Cells Associated with Tumor Regression Recognize Frameshifted Products of the CDKN2A Tumor Suppressor Gene Locus and a Mutated HLA Class I Gene Product. J. Immunol. 172: 6057-6064 [Abstract] [Full Text]
Grube, M., Rezvani, K., Wiestner, A., Fujiwara, H., Sconocchia, G., Melenhorst, J. J., Hensel, N., Marti, G. E., Kwak, L. W., Wilson, W., Barrett, J. A. (2004). Autoreactive, Cytotoxic T Lymphocytes Specific for Peptides Derived from Normal B-Cell Differentiation Antigens in Healthy Individuals and Patients with B-Cell Malignancies. Clin. Cancer Res. 10: 1047-1056 [Abstract] [Full Text]
Sarma, S., Bai, X.-F., Liu, J.-q., May, K. F. Jr., Zheng, P., Liu, Y. (2003). On the Role of Unmutated Antigens in Tumor Rejection in Mice with Unperturbed T-cell Repertoires. Cancer Res. 63: 6051-6055 [Abstract] [Full Text]
Hernandez, J. M., Bui, M. H. T., Han, K.-r., Mukouyama, H., Freitas, D. G., Nguyen, D., Caliliw, R., Shintaku, P. I., Paik, S. H., Tso, C.-L., Figlin, R. A., Belldegrun, A. S. (2003). Novel Kidney Cancer Immunotherapy Based on the Granulocyte- Macrophage Colony-stimulating Factor and Carbonic Anhydrase IX Fusion Gene. Clin. Cancer Res. 9: 1906-1916 [Abstract] [Full Text]
Tso, C.-L., Zisman, A., Pantuck, A., Calilliw, R., Hernandez, J. M., Paik, S., Nguyen, D., Gitlitz, B., Shintaku, P. I., de Kernion, J., Figlin, R., Belldegrun, A. (2001). Induction of G250-targeted and T-Cell-mediated Antitumor Activity against Renal Cell Carcinoma Using a Chimeric Fusion Protein Consisting of G250 and Granulocyte/Monocyte-Colony Stimulating Factor. Cancer Res. 61: 7925-7933 [Abstract] [Full Text]
Hanada, K.-i., Perry-Lalley, D. M., Ohnmacht, G. A., Bettinotti, M. P., Yang, J. C. (2001). Identification of Fibroblast Growth Factor-5 as an Overexpressed Antigen in Multiple Human Adenocarcinomas. Cancer Res. 61: 5511-5516 [Abstract] [Full Text]
Menetrier-Caux, C., Thomachot, M. C., Alberti, L., Montmain, G., Blay, J. Y. (2001). IL-4 Prevents the Blockade of Dendritic Cell Differentiation Induced by Tumor Cells. Cancer Res. 61: 3096-3104 [Abstract] [Full Text]
Ito, M., Shichijo, S., Tsuda, N., Ochi, M., Harashima, N., Saito, N., Itoh, K. (2001). Molecular Basis of T Cell-mediated Recognition of Pancreatic Cancer Cells. Cancer Res. 61: 2038-2046 [Abstract] [Full Text]
Martelange, V., De Smet, C., De Plaen, E., Lurquin, C., Boon, T. (2000). Identification on a Human Sarcoma of Two New Genes with Tumor-specific Expression. Cancer Res. 60: 3848-3855 [Abstract] [Full Text]
Guerra, N., Guillard, M., Angevin, E., Echchakir, H., Escudier, B., Moretta, A., Chouaib, S., Caignard, A. (2000). Killer inhibitory receptor (CD158b) modulates the lytic activity of tumor-specific T lymphocytes infiltrating renal cell carcinomas. Blood 95: 2883-2889 [Abstract] [Full Text]
Van den Eynde, B. J., Gaugler, B., Probst-Kepper, M., Michaux, L., Devuyst, O., Lorge, F., Weynants, P., Boon, T. (1999). A New Antigen Recognized by Cytolytic T Lymphocytes on a Human Kidney Tumor Results from Reverse Strand Transcription. JEM 190: 1793-1800 [Abstract] [Full Text]
Vissers, J. L. M., De Vries, I. J. M., Schreurs, M. W. J., Engelen, L. P. H., Oosterwijk, E., Figdor, C. G., Adema, G. J. (1999). The Renal Cell Carcinoma-associated Antigen G250 Encodes a Human Leukocyte Antigen (HLA)-A2.1-restricted Epitope Recognized by Cytotoxic T Lymphocytes. Cancer Res. 59: 5554-5559 [Abstract] [Full Text]
Koopman, L. A., van der Slik, A. R., Giphart, M. J., Fleuren, G. J. (1999). Human Leukocyte Antigen Class I Gene Mutations in Cervical Cancer. JNCI J Natl Cancer Inst 91: 1669-1677 [Abstract] [Full Text]
Rini, B. I., Selk, L. M., Vogelzang, N. J. (1999). Phase I Study of Direct Intralesional Gene Transfer of HLA-B7 into Metastatic Renal Carcinoma Lesions. Clin. Cancer Res. 5: 2766-2772 [Abstract] [Full Text]
Bateman, A C, Turner, S J, Theaker, J M, Warren, B F, Howell, W M (1999). Polymerase chain reaction based human leucocyte antigen genotyping for the investigation of suspected gastrointestinal biopsy contamination. Gut 45: 259-263 [Abstract] [Full Text]
Yang, D., Nakao, M., Shichijo, S., Sasatomi, T., Takasu, H., Matsumoto, H., Mori, K., Hayashi, A., Yamana, H., Shirouzu, K., Itoh, K. (1999). Identification of a Gene Coding for a Protein Possessing Shared Tumor Epitopes Capable of Inducing HLA-A24-restricted Cytotoxic T Lymphocytes inCancer Patients. Cancer Res. 59: 4056-4063 [Abstract] [Full Text]
Ronsin, C., Chung-Scott, V., Poullion, I., Aknouche, N., Gaudin, C., Triebel, F. (1999). A Non-AUG-Defined Alternative Open Reading Frame of the Intestinal Carboxyl Esterase mRNA Generates an Epitope Recognized by Renal Cell Carcinoma-Reactive Tumor-Infiltrating Lymphocytes In Situ. J. Immunol. 163: 483-490 [Abstract] [Full Text]
Clay, T. M., Custer, M. C., Sachs, J., Hwu, P., Rosenberg, S. A., Nishimura, M. I. (1999). Efficient Transfer of a Tumor Antigen-Reactive TCR to Human Peripheral Blood Lymphocytes Confers Anti-Tumor Reactivity. J. Immunol. 163: 507-513 [Abstract] [Full Text]
Li, Q., Furman, S. A., Bradford, C. R., Chang, A. E. (1999). Expanded Tumor-reactive CD4+ T-Cell Responses to Human Cancers Induced by Secondary Anti-CD3/Anti-CD28 Activation. Clin. Cancer Res. 5: 461-469 [Abstract] [Full Text]
Gaudin, C., Kremer, F., Angevin, E., Scott, V., Triebel, F. (1999). A hsp70-2 Mutation Recognized by CTL on a Human Renal Cell Carcinoma. J. Immunol. 162: 1730-1738 [Abstract] [Full Text]
Menetrier-Caux, C., Montmain, G., Dieu, M.C., Bain, C., Favrot, M.C., Caux, C., Blay, J.Y. (1998). Inhibition of the Differentiation of Dendritic Cells From CD34+ Progenitors by Tumor Cells: Role of Interleukin-6 and Macrophage Colony-Stimulating Factor. Blood 92: 4778-4791 [Abstract] [Full Text]
Gueguen, M., Patard, J.-J., Gaugler, B., Brasseur, F., Renauld, J.-C., Van Cangh, P. J., Boon, T., Van den Eynde, B. J. (1998). An Antigen Recognized by Autologous CTLs on a Human Bladder Carcinoma. J. Immunol. 160: 6188-6194 [Abstract] [Full Text]
Mandruzzato, S., Brasseur, F., Andry, G., Boon, T., Bruggen, P. v. d. (1997). A CASP-8 Mutation Recognized by Cytolytic T Lymphocytes on a Human Head and Neck Carcinoma. JEM 186: 785-793 [Abstract] [Full Text]
Dubey, P., Hendrickson, R. C., Meredith, S. C., Siegel, C. T., Shabanowitz, J., Skipper, J. C.A., Engelhard, V. H., Hunt, D. F., Schreiber, H. (1997). The Immunodominant Antigen of an Ultraviolet-induced Regressor Tumor Is Generated by a Somatic Point Mutation in the DEAD Box Helicase p68. JEM 185: 695-706 [Abstract] [Full Text]